Publications

Performance characteristics of the Cepheid Xpert MTB/RIF test in a tuberculosis prevalence survey

Post Date: 
2012-08-15
Publication: 
PLoS One
Country: 
Background : Xpert MTB/RIF ("Xpert") is a molecular test for detection of Mycobacterium tuberculosis (MTB) in sputum. Performance characteristics have been established for its use during passive tuberculosis (TB) case detection in symptomatic TB suspects, but Xpert performance has not been assessed...

HIV testing behaviors among Latinos in Baltimore City

Post Date: 
2012-08-14
Publication: 
Journal of Immigrant and Minority Health
Country: 
In the US, HIV disproportionately affects Latinos who often present late in the disease. Baltimore has seen a recent rapid growth in its Latino population paralleled by an increasing impact of HIV/AIDS among Latinos. From 2009 to 2010, we performed a cross-sectional survey of Latinos accessing the...

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

Post Date: 
2012-08-01
Publication: 
PLOS One
Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Mycobacterium tuberculosis complex enhances susceptibility of CD4 T Cells to HIV through a TLR2-mediated pathway

Post Date: 
2012-07-23
Publication: 
PLOS One
Among HIV-infected individuals, co-infection with Mycobacterium tuberculosis is associated with faster progression to AIDS. We investigated the hypothesis that M. bovis BCG and M. tuberculosis (Mtb complex) could enhance susceptibility of CD4+ cells to HIV infection. Peripheral blood mononuclear...

Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel

Post Date: 
2012-06-05
Publication: 
Annals of Internal Medicine
Description: After HIV diagnosis, timely entry into HIV medical care and retention in that care are essential to the provision of effective antiretroviral therapy (ART). ART adherence is among the key determinants of successful HIV treatment outcome and is essential to minimize the emergence of...

Authors’ response to Hanrahan et al CID article

Post Date: 
2012-05-15
Publication: 
Clinical Infectious Diseases
Country: 
Reply to letter

Programmatic impact of QuantiFERON-TB Gold In-Tube implementation on latent tuberculosis diagnosis and treatment in a public health clinic

Post Date: 
2012-05-07
Publication: 
PLoS One
Country: 
Background : QuantiFERON-TB Gold In-Tube (QFT-GIT) is considered an alternative to the tuberculin skin test (TST) for the diagnosis of tuberculosis (TB) infection, but the programmatic impact of QFT-GIT implementation is largely unknown. In March, 2010, the Baltimore City Health Department (BCHD)...

Safety, tolerability, and pharmacokinetic interactions between single-dose TMC207 and steady-state efavirenz in healthy volunteers: AIDS Clinical Trials Group (ACTG) Study.

Post Date: 
2012-04-15
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Background: Drug-drug interactions complicate management of coinfection with HIV-1 and Mycobacterium tuberculosis. Bedaquiline (formerly TMC207), an investigational agent for the treatment of tuberculosis, is metabolized by cytochrome P450 (CYP) 3A which may be induced by the antiretroviral drug...

Predictors of mortality in hospitalized children with pandemic H1N1 influenza 2009 in Pune, India

Post Date: 
2012-04-15
Publication: 
Indian Journal of Pediatrics
Country: 
Objective: To analyse the factors associated with increased mortality among Indian Children with H1N1. Methods: Data were abstracted from available hospital records of children less than 12 y of age, who were admitted to Sassoon General Hospital in Pune, India, with confirmed pandemic 2009 H1N1...

A systematic review of HIV/AIDS survival and delayed diagnosis among Hispanics in the United States

Post Date: 
2012-02-01
Publication: 
Journal of Immigrant and Minority Health
Abstract HIV/AIDS disproportionately affects Hispanics. Our objective was to determine the risk of late diagnosis and rate of survival after HIV/AIDS diagnosis among Hispanics compared to other racial/ethnic groups. We performed a systematic review of the PubMed database for peer-reviewed articles...

Determination of a reference interval in a population

Post Date: 
2012-02-01
Publication: 
National Medical Journal of India
Country: 
The reference interval is the most widely used medical decision-making tool that separates healthy from diseased individuals. We briefly discuss the methods used to determine reference interval and its limitations.

Global health education for medical students: New learning opportunities and strategies

Post Date: 
2012-01-17
Publication: 
Medical Teacher
Background: A new course was offered to introduce basic global health concepts to all first year Johns Hopkins medical students, that took advantage of new distance learning capacity to connect medical students in Baltimore with students and faculty in Uganda, Ethiopia, Pakistan and India. Aims:...

Information and communication technology and community-based health sciences training in Uganda: perceptions and experiences of educators and students

Post Date: 
2012-01-15
Publication: 
Informatics for Health and Social Care
Country: 
Chang LW, Mwanika A, Kaye D, Muhwezi WW, Nabirye RC, Mbalinda S, Okullo I, Kennedy CE, Groves S, Sisson SD, Burnham G, Bollinger RC. Information and communication technology and community-based health sciences training in Uganda: perceptions and experiences of educators and students. Inform Health...

Perceptions and valuation of a community-based education and services (COBES) program in Uganda

Post Date: 
2012-01-15
Publication: 
Medical Teacher
Country: 
Information and communication technology (ICT) has been advocated as a powerful tool for improving health education in low-resource settings. However, few evaluations have been performed of ICT perceptions and user experiences in low-resource settings. During late 2009, an internet-based survey on...

Sexually transmitted infections and risk behaviors among transgender persons (Hijras) of Pune, India

Post Date: 
2012-01-15
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Background: The objectives of this cross-sectional study were to determine the prevalence of HIV and sexually transmitted infections (STI) in Hijras (self-identified transgenders of South Asia), study associated risk factors, and compare the prevalence with that in heterosexual men and men having...

HIV transmitted drug resistance in adult and pediatric populations in Panama

Post Date: 
2011-12-15
Publication: 
Revista Panamerica de Salud Publica--Pan American Journal of Public Health
Country: 
Objective: To investigate the prevalence of transmitted drug-resistant HIV among adults in Panama by using a modified World Health Organization Threshold Survey (WHO-TS) and to investigate rates of initial resistance among HIV-positive infants in Panama. Methods: At the Gorgas Memorial Institute,...

Nutrition and disease progression pre-highly active antiretroviral therapy (HAART) and post-HAART: Can good nutrition delay time to HAART and affect response to HAART

Post Date: 
2011-12-15
Publication: 
American Journal of Clinical Nutrition
Several studies have investigated a variety of nutritional supplementation interventions in adults with HIV. In this narrative review, we summarize the evidence from 31 clinical trials that explore clinical benefits of macronutrient and micronutrient supplementation in this population while...

Early mortality in adults initiating antiretroviral therapy (ART) in low- and middle-income countries (LMIC): a systematic review and meta-analysis

Post Date: 
2011-12-15
Publication: 
PLOS One
Background: We systematically reviewed observational studies of early mortality post-antiretroviral therapy (ART) initiation in low- and middle-income countries (LMIC) in Asia, Africa, and Central and South America, as defined by the World Bank, to summarize what is known. Methods and Findings:...

Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India

Post Date: 
2011-12-15
Publication: 
AIDS Care
Country: 
Little is known about birth outcomes for HIV-infected women in India. We examine maternal and neonatal birth outcomes in HIV-infected women within the context of enhanced pre-natal care associated with a randomized clinical trial conducted in Pune, India. Birth outcomes of 212 HIV-infected pregnant...

Peer Health Workers and AIDS Care in Rakai, Uganda: A mixed methods operations research evaluation of a cluster-randomized trial

Post Date: 
2011-12-15
Publication: 
AIDS Patient Care and STDs
Country: 
Settings with limited health care workers are challenging environments for delivery of antiretroviral therapy. One strategy to address this human resource crisis is to task shift through training selected patients as peer health workers (PHWs) to provide care to other individuals receiving...

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