Publications - India

Female global health leadership: Data-driven approaches to close the gender gap

Post Date: 
2019-02-09
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The Lancet
Lancet article investigates gender-based challenges of female health trainees and professionals and identifies interventions

Few eligible for the newly recommended short course MDR-TB regimen at a large Mumbai private clinic

Post Date: 
2019-01-28
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BMC Infectious Diseases
BACKGROUND: India has the world's highest tuberculosis burden, and Mumbai is particularly affected by multidrug resistant tuberculosis (MDR-TB). WHO recommends short, intensive treatment ("Short Course") for previously untreated pulmonary MDR-TB patients but does not require universal drug...

HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries

Post Date: 
2019-01-07
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International Journal of Tuberculosis and Lung Disease
International Journal of Tuberculosis and Lung Disease : The Indo-JHU Clinical Research Parentership participated in this multinational study to determine if it's feasible to provide HIV testing for household contacts of MDR-TB cases.

Is there a connection between gestational diabetes, human immunodeficiency virus infection, and tuberculosis?

Post Date: 
2019-01-01
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International Journal of Tuberculosis and Lung Disease
IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Multiplex-PCR to detect pAmpC β-lactamases among Enterobacteriaceae at a tertiary care laboratory in Mumbai, India

Post Date: 
2018-12-13
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Microbiology
Drug-resistance due to AmpC β-lactamases represents a growing problem worldwide. In this study, a previously collected sample of 108 cefoxitin-resistant clinical isolates was assessed for AmpC β-lactamase production through routine phenotypic testing and double-disc cefoxitin/cloxcallin (DD-CC),...

The mortality burden of multidrug-resistant pathogens in India: a retrospective observational study

Post Date: 
2018-11-08
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Clinical Infectious Diseases
We conducted a retrospective, ten hospital study of the relationship between multidrug-resistant pathogens and mortality in India. This is one of the largest studies undertaken in an LMIC to measure the burden of antibiotic resistance.

Drug-resistant Enterobacteriaceae colonization is associated with healthcare utilization and antimicrobial use among inpatients in Pune, India

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2018-10-04
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BMC Infectious Diseases
BACKGROUND: Healthcare exposure may increase drug-resistant Enterobacteriaceae colonization risk. Nascent antimicrobial stewardship efforts in low- and middle-income countries require setting-specific data. We aimed to evaluate risk factors for inpatient drug resistant Enterobacteriaceae...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

Post Date: 
2018-10-01
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International Journal of Tuberculosis and Lung Disease
Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

Post Date: 
2018-09-24
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BMC Medicine
Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

Ovarian mass - tuberculosis or malignancy? Need for early intensified evaluation

Post Date: 
2018-09-14
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EXCLI Journal
Letter to the Editor Dear Editor, We read with interest the case report by Chien et al. on Peritoneal Tuberculosis (TB) mimicking ovarian cancer (Chien et al., 2016[1]). We want to congratulate the authors on this case report. We encountered a similar case in our clinical setting in western India...

The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

Post Date: 
2018-09-07
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Occupational and Environmental Medicine
Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

Challenges and opportunities for outreach workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) program in India

Post Date: 
2018-09-04
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PLoS One
PLoS One: Prevention of Mother-to-Child Transmission of HIV program in India is one of the largest in the world, and it relies on outreach workers. Our study looked at challenges and opportunities for outreach workers.

The effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

Post Date: 
2018-08-20
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Antimicrobial Agents and Chemotherapy
DM and higher HbA1c increased the risk of not achieving therapeutic targets for pyrazinamide, but higher pyrazinamide concentrations were asociated with worse microbiologic and clinical outcomes

Tuberculin skin test and QuantiFERON-Gold In Tube assay for diagnosis of latent TB infection among household contacts of pulmonary TB patients in high TB burden setting

Post Date: 
2018-08-01
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PLoS One
World Health Organization (WHO) recommends systematic screening of high-risk populations, including household contacts (HHCs) of adult pulmonary tuberculosis (TB) patients, as a key strategy for elimination of TB. QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and tuberculin skin test (TST) are two commonly used tools for the detection of latent tuberculosis infection (LTBI) but may yield differential results, affecting eligibility for TB preventive therapy.

Trends in HbA1c levels and implications for diabetes screening in tuberculosis cases undergoing treatment in India

Post Date: 
2018-07-01
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International Journal of Tuberculosis and Lung Disease
SETTING: The optimal timing of screening for diabetes mellitus (DM) among tuberculosis (TB) cases is unclear due to the possibility of stress hyperglycemia. DESIGN: We evaluated adult (18 years) pulmonary TB cases at treatment initiation as well as at 3 months, 6 months and 12 months. DM was...

Loss to follow‐up and mortality among HIV‐infected adolescents receiving antiretroviral therapy in Pune, India

Post Date: 
2018-06-25
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HIV Medicine
Over 6 years, one-third of HIV+ adolescents in this study discontinued medical treatment, indicating a critical need for retention counselling and closer clinical monitoring.

Effect of baseline micronutrient and inflammation status on CD4 recovery post-cART initiation in the multinational PEARLS trial

Post Date: 
2018-05-29
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Clinical Nutrition
Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation.

Sources of household air pollution and their association with fine particulate matter in low-income urban homes in India

Post Date: 
2018-05-23
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Journal of Exposure Science and Environmental Epidemiology
INTRODUCTION: Household air pollution (HAP) is poorly characterized in low-income urban Indian communities. MATERIALS AND METHODS: A questionnaire assessing sources of HAP and 24 h household concentrations of particulate matter less than 2.5 microns in diameter (PM 2.5 ) were collected in a sample...

Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?

Post Date: 
2018-05-22
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The International Journal of Tuberculosis and Lung Disease
Authors find that screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing tuberculosis and improve management of diabetes.

Addressing knowledge gaps and prevention for tuberculosis-infected Indian adults: a vital part of elimination

Post Date: 
2018-05-02
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BMC Infectious Diseases
BMC Infectious Diseases : Our survey among TB patients' household contacts with evidence of recent exposure found that knowledge is poor and families are confused about disease transmission.

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