Tuberculosis

Tuberculosis (TB) Aftermath

Post Date: 
2020-06-05
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Dr. Jonathan Golub is PI for this study. TB Aftermath seeks to provide evidence for an effective and scalable strategy targeting HHs of treated TB cases, a high priority of the NTEP. Purpose To compare the effectiveness, cost-effectiveness and feasibility of two Active Case Finding (ACF) strategies...

Hybrid Trial for Alcohol Reduction among People with TB and HIV in India

Post Date: 
2020-02-12
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The highest incidence of tuberculosis disease (TB) in the world is in India, accounting for 27% of all new cases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy alcohol use triples the risk of TB in the general population, increasing susceptibility to primary infection...

Pregnancy Associated Immune Responses to Tuberculosis and HIV in India and South Africa (PARTHISA)

Post Date: 
2020-01-14
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Dr. Jyoti Mathad is Co-PI of this study. Purpose: Tuberculosis (TB) is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not...

Increasing Market and Public Health Outcomes Through Scaling Up Affordable Access Models of Short Course Preventive Therapy for TB (IMPAACT4TB)

Post Date: 
2019-12-17
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Primary Objective: This study is being conducted in Brazil, Cambodia, China, Ethiopia, Ghana, Haiti, India, Indonesia, Kenya, Malawi, Mozambique, South Africa, Tanzania, and Zimbabwe. The overall goal is to reduce TB incidence among (1) people living with HIV who are on antiretroviral therapy, and...

Markers of Lung Impairment in HIV-TB Coinfected Indian Adults

Post Date: 
2019-12-11
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Objectives/Aims We will compare the degree of lung impairment between HIV-TB co-infected adults (HIV-TB group) and TB cases without HIV co-infection (TB group) who successfully complete TB therapy. We hypothesize that the HIV-TB group will have a greater degree of lung impairment compared to the TB...

T Cell Biomarkers and T-regulatory Responses to Pediatric TB

Post Date: 
2019-11-21
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The goals of this study are to: Validate host T cell biomarkers for diagnosis of pediatric TB Investigate the phenotype and functions of T-regulatory cells in pediatric TB We will use cryopreserved PBMC samples from CTRIUMPH cohorts: Pediatric unconfirmed TB, confirmed TB, latest Tb, and no TB...

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
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Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and...

Evaluation of a Urinary Biomarker Assay for Diagnosis and Test of Cure for Tuberculosis

Post Date: 
2019-09-09
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Dr. Jeff Tornheim is PI of this study. METHODS This study will make use of biorepository samples from the Cohort for TB Research by the Indo-US Medical Partnership (CTRIUMPh). CTRIUMPh, funded by the US NIH and Indian Department of Biotechnology, is an academic collaboration between Johns Hopkins...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
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Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
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Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB patients living with HIV compared with TB...

Management of Multidrug-resistant Tuberculosis among ART Programs in Low- and Middle-income Countries within the Global IeDEA Network

Post Date: 
2019-07-22
Purpose The purpose of the IeDEA MDR-TB survey is to study the clinical management of HIV patients co-infected with MDR-TB or XDR-TB from the perspective of healthcare workers in ART programs participating in the IeDEA global cohort consortium. Specifically, we aim: to describe diagnostic, referral...

Immune Correlates of LTBI in HIV-exposed Infants

Post Date: 
2019-04-29
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About 2 billion people worldwide harbor asymptomatic latent TB infection (LTBI), activation of which results in progression to TB disease. In areas of high tuberculosis (TB) prevalence, infants and young children have a 3-fold higher risk of progression and death from TB at age < 5 years...

Prevalence of Tuberculosis in Severely Malnourished Indian Children

Post Date: 
2018-12-18
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Dr. Muralidhar Tambe, BJGMC Severely malnourished children are vulnerable population for communicable and non-communicable disease. Diagnosis of TB among...

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
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New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
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We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Immune Responses and Effect of Disulfiram on MTB Infected PBMCs as a Potential Host Directed Therapy

Post Date: 
2018-11-26
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Dr. Mandar Paradkar is lead investigator for this study that is assessing the immune responses of adult pulmonary TB patients enrolled in the CTRIUMPh study, using PBMC samples of those with harmful use of alcohol assessed by AUDIT scores ≥ 8 compared to non-alcoholics (AUDIT < 8). Aim 1: To...

Characterization of TB-specific T Cell Responses in Highly-exposed, but Uninfected Health Care Workers in India

Post Date: 
2018-10-25
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Jyothi Rengarajan, MD, Emory University. Primary Research Question Do health care workers who remain TST negative, despite high-exposure to TB,...

Validating a Novel Functional Correlate of Immune Protection of Tuberculosis

Post Date: 
2018-10-03
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This C-TRIUMPH study is a longitudinal assessment of PBMC samples of progressors and non-progressors among adult household contacts of active TB patients. The purpose of the study is to probe the functional diversity of T cell responses to several of the antigens encoded by Mtb simultaneously in...

Assessing the Impact of Psychosocial Involvement in Health Care Workers with and without Active Tuberculosis at the Byramjee Jeejeebhoy Government Medical College, Pune, India

Post Date: 
2018-09-13
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. The overall goal is to understand the psychosocial involvement in health care workers with and without active tuberculosis. The specific aims of this study are: To understand the...

Evaluation of National Video Directly Observed Therapy Implementation

Post Date: 
2018-08-05
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emocha Mobile Health, Inc., and Johns Hopkins investigators have developed a user-friendly, HIPAA compliant application for asynchronous video directly observed therapy (DOT) miDOT. The miDOT platform consists of a patient-facing mobile application where patients can record videos of themselves...

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Tuberculosis preventive treatment should be considered for all household contacts of pulmonary tuberculosis patients in India

Post Date: 
2020-07-29
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PLoS One
PLoS One: Dr. Mandar Paradkar and colleagues conducted a CTRIUMPH study that supports TB preventive therapy for all household contacts of pulmonary TB patients in India

Once-weekly Rifapentine and Isoniazid for Tuberculosis Prevention in Patients With HIV Taking Dolutegravir-Based Antiretroviral Therapy: A Phase 1/2 Trial

Post Date: 
2020-03-30
Publication: 
Lancet HIV
Short-course preventive therapy with 12 doses of once-weekly rifapentine (900 mg) plus isoniazid (900 mg) could greatly improve tuberculosis control, especially in areas with high co-endemicity with HIV.

TB prevention strategies and unanswered questions for pregnant and postpartum women living with HIV: the need for improved evidence

Post Date: 
2020-03-23
Publication: 
Journal of the International AIDS Society
World TB Day viewpoint on the need for more data about TB treatment for pregnant and postpartum women in J Int AIDS Soc by Drs. Jyoti Mathad and Amita Gupta.

Tuberculosis in children, adolescents, and women

Post Date: 
2020-02-27
Publication: 
Lancet Respiratory Medicine
In this Lancet Respiratory Medicine commentary, Dr. Amita Gupta and colleagues note that TB prevalence among children, adolescents, and women isn't well documented. This poses big challenges for the goal of TB elimination.

Applying a risk-benefit analysis to outcomes in tuberculosis clinical trials

Post Date: 
2020-02-03
Publication: 
Clinical Infectious Diseases
CID: Analyzing efficacy and safety separately in clinical trials could yield misleading study conclusions if there's an increase in efficacy and a decrease in safety

Assessment of the Xpert assay among new pulmonary tuberculosis suspects with and without diabetes mellitus

Post Date: 
2020-01-01
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International Journal of Tuberculosis and Lung Disease
IJTLD: Deshmukh and colleagues: High sensitivity and specificity of Xpert underscores need for rapid scale up for early detection of TB in settings with a high dual burden of TB and DM

Diagnostic Accuracy of a Novel and Rapid Lipoarabinomannan Test for Diagnosing Tuberculosis Among People With Human Immunodeficiency Virus

Post Date: 
2019-12-21
Publication: 
Open Forum Infectious Diseases
Background: The novel Fujifilm SILVAMP TB-LAM (FujiLAM) assay detects mycobacterial lipoarabinomannan in urine and has demonstrated superior sensitivity to the Alere Determine TB-LAM Ag (AlereLAM) assay for detection of tuberculosis among hospitalized people with human immunodeficiency virus (PWH...

Transcriptomic profiles of confirmed pediatric tuberculosis patients and household contacts identifies active tuberculosis, infection, and treatment response among Indian children

Post Date: 
2019-12-04
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Journal of Infectious Diseases
Journal of Infectious Diseases: Gene expression profiles among Indian children with confirmed TB were distinct from those of adults, highlighting the importance of including distinct populations in differential gene expression models

A parsimonious host inflammatory biomarker signature predicts incident TB and mortality in advanced HIV

Post Date: 
2019-11-25
Publication: 
Clinical Infectious Diseases
BACKGROUND: People with advanced HIV (CD4<50) remain at high risk of TB or death despite the initiation of antiretroviral therapy. We aimed to identify immunological profiles that were most predictive of incident TB disease and death. METHODS: The REMEMBER randomized clinical trial enrolled 850...

Lipid mediators of inflammation and resolution in individuals with tuberculosis and tuberculosis-diabetes

Post Date: 
2019-11-11
Publication: 
Prostaglandins and Other Lipid Mediators
Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (i.e., mediators involved in the resolution...

MAL adaptor (TIRAP) S180L polymorphism and severity of disease among tuberculosis patients

Post Date: 
2019-10-31
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Infection, Genetics, and Evolution
Infection, Genetics, and Evolution : We investigated the association of TIRAP variants with severity of TB disease and IP-10 production in humans, which may be useful in predicting poor clinical outcome

Incidence of tuberculosis in HIV-infected adults on first- and second-line antiretroviral therapy in India

Post Date: 
2019-10-29
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BMC Infectious Diseases
In this study among people living with HIV, Akshay Gupte and colleagues found that the risk of acquiring tuberculosis was higher in those receiving first-line antiretrovial therapy versus those receiving second-line medications.

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in people living with HIV

Post Date: 
2019-10-21
Publication: 
Cochrane Database of Systematic Reviews
Why is improving the diagnosis of tuberculosis important? Tuberculosis causes more deaths in people living with HIV than any other disease. The lateral flow urine lipoarabinomannan assay (LF-LAM, Alere Determine™ TB LAM Ag assay) is a World Health Organization-recommended rapid test to assist in detection of active tuberculosis in HIV-positive people with severe HIV disease. Rapid and early tuberculosis diagnosis may allow for prompt treatment and alleviate severe illness and death. An incorrect tuberculosis diagnosis may result in anxiety and unnecessary treatment.

Isoniazid preventive therapy in HIV-infected pregnant and postpartum women

Post Date: 
2019-10-03
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New England Journal of Medicine
New England Journal of Medicine: Dr. Amita Gupta and colleagues found that the current standard of care given to HIV+ pregnant women to prevent TB should wait until 12 weeks after delivery. The study underscores the need to include pregnant women in clinical trials.

Challenges in conducting trials for pediatric tuberculosis meningitis: lessons learned in the field

Post Date: 
2019-10-01
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International Journal of Tuberculosis and Lung Disease
International Journal of Tuberculosis and Lung Disease: Researchers describe the challenges associated with conducting the first randomized clinical trial of antimicrobial agents in pediatric tuberculosis meningitis.

Delays and barriers to early treatment initiation for childhood tuberculosis in India

Post Date: 
2019-10-01
Publication: 
International Journal of Tuberculosis and Lung Disease
BACKGROUND: India accounts for 27% of global childhood tuberculosis (TB) burden. Understanding barriers to early diagnosis and treatment in children may improve care and outcomes. METHODS: A cross-sectional study was performed among 89 children initiated on anti-TB treatment...

Delamanid central nervous system pharmacokinetics in tuberculous meningitis in rabbits and humans

Post Date: 
2019-09-23
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Antimicrobial Agents and Chemotherapy
Central nervous system tuberculosis (TB) is devastating and affects vulnerable populations. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculous meningitis (TBM) specifically are nearly uniformly fatal, with little information being available to guide the treatment of...

Re: A Shorter Regimen for Rifampin-Resistant Tuberculosis

Post Date: 
2019-09-12
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New England Journal of Medicine
Dr. Jeff Tornheim and colleagues respond to an NEJM article about shorter course TB treatment.

Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis

Post Date: 
2019-09-11
Publication: 
PLoS Medicine
Background: Few studies have evaluated the association between preexisting vitamin D deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D levels on TB disease risk. Methods and findings: We assessed the association between baseline vitamin D and incident TB in a...

Evaluation of miLINC to shorten time to treatment for rifampicin-resistant Mycobacterium tuberculosis

Post Date: 
2019-09-01
Publication: 
The International Journal of Tuberculosis and Lung Disease
A suite of mobile health applications shows promise for linking more drug-resisitant TB patients to care and in less time.

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Rifapentine pharmacokinetics and safety in pregnant women with and without HIV on 3HP

Post Date: 
2020-03-11
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Mathad JS , Savic RM, Britto P, Wiesner L, Townley E, Chakhtoura N, Bradford S, Patil S, Vhembo T, Lespinasse D, Langat D, Werarak P, Kamthunzi P, Gupta A, Dooley KE. Rifapentine pharmacokinetics and safety in pregnant women with and without HIV on 3HP. Presented at: CROI 2020. Boston, MA; March 8-...

Early bactericidal activity of meropenem (+ Amox/Clav) with and without rifampin for TB

Post Date: 
2020-03-10
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De Jager V, Abufathi AA, Feyt H, Gupte N, Vanker N, Barnes G, van Brakel E, Nuermberger E, Dorman SE, Svensson EM, Diacon AH, Dooley KE. Early bactericidal activity of meropenem (+ Amox/Clav) with and without rifampin for TB. Presented at: CROI 2020. Boston, Massachusetts. March 8-11, 2020.

Effect of rifamycins on pretomanid exposure in patients with pulmonary TB

Post Date: 
2020-03-10
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Abdelwahab MT , Ignatius E, Denti P, Dooley KE, Gupte N, Dawson R, Barnes G, Narunsky K, Hendricks B. Effect of rifamycins on pretomanid exposure in patients with pulmonary TB. (ID 3688). Presented at: CROI 2020. Boston, Massachusetts. March 8-11, 2020.

Geographic and Individual Risk Factors for TB or Death in the Brief-TB Trial (A5279)

Post Date: 
2020-03-09
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Riviere C , Juste MAJ, Ramchandani R, Gupta A, Benson CA, Masheto G, Supparatpinyo K, Mohapi L, da Silva Escada RO, Mngqibisa R, Kanyama C, Langat D, Swindells S, Chaisson RE, for the A5279/BRIEF TB Study Team. Geographic and Individual Risk Factors for TB or Death in the Brief-TB Trial (A5279)...

Adjusted analysis of effect of IPT on adverse pregnancy outcomes in women with HIV

Post Date: 
2020-03-09
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Theron G , Chakhtoura N, Montepiedra G, Aaron L, Jean-Phillipe P, Weinberg A, McCarthy K, Nematadzira T, Masheto G, Chipato T, Onyango-Makumbi C, Gupta A, the IMPAACTP1078 Team. Adjusted analysis of effect of IPT on adverse pregnancy outcomes in women with HIV. Presented at: CROI 2020. Boston,...

Tuberculosis preventive therapy should be considered for all household contacts of pulmonary TB patients in India

Post Date: 
2020-02-07
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Paradkar M, Chandrasekara P, Jain D, Shivakumar SVBY, Thiruvengadan K, Gupte AN, Thomas B, Kinikar A, Sekar K, Bharadwaj R, Dolla CK, Gaikwad S, Elilarasi S, Lokhande R, Reddy D, Murali L, Kulkarni V, Pradhan N, Hanna LE, Pattabiraman S, Kohli R, Nayagam R, Suryavanshi N, Shrinivasa BM, Cox SR,...

Female tuberculosis (TB) patients with stigma are at increased risk of persistent depression: time to integrate mental health screening into TB care

Post Date: 
2019-11-20
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Suryavanshi N . Female tuberculosis (TB) patients with stigma are at increased risk of persistent depression: time to integrate mental health screening into TB care. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Is there a connection between gestational diabetes and TB?

Post Date: 
2019-11-02
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Alexander M . Is there a connection between gestational diabetes and TB? Speaker. Confronting the crisis: emerging research in maternal-child TB Symposium.50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Increased moxifloxacin dosing among MDR-TB patients with low-level resistance to moxifloxacin did not improve treatment outcomes in a tertiary care centre in Mumbai, India

Post Date: 
2019-11-02
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Tornheim JA , Gajjar I, Shivakumar SVBY, Gupte AN, Kishore G, Karane M, Rodrigues C, Gupta A, Udwadia ZF. Increased moxifloxacin dosing among MDR-TB patients with low-level resistance to moxifloxacin did not improve treatment outcomes in a tertiary care centre in Mumbai, India. 50th Union World...

Confronting the crisis: emerging research in maternal-child TB

Post Date: 
2019-11-02
Mathad J . Symposium Chair. Confronting the crisis: emerging research in maternal-child TB. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

The crisis in maternal TB: a case-based discussion of research gaps

Post Date: 
2019-11-02
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Naik SN . The crisis in maternal TB: a case-based discussion of research gaps. Speaker. Confronting the crisis: emerging research in maternal-child TB Symposium. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Performance of QuantiFERON-TB Gold in Tube (QFT-GIT) and QuantiFERON-TB Gold Plus (QFT-Plus) for detection of Mycobacterium tuberculosis infection in pregnant women in India

Post Date: 
2019-11-01
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Kulkarni V , Bhosale R, Jain D, Deshpande P, Naik N, Alexander M, Patil N, Gupte N, Gupta A, Mathad J. Performance of QuantiFERON-TB Gold in Tube (QFT-GIT) and QuantiFERON-TB Gold Plus (QFT-Plus) for detection of Mycobacterium tuberculosis infection in pregnant women in India. Poster presentation...

Six-week culture conversion predicts tuberculosis treatment outcomes

Post Date: 
2019-11-01
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Pradhan N , Kagal A, Gupte N, Gaikwad S, Barthwa M, Gupta A, Golub JE, Mave V. Six-week culture conversion predicts tuberculosis treatment outcomes. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort

Post Date: 
2019-11-01
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Graham H , Bhosale R, Alexander M, Kinikar A, Khwaja S, Patil N, Mathad J, Shivakoti S, Gupta A. Association of latent TB infection in pregnancy with perinatal health outcomes in an Indian cohort. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November...

Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India

Post Date: 
2019-11-01
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Alexander M , Bhosale R, Naik S, Gupte N, Jain D, Patil N, Pradhan N, Mave V, Gupta A, Mathad J. Inappropriate postpartum weight loss may predict development of active TB: Findings from a cohort study in Pune, India. Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India...

Does treatment of infertile women with probable genital tuberculosis improve fertility outcome?

Post Date: 
2019-11-01
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Naik SN , Chandanwale A, Kadam D, Sambarey PW, Dhumal G, DeLuca A, Jain D, Gupta A, Bollinger R, Mave V. Does treatment of infertile women with probable genital tuberculosis improve fertility outcome? Poster presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-...

Tuberculosis infection and inflammation among HIV-infected adults in India

Post Date: 
2019-10-31
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Kulkarni V . Tuberculosis infection and inflammation among HIV-infected adults in India. Oral Presentation. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

Resistance to Mycobacterium tuberculosis infection among household contacts of MDR TB patients

Post Date: 
2019-10-31
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Baliashvili D , Gandhi NR, Kim S, Gupta A, Churchyard G, Swindells S, Hesseling A, Hughes M, Shah S for the ACTG 5300/IMPAACT I2003 PHOENIx Feasibility Study Team. Resistance to Mycobacterium tuberculosis infection among household contacts of MDR TB patients. Poster presentation. 50th Union World...

High prevalence of tuberculosis infection in children living in households of MDR-TB patients

Post Date: 
2019-10-31
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Kim S , Wu X, Hughes M, Mendoza-Ticona A, Churchyard G, Swindells S, Shah NS, Gupta A, Hesseling A for the A5300/I2003 PHOENIx Feasibility Study Team. High prevalence of tuberculosis infection in children living in households of MDR-TB patients. Short oral presentation. 50th Union World Conference...

Why pharmacokinetics/pharmacodynamics of TB medicines matter in the management of MDR-TB

Post Date: 
2019-10-30
Dooley K . Why pharmacokinetics/pharmacodynamics of TB medicines matter in the management of MDR-TB. Lecture. 50th Union World Conference on Lung Health. Hyderabad, India. October 30-November 2, 2019.

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