Vidya Mave, MD, MPH

Pune, India
Role: 
Faculty
Associate Professor
Vidya Mave, MD, MPH

Dr. Mave is Associate Professor at the Johns Hopkins School of Medicine as well as Director and Clinical Research Site (CRS) Leader of the Johns Hopkins University Baltimore-India Clinical Trials Unit (JHUBI-CTU) in Pune, India. The CTU is a collaborative research partnership between BJGMC in Pune, India and Johns Hopkins School of Medicine that is part of the world’s largest HIV therapeutic trial networks (the AIDS Clinical Trials Group [ACTG] and the International Maternal Pediatric and Adolescent AIDS Clinical Trial Network [IMPAACT]).

Dr. Mave has more than 18 years of experience in clinical practice, education, and research in infectious diseases and has published more than 100 peer-reviewed research articles. Following a short tenure as Assistant Professor of Infectious Diseases at Tulane University School of Medicine, Dr. Mave joined the Johns Hopkins CCGHE. She now leads and coordinates all clinical research activities for the JHUBI-CTU, which conducts phase I, II, and III clinical trials of therapeutic drug interventions for HIV and co-morbid infections, including TB and hepatitis, in adults (including pregnant women) and children. Dr. Mave’s research interests includes antimicrobial resistance, comorbidities (including diabetes, HIV), and the use of novel tools (Hair PK, whole genome sequencing, host biomarkers) to study TB treatment outcomes. In addition, Dr. Mave has mentored more than 20 pre- and postdoctoral trainees from Johns Hopkins.

Dr. Mave received an MD in medicine from Karnatak University, Dharwad, India, and an MPH from Tulane University. She completed her internal medicine training at St. Barnabas Hospital in New York, followed by a post-doctoral fellowship in infectious diseases at Tulane University and Long Island Jewish Medical Center. Dr. Mave is board certified in internal medicine and infectious diseases by the American Board of Internal Medicine.

Leadership

Protocol Vice Chair, A5397/HVTN 603: A Phase 2A/2B Study Evaluating Safety and Immunogenicity of Therapeutic ID93 + GLA-SE Vaccination in Participants with Rifampicin-susceptible Pulmonary TB

ACTIV-2/A5401: Adaptive Platform Treatment for Outpatients with COVID-19 (Adapt Out COVID)

Post Date: 
2021-07-21
   |   
Countries: 
India
United States
   |   
Clinical Sites: 
BJGMC
Rationale: There is an urgent need for a platform to rapidly evaluate therapies in the outpatient setting, to prevent disease progression, and reduce serious complications of COVID-19 and transmission [10]. ACTIV-2/A5401 is a phase II/III randomized, blinded, controlled adaptive platform trial to…

Dynamics and immune mechanisms of QFT response in close contacts of TB cases

Post Date: 
2021-04-05
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Rationale: A vaccine that prevents infection with Mycobacterium tuberculosis (Mtb) (POI vaccine) is an ideal approach to TB control. As Mtb infection (MTBI) is measured indirectly (positive tuberculin skin test (TST) or interferon gamma release assay (IGRA), prevention of IGRA conversion is the…

A Nanopore Biosensor for Leveling MTB Antigens in Blood

Post Date: 
2021-04-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Purpose of the study: The inability to obtain diagnostically useful sputum specimens, or the inability to analyze non-sputum specimens, is a significant contributor to poor diagnostic sensitivity of current TB assays, leading to the WHO to call for the development of non-sputum-based biomarker or…

Pharmacokinetic Assessment of MDR-TB Drugs in the Treatment of TB Meningitis

Post Date: 
2020-08-23
   |   
Countries: 
China
India
South Africa
   |   
Clinical Sites: 
Hinduja Hospital
Rationale: MDR-TBM is a devastating disease with high mortality and severe neurologic sequelae among survivors. We recognize the importance of sufficient drug concentrations at the site of infection for efficacy of anti-TB drugs and believe it is likely that drug distribution into brain and CSF…

Identification of Biomarkers That Can Predict Progression from Latent Tuberculosis Infection to Active Tuberculosis Disease

Post Date: 
2020-08-23
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Purpose: The C-TRIUMPH study has identified 20 household contacts (HHC), who have progressed to active TB from its HHCs cohort (Cohort B). Immunological profiling of TB antigen induced biosignatures, profiling of transcriptional and proteomic biosignatures should provide novel insights into the…

Epidemiology and Clinical Outcomes of COVID-19 in India (ECO-19)

Post Date: 
2020-07-09
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated May 25, 2021 This is a prospective cohort study of adults with suspected COVID-19 to address key knowledge gaps in the epidemiology of disease severity and poor clinical outcomes in India. Results from this study may help clinicians in India focus limited health resources…

Tuberculosis (TB) Aftermath

Post Date: 
2020-06-05
   |   
Countries: 
India
   |   
Clinical Sites: 
DY Patil
Drs. Vidya Mave and Jonathan Golub are co-PIs and Dr. Barthwal from DY Patil Medical College is local site PI for this study. TB Aftermath seeks to provide evidence for an effective and scalable strategy targeting HHs of treated TB cases, a high priority of the NTEP. Purpose To compare the…

Mental Health Outcomes among Health Care Professionals Involved in the Treatment and Care of COVID 19 Patients in India

Post Date: 
2020-06-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Drs. Nikhil Gupta and Nishi Suryavanshi are leading this survey project. This study is investigating the immediate impact of the COVID-19 pandemic on mental health outcomes and overall quality of life and what are the factors associated with it among Indian Health care workers. Among health care…

Prevalence of Risk Factors for Lung Cancer and Facilitators and Barriers for Tobacco Cessation among People Living with HIV

Post Date: 
2020-04-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
India has the world’s third largest HIV epidemic, with 2.1 million people currently living with HIV and an additional 90,000 new infections each year.[29] At the same time, expansion of the HIV response under India’s premier governmental agency – the National AIDS Control Organization (NACO), has…

The Sentinel Research Network of IeDEA: A Prospective Cohort among People Living with HIV

Post Date: 
2020-03-12
   |   
Clinical Sites: 
BJGMC
This study is nested within the TREAT Asia HIV Observational Database initiative. The global scale up of antiretroviral therapy (ART) has significantly improved the immune recovery and life expectancy of people living with HIV (PLHIV). However, PLHIV on long-term ART now face health challenges…

Hybrid Trial for Alcohol Reduction among People with TB and HIV in India

Post Date: 
2020-02-12
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
DY Patil
Dr. Geetanjali Chander is PI and Dr. Kakrani is local site PI at DY Patil Medical College for this study. The highest incidence of tuberculosis disease (TB) in the world is in India, accounting for 27% of all new cases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy…

Pregnancy Associated Immune Responses to Tuberculosis and HIV in India and South Africa (PARTHISA)

Post Date: 
2020-01-14
   |   
Countries: 
India
South Africa
   |   
Clinical Sites: 
BJGMC
Dr. Jyoti Mathad is Co-PI of this study. Purpose: Tuberculosis (TB) is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not…

Increasing Market and Public Health Outcomes Through Scaling Up Affordable Access Models of Short Course Preventive Therapy for TB (IMPAACT4TB)

Post Date: 
2019-12-17
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Primary Objective: This study is being conducted in Brazil, Cambodia, China, Ethiopia, Ghana, Haiti, India, Indonesia, Kenya, Malawi, Mozambique, South Africa, Tanzania, and Zimbabwe. The overall goal is to reduce TB incidence among (1) people living with HIV who are on antiretroviral therapy, and…

Markers of Lung Impairment in HIV-TB Coinfected Indian Adults

Post Date: 
2019-12-11
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Objectives/Aims We will compare the degree of lung impairment between HIV-TB co-infected adults (HIV-TB group) and TB cases without HIV co-infection (TB group) who successfully complete TB therapy. We hypothesize that the HIV-TB group will have a greater degree of lung impairment compared to the TB…

T Cell Biomarkers and T-regulatory Responses to Pediatric TB

Post Date: 
2019-11-21
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
The goals of this study are to: Validate host T cell biomarkers for diagnosis of pediatric TB Investigate the phenotype and functions of T-regulatory cells in pediatric TB We will use cryopreserved PBMC samples from CTRIUMPH cohorts: Pediatric unconfirmed TB, confirmed TB, latest Tb, and no TB…

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and…

A Phase 2a, Double-Blind, Placebo-Controlled, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of ID93 + GLA-SE Vaccine Administered to HIV-Negative Patients at 3 Time Points During Multidrug Therapy for Drug Susceptible Pulmonary TB

Post Date: 
2019-10-28
   |   
Clinical Sites: 
BJGMC
This study was terminated in April 2020. Vidya Mave was PI of this HIV vaccine trial. BACKGOUND: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). TB is one of the leading causes of morbidity and mortality around the world with an estimated 10…

Evaluation of a Urinary Biomarker Assay for Diagnosis and Test of Cure for Tuberculosis

Post Date: 
2019-09-09
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Dr. Jeff Tornheim is PI of this study. METHODS This study will make use of biorepository samples from the Cohort for TB Research by the Indo-US Medical Partnership (CTRIUMPh). CTRIUMPh, funded by the US NIH and Indian Department of Biotechnology, is an academic collaboration between Johns Hopkins…

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB…

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB…

Pages

A Case Study of Intra-Family Clustering of COVID-19 in India

Post Date: 
2021-08-18
   |   
Countries: 
India
Publication: 
European Journal of Pharmaceutical and Medical Research
Background: With unprecedented COVID-19 disease-related morbidity and mortality globally, understanding the transmission dynamics of this disease is of paramount importance for disease control efforts. Despite the lockdown in India, there has been reported an ever-increasing number of infected…

Utility of the interferon-gamma release assay for latent tuberculosis infection screening among indian health-care workers

Post Date: 
2021-07-13
   |   
Countries: 
India
Publication: 
Indian Journal of Community Medicine
Background: The utility of interferon-gamma release assays (IGRAs) for latent tuberculosis infection (LTBI) screening among health-care workers (HCWs) in low- and middle-income countries (LMICs) remains unclear. Methods: This was a prospective cohort study among HCW trainees undergoing annual LTBI…

Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men

Post Date: 
2021-03-10
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Publication: 
International Journal of Tuberculosis and Lung Disease
This study by Samyra Cox and colleagues highlights the need for integrating effective alcohol interventions into TB care.

Detection of genital tuberculosis among women with infertility using best clinical practices in India: An implementation study

Post Date: 
2021-01-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Indian Journal of Tuberculosis
Background Diagnosis of genital tuberculosis (TB) as a cause of infertility still remains a diagnostic dilemma for clinicians, as no standard guidelines exist. The recently proposed best practices for genital TB diagnosis have not been evaluated yet in India. Objectives To implement best practices…

Higher IL-6 Levels and Changes in TGF-β are Associated with Lung Impairment in Pulmonary Tuberculosis

Post Date: 
2021-01-08
   |   
Countries: 
India
Publication: 
ERJ
Pulmonary tuberculosis (PTB) is associated with granuloma formation, necrosis and cavitation in lung tissue. Lung injury in PTB can persist despite microbiological cure and is associated with chronic obstructive pulmonary disease (COPD) independent of smoking exposure[1]. Furthermore, pulmonary…

Measuring TB drug levels in the hair in adults and children to monitor drug exposure and outcomes

Post Date: 
2021-01-01
   |   
Countries: 
India
Publication: 
International Journal of Tuberculosis and Lung Disease
INTRODUCTION: Testing for anti-TB drugs in small hair samples may serve as a non-invasive tool to measure cumulative drug exposure and/or adherence, as these determine treatment success. We aimed to assess how well hair assays of TB drugs predict TB treatment outcomes.METHODS: A small thatch of…

Assessment of persistent depression among TB patients

Post Date: 
2020-11-01
   |   
Countries: 
India
Publication: 
International Journal of Tuberculosis and Lung Disease
(No abstract available)

The burden of anxiety among people living with HIV during the COVID-19 pandemic in Pune, India

Post Date: 
2020-10-23
   |   
Countries: 
India
Publication: 
BMC Public Health
Introduction: Globally, India has the third largest population of people living with HIV (PLHIV) and the second highest number of COVID-19 cases. Anxiety is associated with antiretroviral therapy (ART) nonadherence. It is crucial to understand the burden of anxiety and its sources among Asian…

Mental health and quality of life among healthcare professionals during the COVID-19 pandemic in India

Post Date: 
2020-09-10
   |   
Countries: 
India
Publication: 
Brain and Behavior
Background: The COVID-19 pandemic has placed healthcare professionals (HCP) in stressful circumstances with increased patient loads and a high risk of exposure. We sought to assess the mental health and quality of life (QoL) of Indian HCPs, the fourth highest-burden country for COVID-19. Method:…

Tuberculosis preventive treatment should be considered for all household contacts of pulmonary tuberculosis patients in India

Post Date: 
2020-07-29
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
PLoS One
PLoS One: Dr. Mandar Paradkar and colleagues conducted a CTRIUMPH study that supports TB preventive therapy for all household contacts of pulmonary TB patients in India

Impact of the Fogarty Training Program on Trainee and Institutional Research Capacity Building at a Government Medical College in India

Post Date: 
2020-07-27
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Annals of Global Health
Gauri Dumal and colleagues assess the impact of the 5-year HIV-TB research training program on building individual research capacity at BJGMC.

Mullen Scales of Early Learning Adaptation for Assessment of Indian Children and Application to Tuberculous Meningitis

Post Date: 
2020-07-03
   |   
Countries: 
India
Publication: 
Journal of Tropical Pediatrics
Introduction: Tuberculous meningitis (TBM) results in significant morbidity and mortality among children worldwide. Associated neurocognitive complications are common but not well characterized. The Mullen Scales of Early Learning (MSEL), a well-established measure for assessment of…

A mobile health-facilitated behavioral intervention for community health workers improves exclusive breastfeeding and early infant HIV diagnosis in India: A cluster randomized trial

Post Date: 
2020-07-02
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Journal of the International AIDS Society
When community health workers used a mobile health intervention with HIV+ women to deliver care, there was a higher uptake of exclusive breastfeeding at two months and early infant HIV diagnosis at six weeks

Trends and gender differences in access to HIV care with scale up of national HIV treatment guidelines in India

Post Date: 
2020-06-24
   |   
Countries: 
India
Publication: 
Journal of the International Association of Providers of AIDS Care
Test and treat is the current global standard, yet sex differences persist in access to HIV care. We assessed the differences in presentation and antiretroviral therapy (ART) uptake by sex and ART-eligibility period among ART-naive adults registered at a public ART center in India. Four ART…

Acceptability and Feasibility of a Behavioral and Mobile Health Intervention (COMBIND) Shown to Increase Uptake of Prevention of Mother to Child Transmission (PMTCT) Care in India

Post Date: 
2020-05-23
   |   
Countries: 
India
Publication: 
BMC Public Health
A cluster-randomized trial recently demonstrated that an integrated behavioral and mobile technology intervention improved uptake of key components of a Prevention of Mother to Child Transmission (PMTCT) Option B+ program, among HIV- infected pregnant/breastfeeding women in India.

High Burden of Bloodstream Infections Associated with Antimicrobial Resistance and Mortality in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2020-05-17
Publication: 
Clinical Infectious Diseases
Background: Antimicrobial resistance (AMR) is a growing threat to newborns in low and middle income countries (LMIC). Methods: We performed a prospective cohort study in three tertiary Neonatal Intensive Care Units (NICUs) in Pune, India, to describe the epidemiology of neonatal bloodstream…

Intensified short symptom screening program for Dengue infection during pregnancy, India

Post Date: 
2020-04-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Emerging Infectious Diseases
Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India and pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in India to diagnose dengue during pregnancy. During October 2017-January 2018, we screened pregnant…

High prevalence of late presentation of ART-naïve perinatally infected children for care in Pune, India

Post Date: 
2020-02-19
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
AIDS Care
AIDS Care : There is an urgent need to identify strategies that improve linkage of perinatally infected ART-naïve children to care, and earlier than what is currently observed.

Assessment of the Xpert assay among new pulmonary tuberculosis suspects with and without diabetes mellitus

Post Date: 
2020-01-01
   |   
Clinical Sites: 
BJGMC
Publication: 
International Journal of Tuberculosis and Lung Disease
IJTLD: Deshmukh and colleagues: High sensitivity and specificity of Xpert underscores need for rapid scale up for early detection of TB in settings with a high dual burden of TB and DM

Transcriptomic profiles of confirmed pediatric tuberculosis patients and household contacts identifies active tuberculosis, infection, and treatment response among Indian children

Post Date: 
2019-12-04
   |   
Clinical Sites: 
BJGMC
NIRT
Publication: 
Journal of Infectious Diseases
Journal of Infectious Diseases: Gene expression profiles among Indian children with confirmed TB were distinct from those of adults, highlighting the importance of including distinct populations in differential gene expression models

Pages

Reservoirs of transmission of resistant Gram-negative pathogens responsible for neonatal sepsis among hospitalized neonates in Pune, India

Post Date: 
2020-10-21
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Johnson J, Robinson ML, Naik S, Patil S, Kulkarni R, Kinikar A, Dohe V, Mudshinkar S, Kagal A, Smith RM, Westercamp M, Randive B, Kadam A, Kulkarni V, Mave V, Gupta A, Milstone AM, Manabe YC, for the CDC SHEPheRD India Study Team. Reservoirs of transmission of resistant Gram-negative pathogens…

Comparison of neurocognitive assessment in children with TB Meningitis and healthy controls in Pune, India

Post Date: 
2020-10-20
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Nimkar S, Joshi S, Kinikar A, Valvi C, Gupte N, Thakur KT, Suryavanshi N, Mave V, Dooley KE, Arenivas A. Comparison of neurocognitive assessment in children with TB Meningitis and healthy controls in Pune, India. Poster Presentation. 51st Union World Conference on Lung Health. Virtual Conference…

Blood-based biomarkers of tuberculosis in children integrating metabolomic and transcriptomic data

Post Date: 
2020-10-20
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Tornheim JA, Paradkar M, Fukutani KF, Kinikar A, Mave V, Andrade BB, Gupta A, Karakousis PC. Blood-based biomarkers of tuberculosis in children integrating metabolomic and transcriptomic data. TB Science 2020. Virtual. October 20, 2020.

Predictors of tuberculosis infection in MDR-TB household contacts ≥15 years old.

Post Date: 
2020-03-11
   |   
Countries: 
India
Kim S , Gupta A, Wu X, Hughes M, Dawson R, Mave V, Kumarasamy, Smith B, Rustomgee R, Shah NS, Hesseling A, Swindells S, Churchyard G for the ACTG/IMPAACT A5300/I2003 PHOENIx Feasibility Study Team. Predictors of tuberculosis infection in MDR-TB household contacts ≥15 years old. Presented at: CROI…

Tuberculosis preventive therapy should be considered for all household contacts of pulmonary TB patients in India

Post Date: 
2020-02-07
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Paradkar M, Chandrasekara P, Jain D, Shivakumar SVBY, Thiruvengadan K, Gupte AN, Thomas B, Kinikar A, Sekar K, Bharadwaj R, Dolla CK, Gaikwad S, Elilarasi S, Lokhande R, Reddy D, Murali L, Kulkarni V, Pradhan N, Hanna LE, Pattabiraman S, Kohli R, Nayagam R, Suryavanshi N, Shrinivasa BM, Cox SR,…

Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India

Post Date: 
2019-11-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Alexander M , Bhosale R, Naik S, Gupte N, Jain D, Patil N, Pradhan N, Mave V, Gupta A, Mathad J. Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India…

Does treatment of infertile women with probable genital tuberculosis improve fertility outcome?

Post Date: 
2019-11-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Naik SN , Chandanwale A, Kadam D, Sambarey PW, Dhumal G, DeLuca A, Jain D, Gupta A, Bollinger R, Mave V. Does treatment of infertile women with probable genital tuberculosis improve fertility outcome? Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-…

Six-week culture conversion predicts tuberculosis treatment outcomes

Post Date: 
2019-11-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Pradhan N , Kagal A, Gupte N, Gaikwad S, Barthwa M, Gupta A, Golub JE, Mave V. Six-week culture conversion predicts tuberculosis treatment outcomes. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Pitfalls in Chest X-ray Scoring of Patients Receiving Treatment for Active Tuberculosis in Pune, India

Post Date: 
2019-03-28
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Orsini E , Gupte A, Paradkar M, Jain D, Raskar S, Lokhande R, Mave V, Gupta A. Pitfalls in Chest X-ray Scoring of Patients Receiving Treatment for Active Tuberculosis in Pune, India. Johns Hopkins Global Health Day 2019. Baltimore, MD. March 28, 2019.

The prevalence of perinatal depression and associated birth outcomes in Pune, India

Post Date: 
2019-02-11
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Grossman TB , Mathad JS, Suryavanshi N, Alexander M, Mave V, Bhosale R, Gupta A. The prevalence of perinatal depression and associated birth outcomes in Pune, India. Society for Maternal-Fetal Medicine 39th Annual Pregnancy Meeting. Las Vegas, NV. February 11-16, 2019.

IL-6, TIMP-2 and TGFβ-2 Are Associated with Respiratory Impairment During and Following Successful Treatment of Pulmonary Tuberculosis

Post Date: 
2019-02-04
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Gupte A , Paradkar M, Selvaraju S, Kumar P, Lokhande R, Kulkarni V, Hanna LE, Thiruvengadam K, Sekar K, Momin A, Shivakumar SVBY, Gupte N, Babu S, Salvi S, Golub J, Checkley W, Bollinger RC, Andrade B, Mave V, Chandrasekaran P, Gupta A. IL-6, TIMP-2 and TGFβ-2 are associated with respiratory…

Host Lipidomic Profile Associated with Adverse Tuberculosis Treatment Outcomes

Post Date: 
2019-02-04
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Shivakoti R , Chandrasekaran P, Hannah LE, Thiruvengadam K, Saravanan N, Karunaianatham R, Gupta A, Mave V, Gupte N, Kulkarni V, Pradhan N, Gupte A, Paradkar M, Shivakumar SVBY, Bharadwaj, Kagal A, Gaikwad S, Sangle S, Borkowski K, Newman J, Fiehn O. Host Lipidomic Profile Associated with Adverse…

Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India

Post Date: 
2018-10-26
   |   
Clinical Sites: 
BJGMC
Dhumal G, DeLuca A, Chandanwale A, Kadam D, Joshi S, Kinikar A, Suryavanshi N, Mave V, Gupta A, Bollinger R. Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India. Session: Building…

Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin

Post Date: 
2018-10-25
Mave V, Gupte N, Gaikwad S, Barthwal M, Chon S, Gupte A, Gupta A, Golub J. Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin. Presented at 49th Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Sub-therapeutic Rifampicin Concentration is Associated with Unfavourable Treatment Outcomes in Pulmonary Tuberculosis Patients on Thrice Weekly Regimens in India

Post Date: 
2018-10-25
Ramachandran G, Chandrasekaran P, Kumar AKH, Kannan T, Gomathi NS, Gaikwad S, Gupta A, Mave V, for C-TRIUMPh team. Sub-therapeutic Rifampicin Concentration is Associated with Unfavourable Treatment Outcomes in Pulmonary Tuberculosis Patients on Thrice Weekly Regimens in India. Session: Clinical…

Regional Prospective Observational Research in TB (RePORT) India: Biomarkers, Diagnostics, and Comorbidities

Post Date: 
2018-10-24
Christopher DJ, Kornfeld H, Ellner J, Mave V, Rustomjee R, Rodrigues C, Gupta A. Regional Prospective Observational Research in TB (RePORT) India: Biomarkers, Diagnostics, and Comorbidities. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Mobile Phone Access and Comfort: Implications for HIV and Tuberculosis Care in India and South Africa

Post Date: 
2018-10-04
   |   
Countries: 
India
South Africa
   |   
Clinical Sites: 
BJGMC
Cox SN , Elf J, Lokhande R, Ogale YP, DiAndreth L, Dupuis E, Milovanovic M, Mpongose N, Martinson N, Mave V, Suryavanshi N, Gupta A, Golub JE, Mathad JS. Mobile Phone Access and Comfort: Implications for HIV and Tuberculosis Care in India and South Africa. I DSA. IDWeek 2018. San Francisco, CA,…

Perinatal Depression among HIV and TB Infected and Uninfected Women in an Urban Slum in India: Prevalence and Associated Birth Outcomes

Post Date: 
2018-10-04
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Grossman TB , Bhosale R, Alexander M, Suryavanshi N, Mave V, Jain D, Patil NU, Gupta A, Mathad JS. Perinatal depression among HIV and TB infected and uninfected women in an urban slum in India: prevalence and associated birth outcomes. IDSA. ID Week 2018. San Francisco, CA. October 3-7, 2018.

Antibiotic Use and Drug-Resistant Late-Onset Infections Among Neonates Admitted to Neonatal Intensive Care Units in Pune, India

Post Date: 
2018-08-28
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
DY Patil
KEM Hospital
Agarkhedkar S, Armstrong D, Bharadwaj R, Cox SR, Dohe V, Gupta A, Gupte N, Johnson J, Kadam A, Kinikar A, Malwade S, Manabe Y, Mave V, Milstone A, Parikh T, Rajput U, Randive B, Robinson M , Smith R, Suryavanshi N, Vaidya U, Westercamp M. Antibiotic Use and Drug-Resistant Late-Onset Infections…

Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster Randomized Trial

Post Date: 
2018-07-24
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Suryavanshi N, Kadam A, Hegde A, Sivalenka S, Kumar VS, McKenzie-White J, Kanade S, Gupta A, Bollinger RC, Shankar A, Gupte N, Mave V. Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster…

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Akshay Gupte, PhD, MBBS, MSPH, PhD

Instructor of Medicine
Akshay Gupte
Dr. Gupte is Instructor of Medicine at CCGHE. His research focuses on the intersection of infectious and chronic lung diseases in low- and middle-income countries. Dr. Gupte leads several Indo-US collaborative studies to describe the epidemiology and pathogenesis of lung impairment in TB/HIV/diabetes, measure its impact on poor clinical outcomes, and identify therapeutic and programmatic interventions to improve post-TB lung health and longevity. He is an active member of several multi-national TB/HIV research consortia such as the TB Transformative Science Working Group of the ACTG, the TB…

Jessica Elf, MPH, PhD

Assistant Professor, Colorado State University
Dr. Jessica Elf is an Assistant Professor of Epidemiology in the Department of Environmental and Radiological Health Sciences at Colorado State University. Dr. Elf’s research focuses on the epidemiology and health impacts of air pollution and tobacco use, with an emphasis on the HIV and tuberculosis (TB) co-epidemic. Her work aims to describe the overlap of air pollution and tobacco with these epidemics and the subsequent impact on TB and HIV health outcomes. In addition to risk characterization, her work focuses on subsequent mitigation strategies and interventions that are effective,…

Jeff Tornheim, MD, MPH

Assistant Professor
Jeff Tornheim, MD, MPH
Jeff Tornheim, MD, MPH, is Assistant Professor in the Division of Infectious Diseases here at Johns Hopkins University School of Medicine. His research explores the application of new diagnostic technologies to improved health outcomes in the treatment of drug resistant tuberculosis among both adult and pediatric patients in India. Dr. Tornheim recently completed his infectious diseases fellowship at Johns Hopkins, during which he worked with Drs. Amita Gupta, Vidya Mave, Bob Bollinger of Johns Hopkins, and with Dr. Zarir Udwadia at the Hinduja Hospital in Mumbai. His interest in clinical…

Matt Robinson, MD

Assistant Professor
Baltimore, Maryland
Dr. Matt Robinson
Matthew Robinson, MD, is Assistant Professor in the Division of Infectious Diseases at Johns Hopkins University School of Medicine, and he serves on the Advisory Team for the and serves on the Advisory Team for the Johns Hopkins Precision Medicine Center of Excellence for COVID-19. His research focuses on the diagnosis of acute febrile illness and its implication on antimicrobial stewardship and resistance in tropical low- and middle-income countries. Dr. Robinson is assessing the etiology of febrile illness in patients presenting to a hospital in Pune, India and determining how diagnosis…

Matthew Murrill

Baltimore, Maryland
Matthew Murrill is an MD-PhD student in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. In 2016, he was named an IDSA Education and Research Foundation Medical Scholar. After completing undergraduate studies in chemistry at Maryville College, he moved to Kolkata, India, as a Fulbright-Nehru fellow to research the sources and health effects of groundwater arsenic contamination in Eastern India with the School of Environmental Studies – Jadavpur University. He then worked for Calcutta Kids, a non-governmental organization, to establish a childhood diarrhea…

Nicky Mehtani, MD

Pune, India
Dr. Mehtani is a second year internal medicine resident at Johns Hopkins Hospital. After studying Global Health Technologies as an undergraduate at Rice University, she pursued a medical degree at Johns Hopkins, where she also earned her MPH at the Bloomberg School of Public Health. As an MPH and medical student, she worked with Dr. Kathleen Page in 2015-2016, analyzing Baltimore City STI surveillance data to help understand the initial effects of the Affordable Care Act on the demand for publicly-funded STD Clinics, and she continued to work on a three-year follow-up study of this issue as a…

Prarthana Vasudevan

Baltimore, Maryland
Prar Vasudevan is an international health graduate student at the Johns Hopkins School of Public Health. In Autumn 2015, she conducted a field placement in Pune, India, at BJGMC under Dr. Vidya Mave, where she worked on the study titled Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes. She is a 2015 recipient of the Global Health Established Field Placement Grant. From Prar Vasudevan’s Field Report: At BJMC, I had the opportunity to make rounds in the hospital’s ART Clinic, Labor & Delivery wards, and children’s wards. I was immediately struck by the fact…

Yasmin Ogale

Yasmin Ogale received her MPH from Bloomberg School of Public Health in 2015. From September to December 2014, she conducted a field study in Pune, India, under the guidance of Dr. Jonathan Golub, on indoor air pollution and tuberculosis. Ms. Ogale is a 2014 recipent of the Global Health Established Field Placement Grant.

Jeff Tornheim, MD, MPH

Infectious Disease Fellow
Baltimore, Maryland
Jeff Tornheim, MD, MPH, is a clinical fellow in the Division of Infectious Disease here at Johns Hopkins University School of Medicine. After completing undergraduate studies in International Development and Economics at Brandeis University he moved to East Africa where he engaged in health system strengthening for returning refugees to South Sudan and worked with the Centers for Disease Control and Prevention (CDC) on the epidemiology of pneumonia and diarrhea in Western Kenya. He completed a joint MD/MPH at Mount Sinai School of Medicine, with his thesis evaluating the impact of water…

Erica Orsini, MD

Pune, India
From January 3, 2018 to February 26, 2018, Dr. Orsini worked under Drs. Vidya Mave and Amita Gupta to observe clinical rounds and provide support to the BJGMC Clinical Research Site. She also supported provides the CTRIUMPh substudy entitled “Residual Respiratory Impairment Following Pulmonary TB” and the study entitled “Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients.”

Rahul Rajkumar, MD

Pune, India
Dr. Rahul Rajkumar visited BJGMC from January 9, 2018 to January 20, 2018, where he provided targeted lab support on a CDC ShePHERD protocol, “Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India.” Dr. Rajkumar is a Johns Hopkins Master of Public Health (MPH) student with a medical degree. Dr. Rajkumar is mentored by Dr. Yuka Manabe, and worked under Derek Armstrong, a Johns Hopkins microbiologist who collaborates closely with BJGMC on lab strengthening activities. Whiel on site, Dr. Rajkumar supported Derek Armstrong in conducting quality checks of specific…

Jessica Elf, MPH, PhD

Post Doctoral Fellow
Dr. Jessica Elf was a post doctoral fellow in the Department of International Health at the Johns Hopkins School of Public Health. Her primary research focus was on the epidemiology and health impacts of tobacco use and exposure to indoor air pollution from the combustion of biomass fuels. She is a former Fogarty Fellow who lived and worked in Pune, India conducting research for her thesis project, which investigated the association between indoor air pollution and tuberculosis. She completed her undergraduate education in nutrition at the University of Florida and received an MPH and…

Matt Robinson, MD

Research Fellow
Baltimore, Maryland
Matthew Robinson, MD, is a research fellow in the Division of Infectious Diseases at Johns Hopkins University School of Medicine. His research focuses on the diagnosis of acute febrile illness and its implication on antimicrobial stewardship and resistance in tropical low- and middle-income countries. Matt is working with Dr. Gupta, Dr. Mave, and Dr. Cosgrove to assess the etiology of febrile illness in patients presenting to a hospital in Pune, India and to determine how diagnosis impacts antibiotic use. He is also working on a CDC-funded project to evaluate the source of antimicrobial…

Akshay Gupte, PhD, MBBS, MSPH

Junior Investigator
Akshay Gupte
Akshay Gupte is a junior investigator trained in medicine, clinical research, and global health. His research interests include exploring approaches to host directed adjuvant therapies in tuberculosis (TB) and studying the impact of TB and HIV on lung health of populations. Dr. Gupte leads an Indo-US collaborative study exploring the impact of TB disease; alone and in combination with smoking, air pollution, HIV and diabetes mellitus; on respiratory impairment and risk of chronic obstructive pulmonary disease in India. He is also a co-investigator on the CTRIUMPH study—a multi-center cohort…

An Update on COVID-19 and India

Post Date: 
2021-10-01
Source: 
Johns Hopkins Bloomberg School of Public Health
Last spring, India experienced a catastrophic wave of COVID-19 infections with more than 100,000 cases per day, exceeding hospital capacity in some areas and leading to oxygen shortages.

Mentoring your mentor

Post Date: 
2021-02-07
Source: 
YouTube
How do you mentor your mentor and how establishing a structure can overcome some of the hurdles in building this relationship.

Research Update: TB Trials Conducted by JHU-India Team Will Shorten Drug-Susceptible TB Treatment for Children and Adults

Post Date: 
2020-12-07
Research Updated
Reporting from the virtual 51st Union Conference on Lung Health, the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) announced promising findings from 2 TB trials

Investigator Spotlight

Post Date: 
2020-12-01
Source: 
ACTG
Dr. Vidya Mave is Leader and Director of Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University (BJGMC-JHU) CRS based in Pune, India…

ACTG Site Spotlight: BJGMC-JHU Clinical Research Site, Pune, India

Post Date: 
2020-05-05
Source: 
ACTG Network Newsletter
ACTG Logo
The BJGMC-JHU Clinical Research site in Pune, India, is highlighted in this article.

Pune part of clinical trial to prevent TB in people exposed to multi-drug resistant cases

Post Date: 
2019-08-28
Source: 
The Indian Express
PHOENIX Study Team Members meet with local government health officials in Pune
Indian Express: Drs. Vidya Mave and Nishi Suryavanshi are quoted in this news article about a recent PHOENIx trial event at BJGMC Clinical Research Site

BJGMC Team Convenes PHOENIx Pre-study Event for Maharashtra Government TB Program Officials

Post Date: 
2019-08-19
Meeting participants, Group Photo
Collaboration and coordination with local government TB program officials are critical for ensuring transparency and a shared understanding of the study’s purpose, methods, consent process, logistics, and potential implications for India’s national TB control efforts.

Celebration of the Dedicated Participants and Staff of the REPRIEVE Study in Pune, India

Post Date: 
2019-02-18
REPRIEVE Team Members of the BJGMC Clinical Research Site
Staff and nearly 140 participants in the REPRIEVE study gathered for a community event in Pune, India

World AIDS Week Is Local at BJGMC in Pune, India

Post Date: 
2018-12-20
Performers conduct a play to raise awareness about HIV and HPV
The BJGMC Clinical Research Site convened community awareness activities that focused on HIV and HPV

BJGMC Clinical Research Team Exceeds 6,000 Participant Enrollments in 4 Years

Post Date: 
2018-08-03
Group Photo, BJGMC Clinical Research Site, 2016, Pune, India
The Indo-JHU Clinical Research partnership at BJGMC in Pune, India, is now one of the top enrollers among all ACTG research sites internationally.

World Tuberculosis (TB) Day Recognized with Community Event at BJGMC

Post Date: 
2018-04-17
World Health Day group activities at BJGMC Clinical Research Site in Pune, India
This year’s themes: Maintaining healthy nutrition, addressing mental health challenges, and the latest in TB research.

Uniting for a Healthier India

Post Date: 
2018-02-14
“The Indo-US clinical research & education partnership started with a single NIH grant to study maternal-infant HIV transmission.” Now with 76 studies underway, this short film chronicles the history & impact of our work in India.

Celebrating Johns Hopkins Medicine’s impact in India

Post Date: 
2017-12-13
Source: 
The Campaign for Johns Hopkins Medicine
In 4 years, the CCGHE has tripled its capacity for conducting research on grave health threats, thanks to strong philanthropic support.

CCGHE Joins 12-Country UNITAID Effort to Control TB

Post Date: 
2017-11-08
Shorter course to prevent progression of latent TB to active disease is the aim of the effort.

Indo-Hopkins Partnership Seeks Causes of Sepsis in the NICU

Post Date: 
2017-08-10
Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

Vidya Mave Promoted to Assistant Professor

Post Date: 
2017-06-06
Dr. Vidya Mave oversees clinical research & visiting researchers in India, including students conducting global health field studies

Women’s Empowerment at BJGMC World TB Day 2017

Post Date: 
2017-04-03
Posted 2017-04-03

Health on the Go: Mobile Clinic Delivers TB Services at Point of Need

Post Date: 
2017-03-24
Thanks to Raj and Bharti Shah, CTIS, & the NB Shah Charitable Trust, we are able to reach more people in Maharashtra who need care

Study highlights burden of community-onset antimicrobial resistance in India

Post Date: 
2017-03-21
Source: 
Healio
Healio features an antimicrobial resistance study by Dr. Vidya Mave, et al.

World AIDS Day 2016 at BJGMC

Post Date: 
2016-12-06
Read more about 2016 World AIDS Day activities at the BJGMC Clinical Site in Pune, India.

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