Jyoti Mathad, MD, MSc

Role:

Faculty

Assistant Professor, Weill Cornell Medical College

Dr. Mathad is an Assistant Professor of Medicine and Obstetrics & Gynecology in the the Center for Global Health at Weill Cornell Medical College. She is also a faculty member at the Johns Hopkins Center for Clinical Global Health Education.

Her primary research interests include the immune changes of pregnancy and how they affect the development of tuberculosis (TB) in TB-endemic countries, such as India. Since 2010, she has been conducting research in Pune, India, on the performance of immune-based latent TB diagnostics in pregnant women with and without HIV. She is now leading the PRACHITi study there, which is investigating the impact of pregnancy and HIV on the immune response to M. tuberculosis. Her K23 award focuses on identifying behavioral and immunologic risk factors that predict which women are at highest risk of developing active TB postpartum. She is an investigator in the International Maternal, Pediatric, and Adolescent AIDS Clinical Trials network (IMPAACT), and she is also the principal investigator on a study of the immune changes of pregnancy and TB in Port-au-Prince, Haiti.

Dr. Mathad completed her undergraduate studies in biology at Cornell University and received her medical degree from Albany Medical College. She completed her internal medicine residency at the University of Maryland, where she was chief resident. She returned to New York to complete her fellowship in infectious diseases at Weill Cornell, where she also completed her masters in clinical epidemiology.

Studies/Projects
Publications
Presentations
News

Zika Surveillance among Antenatal Clinic Outpatients in BJ Government Medical College and Sassoon General Hospitals, Pune, India

Post Date:

2017-08-31

Country:

CCGHE is keeping an eye on Zika among pregnant women, which is transmitted by mosquitoes & can cause devastating birth defects.

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition

Post Date:

2017-08-29

Country:

New study in Pune, India, aims to identify the profile of TB antibodies between mothers and infants, and to see if the presence of antibodies lowers risk of infant infection.

Vaginal Microbiota in HIV Infected Pregnant Women

Post Date:

2017-07-14

Country:

Led by Dr. Rupak Shivakoti, this is a nested cross-sectional study of 30 HIV-infected and 60 non-HIV infected pregnant women. Pregnant women that are part of the parent study (“Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis” referred to as PRACHITI study from here on) will...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

Post Date:

2014-10-28

Country:

This is a cross sectional observational study known as PRACHITi (PRegnancy And CHanges In Tuberculosis), meaning “wisdom” in Marathi. It will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date:

2014-09-01

Country:

Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at risk of reactivation and progression to...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date:

2014-09-01

Country:

Purpose: TB is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not understood. Our recent research shows that pregnant women...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date:

2014-04-01

Country:

Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in Botswana, Haiti, South Africa, Tanzania, Thailand, Uganda, and Zimbabwe, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. Background Tuberculosis (TB) is the...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date:

2010-01-01

Country:

Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3-fold higher in resource limited settings (RLS) than...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date:

2007-02-02

Country:

Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

Screening and diagnosis of gestational diabetes in India: A systematic review and meta analysis

Post Date:

2018-03-26

Publication:

Acta Diabetologica

Country:

Review article on prevalence and screening and diagnostic methods for gestational diabetes in India.

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Post Date:

2017-07-01

Publication:

International Journal of Tuberculosis and Lung Disease

Country:

Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression...

Pulmonary infections in pregnancy

Post Date:

2017-06-01

Publication:

Seminars in Respiratory and Critical Care Medicine

Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

The ripple effect: why promoting female leadership in global health matters

Post Date:

2016-12-21

Publication:

Public Health Action

Leadership positions in global health are greatly skewed toward men; the imbalance is more pronounced in low- and middle-income countries (LMICs). The under-representation of women in leadership is a threat to gender equality, and also impacts the improvement of women's health outcomes globally. In...

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date:

2016-10-01

Publication:

Journal of Acquired Immune Deficiency Syndromes

Country:

Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon γ, tumor necrosis factor...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date:

2016-06-15

Publication:

American Journal of Respiratory and Critical Care Medicine

Country:

Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Toward earlier inclusion of pregnant and postpartum women in TB drug trials: consensus statements from an International Expert Panel

Post Date:

2016-01-04

Publication:

Clinical Infectious Diseases

Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15–44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials...

What tuberculosis means for maternal health

Post Date:

2015-03-04

Mrs. Kumar [not her real name] was diagnosed with TB 18 years ago, during her first pregnancy, which ended in miscarriage. She then became depressed and side effects from the TB medications caused her difficulty eating. Three years later, during her second pregnancy, she and her husband were...

Source case investigation for children with TB disease in Pune, India

Post Date:

2014-08-27

Publication:

Tuberculosis Research and Treatment

Country:

Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. Objectives. To...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

Post Date:

2014-03-21

Publication:

PLOS One

Country:

Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date:

2014-03-14

Publication:

Vaccine

Country:

Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental cord:maternal ratios (GMRs) and proportions...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date:

2012-12-15

Publication:

Clinical Infectious Diseases

Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in women...

The Effect of HIV on the Immune Response to Myobacterium tuberculosis in Pregnant Women from Pune, India.

Post Date:

2018-02-15

Presentation Location:

New Delhi, India

Event & Convener:

RePORT India Annual Meeting

Mathad J, Alexander M, Bhosale R, Naik S, Suryavanshi N, Mave V, Deshpande P, Balasubramanian U, Kulkarni V, Kumar P, Babu S, Gupte N, Nevrekar N, Patil S, Chandanwale A, Gupta A.

Biological Differences in Tuberculosis Diagnosis and Disease in Women

Post Date:

2017-10-12

Presentation Location:

Guadalajara, Mexico

Event & Convener:

48th Annual Union World Conference of Lung Health

Symposium Presentation. Mathad J

IMPAACT 2001: Trial of the Pharmacokinetics, Tolerability, and Safety of Once-Weekly Rifapentine and Isoniazid in HIV-infected and HIV-1-uninfected Pregnant and Postpartum Women with Latent Tuberculosis Infection

Post Date:

2017-05-30

Presentation Location:

Washington, DC

Event & Convener:

2017 IMPAACT Annual Meeting

Invited presenter. Tuberculosis Scientific Committee.

Impact of Immune Changes of Pregnancy and HIV Infection on Tuberculosis

Post Date:

2017-02-03

Presentation Location:

Hyderabad, India

Country:

Event & Convener:

6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting

Poster presentation. Mathad J, Alexander M , Bhosale R, Naik S, Shivakoti R, Mave V, Suryavanshi N, Gupte N, Kulkarni V, Pradan N, Patil N, Gupta A

Characteristics Associated with Mobile Phone Access among Tuberculosis Patents in Pune, India

Post Date:

2016-12-04

Presentation Location:

Cape Town, South Africa

Country:

Event & Convener:

46th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.

Poster Presentation. Ogale YP , Elf JL, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J.

Pharmacokinetic Aspects of 3HP in Special Populations

Post Date:

2016-10-29

Presentation Location:

Liverpool, England

Event & Convener:

47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.

Presentation. Mathad J.

IMPAACT P1078: Background, Design and Baseline Data

Post Date:

2016-10-29

Presentation Location:

Liverpool, England

Country:

Event & Convener:

47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.

Presentation. Mathad J on behalf of Gupta A and P1078 Study Team TB APPRISE: Phase IV Randomized Double-blind Placebo-controlled Trial to Evaluate the Safety of Immediate (Antepartum-initiated) vs. Deferred (Postpartum-initiated) Isoniazid Preventive Therapy among HIV-infected Women in High TB...

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

Post Date:

2016-02-24

Presentation Location:

Boston, MA

Country:

Event & Convener:

Conference on Retroviruses and Opportunistic Infections 2016

Poster Presentation: Tuberculosis and Pregnancy. Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date:

2015-12-04

Presentation Location:

Cape Town, South Africa

Event & Convener:

The 46th Union World Conference on Lung Health

Symposium. Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. Moderators: Gupta A, Mathad J.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date:

2015-12-04

Presentation Location:

Capetown, South Africa

Event & Convener:

International Union for Tuberculosis and Lung Disease. 46th Union World Conference on Lung Health.

Symposium: Maternal and Infant TB: Advancing our Understanding of Pathogenesis, Treatment and Prevention.

Characteristics Associated with Mobile Phone Access among TB Patients in Pune, India

Post Date:

2015-12-04

Presentation Location:

Cape Town, South Africa

Country:

Event & Convener:

The 46th Union World Conference on Lung Health

Poster Discussion. Session: What's App Doc? Use of m-Health. Authors: Ogale YP, Elf J, Lokhande R, Mave V, Roy S, Gupta A, Golub J, Mathad J.

Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention

Post Date:

2015-12-04

Presentation Location:

Cape Town, South Africa

Event & Convener:

The 46th Union World Conference on Lung Health

Symposium: Maternal and Infant TB: Advancing Our Understanding of Pathogenesis, Treatment and Prevention. Session Coordinators: Mathad J, Bekker A.

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date:

2015-10-11

Presentation Location:

San Diego, CA

Event & Convener:

ID Week 2015

Poster Session: Latent TB Infection: Diagnosis and Treatment. Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, Mathad J.

How can we encourage female leaders in global health?

Post Date:

2017-08-09

Source:

Global Health Matters

Fogarty Director Dr. Roger Glass asks why so few women are leading global health centers at med schools or filling other leadership roles.

Amita Gupta and colleagues discuss female leadership in academic global health

Post Date:

2017-05-04

Drs. Gupta, Manabe, Mathad discuss need for more women in global health leadership at CUGH's annual meeting.

Tuberculosis test may underreport in pregnant women with HIV

Post Date:

2016-01-28

Source:

Infectious Disease Advisor

Pregnancy may confound tuberculosis (TB) tests results in women with HIV, according to research published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine .

Tuberculosis scare in HIV positive pregnant women: most widely-used tuberculosis test fails to diagnose illness

Post Date:

2016-01-28

Source:

International Business Times

The most commonly-used tuberculosis (TB) test, TST, has failed to detect TB in HIV positive pregnant women. A research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine has revealed that the TB test failed to accurately diagnose the...

Awards and honors across Weill Cornell – Week of March 25-April 3

Post Date:

2015-04-03

Source:

Weill Cornell Newsroom

Dr. Jyoti Mathad, an instructor in medicine, was named an Ujala Foundation Scholar by the Center for Clinical Global Health Education at Johns Hopkins Medicine. Dr. Mathad is one of eight scholars who will work to improve healthcare in India, with a particular focus on fighting tuberculosis. The...