PRACHITI

Zika Surveillance among Antenatal Clinic Outpatients in BJ Government Medical College and Sassoon General Hospitals, Pune, India

Post Date: 
2017-08-31
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Countries: 
India
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Clinical Sites: 
BJGMC
This study was terminated July 21, 2020. Zika virus is a vector-borne disease carried by the mosquito Aedes aegypti . Pregnant women infected with Zika may pass the virus to the fetus, which may cause microcephaly and other severe brain defects. It is also linked to miscarriage, stillbirth, and...

Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition

Post Date: 
2017-08-29
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Countries: 
India
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Clinical Sites: 
BJGMC
New study in Pune, India, aims to identify the profile of TB antibodies between mothers and infants, and to see if the presence of antibodies lowers risk of infant infection.

Vaginal Microbiota in HIV Infected Pregnant Women

Post Date: 
2017-07-14
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Countries: 
India
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Clinical Sites: 
BJGMC
This study is conducted under CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort, supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Led by Dr. Rupak Shivakoti, this is a nested cross-sectional...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

Post Date: 
2016-07-05
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Countries: 
India
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Clinical Sites: 
BJGMC
NIRT
This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association of gestational age with...

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome and Preterm Birth

Post Date: 
2014-10-28
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Countries: 
India
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Clinical Sites: 
BJGMC
NIRT
This study was terminated May 7, 2018. P regnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection, is suppressed in pregnancy. Thus,...

Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date: 
2014-09-01
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Countries: 
India
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Clinical Sites: 
BJGMC
NIRT
This is the Parent Study for CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort. It's supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Purpose: TB is a leading cause of maternal mortality,...

Intensified short symptom screening program for Dengue infection during pregnancy, India

Post Date: 
2020-04-15
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Countries: 
India
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Clinical Sites: 
BJGMC
Publication: 
Emerging Infectious Diseases
Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India and pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in India to diagnose dengue during pregnancy. During October 2017-January 2018, we screened pregnant...

TB prevention strategies and unanswered questions for pregnant and postpartum women living with HIV: the need for improved evidence

Post Date: 
2020-03-23
Publication: 
Journal of the International AIDS Society
World TB Day viewpoint on the need for more data about TB treatment for pregnant and postpartum women in J Int AIDS Soc by Drs. Jyoti Mathad and Amita Gupta.

Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

Post Date: 
2019-08-15
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Countries: 
India
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Clinical Sites: 
BJGMC
Publication: 
PLOS Medicine
PLOS Medicine: Dr. Amita Gupta and colleagues discuss the scientific and ethical basis for including pregnant and lactation women, children, and HIV+ patients in tuberculosis therapeutic clinical trials.

Symptom screening for active tuberculosis in pregnant women living with HIV

Post Date: 
2019-01-24
Publication: 
Cochrane Database of Systematic Reviews
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting...

Is there a connection between gestational diabetes, human immunodeficiency virus infection, and tuberculosis?

Post Date: 
2019-01-01
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Countries: 
India
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Clinical Sites: 
BJGMC
Publication: 
International Journal of Tuberculosis and Lung Disease
IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Post Date: 
2017-07-01
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Countries: 
India
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Clinical Sites: 
BJGMC
Publication: 
International Journal of Tuberculosis and Lung Disease
Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay...

Pulmonary infections in pregnancy

Post Date: 
2017-06-01
Publication: 
Seminars in Respiratory and Critical Care Medicine
Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date: 
2016-01-01
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Countries: 
India
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Clinical Sites: 
BJGMC
Publication: 
International Journal of Tuberculosis and Lung Disease
Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The...

Factors associated with gestational diabetes in HIV+ and HIV- women in Pune, India

Post Date: 
2020-03-09
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Countries: 
India
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Clinical Sites: 
BJGMC
Chebrolu P , Alexander M, Bhosale R, Naik S, Patil N, Gupta A, Mathad J. Factors associated with gestational diabetes in HIV+ and HIV- women in Pune, India. Presented at: CROI 2020. Boston, Massachusetts. March 8-11, 2020.

Performance of QuantiFERON-TB Gold in Tube (QFT-GIT) and QuantiFERON-TB Gold Plus (QFT-Plus) for detection of Mycobacterium tuberculosis infection in pregnant women in India

Post Date: 
2019-11-01
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Countries: 
India
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Clinical Sites: 
BJGMC
Kulkarni V , Bhosale R, Jain D, Deshpande P, Naik N, Alexander M, Patil N, Gupte N, Gupta A, Mathad J. Performance of QuantiFERON-TB Gold in Tube (QFT-GIT) and QuantiFERON-TB Gold Plus (QFT-Plus) for detection of Mycobacterium tuberculosis infection in pregnant women in India. Poster presentation...

Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort

Post Date: 
2019-11-01
   |   
Clinical Sites: 
BJGMC
Graham H , Bhosale R, Alexander M, Kinikar A, Khwaja S, Patil N, Mathad J, Shivakoti S, Gupta A. Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November...

Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India

Post Date: 
2019-11-01
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Countries: 
India
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Clinical Sites: 
BJGMC
Alexander M , Bhosale R, Naik S, Gupte N, Jain D, Patil N, Pradhan N, Mave V, Gupta A, Mathad J. Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India...

Assessing TB-related knowledge and stigma and associated risk factors among pregnant women in low-resource settings of Pune, India

Post Date: 
2019-10-30
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Countries: 
India
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Clinical Sites: 
BJGMC
Mehta S , Murrill M, Suryavanshi N, Bhosale R, Naik S, Patil N, Gupta A, Mathad J, Shivakoti R, Alexander M. Assessing TB-related knowledge and stigma and associated risk factors among pregnant women in low-resource settings of Pune, India. Poster presentation. 50th Union World Conference on Lung...

Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort

Post Date: 
2019-10-30
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Bhosale R , Graham H, Alexander M, Kinikar A, Khwaja S, Patil N, Gupta A, Mathad J, Shivakoti R. Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November...

The prevalence of perinatal depression and associated birth outcomes in Pune, India

Post Date: 
2019-02-11
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Countries: 
India
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Clinical Sites: 
BJGMC
Grossman TB , Mathad JS, Suryavanshi N, Alexander M, Mave V, Bhosale R, Gupta A. The prevalence of perinatal depression and associated birth outcomes in Pune, India. Society for Maternal-Fetal Medicine 39th Annual Pregnancy Meeting. Las Vegas, NV. February 11-16, 2019.

Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes

Post Date: 
2018-10-27
Mathad J, Alexander M, Bhosale R, Shere D, Kulkarni V, Kumar P, Babu S, Gupta A for the PRACHITi Study team. Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes. 49th Annual Union World...

Challenges in TB Diagnosis in Pregnant Women in India: Findings from a Cohort Study in Pune, India

Post Date: 
2018-10-25
Alexander M, Bhosale R, Gupte N, Deshpande P, Kulkarni V, Chandanwale A, Gupta A, Mathad J. Challenges in TB Diagnosis in Pregnant Women in India: Findings from a Cohort Study in Pune, India. Session: LTBI Screening: Challenges and Opportunities. 49th Annual Union World Conference on Lung Health...

Importance of Diagnosis of TB Infection in Pregnant Women in India: Findings from a Cohort Study in Pune, India

Post Date: 
2018-04-24
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Countries: 
India
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Clinical Sites: 
BJGMC
Mathad J. Importance of Diagnosis of TB Infection in Pregnant Women in India: Findings from a Cohort Study in Pune, India. Oral Presentation. Presented at Global Health Research Initiative’s Scientific Conference, Weill Cornell Medical College, April 24, 2018.