Publications

Intensified short symptom screening program for Dengue infection during pregnancy, India

Post Date: 
2020-04-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Emerging Infectious Diseases
Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India and pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in India to diagnose dengue during pregnancy. During October 2017-January 2018, we screened pregnant...

Once-weekly Rifapentine and Isoniazid for Tuberculosis Prevention in Patients With HIV Taking Dolutegravir-Based Antiretroviral Therapy: A Phase 1/2 Trial

Post Date: 
2020-03-30
Publication: 
Lancet HIV
Short-course preventive therapy with 12 doses of once-weekly rifapentine (900 mg) plus isoniazid (900 mg) could greatly improve tuberculosis control, especially in areas with high co-endemicity with HIV.

Undocumented U.S. Immigrants and Covid-19

Post Date: 
2020-03-27
   |   
Countries: 
United States
Publication: 
New England Journal of Medicine
NEJM: Kathleen Page and colleagues outline COVID-19 hardships faced by undocumented immigrants and strategies needed to ensure they have access to care.

Venezuela’s health care crisis now poses a global threat

Post Date: 
2020-03-26
   |   
Countries: 
Venezuela
Publication: 
Foreign Policy
Foreign Policy: Dr. Kathleen Page argues that Venezuela's weak healthcare infrastructure leaves its people defenseless and presents a serious threat to global health, and she advocates for the global community to act now.

Randomized trial of online, interactive decision-support versus guidelines for HIV treatment selection by trainees

Post Date: 
2020-03-25
Publication: 
Clinical Infectious Diseases
CID: Trainees using HIV-ASSIST were significantly more likely to choose appropriate ART regimens compared to those using guidelines alone.

TB prevention strategies and unanswered questions for pregnant and postpartum women living with HIV: the need for improved evidence

Post Date: 
2020-03-23
Publication: 
Journal of the International AIDS Society
World TB Day viewpoint on the need for more data about TB treatment for pregnant and postpartum women in J Int AIDS Soc by Drs. Jyoti Mathad and Amita Gupta.

HIV, Pregnancy, and Isoniazid Preventive Therapy. Reply

Post Date: 
2020-03-19
   |   
Countries: 
India
Publication: 
The New England Journal of Medicine
Gupta et al. (Oct. 3 issue)1 report a higher incidence of adverse pregnancy outcomes among women with human immunodeficiency virus (HIV) infection who were exposed to isoniazid preventive therapy (IPT) during the second and third trimesters than among those not exposed to IPT during pregnancy. From...

Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda

Post Date: 
2020-03-17
   |   
Countries: 
Uganda
Publication: 
The Lancet HIV
BACKGROUND: International and global organisations advocate targeting interventions to areas of high HIV prevalence (ie, hotspots). To better understand the potential benefits of geo-targeted control, we assessed the extent to which HIV hotspots along Lake Victoria sustain transmission in...

Hepatotoxicity and Liver-Related Mortality in Women of Child-Bearing Potential Living With HIV and High CD4 Counts Initiating Efavirenz-Containing Regimens

Post Date: 
2020-03-12
Publication: 
Clinical Infectious Diseases
Background: Severe hepatotoxicity in people with HIV receiving efavirenz (EFV) has been reported. We assessed the incidence and risk factors of hepatotoxicity in women of child-bearing age initiating EFV-containing regimens. Methods: In the PROMISE trial, ART-naïve pregnant women with HIV and CD4...

Tuberculosis in children, adolescents, and women

Post Date: 
2020-02-27
Publication: 
Lancet Respiratory Medicine
In this Lancet Respiratory Medicine commentary, Dr. Amita Gupta and colleagues note that TB prevalence among children, adolescents, and women isn't well documented. This poses big challenges for the goal of TB elimination.

Migration, hotspots, and dispersal of HIV infection in Rakai, Uganda

Post Date: 
2020-02-20
   |   
Countries: 
Uganda
Publication: 
Nature Communications
Abstract HIV prevalence varies markedly throughout Africa, and it is often presumed areas of higher HIV prevalence (i.e., hotspots) serve as sources of infection to neighboring areas of lower prevalence. However, the small-scale geography of migration networks and movement of HIV-...

Whole genome enrichment approach for rapid detection of Mycobacterium tuberculosis and drug resistance-associated mutations from direct sputum sequencing

Post Date: 
2020-02-20
Publication: 
Tuberculosis
Tuberculosis is the leading cause of death among infectious diseases worldwide. Detection of Mycobacterium tuberculosis (Mtb), using routine culture-based methods is time consuming resulting in delayed diagnosis and poor treatment outcomes. Currently available molecular tests provide faster...

High prevalence of late presentation of ART-naïve perinatally infected children for care in Pune, India

Post Date: 
2020-02-19
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
AIDS Care
AIDS Care : There is an urgent need to identify strategies that improve linkage of perinatally infected ART-naïve children to care, and earlier than what is currently observed.

Compliance of private pharmacies in Uganda with controlled prescription drugs regulations: A mixed-methods study

Post Date: 
2020-02-08
   |   
Countries: 
Uganda
Publication: 
Substance Abuse Treatment, Prevention, and Policy
Background: Controlled prescription drug use disorders are a growing global health challenge in Sub-Saharan Africa. Effective supply chain regulations on dispensing and stock control are important for controlling this epidemic. Since compliance with these regulations in resource-limited countries...

Applying a risk-benefit analysis to outcomes in tuberculosis clinical trials

Post Date: 
2020-02-03
Publication: 
Clinical Infectious Diseases
CID: Analyzing efficacy and safety separately in clinical trials could yield misleading study conclusions if there's an increase in efficacy and a decrease in safety

Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda

Post Date: 
2020-01-14
   |   
Countries: 
Uganda
Publication: 
Lancet HIV
Background: International and global organisations advocate targeting interventions to areas of high HIV prevalence (ie, hotspots). To better understand the potential benefits of geo-targeted control, we assessed the extent to which HIV hotspots along Lake Victoria sustain transmission in...

Assessment of the Xpert assay among new pulmonary tuberculosis suspects with and without diabetes mellitus

Post Date: 
2020-01-01
   |   
Clinical Sites: 
BJGMC
Publication: 
International Journal of Tuberculosis and Lung Disease
IJTLD: Deshmukh and colleagues: High sensitivity and specificity of Xpert underscores need for rapid scale up for early detection of TB in settings with a high dual burden of TB and DM

Diagnostic Accuracy of a Novel and Rapid Lipoarabinomannan Test for Diagnosing Tuberculosis Among People With Human Immunodeficiency Virus

Post Date: 
2019-12-21
Publication: 
Open Forum Infectious Diseases
Background: The novel Fujifilm SILVAMP TB-LAM (FujiLAM) assay detects mycobacterial lipoarabinomannan in urine and has demonstrated superior sensitivity to the Alere Determine TB-LAM Ag (AlereLAM) assay for detection of tuberculosis among hospitalized people with human immunodeficiency virus (PWH...

Addressing the global burden of hepatitis B virus while developing long-acting injectables for the prevention and treatment of HIV

Post Date: 
2019-12-20
Publication: 
Lancet HIV
Lancet HIV: Dr. Bob Bollinger and colleagues discuss the urgent need and opportunity to include activity against Hepatitis B in formulations of long-acting drugs for HIV prevention and treatment

Transcriptomic profiles of confirmed pediatric tuberculosis patients and household contacts identifies active tuberculosis, infection, and treatment response among Indian children

Post Date: 
2019-12-04
   |   
Clinical Sites: 
BJGMC
NIRT
Publication: 
Journal of Infectious Diseases
Journal of Infectious Diseases: Gene expression profiles among Indian children with confirmed TB were distinct from those of adults, highlighting the importance of including distinct populations in differential gene expression models

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