Patient treatment adherence

Clinical Sites:

By assessing psychological distress, Indo-JHU researchers hope to better understand the correlation between depression and TB severity.

Evaluation of Video-Based Directly Observed Therapy for Tuberculosis in India

Post Date:

2018-05-14

Countries:

This study was designed to evaluate Directly Observed Therapy conducted through miDOT, a secure mobile health interface, with traditional in-person Directly Observed Therapy.

Characteristics Associated with Mobile Phone Usage among TB Populations in Pune, India

Post Date:

2017-10-02

Countries:

Clinical Sites:

With 8.6 million people affected worldwide in 2012, the control and prevention of tuberculosis (TB) has become an international priority. In order to reduce burdens and achieve global goals for TB control, new and innovative tools are necessary. With a growing number of mobile phone subscriptions...

Risk Factors for Unfavourable Treatment Outcomes among Multidrug-Resistant Tuberculosis Patients in Public Sector Treatment in Pune

Post Date:

2017-03-29

Countries:

This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. This study seeks to identify risk factors associated with unfavourable treatment outcomes (death, treatment failure, default, XDR-TB) among multidrug-resistant tuberculosis (MDR-TB)...

Measuring TB Drugs in Hair as a Tool to Monitor Adherence, Exposure and Response in Patients with HIV

Post Date:

2016-08-16

Countries:

Clinical Sites:

NIRT

Our study will examine whether hair levels of two key first line tuberculosis drugs will be useful markers to identify individuals at highest risk of treatment failure in active tuberculosis. Our study aims to provide a lowcost clinical tool using hair that can be noninvasively collected to monitor...

mHealth-enhanced Peer Navigation Intervention for PrEP Delivery among MSM at STD Clinics

Post Date:

2016-08-01

Countries:

Using mixed methodology (quantitative surveys, qualitative interviews, and administrative data), this study will assess acceptability and feasibility of an mHealth-enhanced peer navigation to promote PrEP initiation, retention and adherence among men who have sex with men (MSM) in the Baltimore...

miDOT (Directly Observed Therapy)

Post Date:

2015-11-01

Designed by Dr. Maunank Shah, the miDOT mobile health application is a video-based Directly Observed Therapy interface that uses the emocha Mobile Health platform to remotely connect patients on long-term tuberculosis therapy with clinicians who are required to witness patients taking...

Community Health Workers, mHealth, and Combination HIV Prevention in a Hotspot: A Randomized Trial (mLAKE)

Post Date:

2015-04-01

Countries:

Led by Dr. Larry Chang, the mLAKE study in Uganda is examining whether community health workers equipped with cellphones and the emocha Mobile Health platform are able to successfully promote HIV treatment and prevention services in households in a fishing community in East Africa with a very high...

Tuberculosis Noon Conference

Post Date:

2013-10-24

Countries:

Clinical Sites:

This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

Community Home Based India Prevention of Mother to Child Transmission of HIV (COMBIND)

Post Date:

2013-09-02

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Clinical Sites:

CCGHE is assessing whether equipping Community Health Workers with mobile health technology and involving them in technology training and personal empowerment seminars can help prevent mother-to-child transmission of HIV. CHWs who care for HIV + pregnant and nursing women are using the emocha...

HIV Latino Outreach Program, Baltimore City Health Department

Post Date:

2008-01-01

Countries:

Dr. Kathleen Page founded and directs the Baltimore City Health Department’s HIV Latino Outreach Program, which provides more than 1000 HIV tests per year to Baltimore's Latino community, and provides linkages to care services for those testing positive.

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date:

2007-02-02

Countries:

Clinical Sites:

Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date:

2007-01-01

Countries:

Clinical Sites:

Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

Predictors of Antiretroviral Adherence, Plasma HIV RNA Levels and Antiretroviral Resistance Among Patients with HIV Attending Private Clinics in Mumbai, India

Post Date:

2004-12-02

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This study was terminated November 16, 2006.

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

Post Date:

2000-01-01

Countries:

This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

Willingness to take multidrug-resistant tuberculosis (MDR-TB) preventive therapy among Adult and adolescent household contacts of MDR-TB index cases: an international multi-site cross-sectional study.

Post Date:

2019-03-28

Countries:

Publication:

Clinical Infectious Diseases

Abstract BACKGROUND: Household contacts (HHCs) of individuals with multidrug-resistant tuberculosis (MDR-TB) are at high risk of infection and subsequent disease. There is limited evidence on the willingness of MDR-TB HHCs to take MDR-TB preventive therapy (TPT) to decrease their risk of TB disease...

One month of rifapentine plus isoniazid to prevent HIV-related tuberculosis

Post Date:

2019-03-14

Publication:

New England Journal of Medicine

Exciting findings from A5279: One month of Rifapentine with isonaizid is as effective as a 9-month course of isoniazid alone!

Enhanced immigration enforcement in the USA and the transnational continuity of HIV care for Latinx migrants in deportation proceedings

Post Date:

2018-10-15

Countries:

Publication:

Lancet HIV

In our work as clinicians, researchers, and immigrant rights advocates, we have noted increased anxiety about the possibility of deportation and disruptions in care among immigrants with HIV. Before the 2016 US elections, patients rarely asked about HIV treatment in their home countries. However,...

Advancing patient-centered care in tuberculosis management: A mixed-methods appraisal of video directly observed therapy

Post Date:

2018-04-26

Countries:

Publication:

Open Forum Infectious Diseases

BACKGROUND: Directly observed therapy (DOT) remains an integral component of treatment support and adherence monitoring in tuberculosis care. In-person DOT is resource intensive and often burdensome for patients. Video DOT (vDOT) has been proposed as an alternative to increase treatment flexibility...

Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial

Post Date:

2018-04-19

Countries:

Clinical Sites:

Publication:

Trials

Trials: Evidence for TB treatment in kids is largely based on adult studies. The SHINE study aims to fix this

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Post Date:

2017-12-07

Countries:

Clinical Sites:

NIRT

Publication:

PLOS One

PLOS One: Mave and colleagues compared TB drug exposure in plasma and hair samples among a small cohort of children.

Identifying models of HIV care and treatment service delivery in Tanzania, Uganda, and Zambia using cluster analysis and Delphi survey

Post Date:

2017-12-06

Countries:

Publication:

BMC Health Services Research

BACKGROUND: Organization of HIV care and treatment services, including clinic staffing and services, may shape clinical and financial outcomes, yet there has been little attempt to describe different models of HIV care in sub-Saharan Africa (SSA). Information about the relative benefits and...

Challenges in the evaluation of interventions to improve engagement along the HIV care continuum in the United States: a systematic review

Post Date:

2017-07-17

Countries:

Publication:

AIDS and Behavior

Dr. Maunank Shah & colleagues review interventions to keep HIV patients linked to care.

Design and implementation of a community health worker HIV treatment and prevention intervention in an HIV hot spot fishing community in Rakai, Uganda

Post Date:

2017-05-22

Countries:

Publication:

Journal of the International Association of Providers of AIDS Care

Abstract Innovative approaches are needed to increase engagement in HIV treatment and prevention services, particularly in HIV hot spots. Here, we detail our design, training approach, and early implementation experiences of a community-based HIV intervention called "health scouts." The...

Qualitative insights into implementation, processes, and outcomes of a randomized trial on peer support and HIV care engagement in Rakai, Uganda

Post Date:

2017-01-10

Countries:

Publication:

BMC Infectious Diseases

BACKGROUND: People living with human immunodeficiency virus (HIV) who have not yet initiated antiretroviral therapy (ART) can benefit from being engaged in care and utilizing preventive interventions. Community-based peer support may be an effective approach to promote these important HIV services...

Community-based interventions to improve and sustain antiretroviral therapy adherence, retention in HIV care and clinical outcomes in low- and middle-income countries for achieving the UNAIDS 90-90-90 targets

Post Date:

2016-07-30

Countries:

Publication:

Current HIV/AIDS Reports

Little is known about the effect of community versus health facility-based interventions to improve and sustain antiretroviral therapy (ART) adherence, virologic suppression, and retention in care among HIV-infected individuals in low- and middle-income countries (LMICs). We systematically searched...

Determinants of default from tuberculosis treatment among patients with drug-susceptible tuberculosis in Karachi, Pakistan: a mixed methods study

Post Date:

2015-11-12

Countries:

Pakistan

Publication:

PLOS One

Purpose: Non-adherence to tuberculosis therapy can lead to drug resistance, prolonged infectiousness, and death; therefore, understanding what causes treatment default is important. Pakistan has one of the highest burdens of tuberculosis in the world, yet there have been no qualitative...

Effectiveness of peer support on care engagement and preventive care intervention utilization among pre-antiretroviral therapy, HIV-infected adults in Rakai, Uganda: a randomized trial

Post Date:

2015-08-14

Countries:

Publication:

AIDS and Behavior

442 pre-ART, HIV-infected adults were randomized to peer support consisting of structured home visits to promote clinic attendance and preventive care intervention use or standard of care. At baseline, 62 % reported previously visiting an HIV clinic, 45 % reported taking cotrimoxazole prophylaxis,...

Impact of patient-selected care buddies on adherence to HIV care, disease progression and conduct of daily life among pre-antiretroviral HIV-infected patients in Rakai, Uganda: a randomized controlled trial

Post Date:

2015-06-01

Countries:

Publication:

Journal of Acquired Immune Deficiency Syndromes

Background: Data are limited on effects of household or community support persons ("care buddies") on enrollment into and adherence to pre-antiretroviral HIV care. We assessed the impact of care buddies on adherence to HIV clinic appointments, HIV progression, and conduct of daily life among pre-...

Durable suppression of HIV-1 after virologic monitoring-based antiretroviral adherence counseling in Rakai, Uganda

Post Date:

2015-05-26

Countries:

Publication:

PLOS One

Objectives: HIV viral load is recommended for monitoring antiretroviral treatment and identifying treatment failure. We assessed the durability of viral suppression after viral load-triggered adherence counseling among patients with HIV viremia 6 months after ART initiation. Design: Observational...

Analysis of latent tuberculosis infection treatment adherence among refugees and other patient groups referred to the Baltimore City Health Department TB clinic

Post Date:

2015-02-15

Countries:

Publication:

Journal of Immigrant and Minority Health

We sought to determine the proportion of refugee patients at the Baltimore City Health Department Tuberculosis program (BCHD-TB) successfully completing latent tuberculosis infection (LTBI) treatment, as compared to other referral groups, and to identify factors associated with treatment completion...

Activism on rifapentine pricing: removing cost barriers to improve the uptake of tuberculosis research innovations

Post Date:

2014-12-21

Publication:

Public Health Action

As recent advances have been made in developing tools to fight tuberculosis (TB), there is also a trend towards increasing advocacy by the civil society for TB research and access. One recent successful effort to increase access to treatment options for TB involved a collaborative effort to...

Leveraging information technology to address the health workforce gap

Post Date:

2013-11-01

Publication:

Bulletin of the World Health Organization

According to some estimates, the world needs more than 4 million additional physicians, nurses, pharmacists, laboratory technicians, midwives, community health workers (CHWs) and other front-line health workers. However, there is also a shortage of faculty that can provide high-quality...

HIV/AIDS education in traditional Indian systems of medicine: faculty perspectives

Post Date:

2013-10-24

Countries:

Publication:

Journal of Traditional Medicine and and Clinical Naturopathy

In India, HIV-infected individuals face numerous challenges in their search for treatments. Currently, western allopathic medicine (hereinafter ‘biomedicine’) offers antiretroviral therapy (ART) for HIV/AIDS and associated co-morbidities that have prolonged survival and improved quality of...

A qualitative study of barriers to enrollment into free HIV care: perspectives of never-in-care HIV-positive patients and providers in Rakai, Uganda

Post Date:

2013-07-23

Countries:

Publication:

BioMed Research International

Background: Early entry into HIV care is low in Sub-Saharan Africa. In Rakai, about a third (31.5%) of HIV-positive clients who knew their serostatus did not enroll into free care services. This qualitative study explored barriers to entry into care from HIV-positive clients who had never enrolled...

Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster Randomized Trial

Post Date:

2018-07-24

Countries:

Clinical Sites:

Suryavanshi N, Kadam A, Hegde A, Sivalenka S, Kumar VS, McKenzie-White J, Kanade S, Gupta A, Bollinger RC, Shankar A, Gupte N, Mave V. Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster...

Impact of INH Adherence on TB Incidence and Mortality by Week 96 in ACTG 5274 Trial

Post Date:

2017-02-14

Countries:

Clinical Sites:

Gupta A , Sun X, Miyahara S, Matoga M, Langat D, Riviere C, Bisson C, Kumwenda J, Hosseinipour MC, for the ACTG A5274/REMEMBER Study Team. Impact of INH Adherence on TB Incidence and Mortality by Week 96 in ACTG 5274 Trial. CROI 2017. Seattle, Washington. 2017.

Outreach Workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) Programme in India: Challenges and Opportunities

Post Date:

2016-07-21

Countries:

Clinical Sites:

Suryavanshi N , Mave V, Kadam A, Kanade S, Sivalenka S, Sampath K, Harve P, Gupta RS, Hegde A, McKenzie-White J, Gupte N, Gupta A, Bollinger RC, Shankar AV. Outreach Workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) Programme in India: Challenges and Opportunities. 21st...

A Cluster-Randomized Trial to Promote Combination HIV Prevention Using M-health-Supported CHWs in a High-Prevalence Fishing Community: Design and Baseline Characteristics of the mLAKE Trial in Rakai, Uganda

Post Date:

2016-07-21

Countries:

Chang L, Mbabali I, Kong X, Hutton H, Long A, Thomas A, Bugos E, Ssekasanvu J, Kennedy C, Amico R, Nalugoda F, Reynolds S, Quinn T, Serwadda D, Wawer M, Gray R, Nakigozi G. A Cluster-Randomized Trial to Promote Combination HIV Prevention Using M-health-Supported CHWs in a High-Prevalence Fishing...

Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care

Post Date:

2016-07-20

Countries:

South Africa

Farley JE , Seiguer S, Naicker M, McKenzie-White J, Greg C, Elmi M, Stevens W, Stewart-Isherwood L. Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care. 21st International AIDS Conference...

Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community

Post Date:

2016-02-23

Countries: