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Loss to follow‐up and mortality among HIV‐infected adolescents receiving antiretroviral therapy in Pune, India

Post Date:

2018-06-25

Countries:

India

Clinical Sites:

BJGMC

Publication:

HIV Medicine

Over 6 years, one-third of HIV+ adolescents in this study discontinued medical treatment, indicating a critical need for retention counselling and closer clinical monitoring.

Three years post-Affordable Care Act sexually transmitted disease clinics remain critical among vulnerable populations

Post Date:

2018-06-18

Publication:

American Journal of Preventive Medicine

INTRODUCTION: The purpose of the study is to examine whether demand for publicly funded sexually transmitted disease clinics changed after Affordable Care Act implementation. METHODS: The percentages of total incident sexually transmitted infections in Baltimore City that occurred at publicly...

Developing an assessment framework for essential internal medicine subspecialty topics

Post Date:

2018-06-15

Countries:

United States

Publication:

Journal of Graduate Medical Education

Our assessment framework revealed knowledge and practice gaps in tuberculosis diagnosis among internal medicine residents.

Effect of baseline micronutrient and inflammation status on CD4 recovery post-cART initiation in the multinational PEARLS trial

Post Date:

2018-05-29

Countries:

India

Publication:

Clinical Nutrition

Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation.

Sources of household air pollution and their association with fine particulate matter in low-income urban homes in India

Post Date:

2018-05-23

Countries:

India

Clinical Sites:

BJGMC

Publication:

Journal of Exposure Science and Environmental Epidemiology

INTRODUCTION: Household air pollution (HAP) is poorly characterized in low-income urban Indian communities. MATERIALS AND METHODS: A questionnaire assessing sources of HAP and 24 h household concentrations of particulate matter less than 2.5 microns in diameter (PM 2.5 ) were collected in a sample...

Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?

Post Date:

2018-05-22

Countries:

India

Clinical Sites:

BJGMC

Publication:

The International Journal of Tuberculosis and Lung Disease

Authors find that screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing tuberculosis and improve management of diabetes.

The global neurological burden of tuberculosis

Post Date:

2018-05-18

Publication:

Seminars in Neurology

Central nervous system (CNS) involvement of tuberculosis (TB) is the most severe manifestation of TB and accounts for approximately 5 to 10% of all extrapulmonary TB (EPTB) cases and approximately 1% of all TB cases. TB meningitis (TBM) is the most common form of CNS TB, though other forms occur,...

Group mentorship model to enhance the efficiency and productivity of PhD research training in Sub-Saharan Africa

Post Date:

2018-05-04

Countries:

Uganda

Publication:

Annals of Global Health

Annals of Global Health : Systems capacity building approach to PhD training allowed strong outputs at lower cost and with relatively few additional mentors to train independent scientists able to conduct original research and mentor others.

Addressing knowledge gaps and prevention for tuberculosis-infected Indian adults: a vital part of elimination

Post Date:

2018-05-02

Countries:

India

Clinical Sites:

BJGMC

Publication:

BMC Infectious Diseases

BMC Infectious Diseases : Our survey among TB patients' household contacts with evidence of recent exposure found that knowledge is poor and families are confused about disease transmission.

Hepatotoxicity during isoniazid preventive therapy and antiretroviral therapy in people living with HIV with severe immunosuppression: a secondary analysis of a multi-country open-label randomized controlled clinical trial

Post Date:

2018-05-01

Publication:

Journal of Acquired Immune Deficiency Syndromes

BACKGROUND: Hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) has not been well studied in severely immunosuppressed people with HIV. Our objective was to determine risk factors for hepatotoxicity in severely immunosuppressed individuals taking IPT...

MDR-TB in children: back to the basics

Post Date:

2018-05-01

Countries:

United States

Publication:

The International Journal of Tuberculosis and Lung Disease

IJTLD: Summary of the Pediatric Multidrug-Resistant Tuberculosis Clinical Trials Landscape Meeting: a primer of current directions.

Advancing patient-centered care in tuberculosis management: A mixed-methods appraisal of video directly observed therapy

Post Date:

2018-04-26

Countries:

United States

Publication:

Open Forum Infectious Diseases

BACKGROUND: Directly observed therapy (DOT) remains an integral component of treatment support and adherence monitoring in tuberculosis care. In-person DOT is resource intensive and often burdensome for patients. Video DOT (vDOT) has been proposed as an alternative to increase treatment flexibility...

Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial

Post Date:

2018-04-19

Countries:

India

Clinical Sites:

BJGMC

Publication:

Trials

Trials: Evidence for TB treatment in kids is largely based on adult studies. The SHINE study aims to fix this

Migration and risk of HIV acquisition in Rakai, Uganda: a population-based cohort study

Post Date:

2018-04-15

Countries:

Uganda

Publication:

Lancet HIV

BACKGROUND: In sub-Saharan Africa, migrants typically have higher HIV prevalence than non-migrants; however, whether HIV acquisition typically precedes or follows migration is unknown. We aimed to investigate the risk of HIV after migration in Rakai District, Uganda. METHODS: In a prospective...

Prevention of HIV-1 transmission through breastfeeding:efficacy of safety of maternal antiretroviral therapy versus infant nevirapine prophylaxis for duration of breastfeeding in HIV-1-infected women with high CD4 cell count (IMPAACT PROMISE)

Post Date:

2018-04-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

Journal of Acquired Immune Deficiency Syndromes

BACKGROUND: No randomized trial has directly compared the efficacy of prolonged infant antiretroviral prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child transmission throughout the breastfeeding period. SETTING: Fourteen sites in Sub-Saharan Africa and India...

HIV viral suppression and geospatial patterns of HIV antiretroviral therapy treatment facility use in Rakai, Uganda

Post Date:

2018-03-27

Countries:

Uganda

Publication:

AIDS

OBJECTIVE: To assess geospatial patterns of HIV antiretroviral therapy (ART) treatment facility use and whether they were impacted by viral load suppression. METHODS: We extracted data on the location and type of care services utilized by HIV-positive persons accessing ART between February 2015 and...

Screening and diagnosis of gestational diabetes in India: A systematic review and meta analysis

Post Date:

2018-03-26

Countries:

India

Publication:

Acta Diabetologica

Review article on prevalence and screening and diagnostic methods for gestational diabetes in India.

Vector-borne disease is a common cause of hospitalized febrile illness in India

Post Date:

2018-03-26

Clinical Sites:

BJGMC

Publication:

American Journal of Tropical Medicine and Hygiene

Diagnostic strategies adapted for season and age may reduce diagnostic uncertainty and identify causative organisms in treatable, fatal causes of AFI.

Pyrosequencing to resolve discrepant Xpert MTB/RIF and Mycobacterial Growth Indicator Tube 960

Post Date:

2018-03-26

Countries:

India

Clinical Sites:

Hinduja Hospital

Publication:

Lung India

Lung India: Indo-JHU researchers find that pyrosequencing can clear up discrepancies about drug resistance in TB.

Intestinal barrier dysfunction and microbial translocation in HIV-infected pregnant women is associated with preterm birth

Post Date:

2018-03-24

Countries:

India

Clinical Sites:

BJGMC

NIRT

Publication:

Clinical Infectious Diseases

Our results show select immune markers can identify women at higher risk for PTB in HIV-1-infected populations and suggest modulating gut barrier integrity and microbial translocation may affect PTB.