Publications - Tuberculosis

The global landscape of tuberculosis therapeutics

Post Date:

2018-11-07

Publication:

Annual Review of Medicine

Abstract Tuberculosis (TB) is one of the oldest infections afflicting humans yet remains the number one infectious disease killer worldwide. Despite decades of experience treating this disease, TB regimens require months of multidrug therapy, even for latent infections. There have been important...

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

Post Date:

2018-09-24

Countries:

India

Clinical Sites:

BJGMC

Publication:

BMC Medicine

Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

Report of the Technical Consultation on Advances in Clinical Trial Design for Development of New TB Treatments

Post Date:

2018-09-17

Publication:

WHO Task Force on Introduction of New TB Drugs and Treatment Regimens

Dr. Amita Gupta was a member of this TB technical consultation, convened in March 2018 in Switzerland.

The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

Post Date:

2018-09-07

Countries:

India

Clinical Sites:

BJGMC

Publication:

Occupational and Environmental Medicine

Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)

Post Date:

2018-09-01

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Current guidelines recommend evaluation of the household contacts of individuals with multidrug-resistant tuberculosis; however, implementation of this policy is challenging.

Failure in TB control: why should the rapid diagnostic test bear the blame?

Post Date:

2018-09-01

Publication:

International Journal of Tuberculosis and Lung Disease

Dr. Sachit Atre's correspondence published in the International Journal of Tuberculosis and Lung Disease.

The effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

Post Date:

2018-08-20

Countries:

Clinical Sites:

Publication:

Antimicrobial Agents and Chemotherapy

DM and higher HbA1c increased the risk of not achieving therapeutic targets for pyrazinamide, but higher pyrazinamide concentrations were asociated with worse microbiologic and clinical outcomes

Challenges of TB and co-treatment: updates and insights

Post Date:

2018-08-04

Publication:

Current Opinion in HIV and AIDS

PURPOSE OF REVIEW: In the past few years, tuberculosis (TB) has overtaken HIV as the infectious disease with the highest global mortality. Successful management of this syndemic will require improved diagnostic tests, shorter preventive therapies, and more effective treatments, particularly in...

Tuberculin skin test and QuantiFERON-Gold In Tube assay for diagnosis of latent TB infection among household contacts of pulmonary TB patients in high TB burden setting.

Post Date:

2018-08-01

Countries:

India

Publication:

PLoS One

World Health Organization (WHO) recommends systematic screening of high-risk populations, including household contacts (HHCs) of adult pulmonary tuberculosis (TB) patients, as a key strategy for elimination of TB. QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and tuberculin skin test (TST) are two commonly used tools for the detection of latent tuberculosis infection (LTBI) but may yield differential results, affecting eligibility for TB preventive therapy.

Trends in HbA1c levels and implications for diabetes screening in tuberculosis cases undergoing treatment in India

Post Date:

2018-07-01

Countries:

India

Clinical Sites:

BJGMC

DY Patil

Publication:

International Journal of Tuberculosis and Lung Disease

SETTING: The optimal timing of screening for diabetes mellitus (DM) among tuberculosis (TB) cases is unclear due to the possibility of stress hyperglycemia. DESIGN: We evaluated adult (18 years) pulmonary TB cases at treatment initiation as well as at 3 months, 6 months and 12 months. DM was...

Internal medicine residents' knowledge and practice of pulmonary tuberculosis diagnosis

Post Date:

2018-06-27

Countries:

United States

Publication:

Open Forum Infectious Diseases

BACKGROUND: Internal medicine physicians are often the first providers to encounter patients with a new diagnosis of tuberculosis. Given the public health risks of missed tuberculosis cases, assessing internal medicine residents' ability to diagnose tuberculosis is important. METHODS: Internal...

Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?

Post Date:

2018-05-22

Countries:

India

Clinical Sites:

BJGMC

Publication:

The International Journal of Tuberculosis and Lung Disease

Authors find that screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing tuberculosis and improve management of diabetes.

The global neurological burden of tuberculosis

Post Date:

2018-05-18

Publication:

Seminars in Neurology

Central nervous system (CNS) involvement of tuberculosis (TB) is the most severe manifestation of TB and accounts for approximately 5 to 10% of all extrapulmonary TB (EPTB) cases and approximately 1% of all TB cases. TB meningitis (TBM) is the most common form of CNS TB, though other forms occur,...

Addressing knowledge gaps and prevention for tuberculosis-infected Indian adults: a vital part of elimination

Post Date:

2018-05-02

Countries:

India

Clinical Sites:

BJGMC

Publication:

BMC Infectious Diseases

BMC Infectious Diseases : Our survey among TB patients' household contacts with evidence of recent exposure found that knowledge is poor and families are confused about disease transmission.

Hepatotoxicity during isoniazid preventive therapy and antiretroviral therapy in people living with HIV with severe immunosuppression: a secondary analysis of a multi-country open-label randomized controlled clinical trial

Post Date:

2018-05-01

Publication:

Journal of Acquired Immune Deficiency Syndromes

BACKGROUND: Hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) has not been well studied in severely immunosuppressed people with HIV. Our objective was to determine risk factors for hepatotoxicity in severely immunosuppressed individuals taking IPT...

Advancing patient-centered care in tuberculosis management: A mixed-methods appraisal of Video Directly Observed Therapy

Post Date:

2018-04-26

Countries:

United States

Publication:

Open Forum Infectious Diseases

OFID : Video DOT is an acceptable option for measurement of TB treatment adherence & may allow more treatment doses to be observed

Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial

Post Date:

2018-04-19

Countries:

India

Clinical Sites:

BJGMC

Publication:

Trials

Trials: Evidence for TB treatment in kids is largely based on adult studies. The SHINE study aims to fix this

Pyrosequencing to resolve discrepant Xpert MTB/RIF and Mycobacterial Growth Indicator Tube 960

Post Date:

2018-03-26

Countries:

India

Clinical Sites:

Hinduja Hospital

Publication:

Lung India

Lung India: Indo-JHU researchers find that pyrosequencing can clear up discrepancies about drug resistance in TB.

Suboptimal antituberculosis drug concentrations and outcomes in small and HIV‐coinfected children in India: Recommendations for dose modifications

Post Date:

2017-12-16

Countries:

India

Publication:

Clinical Pharmacology and Therapeutics

This work aimed to evaluate the once-daily antituberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin, and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis undergoing...

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Post Date:

2017-12-07

Countries:

India

Clinical Sites:

BJGMC

NIRT

Publication:

PLOS One

PLOS One: Mave and colleagues compared TB drug exposure in plasma and hair samples among a small cohort of children.

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