Genomics

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Characterization of TB-specific T Cell Responses in Highly-exposed, but Uninfected Health Care Workers in India

Post Date: 
2018-10-25
   |   
Countries: 
   |   
Clinical Sites: 
This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Jyothi Rengarajan, MD, Emory University. Primary Research Question Do health care workers who remain TST negative, despite high-exposure to TB,...

Assessing Tuberculosis Transmission Dynamics, Drug Resistance and Recurrence Using Whole Genome Sequencing in Pune, India

Post Date: 
2018-06-12
   |   
Countries: 
Indo-JHU researchers are using combined geospatial and genotyping methods to describe TB transmission dynamics in a hyperlocal region of Pune City in Western India.

MDR-TB Free: Monitoring Adverse Effects, Utilizing Resources Optimally, Knowing Resistance Patterns, and Treatment Strategy

Post Date: 
2017-03-24
   |   
Countries: 
   |   
Clinical Sites: 
This study is also known as MDR-TB MUKT: M onitoring Adverse Effects, U tilizing Resources Optimally, K nowing Resistance Patterns, and T reatment Strategy. Purpose: To establish an observational cohort of MDR-TB cases and household contacts with accompanying biorepository at PD Hinduja National...

Whole Genome Sequencing and Trek Sensititre Testing of Stored Isolates of Drug-resistant Tuberculosis from a Clinical Cohort at Hinduja Hospital, Mumbai

Post Date: 
2016-05-02
   |   
Countries: 
   |   
Clinical Sites: 
Among HIV-positive TB patients presenting to Médecins San Frontières (MSF) clinics in Mumbai, 78% carried MDR-TB strains, with nearly half also found to have additional drug resistance. A previously published cohort of 202 patients cared for at these MSF clinics have enrolled in a cross-sectional...

Whole Genome Sequencing of Clinical Isolates from Patients with Multidrug Resistant Tuberculosis in India 

Post Date: 
2015-11-12
   |   
Countries: 
   |   
Clinical Sites: 
Comparative genomic analysis using whole genome sequencing (WGS) offers an opportunity to understand the specific mutations associated with drug resistance and the phenotypic behavior of TB. As treatment programs incorporate more molecular diagnostics such as Xpert MTB/RIF and line probe assays, it...

Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system

Post Date: 
2016-06-13
Publication: 
Neurology, Neuroimmunology and Neuroinflammation
OBJECTIVE: To determine the feasibility of next-generation sequencing (NGS) microbiome approaches in the diagnosis of infectious disorders in brain or spinal cord biopsies in patients with suspected CNS infections. METHODS: In a prospective pilot study, we applied NGS in combination with a new...

Linezolid Resistance in Mycobacterium Tuberculosis Isolates at a Tertiary Care Center in Mumbai, India, by Whole Genome Sequencing

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Tornheim JA , Diricks M, Katrien DB, Sadani M, Shetty A, Rodrigues C. Linezolid Resistance in Mycobacterium Tuberculosis Isolates at a Tertiary Care Center in Mumbai, India, by Whole Genome Sequencing. RePORT India 2019 Joint Leadership Meeting. Chennai, India. February 4-6, 2019.

Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance

Post Date: 
2019-02-04
   |   
Countries: 
   |   
Clinical Sites: 
Kambli P , Tornheim JA, Soundararajan L, Priyadarshini S, Gupta R, Ramprasad VL, Gupta A, Rodrigues C. Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance. 8th Annual Regional Prospective Observational Research for Tuberculosis...

Drug Susceptibility of Rifampin-resistant Tuberculosis using Whole Genome Sequencing to Identify Genes of Interest in Pune, India

Post Date: 
2018-02-15
   |   
Countries: 
   |   
Clinical Sites: 
Tornheim JA, Madugundu AK, Pradhan N, Bharadwaj R, Mave V, Golub J, Pandey A, Gupta A. Drug Susceptibility of Rifampin-resistant Tuberculosis using Whole Genome Sequencing to Identify Genes of Interest in Pune, India. RePORT India Annual Meeting. New Delhi, India.

Drug Susceptibility of Rifampin-resistant Tuberculosis using Whole Genome Sequencing to Identify Genes of Interest in Pune, India

Post Date: 
2017-10-12
   |   
Clinical Sites: 
Tornheim JA , Madugundu AK, Pradhan N, Bharadwaj R, Mave V, Golub J, Pandey A, Gupta A. Drug Susceptibility of Rifampin-resistant Tuberculosis using Whole Genome Sequencing to Identify Genes of Interest in Pune, India. 48th Annual Union World Conference of Lung Health. Guadalajara, Mexico.

Communicating Whole Genome Sequencing Results for Tuberculosis: What Does It Mean and Who Needs to Know?

Post Date: 
2017-04-25
   |   
Countries: 
   |   
Clinical Sites: 
Tornheim, J. Communicating Whole Genome Sequencing Results for Tuberculosis: What Does It Mean and Who Needs to Know? Foundation for Medical Research. Mumbai, India.