Publications by Year (2012)

QuantiFERON-TB gold in-tube implementation for latent tuberculosis diagnosis in a public health clinic: a cost-effectiveness analysis

Post Date: 
2012-12-19
Publication: 
BMC Infectious Diseases
Country: 
Background : The tuberculin skin test (TST) has limitations for latent tuberculosis infection (LTBI) diagnosis in low-prevalence settings. Previously, all TST-positive individuals referred from the community to Baltimore City Health Department (BCHD) were offered LTBI treatment, after active TB was...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date: 
2012-12-15
Publication: 
Clinical Infectious Diseases
Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in...

Household-based HIV counseling and testing as a platform for referral to HIV care and medical male circumcision in Uganda: a pilot evaluation

Post Date: 
2012-12-13
Publication: 
PLOS One
Country: 
Background: Combination HIV prevention initiatives incorporate evidence-based, biomedical and behavioral interventions appropriate and acceptable to specific populations, aiming to significantly reduce population-level HIV incidence. Knowledge of HIV serostatus is key to linkages to HIV care and...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

Post Date: 
2012-10-31
Publication: 
BMC Infectious Diseases
Country: 
Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from the Six...

A novel educational strategy targeting health care workers in underserved communities in Central America to integrate HIV into primary medical care

Post Date: 
2012-10-24
Publication: 
PLOS
Background: Current educational strategies to integrate HIV care into primary medical care in Central America have traditionally targeted managers or higher-level officials, rather than local health care workers (HCWs). We developed a complementary online and on-site interactive training program to...

Pooled individual data analysis of five randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission

Post Date: 
2012-10-19
Publication: 
Clinical Infectious Diseases
Background: In resource-limited settings, mothers infected with human immunodeficiency virus type 1 (HIV-1) face a difficult choice: breastfeed their infants but risk transmitting HIV-1 or not breastfeed their infants and risk the infants dying of other infectious diseases or...

Research capacity-building program for clinicians and staff at a community-based HIV clinic in Uganda: A pre/post evaluation

Post Date: 
2012-10-01
Publication: 
Journal of the Association of Nurses in AIDS Care
Country: 
Developing capacity for HIV research and clinical practice is critically needed in resource-limited countries. The purpose of this study was to evaluate a research capacity building program for community-based participants in preparation and conduct of mHealth interventions. A descriptive,...

Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India

Post Date: 
2012-10-01
Publication: 
Journal of the International Association of Providers of AIDS Care
Country: 
Distance learning is an important tool for training HIV health workers. However, there is limited evidence on design and evaluation of distance learning HIV curricula and tools. We therefore designed, implemented, and evaluated a distance learning course on HIV management for clinical care...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date: 
2012-10-01
Publication: 
HIV Clinical Trials
Country: 
A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Cost analyses of peer health worker and mHealth support interventions for improving AIDS care in Rakai, Uganda

Post Date: 
2012-09-12
Publication: 
AIDS Care
Country: 
A cost analysis study calculates resources needed to deliver an intervention and can provide useful information on affordability for service providers and policy-makers. We conducted cost analyses of both a peer health worker (PHW) and a mHealth (mobile phone) support intervention. Excluding...

Performance characteristics of the Cepheid Xpert MTB/RIF test in a tuberculosis prevalence survey

Post Date: 
2012-08-15
Publication: 
PLoS One
Country: 
Background : Xpert MTB/RIF ("Xpert") is a molecular test for detection of Mycobacterium tuberculosis (MTB) in sputum. Performance characteristics have been established for its use during passive tuberculosis (TB) case detection in symptomatic TB suspects, but Xpert performance has not been assessed...

HIV testing behaviors among Latinos in Baltimore City

Post Date: 
2012-08-14
Publication: 
Journal of Immigrant and Minority Health
Country: 
In the US, HIV disproportionately affects Latinos who often present late in the disease. Baltimore has seen a recent rapid growth in its Latino population paralleled by an increasing impact of HIV/AIDS among Latinos. From 2009 to 2010, we performed a cross-sectional survey of Latinos...

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

Post Date: 
2012-08-01
Publication: 
PLOS One
Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Mycobacterium tuberculosis complex enhances susceptibility of CD4 T Cells to HIV through a TLR2-mediated pathway

Post Date: 
2012-07-23
Publication: 
PLOS One
Among HIV-infected individuals, co-infection with Mycobacterium tuberculosis is associated with faster progression to AIDS. We investigated the hypothesis that M. bovis BCG and M. tuberculosis (Mtb complex) could enhance susceptibility of CD4+ cells to HIV infection. Peripheral blood...

Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel

Post Date: 
2012-06-05
Publication: 
Annals of Internal Medicine
Description: After HIV diagnosis, timely entry into HIV medical care and retention in that care are essential to the provision of effective antiretroviral therapy (ART). ART adherence is among the key determinants of successful HIV treatment outcome and is essential to minimize the emergence of...

Authors’ response to Hanrahan et al CID article

Post Date: 
2012-05-15
Publication: 
Clinical Infectious Diseases
Country: 
Reply to letter

Programmatic impact of QuantiFERON-TB Gold In-Tube implementation on latent tuberculosis diagnosis and treatment in a public health clinic

Post Date: 
2012-05-07
Publication: 
PLoS One
Country: 
Background : QuantiFERON-TB Gold In-Tube (QFT-GIT) is considered an alternative to the tuberculin skin test (TST) for the diagnosis of tuberculosis (TB) infection, but the programmatic impact of QFT-GIT implementation is largely unknown. In March, 2010, the Baltimore City Health Department (BCHD)...

Safety, tolerability, and pharmacokinetic interactions between single-dose TMC207 and steady-state efavirenz in healthy volunteers: AIDS Clinical Trials Group (ACTG) Study.

Post Date: 
2012-04-15
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Background: Drug-drug interactions complicate management of coinfection with HIV-1 and Mycobacterium tuberculosis. Bedaquiline (formerly TMC207), an investigational agent for the treatment of tuberculosis, is metabolized by cytochrome P450 (CYP) 3A which may be induced by the antiretroviral...

Predictors of mortality in hospitalized children with pandemic H1N1 influenza 2009 in Pune, India

Post Date: 
2012-04-15
Publication: 
Indian Journal of Pediatrics
Country: 
Objective: To analyse the factors associated with increased mortality among Indian Children with H1N1. Methods: Data were abstracted from available hospital records of children less than 12 y of age, who were admitted to Sassoon General Hospital in Pune, India, with...

Determination of a reference interval in a population

Post Date: 
2012-02-01
Publication: 
National Medical Journal of India
Country: 
The reference interval is the most widely used medical decision-making tool that separates healthy from diseased individuals. We briefly discuss the methods used to determine reference interval and its limitations.

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