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Randomized Trial of Safety of Isoniazid Preventive Therapy During or After Pregnancy

Post Date:

2018-03-07

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Clinical Sites:

Gupta A, Montepiedra G, Aaron L, Theron G, McCarthy K, Onyango-Makumbi C, Chipate T, Masheto G, Shin K, Zimmer B, Sterling TR, Chakhtoura N, Jean-Philippe P, Weinberg A for the IMPAACT P1078/TB APPRISE Study Team. Randomized Trial of Safety of Isoniazid Preventive Therapy During or After Pregnancy...

GLP-1 and C-Peptide are Associated with Insulin Resistance among PLWH in India

Post Date:

2018-03-07

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Countries:

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Clinical Sites:

Marbaniang I, Sangle S, Kadam D, Kulkarni V, Shere D, Gupte N, Gupta A, Mave V. GLP-1 and C-Peptide are Associated with Insulin Resistance among PLWH in India. CROI 2018. Boston, MA. 2018

Inflammation in HIV-Infected Pregnant Women is Associated with Pre-term Birth

Post Date:

2018-03-07

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Countries:

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Clinical Sites:

Shivakoti R , Gupte N, Kumar NP, Kulkarni V, Balasubramanian U, Bhosale R, Sambarey P, Kinikar A, Bharadwaj R, Patil S, Inamdar S, Suryavanshi N, Babu S, Bollinger R, Gupta A. Inflammation in HIV-Infected Pregnant Women is Associated with Pre-term Birth. CROI 2018. Boston, MA. 2018

One Month of Rifapentine/Isoniazid to Prevent TB In People With HIV: Brief-TB/A5279

Post Date:

2018-03-05

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Countries:

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Clinical Sites:

Swindells S, Ramchandani R, Gupta A, Benson CA, Leon-Cruz JT, Omoz-Oarhe A, Juste MAJ, Lama JR, Valencia JA, Badal-Faesen S, Moran LE, Fletcher CV, Nuermberger E, Chaisson RE. One Month of Rifapentine/Isoniazid to Prevent TB In People With HIV: Brief-TB/A5279. CROI 2018. Boston, MA. 2018

Clinical Profile of Tuberculous Meningitis in a Tertiary Care Center in India. 5th Global Forum on TB Vaccines. New Delhi, India

Post Date:

2018-02-21

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Clinical Sites:

Basavaraj A. Clinical Profile of Tuberculous Meningitis in a Tertiary Care Center in India. Poster presented at 5th Global Forum on TB Vaccines. New Delhi, India. February 20-23, 2018.

Infection Free “Resistors” among Household Contacts of Culture-Confirmed Adult Pulmonary TB Cases

Post Date:

2018-02-21

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Countries:

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Clinical Sites:

Hinduja Hospital

Mave V , Chandrasekaran P, Paradkar M, Gupte A, Pradhan N, Kannan GN, Shivakumar SVBY, Kulkarni V, Dhanasekaran K, Subramanyam B, Selvaraju S, Murali L, Bharadwaj R, Gaikwad S, Meshram S, Kinikar A, Hanna LE, Swaminathan S, Gupte N, Gupta A. Infection Free “Resistors” among Household Contacts of...

TB Infection Among Household Contacts: Preventive Therapy for All?

Post Date:

2018-02-21

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Countries:

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Clinical Sites:

Dolla CK, Paradkar M, Gupte A, Thiruvenkadam K, Gupte N, Kulkarni A, Balasubranian U, Hanna LE, Dhanasekaran K, Bharadwaj R, Shivakumar SVBY, Gaikwad S, Meshram S, Kohli R, Lokhande R, Thomas B, Kinikar A, Swaminathan S, Mave V, Gupta A, Chandrasekaran P. TB Infection Among Household Contacts:...

Incidence of Mycobacterium tuberculosis Infection among Household Contacts of Adult Pulmonary Tuberculosis Cases in India

Post Date:

2018-02-20

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Countries:

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Clinical Sites:

Selvaraju S, Thiruvenkadam K, Paradkar M , Marinaik SB, Bharadwaj R, Rajagopalan S, Gaikwad S, Pattabiraman S, Kinikar A, Sivaramakrishnan GN, Meshram S, Hanna LE, Lokhande R, Dhanasekaran K, Gupte A, John S, Gupte N, Thomas B, Kukarni V, Ayyanu S, Kohli R, Shivakumar SVBY, Swaminathan S, Mave V,...

Drug Susceptibility of Rifampin-resistant Tuberculosis using Whole Genome Sequencing to Identify Genes of Interest in Pune, India

Post Date:

2018-02-15

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Countries:

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Clinical Sites:

Hinduja Hospital

Tornheim JA, Madugundu AK, Pradhan N, Bharadwaj R, Mave V, Golub J, Pandey A, Gupta A. Drug Susceptibility of Rifampin-resistant Tuberculosis using Whole Genome Sequencing to Identify Genes of Interest in Pune, India. RePORT India Annual Meeting. New Delhi, India.

The Effect of HIV on the Immune Response to Myobacterium tuberculosis in Pregnant Women from Pune, India.

Post Date:

2018-02-15

Mathad J, Alexander M, Bhosale R, Naik S, Suryavanshi N, Mave V, Deshpande P, Balasubramanian U, Kulkarni V, Kumar P, Babu S, Gupte N, Nevrekar N, Patil S, Chandanwale A, Gupta A. The Effect of HIV on the Immune Response to Myobacterium tuberculosis in Pregnant Women from Pune, India. RePORT India...

Incidence of Mycobacterium tuberculosis Infection among Household Contacts of Adult Pulmonary Tuberculosis Cases in India

Post Date:

2018-02-15

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Countries:

Paradkar M, Dhanasekaran K, Kinikar A, Kulkarni R, Bharadwaj R, Gaikwad S, Lokhande R, Meshram S, Dolla CK, Selvaraju S, Murali L, Thiruvengadam K, Jain D, Rajagopal S, Kulkarni V, Pradhan N, John S, Kohli R, Nayagam R, Shivakumar SVBY, Suryavanshi N, Cox SR, Gupte A, Chandrasekaran P, Mave V,...

Poor Understanding of TB Infection among At-risk Tuberculin Skin-test Positive Household Contacts of Pulmonary TB Cases in Pune, India

Post Date:

2018-02-15

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Countries:

Dhumal G, DeLuca A, Paradkar M, Suryavanshi N, Mave V, Kohli R, Shivakumar SVBY, Kadam D, Gupta A. Poor Understanding of TB Infection among At-risk Tuberculin Skin-test Positive Household Contacts of Pulmonary TB Cases in Pune, India. RePORT India Annual Meeting. New Delhi, India.

Linezolid Experience Among MDR-TB Patients in Mumbai

Post Date:

2018-02-15

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Countries:

Tornheim JA, Ganatra S, Deluca A, Banka R, Rodrigues C, Gupta A, Udwadia ZF. Linezolid Experience Among MDR-TB Patients in Mumbai. RePORT India Annual Meeting. New Delhi, India.

Risk Factors Associated with Unfavorable Outcomes in a Cohort of Pulmonary TB Patients

Post Date:

2018-02-15

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Countries:

Dhanasekaran K , Chandrasekaran P, Paradkar M, Marinaik SB, Gupte A, Dolla CK, Joseph B, Subramanyam B, Sivaramakrishnan GR, Thiruvengadam K, Gupte N, Rajagopal S, Pradhan N, Selvaraju S, Kulkarni V, Hannah LE, Nayakam R, Suryavanshi N, Shivakumar SVBY, Mave V, Thomas B, Bharadwaj R, Gaikwad S,...

Hyperhomocysteinemia Screening: A Missed Opportunity to Mitigate CVD Risk among Asian Indian HIV-infected Adults?

Post Date:

2017-12-28

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Countries:

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Clinical Sites:

Marbaniang I , Sangle S, Kulkarni V, Deshpande P, Shere D, Gupte N, Gupta A, Mave V. Hyperhomocysteinemia Screening: A Missed Opportunity to Mitigate CVD Risk among Asian Indian HIV-infected Adults? AAPI Global Health Summit. American Association of Physicians of Indian Origin. Kolkata, India.

Leveraging Collective Impact to Promote India's Development: The Role of the Indian Diaspora in the Fight Against Tuberculosis

Post Date:

2017-11-09

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Countries:

Gupta, A. Leveraging Collective Impact to Promote India's Development: The Role of the Indian Diaspora in the Fight Against Tuberculosis. Roundtable Event. USAID, American India Foundation, Dasra, Indiaspora, Intellecap. Georgetown University, Washington, DC.

Delays and Barriers to Early Treatment Initiation for Childhood Tuberculosis in India

Post Date:

2017-10-13

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Clinical Sites:

Valvi C , Chandanwale A, Khadse A, Kulkarni R, Kadam D, Dhumal G, Bollinger RC, Deluca A. Delays and Barriers to Early Treatment Initiation for Childhood Tuberculosis in India. 48th Annual Union World Conference of Lung Health. Guadalajara, Mexico. October 13, 2017.

Accessing MDR-TB Exposed Households: the PHOENiX MDR-TB Feasibility Study

Post Date:

2017-10-13

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Clinical Sites:

Gupta A. Accessing MDR-TB Exposed Households: the PHOENiX MDR-TB Feasibility Study. 48th Annual Union World Conference of Lung Health. Guadalajara, Mexico.

Meet the Expert: Managing Tuberculosis in Pregnant Women and Newborns

Post Date:

2017-10-13

Gupta A. Meet the Expert: Managing Tuberculosis in Pregnant Women and Newborns. 48th Annual Union World Conference of Lung Health. Guadalajara, Mexico.

High Burden of Genital TB Among Women with Infertility in India - Need for an Intensified Approach

Post Date:

2017-10-13

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Clinical Sites:

Naik SN , Chandanwale A, Joshi S, Mave V, Dhumal G, DeLuca A, Gupta A, Bollinger R. High Burden of Genital TB Among Women with Infertility in India - Need for an Intensified Approach. 48th Annual Union World Conference of Lung Health. Guadalajara, Mexico. October 13, 2017.

Pages

Community-based health

Disease diagnosis

Drug resistance

Healthcare access and retention

MDR-TB

mHealth

Patient treatment adherence

Chronic disease

Diabetes

Nutrition

HIV

Maternal and child health

Environmental pollutants

Pediatrics

Antiretroviral therapy

Fever

Healthcare worker safety

Medical training

Pregnancy

Research training

Microbiome

Other

Social and behavioral research

Education: Distance

Education: Online

Cancer

Genomics

Sexually transmitted infections (non-HIV)

Depression

Stigma

Transcriptomics

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25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date:

2014-07-15

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Countries:

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Clinical Sites:

Publication:

The Journal of Infectious Diseases

Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods...

Socioeconomic determinants of mortality in HIV: evidence from a clinical cohort in Uganda

Post Date:

2014-05-15

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Countries:

Publication:

Journal of Acquired Immune Deficiency Syndromes

Objective: To delineate the association between baseline socioeconomic status (SES) indicators and mortality and lost to follow-up (LTFU) in a cohort of HIV-infected individuals enrolled in antiretroviral therapy (ART) in urban Uganda. Design: Retrospective...

Barriers and delays in tuberculosis diagnosis and treatment services: does gender matter

Post Date:

2014-04-28

Publication:

Tuberculosis Research and Treatment

Background: Tuberculosis (TB) remains a global public health problem with known gender-related disparities. We reviewed the quantitative evidence for gender-related differences in accessing TB services from symptom onset to treatment initiation. Methods: Following a...

Change in Vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

Post Date:

2014-04-21

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Countries:

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Clinical Sites:

Publication:

PLOS One

Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D...

The evolving role of advocacy in tuberculosis

Post Date:

2014-04-02

Publication:

The Lancet Respiratory Medicine

Tuberculosis advocacy has changed the disease from a silent epidemic to one with many voices that seek increased political will and investment in research.1 Tuberculosis advocacy has gained strength as a mechanism to improve research, increase access to new methods to fight tuberculosis, and...

Peer Health Workers and AIDS Care in Rakai, Uganda: A mixed methods operations research evaluation of a cluster-randomized trial

Post Date:

2011-12-15

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Countries:

Publication:

AIDS Patient Care and STDs

Settings with limited health care workers are challenging environments for delivery of antiretroviral therapy. One strategy to address this human resource crisis is to task shift through training selected patients as peer health workers (PHWs) to provide care to other individuals receiving...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

Post Date:

2014-03-21

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Countries:

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Clinical Sites:

Publication:

PLOS One

Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Biomarkers for sepsis: a review with special attention to India

Post Date:

2014-03-19

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Countries:

Publication:

BioMed Research International

Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date:

2014-03-14

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Countries:

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Clinical Sites:

Publication:

Vaccine

Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental...

Field evaluation of PIMA point-of-care CD4 testing in Rakai, Uganda

Post Date:

2014-03-10

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Countries:

Publication:

PLOS One

Objective: To assess the accuracy of PIMA Point-of-Care (POC) CD4 testing in rural Rakai, Uganda. Methods: 903 HIV positive persons attending field clinics provided a venous blood sample assessed on site using PIMA analyzers per manufacturer's specifications. The...

The role of viral introductions in sustaining community-based HIV epidemics in rural Uganda: evidence from spatial clustering, phylogenics, and egocentric transmission models

Post Date:

2014-03-04

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Countries:

Publication:

PLOS One

Background: It is often assumed that local sexual networks play a dominant role in HIV spread in sub-Saharan Africa. The aim of this study was to determine the extent to which continued HIV transmission in rural communities—home to two-thirds of the African population—is driven by intra-...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

Post Date:

2014-02-15

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Countries:

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Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged...

Challenges to disclosure of HIV status to perinatally infected children: a study of caregiver perspectives in Pune, India

Post Date:

2014-06-15

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Countries:

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Clinical Sites:

Publication:

Journal of Pediatric Infectious Diseases

Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

Post Date:

2014-07-15

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Countries:

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Clinical Sites:

Publication:

HIV Medicine

Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its...

Mortality and long-term virologic outcomes in children and infants treated with lopinavir/ritonavir

Post Date:

2013-12-15

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Countries:

Publication:

Pediatric Infectious Disease Journal

Background: There is scant data on young children receiving protease inhibitor-based therapy in real-life resource-limited settings and on the optimal timing of therapy among children who survive infancy. Our aim was to evaluate outcomes at the Hospital del Niño, Panama, where children have...

Pediatric tuberculosis in young children in India: a prospective study

Post Date:

2013-11-11

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Countries:

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Clinical Sites:

Publication:

BioMed Research International

Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with...

The Exposure Assessment in current time (EXACT) study: implementation, feasibility and acceptability of real-time data collection in a community cohort of illicit drug users

Post Date:

2013-11-06

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Countries:

Publication:

AIDS Research and Treatment

Objective: We describe the study design and evaluate the implementation, feasibility, and acceptability of an ecological momentary assessment (EMA) study of illicit drug users. Design. Four sequential field trials targeting observation of 30 individuals followed for a four week period...

Leveraging information technology to address the health workforce gap

Post Date:

2013-11-01

Publication:

Bulletin of the World Health Organization

According to some estimates, the world needs more than 4 million additional physicians, nurses, pharmacists, laboratory technicians, midwives, community health workers (CHWs) and other front-line health workers. However, there is also a shortage of faculty that can provide high-quality...

HIV/AIDS education in traditional Indian systems of medicine: faculty perspectives

Post Date:

2013-10-24

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Countries:

Publication:

Journal of Traditional Medicine and and Clinical Naturopathy

In India, HIV-infected individuals face numerous challenges in their search for treatments. Currently, western allopathic medicine (hereinafter ‘biomedicine’) offers antiretroviral therapy (ART) for HIV/AIDS and associated co-morbidities that have prolonged survival and improved quality of...

India’s new policy to protect research participants

Post Date:

2013-07-31

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Countries:

Publication:

The BMJ

Editorial Introduction: India, the country with the largest disease burden in the world,1 is now a major international hub for clinical research. However, a recent policy that was meant to mitigate important ethical concerns may have profound and unintended consequences for public health and...

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