Nutrition

Topic Activities

Impact of Diabetes on TB Treatment Outcomes: Nested Study: Lipid Mediators of Inflammation in TB and TB-Diabetes

Post Date: 
2017-10-02
Studies have shown that individuals with Tuberculosis (TB) and diabetes (TB-DM) have a distinct immune profile compared to individuals with TB alone. Individuals with TB-DM have higher inflammation, a higher bacillary load, increased Th1 immune responses and a defective neutrophil and macrophage...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

Post Date: 
2016-07-05
Country: 
This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association of gestational age with...

Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes

Post Date: 
2016-07-01
Country: 
The primary objective of this study is to determine the feasibility and operational logistics of collecting stool for microbiome analysis, detailed nutritional assessment using a food-frequency questionnaire for dietary intake and serum for inflammatory markers in order to determine factors that...

Barriers for Intervention to Prevent Occupationally Acquired Tuberculosis in Healthcare Workers

Post Date: 
2015-05-21
Country: 
Observational study to assess the current status of implementation of interventions for preventing occupationally acquired TB in HCW. Identify the barriers to implementing these interventions

Impact of Diabetes on TB Treatment Outcomes

Post Date: 
2013-02-01
Country: 
CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2010-01-01
Country: 
Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3-fold higher in resource limited settings (RLS) than...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
Country: 
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-02-06
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. Methods: We...

Efficacy of six-week extended-dose nevirapine varies by infant birth weight with greatest relative efficacy in low birth weight infants

Post Date: 
2016-09-30
Publication: 
PLOS One
Country: 
Low birth weight (LBW), defined by the World Health Organization (WHO) as birth weight less than 2500 g, is a significant public health issue in resource-limited settings, particularly in Sub Saharan Africa and South Asia where the estimated annual incidence is 14% and 28–31%, respectively, and the...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

Post Date: 
2016-04-01
Publication: 
The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of...

Low Vitamin-D levels combined with PKP3-SIGIRR-TMEM16J host variants is strongly associated with tuberculosis and death in HIV-infected and -exposed infants

Post Date: 
2016-02-12
Publication: 
PLOS One
Country: 
Background: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. Methods: A case-cohort sample of 466 South African infants enrolled in P1041 trial...

Prevalence and risk factors of micronutrient deficiencies pre- and post-antiretroviral therapy (ART) among a diverse multicountry cohort of HIV-infected adults

Post Date: 
2016-02-10
Publication: 
Clinical Nutrition
Background & Aims: HIV-infected adults have increased risk of several individual micronutrient deficiencies. However, the prevalence and risk factors of concurrent and multiple micronutrient deficiencies and whether micronutrient concentrations change after antiretroviral therapy (ART)...

Soluble CD14: An independent biomarker for risk of HIV mother-to-child transmission in setting of pre- and post-exposure antiretroviral prophylaxis

Post Date: 
2015-10-06
Publication: 
The Journal of Infectious Diseases
Elevated soluble CD14 (sCD14) concentrations, a marker of monocyte activation, predicts adverse outcomes in human immunodeficiency virus (HIV)-infected adults. To examine the association of sCD14 concentrations with the risk of mother-to-child transmission (MTCT) of HIV, we nested a case-control...

Concurrent anemia and elevated CRP predicts HIV clinical treatment failure, including TB, post-antiretroviral therapy initiation

Post Date: 
2015-07-01
Publication: 
Clinical Infectious Diseases
Background: Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (HIV)...

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

Post Date: 
2015-03-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western India...

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Post Date: 
2015-02-26
Publication: 
PLOS One
Objective: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. Design: Nested case-control study (n = 332) within ACTG PEARLS trial of three ART regimens among 1571 HIV-infected,...

Pre-antiretroviral therapy selenium status predicts WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Post Date: 
2014-11-13
Publication: 
Nutrients
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus...

25-Hydroxyvitamin D insufficiency and deficiency is associated with HIV disease progression and virological failure post-antiretroviral therapy initiation in diverse multinational settings

Post Date: 
2014-07-15
Publication: 
The Journal of Infectious Diseases
Background: Low 25-hydroxyvitamin D (25(OH)D) has been associated with increased HIV mortality, but prospective studies assessing treatment outcomes after combination antiretroviral therapy (cART) initiation in resource-limited settings are lacking. Methods: A case-cohort study (N = 411) was nested...

Change in Vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

Post Date: 
2014-04-21
Publication: 
PLOS One
Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D levels,...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

Post Date: 
2012-10-31
Publication: 
BMC Infectious Diseases
Country: 
Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from the Six Week Extended Nevirapine (SWEN)...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date: 
2012-10-01
Publication: 
HIV Clinical Trials
Country: 
A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Nutrition and disease progression pre-highly active antiretroviral therapy (HAART) and post-HAART: Can good nutrition delay time to HAART and affect response to HAART

Post Date: 
2011-12-15
Publication: 
American Journal of Clinical Nutrition
Several studies have investigated a variety of nutritional supplementation interventions in adults with HIV. In this narrative review, we summarize the evidence from 31 clinical trials that explore clinical benefits of macronutrient and micronutrient supplementation in this population while...

Selenium and HIV-1: Hope or hype?

Post Date: 
2007-12-10
Publication: 
Archives of Internal Medicine
We read with great interest the article by Hurwitz et al on the impact of selenium supplementation in patients infected with human immunodeficiency virus type 1 (HIV-1). Studies examining the association between micronutrients and HIV, particularly prospective studies, have been limited to date...

Necrotizing enterocolitis associated with Clostridium perfringens type A in previously healthy North-American adults

Post Date: 
2005-07-15
Publication: 
Journal of the American College of Surgeons
Background: Necrotizing enteritis associated with Clostridium perfringens type C ("pigbel") is a well-known syndrome in severely protein-deprived populations in the Pacific. It is exceedingly rare in the developed world. C perfringens type A is a common cause of acute gastroenteritis and, in a...

Prevalence of Vitamin D Deficiency among Indian Children with Tuberculosis and Age- and Sex-matched Controls

Post Date: 
2017-10-13
Presentation Location: 
Guadalajara, Mexico
Event & Convener: 
48th Annual Union World Conference of Lung Health
Fogarty Scholar Presentation. Kinikar A , Chandanwale A, Dixit S, Jubilus J, Jain S, Bharadwaj R, Mave V, Gupte N, DeLuca A, Gupta A, Bollinger RC

Prevalence of and Risk Factors for Diabetes mellitus among Pulmonary Tuberculosis Patients in Pune, India.

Post Date: 
2016-07-16
Presentation Location: 
Durban, South Africa
Country: 
Event & Convener: 
TB2016. International AIDS Society.
Poster presentation.

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth

Post Date: 
2016-06-10
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
JHU Center for AIDS Research Annual Meeting
Presentation

Prevalence and Risk Factors of Multiple Micronutrient Deficiencies Pre- and Post-ART

Post Date: 
2015-02-24
Presentation Location: 
Seattle, Washington
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2015
Poster Presentation. Shivakoti R, Christian P, Gupte N, Kanyama C, Berendes S, Lama JR, Semba RD, Campbell TB, Gupta A for the NWCS 319 and PEARLS Study Team.

Prevalence and Risk Factors of Multiple Micronutrient Deficiencies Pre- and Post-ART

Post Date: 
2015-02-24
Presentation Location: 
Seattle, WA
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2015
Poster Presentation. Shivakoti R, Christian P, Gupte N, Kanyama C, Berendes S, Lama JR, Semba RD, Campbell TB, Gupta A for the NWCS 319 and PEARLS Study Team.

Metabolic Complications/Inflammation Lecture

Post Date: 
2015-01-10
Presentation Location: 
Mumbai, India
Event & Convener: 
5th National Conference on HIV/AIDS Therapy
TB and HIV Co-Morbidities & IRIS Panel Discussion. Gupta A

Vitamin D and TMEM16J Host Variants Associated with TB and Death in HIV Infected and Exposed Infants

Post Date: 
2014-06-13
Presentation Location: 
Baltimore, MD
Event & Convener: 
Johns Hopkins Center for TB Research Annual Scientific Meeting
Presentation

High Prevalence of Vitamin D Deficiency among HIV-infected Breastfeeding Mothers in Pune, India, Has No Association with Mother-to-child Transmission of HIV

Post Date: 
2011-07-17
Presentation Location: 
Rome, Italy
Event & Convener: 
6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
Presentation.

Nutrition and disease progression Pre- and Post-HAART: can good nutrition delay time to and response to HAART?

Post Date: 
2010-07-27
Presentation Location: 
Washington, DC
Event & Convener: 
Nutrition in Clinical Management of HIV Infected Adolescents (>14 yr) and Adults including Pregnant and Lactating Women: What do we know, what can we do, and where do we go from here? NIH
Presentation

Malnutrition, HIV and antiretroviral treatment outcomes: Current knowledge and controversies

Post Date: 
2009-07-08
Presentation Location: 
New York, NY
Event & Convener: 
Cornell Medical School, Division of Infectious Diseases
Presentation