RePORT India

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and...

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Immune Responses and Effect of Disulfiram on MTB Infected PBMCs as a Potential Host Directed Therapy

Post Date: 
2018-11-26
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Mandar Paradkar is lead investigator for this study that is assessing the immune responses of adult pulmonary TB patients enrolled in the CTRIUMPh study, using PBMC samples of those with harmful use of alcohol assessed by AUDIT scores ≥ 8 compared to non-alcoholics (AUDIT < 8). Aim 1: To...

Validating a Novel Functional Correlate of Immune Protection of Tuberculosis

Post Date: 
2018-10-03
   |   
Countries: 
   |   
Clinical Sites: 
This C-TRIUMPH study is a longitudinal assessment of PBMC samples of progressors and non-progressors among adult household contacts of active TB patients. The purpose of the study is to probe the functional diversity of T cell responses to several of the antigens encoded by Mtb simultaneously in...

Assessing Psychological Distress among Tuberculosis Patients and Their Household Members

Post Date: 
2018-07-17
   |   
Countries: 
   |   
Clinical Sites: 
By assessing psychological distress, Indo-JHU researchers hope to better understand the correlation between depression and TB severity.

Molecular Signatures of Tuberculosis-Diabetes Interaction: Metabolomics Study

Post Date: 
2018-06-15
   |   
Countries: 
   |   
Clinical Sites: 
This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Type 2 diabetes mellitus (DM) is an acquired host...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Transcriptomics Study

Post Date: 
2018-06-15
   |   
Countries: 
   |   
Clinical Sites: 
This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Type 2 diabetes is an acquired host factor that...

Predictors of Resistance Emergence Evaluation in Multidrug Resistant-Tuberculosis Patients on Treatment (PREEMPT Pilot Study)

Post Date: 
2018-03-20
   |   
Countries: 
   |   
Clinical Sites: 
Indo-JHU Clinical Resarch Partnership is participating with Brazilian colleagues in a 3-year effort led by Boston University to identify what contributes to TB drug resistance.

Targeting Mycobacterium Tuberculosis Persisters by Enhancing Stringent Response-specific Cellular Immunity

Post Date: 
2017-09-11
   |   
Countries: 
   |   
Clinical Sites: 
C-TRIUMPH nested study begins to see if stringent response antigen is enhanced while treating drug-susceptible TB using the first-line anti-TB regimen.

The Role of Innate Immunity in the Acquisition of Sterile Protection against TB Infection

Post Date: 
2017-08-25
   |   
Countries: 
   |   
Clinical Sites: 
This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Tuberculosis (TB) is a major global health problem...

Validation of Transcriptional Signature to Predict Active TB Disease among Advanced HIV Patients

Post Date: 
2017-08-15
   |   
Countries: 
   |   
Clinical Sites: 
There have been tremendous advances in the diagnosis of patients with tuberculosis (TB) based on nucleic acid amplification of bacteria in the sputum. The GenXpert MTB/RIF provides results in 2 hours. However, in HIV-infected sputum smear is often negative for AFB and the sensitivity of GenXpert...

Association of Lipid Mediators of Inflammation with TB Treatment Outcomes

Post Date: 
2017-08-03
   |   
Countries: 
   |   
Clinical Sites: 
This study was terminated July 22, 2019. This study used stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Recent studies...

Biomarkers for Tuberculosis Diagnosis and Treatment Response

Post Date: 
2017-03-24
   |   
Countries: 
   |   
Clinical Sites: 
This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Aims: To develop non-sputum, blood-based tools for TB diagnosis and...

Transcriptomic and Metabolomic Analysis of Microbiologically Confirmed Pediatric Tuberculosis Patients and Uninfected Household Contacts

Post Date: 
2016-09-01
   |   
Countries: 
   |   
Clinical Sites: 
This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. The objectives for this study are to: Assess the...

Comparison of Available Purified-protein Derivative (PPD) Tuberculin Skin Test (TST) Antigen Solutions in Detecting Latent Tuberculosis Infection in India

Post Date: 
2016-04-21
   |   
Countries: 
   |   
Clinical Sites: 
This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Given the worldwide shortage of PPD TST antigen solutions, it is...

The Human Virome in Health and Disease

Post Date: 
2016-02-21
   |   
Countries: 
   |   
Clinical Sites: 
This study is part of the Antimicrobial Resistance study referenced below, Some samples were used from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB...

Residual Respiratory Impairment Following Pulmonary Tuberculosis

Post Date: 
2015-09-13
   |   
Countries: 
   |   
Clinical Sites: 
This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Many TB patients have residual respiratory impairment despite...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH)

Post Date: 
2013-09-28
   |   
Countries: 
   |   
Clinical Sites: 
Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB research...

Assessing the Association of Indoor Air Pollution with Tuberculosis in Adult Women and Children under 5 Years of Age

Post Date: 
2013-09-15
   |   
Countries: 
This study is conducted the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Addressing social and environmental risk factors contributing to TB...

Pages

Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored

Post Date: 
2019-07-31
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
PLoS One
BACKGROUND: More than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of increasing...

Infection free "resisters" among household contacts of adult pulmonary tuberculosis

Post Date: 
2019-07-18
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
PLoS One
Despite substantial exposure to infectious pulmonary tuberculosis (TB) cases, some household contacts (HHC) never acquire latent TB infection (LTBI). Characterizing these "resisters" can inform who to study immunologically for the development of TB vaccines. We enrolled HHCs of culture-confirmed...

Mobile phone access and comfort: implications for HIV and tuberculosis care in India and South Africa.

Post Date: 
2019-07-01
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
SETTING: India and South Africa shoulder the greatest burden of tuberculosis (TB) and human immunodeficiency virus (HIV) infection respectively, but care retention is suboptimal. OBJECTIVE: We conducted a study in Pune, India, and Matlosana, South Africa to identify the factors associated with...

Assessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD

Post Date: 
2019-05-23
   |   
Countries: 
Publication: 
PLoS One
New in PLoS One: We found a high burden of lung function defects and COPD in tuberculosis cases who successfully completed treatment, suggesting a need for lung function screening as part of patient management.

Sub-therapeutic rifampicin concentration is associated with unfavourable tuberculosis treatment outcomes

Post Date: 
2019-05-10
   |   
Countries: 
Publication: 
Clinical Infectious Diseases
Rifampicin concentrations were sub-therapeutic in most Indian patients taking a thrice-weekly TB regimen

Few eligible for the newly recommended short course MDR-TB regimen at a large Mumbai private clinic

Post Date: 
2019-01-28
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
BMC Infectious Diseases
BACKGROUND: India has the world's highest tuberculosis burden, and Mumbai is particularly affected by multidrug resistant tuberculosis (MDR-TB). WHO recommends short, intensive treatment ("Short Course") for previously untreated pulmonary MDR-TB patients but does not require universal drug...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

Post Date: 
2018-10-01
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

Post Date: 
2018-09-07
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Occupational and Environmental Medicine
Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

The effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

Post Date: 
2018-08-20
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Antimicrobial Agents and Chemotherapy
DM and higher HbA1c increased the risk of not achieving therapeutic targets for pyrazinamide, but higher pyrazinamide concentrations were asociated with worse microbiologic and clinical outcomes

Sources of household air pollution and their association with fine particulate matter in low-income urban homes in India

Post Date: 
2018-05-23
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Journal of Exposure Science and Environmental Epidemiology
INTRODUCTION: Household air pollution (HAP) is poorly characterized in low-income urban Indian communities. MATERIALS AND METHODS: A questionnaire assessing sources of HAP and 24 h household concentrations of particulate matter less than 2.5 microns in diameter (PM 2.5 ) were collected in a sample...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date: 
2016-02-25
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
BMJ Open
Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB...

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date: 
2016-01-01
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The cost-...

Improving diagnostic capability for HPV disease internationally within the NIH-NIAID-Division of AIDS Clinical Trial Networks

Post Date: 
2013-12-15
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
American Journal of Clinical Pathology
OBJECTIVES: To evaluate an external quality assurance (EQA) program for the laboratory diagnosis of human papillomavirus (HPV) disease that was established to improve international research capability within the Division of AIDS at the National Institute of Allergy and Infectious Disease-supported...

Female tuberculosis (TB) patients with stigma are at increased risk of persistent depression: time to integrate mental health screening into TB care

Post Date: 
2019-11-20
   |   
Clinical Sites: 
Suryavanshi N . Female tuberculosis (TB) patients with stigma are at increased risk of persistent depression: time to integrate mental health screening into TB care. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Impact of Standard or Increased Moxifloxacin Dose Among MDR-TB Patients in Mumbai with Low-Level Resistance

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Tornheim JA , Udwadia ZF, Porwal S, Kishore G, Gajjar I, Karane M, Shivakumar SVBY, Rodrigues C, Gupta A. Impact of Standard or Increased Moxifloxacin Dose Among MDR-TB Patients in Mumbai with Low-Level Resistance. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT)...

IL-6, TIMP-2 and TGFβ-2 Are Associated with Respiratory Impairment During and Following Successful Treatment of Pulmonary Tuberculosis

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Gupte A , Paradkar M, Selvaraju S, Kumar P, Lokhande R, Kulkarni V, Hanna LE, Thiruvengadam K, Sekar K, Momin A, Shivakumar SVBY, Gupte N, Babu S, Salvi S, Golub J, Checkley W, Bollinger RC, Andrade B, Mave V, Chandrasekaran P, Gupta A. IL-6, TIMP-2 and TGFβ-2 are associated with respiratory...

Linezolid Resistance in Mycobacterium Tuberculosis Isolates at a Tertiary Care Center in Mumbai, India, by Whole Genome Sequencing

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Tornheim JA , Diricks M, Katrien DB, Sadani M, Shetty A, Rodrigues C. Linezolid Resistance in Mycobacterium Tuberculosis Isolates at a Tertiary Care Center in Mumbai, India, by Whole Genome Sequencing. RePORT India 2019 Joint Leadership Meeting. Chennai, India. February 4-6, 2019.

Determination of Plasma Clofazimine Levels by Liquid Chromatography-Mass Spectrometry

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Chawla PK , Lokhande RV, Naik PR, Dherai AJ, Udwadia ZF, Mahashur AA, Pinto L, Soman R, Rodrigues C, Gupta A, Tornheim JA, Martinson N, Variava E, Weisner L, Joubert A, Ashavaid TF. Determination of Plasma Clofazimine Levels by Liquid Chromatography-Mass Spectrometry. 8th Annual Regional...

Determination of Serum Linezolid Levels by HPLC

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Chawla PK , Lokhande RV, NaiF PR, Dherai AJ, Udwadia ZF, Mahashur AA, Soman R, Rodrigues C, Gupta A, Tornheim JA, Ashavaid TK. Determination of Serum Linezolid Levels by HPLC. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership meeting – ‘’...

Mental Health and TB: High Prevalence of Depression among Drug-resistant TB Patients not Associated with Cycloserine

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Shivakumar SVBY , Tornheim JA, Gajjar I, Porwal S, Kishore G, Karane M, Sayed S, Chawla PK, Rodrigues C, Ashavaid TK, Gupta A, Udwadia ZF. Mental Health and TB: High prevalence of depression among drug-resistant TB patients not associated with cycloserine. 8th Annual Regional Prospective...

Quality of Life Among MDR-TB Patients from the Public Sector in Mumbai

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Gajjar IN , Udwadia ZF, Kishore G, Karane M, Sayed S, Sawant N, Chawla PK, Rodrigues C, Ashavaid TK, Shivakumar SVBY, Gupta A, Tornheim JA. Quality of Life Among MDR-TB Patients from the Public Sector in Mumbai. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India...

Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Kambli P , Tornheim JA, Soundararajan L, Priyadarshini S, Gupta R, Ramprasad VL, Gupta A, Rodrigues C. Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance. 8th Annual Regional Prospective Observational Research for Tuberculosis...

Host Lipidomic Profile Associated with Adverse Tuberculosis Treatment Outcomes

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Shivakoti R , Chandrasekaran P, Hannah LE, Thiruvengadam K, Saravanan N, Karunaianatham R, Gupta A, Mave V, Gupte N, Kulkarni V, Pradhan N, Gupte A, Paradkar M, Shivakumar SVBY, Bharadwaj, Kagal A, Gaikwad S, Sangle S, Borkowski K, Newman J, Fiehn O. Host Lipidomic Profile Associated with Adverse...

Does Smoking Have an Impact on TB Treatment Outcomes?

Post Date: 
2018-10-27
Thomas B, Kannan T, Rani V, Gupte N, Gupta A, Deluca A, Suryavanshi N, Kohli R, Chandrasekaran P for the CTRIUMPH RePORT India Study Team. Does Smoking Have an Impact on TB Treatment Outcomes? A Prospective Cohort Study from India. Session: Tobacco Use in Various Populations: Implications for...

Alcohol Use Disorder, Drinking Patterns, and Tuberculosis Treatment Failure in Indian Patients

Post Date: 
2018-10-25
Samyra R Cox, Andrea Deluca, Beena Thomas, Nishi Suryavanshi, Divyashri Jain, Mandar Paradkar, Nikhil Gupte, Akshay Gupte, Bob Bollinger, Shri Vijay Bala Yogendra Shivakumar, Kannan Thiruvengadam, Geetanjali Chander, Vidya Mave, Padmapriyadarshini Chandrasekaran, Amita Gupta for the CTRIUMPh Study...

Time to culture conversion, identifying independent modifiable risk factors in Indian patients

Post Date: 
2018-10-25
Gupte N, Gupte A, Sivaramakrishnan GN, Pradhan N, Shivakumar SVBY, Gupta A, Mave V, Chandrasekaran P for the CTRIUMPh RePORT India team. Time to culture conversion, identifying independent modifiable risk factors in Indian patients. Presented at 49th Union World Conference on Lung Health. The Hague...

Incidence of Mycobacterium tuberculosis Infection among Household Contacts of Adult Pulmonary Tuberculosis Cases in India

Post Date: 
2018-02-20
   |   
Countries: 
   |   
Clinical Sites: 
Selvaraju S, Thiruvenkadam K, Paradkar M , Marinaik SB, Bharadwaj R, Rajagopalan S, Gaikwad S, Pattabiraman S, Kinikar A, Sivaramakrishnan GN, Meshram S, Hanna LE, Lokhande R, Dhanasekaran K, Gupte A, John S, Gupte N, Thomas B, Kukarni V, Ayyanu S, Kohli R, Shivakumar SVBY, Swaminathan S, Mave V,...

Incidence of Mycobacterium tuberculosis Infection among Household Contacts of Adult Pulmonary Tuberculosis Cases in India

Post Date: 
2018-02-15
   |   
Countries: 
Paradkar M, Dhanasekaran K, Kinikar A, Kulkarni R, Bharadwaj R, Gaikwad S, Lokhande R, Meshram S, Dolla CK, Selvaraju S, Murali L, Thiruvengadam K, Jain D, Rajagopal S, Kulkarni V, Pradhan N, John S, Kohli R, Nayagam R, Shivakumar SVBY, Suryavanshi N, Cox SR, Gupte A, Chandrasekaran P, Mave V,...

High Burden of Diabetes and Prediabetes among Adult Household Contacts of India

Post Date: 
2017-09-13
   |   
Countries: 
   |   
Clinical Sites: 
Shivakumar SVBY , Chandrasekaran P, Kumar AJMV, Paradkar M, Dhanasekaran K, Suryavanshi N, Thomas B, Kohli R, Thiruvengadam K, Kulkarni V, Hannah LE, Sivaramakrishnan GN, Pradhan N, Dolla C, Gupte A, Ramachandran G, DeLuca A, Meshram S, Bhardawaj R, Bollinger RC, Golub J, Selvaraj K, Gupte N,...

CTRIUMPh Pediatric Biomarker Substudy

Post Date: 
2017-05-30
   |   
Countries: 
   |   
Clinical Sites: 
Tornheim J . Paradkar M. CTRIUMPh Pediatric Biomarker Substudy. 2017 IMPAACT Annual Meeting. Washington, DC. 2017.

Alcohol Use Among Adult Pulmonary and Extra-pulmonary TB Cases in the C-TRIUMPH India Cohort

Post Date: 
2017-02-03
   |   
Countries: 
   |   
Clinical Sites: 
John S , DeLuca A, Paradkar M, Nayagam R, Shivakumar SVBY, Gupte A, Gupte N, Thomas B, Suryavanshi N, Kolhi R, Golub J, Kulkarni V, Pradhan N, Mave V, Chandrasekaran P, Gupta A. Alcohol Use Among Adult Pulmonary and Extra-pulmonary TB Cases in the C-TRIUMPH India Cohort. 6th Annual Regional...

Descriptive Baseline Characteristics, Treatment Outcomes and Biorepository of Pediatric TB Cases in CTRIUMPh-RePORT India Prospective Cohort

Post Date: 
2017-02-03
   |   
Countries: 
   |   
Clinical Sites: 
Paradkar M , Kavitha D, Shiva Kumar SVBY, Khadse S, Khwaja S, Hari K, Rani N, Thiruvengadam K, Gupte N, Raskar S, Jain D, Suryavanshi S, Kohli R, Kulkarni V, Pradhan N, Sathyamurthi B, Tornheim J, Gupte A, DeLuca A, Mave V, Chandrasekaran P, Gupta A for the CTRIUMPH Study Team. Descriptive Baseline...