Tuberculosis

Topic Activities

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

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2018-12-13
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A new study has been launched in India and South Africa to identify functional relationships between genomics and metabolomics and to characterize fundamental biological systems underlying resistance to Mtb infection.

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

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2018-12-13
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We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

C-TRIUMPH: Immune Responses and Effect of Disulfiram on MTB Infected PBMCs as a Potential Host Directed Therapy

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2018-11-26
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Dr. Mandar Paradkar is lead investigator for this study that is assessing the immune responses of adult pulmonary TB patients enrolled in the CTRIUMPh study, using PBMC samples of those with harmful use of alcohol assessed by AUDIT scores ≥ 8 compared to non-alcoholics (AUDIT < 8). Aim 1: To...

C-TRIUMPH: Validating a Novel Functional Correlate of Immune Protection of Tuberculosis

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2018-10-03
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This is a longitudinal assessment of PBMC samples of progressors and non-progressors among adult household contacts of active TB patients. The purpose of the study is to probe the functional diversity of T cell responses to several of the antigens encoded by Mtb simultaneously in subjects covering...

Assessing the Impact of Psychosocial Involvement in Health Care Workers with and without Active Tuberculosis at the Byramjee Jeejeebhoy Government Medical College, Pune, India

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2018-09-13
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This study is sposored by the Fogarty International Center at the U.S. National Institutes of Health. The overall goal is to understand the psychosocial involvement in health care workers with and without active tuberculosis. The specific aims of this study are: To understand the psychosocial...

Assessing Psychological Distress among Tuberculosis Patients and Their Household Members

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2018-07-17
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By assessing psychological distress, Indo-JHU researchers hope to better understand the correlation between depression and TB severity.

Assessing the Feasibility and Acceptability of a Computer-based Avatar-delivered Alcohol Reduction Intervention

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2018-07-05
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Study is assessing whether computer-delivered alcohol screening and intervention helps overcome barriers to treatment in India.

Molecular Signatures of Tuberculosis-Diabetes Interaction: Metabolomics Study

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2018-06-15
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Type 2 diabetes mellitus (DM) is an acquired host factor that increases the risk for and severity of pulmonary tuberculosis (PTB). A report published in 2007 estimated that, in India, DM accounted for 14.8% (range 7.1% to 23.8%) of PTB and 20.2% (8.3% to 41.9%) of smear-positive PTB. Emerging data...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Transcriptomics Study

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2018-06-15
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Type 2 diabetes is an acquired host factor that increases the risk for and severity of pulmonary tuberculosis. A report published in 2007 estimated that, in India, diabetes accounted for 14.8% (range 7.1% to 23.8%) of pulmonary tuberculosis and 20.2% (8.3% to 41.9%) of smear-positive cases...

Assessing Tuberculosis Transmission Dynamics, Drug Resistance and Recurrence Using Whole Genome Sequencing in Pune, India

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2018-06-12
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Indo-JHU researchers are using combined geospatial and genotyping methods to describe TB transmission dynamics in a hyperlocal region of Pune City in Western India.

Optimal Approach for TB Screening among HIV Infected Indian Children

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2018-06-11
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This study was funded by the Fogarty International Center at the U.S. National Institutes of Health. Determining TB status (ie, uninfected, latent, and active TB disease) is more difficult among children, particularly HIV-infected children. Diagnosis of TB disease is more difficult among HIV...

Evaluation of Video-Based Directly Observed Therapy for Tuberculosis in India

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2018-05-14
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This study was designed to evaluate Directly Observed Therapy conducted through miDOT, a secure mobile health interface, with traditional in-person Directly Observed Therapy.

Predictors of Resistance Emergence Evaluation in Multidrug Resistant-Tuberculosis Patients on Treatment (PREEMPT Pilot Study)

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2018-03-20
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Indo-JHU Clinical Resarch Partnership is participating with Brazilian colleagues in a 3-year effort led by Boston University to identify what contributes to TB drug resistance.

A Multicenter Phase II/II Double-Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of VPM1002 in the Prevention of Tuberculosis (TB) Recurrence in Pulmonary TB Patients After Successful TB Treatment in India

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2018-01-23
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Dr. Vidya Mave is leading this clinical trial evaluating the safety and efficacy of a new recombinant BCG vaccine.

Assessing the Impact of the Fogarty HIV-TB Training Program at the Byramjee Jeejeebhoy Government Medical College, Pune, India

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2018-01-19
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This study was funded by the Fogarty International Center at the U.S. National Institutes of Health. Johns Hopkins University was funded in 2013 to establish a new post-doctoral training program in HIV-TB epidemiology, clinical and laboratory research, for junior faculty of the Byramjee Jeejeebhoy...

Perceptions of HCWs on Barriers and Opportunities to Airborne Infection Control Guideline Implementation

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2017-12-07
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This study was funded by the Fogarty International Center at the U.S. National Institutes of Health. Led by Dr. Nishi Suryavanshi, this qualitative, cross-sectional study is assessing healthcare worker (HCW) perceptions about barriers and facilitators to the uptake of airborne infection control (...

A5302: BioBank for Surrogate Marker Research for TB (B-SMART)

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2017-11-21
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A5302 is a multi-center trial of the AIDS Clinical Trials Group (ACTG) in collaboration with the Tuberculosis Trials Consortium (TBTC).This study will be conducted at the BJ Government Medical College (BJGMC) in Pune, India. Study staff of the BJGMC will conduct the study and Johns Hopkins...

The Role of GeneXpert in Bacterial Diagnosis of Spinal Tuberculosis

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2017-10-26
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This study was funded by the Fogarty International Center at the U.S. National Institutes of Health. India has the maximum burden of tuberculosis (TB) in the world. In 2014, there were an estimated 9.6 million incident cases of TB (range, 9.1 million–10.0 million) globally, equivalent to 133 cases...

Characteristics Associated with Mobile Phone Usage among TB Populations in Pune, India

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2017-10-02
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With 8.6 million people affected worldwide in 2012, the control and prevention of tuberculosis (TB) has become an international priority. In order to reduce burdens and achieve global goals for TB control, new and innovative tools are necessary. With a growing number of mobile phone subscriptions...

Impact of Diabetes on TB Treatment Outcomes: Nested Study: Lipid Mediators of Inflammation in TB and TB-Diabetes

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2017-10-02
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Studies have shown that individuals with Tuberculosis (TB) and diabetes (TB-DM) have a distinct immune profile compared to individuals with TB alone. Individuals with TB-DM have higher inflammation, a higher bacillary load, increased Th1 immune responses and a defective neutrophil and macrophage...

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HIV Testing Uptake Among the Household Contacts of Multidrug-resistant Tuberculosis Index Cases in Eight Countries

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2019-01-07
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International Journal of Tuberculosis and Lung Disease
International Journal of Tuberculosis and Lung Disease : The Indo-JHU Clinical Research Parentership participated in this multinational study to determine if it's feasible to provide HIV testing for household contacts of MDR-TB cases.

The global landscape of tuberculosis therapeutics

Post Date: 
2018-11-07
Publication: 
Annual Review of Medicine
Abstract Tuberculosis (TB) is one of the oldest infections afflicting humans yet remains the number one infectious disease killer worldwide. Despite decades of experience treating this disease, TB regimens require months of multidrug therapy, even for latent infections. There have been important...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

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2018-10-01
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International Journal of Tuberculosis and Lung Disease
Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

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2018-09-24
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BMC Medicine
Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

Report of the Technical Consultation on Advances in Clinical Trial Design for Development of New TB Treatments

Post Date: 
2018-09-17
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WHO Task Force on Introduction of New TB Drugs and Treatment Regimens
Dr. Amita Gupta was a member of this TB technical consultation, convened in March 2018 in Switzerland.

Ovarian mass - tuberculosis or malignancy? Need for early intensified evaluation

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2018-09-14
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EXCLI Journal
Letter to the Editor Dear Editor, We read with interest the case report by Chien et al. on Peritoneal Tuberculosis (TB) mimicking ovarian cancer (Chien et al., 2016[1]). We want to congratulate the authors on this case report. We encountered a similar case in our clinical setting in western India...

The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

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2018-09-07
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Occupational and Environmental Medicine
Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)

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2018-09-01
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International Journal of Tuberculosis and Lung Disease
Current guidelines recommend evaluation of the household contacts of individuals with multidrug-resistant tuberculosis; however, implementation of this policy is challenging.

Failure in TB control: why should the rapid diagnostic test bear the blame?

Post Date: 
2018-09-01
Publication: 
International Journal of Tuberculosis and Lung Disease
Dr. Sachit Atre's correspondence published in the International Journal of Tuberculosis and Lung Disease.

The effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

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2018-08-20
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Antimicrobial Agents and Chemotherapy
DM and higher HbA1c increased the risk of not achieving therapeutic targets for pyrazinamide, but higher pyrazinamide concentrations were asociated with worse microbiologic and clinical outcomes

Challenges of TB and co-treatment: updates and insights

Post Date: 
2018-08-04
Publication: 
Current Opinion in HIV and AIDS
PURPOSE OF REVIEW: In the past few years, tuberculosis (TB) has overtaken HIV as the infectious disease with the highest global mortality. Successful management of this syndemic will require improved diagnostic tests, shorter preventive therapies, and more effective treatments, particularly in...

Tuberculin skin test and QuantiFERON-Gold In Tube assay for diagnosis of latent TB infection among household contacts of pulmonary TB patients in high TB burden setting

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2018-08-01
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PLoS One
World Health Organization (WHO) recommends systematic screening of high-risk populations, including household contacts (HHCs) of adult pulmonary tuberculosis (TB) patients, as a key strategy for elimination of TB. QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and tuberculin skin test (TST) are two commonly used tools for the detection of latent tuberculosis infection (LTBI) but may yield differential results, affecting eligibility for TB preventive therapy.

Trends in HbA1c levels and implications for diabetes screening in tuberculosis cases undergoing treatment in India

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2018-07-01
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International Journal of Tuberculosis and Lung Disease
SETTING: The optimal timing of screening for diabetes mellitus (DM) among tuberculosis (TB) cases is unclear due to the possibility of stress hyperglycemia. DESIGN: We evaluated adult (18 years) pulmonary TB cases at treatment initiation as well as at 3 months, 6 months and 12 months. DM was...

Internal medicine residents' knowledge and practice of pulmonary tuberculosis diagnosis

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2018-06-27
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Open Forum Infectious Diseases
BACKGROUND: Internal medicine physicians are often the first providers to encounter patients with a new diagnosis of tuberculosis. Given the public health risks of missed tuberculosis cases, assessing internal medicine residents' ability to diagnose tuberculosis is important. METHODS: Internal...

Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?

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2018-05-22
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The International Journal of Tuberculosis and Lung Disease
Authors find that screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing tuberculosis and improve management of diabetes.

The global neurological burden of tuberculosis

Post Date: 
2018-05-18
Publication: 
Seminars in Neurology
Central nervous system (CNS) involvement of tuberculosis (TB) is the most severe manifestation of TB and accounts for approximately 5 to 10% of all extrapulmonary TB (EPTB) cases and approximately 1% of all TB cases. TB meningitis (TBM) is the most common form of CNS TB, though other forms occur,...

Addressing knowledge gaps and prevention for tuberculosis-infected Indian adults: a vital part of elimination

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2018-05-02
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BMC Infectious Diseases
BMC Infectious Diseases : Our survey among TB patients' household contacts with evidence of recent exposure found that knowledge is poor and families are confused about disease transmission.

Hepatotoxicity during isoniazid preventive therapy and antiretroviral therapy in people living with HIV with severe immunosuppression: a secondary analysis of a multi-country open-label randomized controlled clinical trial

Post Date: 
2018-05-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
BACKGROUND: Hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) has not been well studied in severely immunosuppressed people with HIV. Our objective was to determine risk factors for hepatotoxicity in severely immunosuppressed individuals taking IPT...

Advancing patient-centered care in tuberculosis management: A mixed-methods appraisal of Video Directly Observed Therapy

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2018-04-26
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Open Forum Infectious Diseases
OFID : Video DOT is an acceptable option for measurement of TB treatment adherence & may allow more treatment doses to be observed

Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial

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2018-04-19
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Trials
Trials: Evidence for TB treatment in kids is largely based on adult studies. The SHINE study aims to fix this

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Does Smoking Have an Impact on TB Treatment Outcomes?

Post Date: 
2018-10-27
Thomas B, Kannan T, Rani V, Gupte N, Gupta A, Deluca A, Suryavanshi N, Kohli R, Chandrasekaran P for the CTRIUMPH RePORT India Study Team. Does Smoking Have an Impact on TB Treatment Outcomes? A Prospective Cohort Study from India. Session: Tobacco Use in Various Populations: Implications for...

Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India

Post Date: 
2018-10-27
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Dhumal G, DeLuca A, Chandanwale A, Kadam D, Joshi S, Kinikar A, Suryavanshi N, Mave V, Gupta A, Bollinger R. Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India. Session: Building...

Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes

Post Date: 
2018-10-27
Mathad J, Alexander M, Bhosale R, Shere D, Kulkarni V, Kumar P, Babu S, Gupta A for the PRACHITi Study team. Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes. 49th Annual Union World...

TB Stigma and Its Impact on Enrolling Household Contacts in Clinical Trials and Cohort Studies: An Indian Perspective

Post Date: 
2018-10-27
Suryavanshi N. TB Stigma and Its Impact on Enrolling Household Contacts in Clinical Trials and Cohort Studies: An Indian Perspective. Symposium: Tuberculosis Contact Investigation in High Tuberculosis Burden Settings. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands...

Utility of QGIT as an Adjunct to TST for Screening of Latent Tuberculosis Infection among Indian Healthcare Workers

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2018-10-26
Girish S, Kinikar A, Pardeshi G, Shelke S, Basavaraj A, Chandanwale A, Gupte N, Bollinger R. Utility of QGIT as an Adjunct to TST for Screening of Latent Tuberculosis Infection among Indian Healthcare Workers. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24...

Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin

Post Date: 
2018-10-26
Mave V, Gupte N, Gaikwad S, Barthwal M, Chon S, Gupte A, Gupta A, Golub J. Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin. Presented at 49th Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Addressing policy needs for controlling TB and multidrug-resistant TB (MDR-TB): a biosocial inquiry among patients in Pune city in Western Maharashtra, India

Post Date: 
2018-10-26
Atre S. Addressing policy needs for controlling TB and multidrug-resistant TB (MDR-TB): a biosocial inquiry among patients in Pune city in Western Maharashtra, India. Presented at 49th Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Managing Tuberculosis in Pregnancy. Meet the Expert Session

Post Date: 
2018-10-26
Gupta A. Managing Tuberculosis in Pregnancy. Meet the Expert Session. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Factors Associated with Loss to Follow-up and Mortality in Public Sector MDR TB Treatment in Western Maharashtra, India from 2015-2016

Post Date: 
2018-10-26
Murrill M, More SW, Kamble S, Kulkarni V, Dowdy D, Gupta A. Factors Associated with Loss to Follow-up and Mortality in Public Sector MDR TB Treatment in Western Maharashtra, India from 2015-2016. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24,-27, 2018.

The TEKO trial: implementation of the QuantiFERON®-TB Gold In-Tube test at CD4 blood draw for diagnosing latent tuberculosis among newly diagnosed HIV-infected adults in South Africa

Post Date: 
2018-10-26
Golub J, Lebina L, Chon S, Cohn S, Jack T, Masonoke K, Variava E, Martinson N, TEKO team. The TEKO trial: implementation of the QuantiFERON®-TB Gold In-Tube test at CD4 blood draw for diagnosing latent tuberculosis among newly diagnosed HIV-infected adults in South Africa. 49th Annual Union World...

What Is the Right Dose of Pyrazinamide?

Post Date: 
2018-10-25
Dooley K. What Is the Right Dose of Pyrazinamide? Symposium: Optimisation of Standard Drugs in the Treatment of Tuberculosis, Finally?

BRIEF TB Treatment of Latent TB Infection With One Month of Isoniazid & Rifapentine in HIV-Infected People: Interaction of Treatment & CD4 Count

Post Date: 
2018-10-25
Swindells S, Ramchandami R, Gupta A, Sanchez J, Juste MAJ, Mwelase N, Chaisson R, BRIEF TB Study Team. BRIEF TB Treatment of Latent TB Infection With One Month of Isoniazid & Rifapentine in HIV-Infected People: Interaction of Treatment & CD4 Count. Session: TB Infection: From Latent to...

Impact of Maternal Isoniazid Preventive Therapy (IPT) Timing on Acquisition of Infant TB Infection (TBI) in the IMPAACT P1078/TB APPRISE Trial

Post Date: 
2018-10-25
Gupta A , Aaron L, Montepiedra G, Theron G, Chipato T, Onyango-Makumbi C, Stranix-Chibanda L, Weinberg A, for the IMPAACT P1078/TB APPRISE Study Team. Impact of Maternal Isoniazid Preventive Therapy (IPT) Timing on Acquisition of Infant TB Infection (TBI) in the IMPAACT P1078/TB APPRISE Trial. 49th...

Preventive Therapy for PLWH - 3HP. MTE HIV Meet the Expert Session

Post Date: 
2018-10-25
Dooley K. Preventive Therapy for PLWH - 3HP. MTE HIV Meet the Expert Session. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Alcohol Use Disorder, Drinking Patterns, and Tuberculosis Treatment Failure in Indian Patients

Post Date: 
2018-10-25
DeLuca A, Thomas B, Suryavanshi N , Jain D, Paradkar M, Gupte A, Chandrasekaran P, Gupta A for the CTRIUMPH RePORT India Study Team. Alcohol Use Disorder, Drinking Patterns, and Tuberculosis Treatment Failure in Indian Patients. 49th Annual Union World Conference on Lung Health. The Hague, The...

Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis

Post Date: 
2018-10-25
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Gupte A, Kumar P, Kulkarni V, Bharadwaj R, Andrade B, Mave V, Chandrasekaran P, Gupta A. Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-...

Challenges in TB Diagnosis in Pregnant Women in India: Findings from a Cohort Study in Pune, India

Post Date: 
2018-10-25
Alexander M, Bhosale R, Gupte N, Deshpande P, Kulkarni V, Chandanwale A, Gupta A, Mathad J. Challenges in TB Diagnosis in Pregnant Women in India: Findings from a Cohort Study in Pune, India. Session: LTBI Screening: Challenges and Opportunities. 49th Annual Union World Conference on Lung Health...

Sub-therapeutic Rifampicin Concentration is Associated with Unfavourable Treatment Outcomes in Pulmonary Tuberculosis Patients on Thrice Weekly Regimens in India

Post Date: 
2018-10-25
Ramachandran G, Chandrasekaran P, Kumar AKH, Kannan T, Gomathi NS, Gaikwad S, Gupta A, Mave V, for C-TRIUMPh team. Sub-therapeutic Rifampicin Concentration is Associated with Unfavourable Treatment Outcomes in Pulmonary Tuberculosis Patients on Thrice Weekly Regimens in India. Session: Clinical...

Host Inflammation Markers IFN- γ, IL-6 and IL-15 Strongly Associated with Risk of Incident TB in Advanced HI

Post Date: 
2018-10-25
Manabe YC, Gupte N, Leong S, Kintali M, Bisson G, Hosseinipour M, Salgame P, Gupta A for the ACTG 5274 REMEMBER and NWCS 408 Study Team. Host Inflammation Markers IFN- γ, IL-6 and IL-15 Strongly Associated with Risk of Incident TB in Advanced HI. Session: Diagnosis, Screening, Prediction of Disease...

Time to culture conversion, identifying independent modifiable risk factors in Indian patients

Post Date: 
2018-10-25
Gupte N, Gupte A, Sivaramakrishnan GN, Pradhan N, Shivakumar SVBY, Gupta A, Mave V, Chandrasekaran P for the CTRIUMPh RePORT India team. Time to culture conversion, identifying independent modifiable risk factors in Indian patients. Presented at 49th Union World Conference on Lung Health. The Hague...

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RePORT India Tuberculosis Consortium Common Protocol

Post Date: 
2016-01-01
Vidya Mave, Chair, 2016–Present

Regional Prospective Observational Research for Tuberculosis (RePORT) India Executive Committee

Post Date: 
2014-01-01
US Chair, 2016-Present US Co-chair, 2014-2016

Maryland Tuberculosis Guidelines Committee

Post Date: 
2014-01-01
Maunank Shah, Member, 2014.

IMPAACT Clinical Trial Network Tuberculosis Scientific Committee

Post Date: 
2012-01-01
Vice Chair Elect, 2012-Present

2012 43rd Union World Conference on Lung Health Conference Committee

Post Date: 
2012-01-01
Abstract Reviewer, 2012

ACTG Clincial Trial Group, Women's Health Inter-Network Scientific Committee

Post Date: 
2011-01-01
Tuberculosis Working Group Member, 2011-2013

ACTG Tuberculosis Transformative Science Group

Post Date: 
2011-01-01
Amita Gupta: Elected Member, 2011-2013 Vidya Mave: Elected Member, 2016-2017

International Union Against Tuberculosis and Lung Disease

Post Date: 
2009-01-01
Amita Gupta, Member, 2009-Present. Maunank Shah, Member, 2009–Present.