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Hair Concentrations of Anti-tuberculosis Drugs Among HIV-infected and Uninfected Children in India
In the developing world, tuberculosis (TB) is a major cause of mortality among HIV-infected children, a population where measuring treatment adherence and drug levels is difficult. We propose an innovative therapeutic drug monitoring (TDM) tool that measures drug concentration in hair samples to estimate the average level of drug exposure over weeks to months. Since hair samples are easy and painless to collect and can be stored and shipped at room temperature without biohazardous constraints, demonstrating the utility of this form of TDM in pediatric TB would advance the field. This effort is looking at the use of an anti-TB drug hair assay as a therapeutic drug monitoring (TDM) tool among young children receiving anti-TB treatment in India. This tool measures drug concentration in hair samples to estimate the average level of drug exposure over weeks to months.