Study/Projects by Year (2015)

Whole Genome Sequencing of Clinical Isolates from Patients with Multidrug Resistant Tuberculosis in India 

Post Date: 
2015-11-12
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated August 9, 2019. Comparative genomic analysis using whole genome sequencing (WGS) offers an opportunity to understand the specific mutations associated with drug resistance and the phenotypic behavior of TB. As treatment programs incorporate more molecular diagnostics such...

miDOT (Directly Observed Therapy)

Post Date: 
2015-11-01
Designed by Dr. Maunank Shah, the miDOT mobile health application is a video-based Directly Observed Therapy interface that uses the emocha Mobile Health platform to remotely connect patients on long-term tuberculosis therapy with clinicians who are required to witness patients taking...

Smallpox Comes Back to Life in Microbe Hunters

Post Date: 
2015-10-22
Baltimore, MD—The world may have been declared free of smallpox in 1980, but the eradication campaign was revived Tuesday in a multimedia presentation at the Johns Hopkins Medical Campus. The event featured a screening of the film Microbe Hunters: Smallpox , by the Johns Hopkins Center for Clinical...

Identifying Strategies to Optimize Prevention, Diagnosis, and Care of Tuberculosis in Health Care Workers of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospital, Pune, India

Post Date: 
2015-10-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated July 25, 2019. The BJGMC-JHU Fogarty program has identified tuberculosis in health care workers (HCW) as the program's most significant priority. Between June 2011 and December 2013, a total of 47 TB cases were identified among HCW's at the BJGMC Sassoon General Hospital...

Residual Respiratory Impairment Following Pulmonary Tuberculosis

Post Date: 
2015-09-13
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Many TB patients have residual respiratory impairment despite...

A5300/IMPAACT2003: Study of MDR TB Cases and Their Household Contacts: Operational Feasibility to Inform PHOENIx Trial Design

Post Date: 
2015-09-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This clinical trial was terminated July 18, 2017. It was a study conducted under both the AIDS Clinical Trial Group (ACTG) and the the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network, and funded by the U.S. National Institutes of Health. Dr. Amita Gupta was...

Prevalence Survey of Risk Factors for Tuberculosis and Non-communicable Diseases in an HIV-positive Population in Pune, India

Post Date: 
2015-08-17
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study is conducted under the TREAT Asia Network and funded by amfAR. The primary objective of this study is to assess the prevalence of risk factors for tuberculosis and non-communicable diseases (NCDs)--coronary artery disease and diabetes mellitus--among HIV-positive patients. The study will...

RePORT: C-TRIUMPH: Substudy on Understanding of Tuberculosis Infection and Preventive Therapy among Skin-Test Positive Household Contacts of Tuberculosis Cases

Post Date: 
2015-08-13
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was conducted from June 2015–May 2018. It is both relevant and important to gauge awareness of IPT (Isoniazieas an option for preventing TB among those who are tuberculin skin test (TST) positive, given India’s vast TB-infected population pool that are at risk for progressing to active...

A5290: A Randomized, Phase 2b Study of a Double-Dose Lopinavir/Ritonavir-Based Antiretroviral Regimen with Rifampin-Based Tuberculosis Treatment versus a Standard-Dose Lopinavir/Ritonavir-Based Antiretroviral Regimen with Rifabutin-Based Tuberculosis...

Post Date: 
2015-07-07
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated February 23, 2016; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health.. Full Title: A5290, A Randomized, Phase 2b Study of a Double-Dose Lopinavir/Ritonavir-Based Antiretroviral Regimen with Rifampin-Based...

Bacterial Antimicrobial Resistance Patterns in Pune, India: Substudy on Community Health-Seeking Behavior Among Patients Admitted with Acute Febrile Illness

Post Date: 
2015-05-28
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Objectives: To describe the patterns of health-care seeking behavior and prior outpatient care among patients admitted with acute febrile illness to Sassoon Hospital To determine the effects of outpatient behaviors and prior treatments on the antimicrobial resistance patterns of stool colonizing...

Barriers for Intervention to Prevent Occupationally Acquired Tuberculosis in Healthcare Workers

Post Date: 
2015-05-21
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated April 20, 2017; it was funded by the Fogarty International Center at the U.S. National Institutes of Health. Observational study to assess the current status of implementation of interventions for preventing occupationally acquired TB in HCW. Identify the barriers to...

Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes

Post Date: 
2015-05-07
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
This study was conducted from May 2015–May 2018. Led by Dr. Rupak Shivakoti, the primary objective was to determine the feasibility and operational logistics of collecting stool for microbiome analysis, detailed nutritional assessment using a food-frequency questionnaire for dietary intake and...

Risk of Tuberculosis among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

Post Date: 
2015-04-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated April 24, 2018. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. A retrospective study of health care workers (HCWs) was conducted by investigators of the Byramjee Jeejeebhoy Medical and Sassoon General Hospitals (BJMC-SGH) in...

Community Health Workers, mHealth, and Combination HIV Prevention in a Hotspot: A Randomized Trial (mLAKE)

Post Date: 
2015-04-01
   |   
Countries: 
Uganda
Led by Dr. Larry Chang, the mLAKE study in Uganda is examining whether community health workers equipped with cellphones and the emocha Mobile Health platform are able to successfully promote HIV treatment and prevention services in households in a fishing community in East Africa with a very high...

Enhancing Models of HIV, Viral Hepatitis, STIs and Tuberculosis to Inform and Improve Public Health Impact

Post Date: 
2015-01-01
   |   
Countries: 
United States
This study was terminated September 30, 2018. Dr. Maunank Shah was the Project Leader for HIV modeling for this effort led by Emory University and funded by the U.S. Centers for Disease Control and Prevention.