Disease diagnosis

Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients in Pune, India

Post Date: 
2017-08-07
Country: 
Antimicrobial resistance, a leading threat to human health, is enabled by unnecessary antibiotic use. Strategies to reduce unnecessary antibiotic use in India, the world’s largest antibiotic consumer, are urgently needed. Although most patients hospitalized in India with acute febrile illness...

RePORT: C-TRIUMPH: Biomarkers for Tuberculosis Diagnosis and Treatment Response

Post Date: 
2017-03-24
Country: 
Aims: To develop non-sputum, blood-based tools for TB diagnosis and treatment, we urgently need biomarkers that identify active TB (ATB) cases and accurately distinguish them from latent TB infection (LTBI). Such biomarkers, when validated in diverse populations, can be developed into improved...

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

Post Date: 
2017-03-01
Country: 
In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

Cost-effectiveness of Xpert MTB/RIF for Diagnosing Pulmonary Tuberculosis in HIV-positive Patients

Post Date: 
2016-12-01
Country: 
This is a prospective cross-sectional study which will be conducted at BJGMC in Pune, India. The aim of this study is to see whether Xpert MTB/RIF is useful for early detection of pulmonary tuberculosis, and therefore cost-effective, as compared with sputum microscopy and the gold standard tests...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date: 
2016-09-19
Country: 
Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

RePORT: C-TRIUMPH: Substudy on Comparison of Available Purified-protein Derivative (PPD) Tuberculin Skin Test (TST) Antigen Solutions in Detecting Latent Tuberculosis Infection in India

Post Date: 
2016-04-21
Country: 
Given the worldwide shortage of PPD TST antigen solutions, it is important to establish the sensitivity of the commercially available SPAN diagnostic TST when compared products used in international settings. This study aims to establish whether the SPAN diagnostic product is bioequivalent to PPDs...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India: Substudy on the Characterization of the Human Virome

Post Date: 
2016-02-21
Country: 
Objective 1: To use novel molecular techniques to characterize the human virome in the circulating blood of patients in clinical settings who presented to an acute care setting with an acute febrile illness and in whom a diagnosis cannot be achieved by conventional methods. Healthy controls will be...

Predictive Val. of TB-symptom Screen in HIV-infected & -uninfected Pregnant Women in Pune, India. Substudy: Studying Molecular Mechanisms Leading to Suppressed Immunity in Pregnancy & Studying Relationship between Diet, Gut Microbiome, & Inflammation

Post Date: 
2014-10-28
Country: 
Pregnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection, is suppressed in pregnancy. Thus, pregnant women are especially vulnerable to TB...

miLINC: MDR-TB South Africa - Patient Linkage to and Retention in Care

Post Date: 
2014-10-06
Country: 
Mycobacterium tuberculosis (TB) remains the leading cause of death among persons living with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) in southern Africa. Drug-resistant TB remains a growing threat to public health despite advances made in diagnosis and...

PreventionRx Study: Home-based Counseling and Testing in Uganda

Post Date: 
2014-08-27
Country: 
A ‘platform’ for evaluating combination HIV prevention & care-HIV counseling & testing is essential to optimize HIV services. In collaboration with the University of Washington and the Integrated Community Based Initiatives (ICOBI) NGO in Uganda, CCGHE has adapted the emocha ® platform to...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India

Post Date: 
2013-01-10
Country: 
Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

Project Connect Baltimore: Connecting Young Males to Sexual/Reproductive Healthcare

Post Date: 
2012-10-01
Country: 
To design, implement and evaluate a male-friendly and culturally appropriate guide for increasing access to and use of human immunodeficiency virus (HIV)/sexually transmitted disease (STD) testing and sexual/reproductive healthcare (SRHC) among African American and Latino males.

HIV Latino Outreach Program, Baltimore City Health Department

Post Date: 
2008-01-01
Country: 
Dr. Kathleen Page founded and directs the Baltimore City Health Department’s HIV Latino Outreach Program, which provides more than 1000 HIV tests per year to Baltimore's Latino community, and provides linkages to care services for those testing positive.

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
Country: 
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

Presence of human hepegivirus-1 in a cohort of people who inject drugs

Post Date: 
2017-06-07
Publication: 
Annals of Internal Medicine
Findings on the sensitivity of next-generation metagenomic sequencing for discovery of new viral infections.

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date: 
2017-04-01
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
SETTING: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children . DESIGN: Children (age 5 years or younger) with suspected TB were...

Prevalence of HIV testing provision at community organizations serving young people in a mid-Atlantic city, 2013-2014

Post Date: 
2017-03-31
Publication: 
Public Health Reports
Country: 
Objectives: Little is known about the prevalence of human immunodeficiency virus (HIV) testing at community organizations or the organizational characteristics associated with testing. The objective of this study was to describe (1) the prevalence of HIV testing at community organizations serving...

Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date: 
2017-03-27
Publication: 
The American Journal of Tropical Medicine and Hygiene
After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

Cost-effectiveness of CRAG-LFA screening for cryptococcal meningitis among people living with HIV in Uganda

Post Date: 
2017-03-23
Publication: 
BMC Infectious Diseases
Country: 
Background : Cryptococcal meningitis (CM) constitutes a significant source of mortality in resource-limited regions. Cryptococcal antigen (CRAG) can be detected in the blood before onset of meningitis. We sought to determine the cost-effectiveness of implementing CRAG screening using the recently...

Public health clinic-based hepatitis C testing and linkage to care in Baltimore

Post Date: 
2016-05-15
Publication: 
Journal of Viral Hepatitis
Country: 
Testing and linkage to care are important determinants of hepatitis C virus (HCV) treatment effectiveness. Public health clinics serve populations at high risk of HCV. We investigated their potential to serve as sites for HCV testing, initiation of and linkage to HCV care. Cross-sectional study of...

Infectious Diseases (ID) Learning Unit: How rapidly to evaluate for active tuberculosis disease in low-prevalence settings

Post Date: 
2016-03-11
Publication: 
Open Forum Infectious Diseases
Country: 
With declining tuberculosis (TB) incidence in low-prevalence settings, many clinicians are likely unaware that the approach to diagnosing active TB is evolving with newer technologies. Rapid molecular assays are commercially available, and more are likely to enter the market in the coming years...

The epidemiologic and economic impact of improving HIV testing, linkage, and retention in care in the United States

Post Date: 
2016-01-15
Publication: 
Clinical Infectious Diseases
Country: 
Background : Recent guidelines advocate early antiretroviral therapy (ART) to decrease human immunodeficiency virus (HIV) morbidity and prevent transmission, but suboptimal engagement in care may compromise impact. We sought to determine the economic and epidemiologic impact of incomplete...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date: 
2016-01-14
Publication: 
American Journal of Respiratory and Critical Care Medicine
Country: 
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Senior center-based hepatitis C screening in Baltimore

Post Date: 
2016-01-06
Publication: 
Open Forum Infectious Diseases
Country: 
Abstract Despite significant advancements in hepatitis C virus (HCV) treatments, the majority of individuals infected with HCV remain undiagnosed. We report on senior citizen center-based HCV testing in Baltimore, which revealed a 9.4% prevalence of infection. Our data suggest that community-based...

Post-arrival tuberculosis screening at a local health department of high-risk immigrants

Post Date: 
2015-07-15
Publication: 
American Journal of Public Health
Country: 
Objectives : We sought to characterize postimmigration tuberculosis (TB) care for Class B immigrants and refugees at the Baltimore City Health Department TB program (BCHD), and to determine the proportion of immigrants with active TB or latent TB infection (LTBI) in this high-risk population...

Policy Guidance: The Use of Lateral-Flow Urine LAM for Diagnosis and Screening of Active TB in People Living with HIV

Post Date: 
2015-06-30
Publication: 
WHO: The Use of Lateral-Flow Urine LAM for Diagnosis and Screening of Active TB in People Living with HIV
Background : Tests based on the detection of mycobacterial lipoarabinomannan (LAM) antigen in urine have emerged as potential point-of-care tests for tuberculosis (TB). LAM antigen is a lipopolysaccharide present in mycobacterial cell walls, which is released from metabolically active or...

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda

Post Date: 
2015-02-15
Publication: 
BMC Infectious Diseases
Country: 
Background : Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be missed; delays in diagnosis can be fatal. Given the duration for MTB growth in...

Implementing a large scale systematic tuberculosis screening program in correctional facilities in South Africa

Post Date: 
2015-01-08
Publication: 
Open Forum Infectious Diseases
Country: 
Background : Tuberculosis (TB) prevalence is high in correctional facilities in southern Africa. With support from local South African nongovernmental organizations, the South African Department of Correctional Services initiated a program of systematically screening newly admitted and current...

High proportion of indeterminate QuantiFERON-TB Gold In-Tube results in an inpatient population are related to host factors and pre-analytical steps

Post Date: 
2014-09-19
Publication: 
Open Forum Infectious Diseases
Country: 
Background: QuantiFERON-TB Gold In-Tube test (QFT-GIT) can be used as an alternative to tuberculin skin testing (TST) for the targeted testing of latent tuberculosis. Due to many shortcomings with TST, QFT-GIT usage is increasing. QFT-GIT implementation in the inpatient setting remains unclear...

Economic challenges associated with tuberculosis diagnostic development

Post Date: 
2014-08-15
Publication: 
Expert Review of Pharmacoeconomics and Outcomes Research
Tuberculosis remains a global health crisis in part due to underdiagnosis. Technological innovations are needed to improve diagnostic test accuracy and reduce the reliance on expensive laboratory infrastructure. However, there are significant economic challenges impeding the development and...

Editorial commentary: Xpert MTB/RIF testing for individuals with presumed tuberculosis: implications for infection control and rapid tuberculosis detection in the United States.

Post Date: 
2014-08-04
Publication: 
Clinical Infectious Diseases
Country: 
Despite recent declines in incidence, tuberculosis remains a significant public health problem in the United States, with almost 10 000 new cases each year. As the disease becomes less common in the United States, diagnostic delays occur because of diverse clinical presentations and suboptimal...

Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults

Post Date: 
2014-07-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective : In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack of accurate, rapid tuberculosis diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic test for detection...

Cost-effectiveness of rapid susceptibility testing against second line drugs for tuberculosis

Post Date: 
2014-06-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Background : Drug susceptibility testing (DST) against second-line tuberculosis drugs (SLDs) is essential for improving outcomes among multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) cases. Objective : To evaluate the potential cost-effectiveness of rapid DST for...

Comparative performance of urinary lipoarabinomannan assays and Xpert MTB/RIF in HIV-infected individuals

Post Date: 
2014-06-01
Publication: 
AIDS
Country: 
Background : Xpert MTB/RIF ('Xpert') and urinary lipoarabinomannan (LAM) assays offer rapid tuberculosis (TB) diagnosis, but have suboptimal sensitivity when used individually in HIV-positive patients. The yield of these tests used in combination for the diagnosis of active TB among HIV-infected TB...

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HIV Testing Uptake Among Household Contacts of MDR-TB Index Cases in Eight Countries

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Event & Convener: 
CROI 2017
Poster Presentation. Opollo VS, Wu X, Lando R, Swindells S, Gupta A, Hesseling A, Dawson R, Hughes MD, Shah S

Etiology of Acute Febrile Illness among Hospitalized Adults and Children at a Public Tertiary-Care Center in Pune, India

Post Date: 
2016-10-27
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster Abstract Session: Oh One World: Infections from Near and Far. Robinson M , Balasubramanian U, Raichur P, Kadam D, Khadse S, Marbaniang I, Kanade S, Sachs J, Basavaraj A, Bharadwaj R, Kinikar A, Kulkarni V, Kagal A, Gupta A, Mave V

Xpert® MTB/RIF Assay for Pulmonary Tuberculosis Diagnosis in Patients with Diabetes Mellitus

Post Date: 
2016-10-27
Presentation Location: 
Durban, South Africa
Event & Convener: 
47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Poster Presentation. Mave V , Gupte N, Meshram S, Kagal A, Gupta A, Bharadwaj R, Pradhan N, Deshmukh S, Atre S, Golub J

Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care

Post Date: 
2016-07-20
Presentation Location: 
Durban, South Africa
Country: 
Event & Convener: 
21st International AIDS Conference. International AIDS Society.
Poster Presentation. Farley JE , Seiguer S, Naicker M, McKenzie-White J, Greg C, Elmi M, Stevens W, Stewart-Isherwood L

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date: 
2015-12-04
Presentation Location: 
Cape Town, South Africa
Country: 
Event & Convener: 
The 46th Union World Conference on Lung Health
Poster Session. TB Diagnostic Challenges: Molecular and Other Techniques. Authors: Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V.

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date: 
2015-10-11
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Poster Session: Latent TB Infection: Diagnosis and Treatment. Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, Mathad J.

Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics

Post Date: 
2015-10-11
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Presentation. Chida N, Gupta A, Bollinger B, Melia M.

A Man from Central America with Progressive Shortness of Breath

Post Date: 
2015-10-07
Presentation Location: 
San Diego, CA
Event & Convener: 
ID Week 2015
Case Report. Fellows' Day Workshop.

The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India

Post Date: 
2015-05-01
Presentation Location: 
Denver, CO
Country: 
Event & Convener: 
American Thoracic Society International Conference
Poster Session: Latent TB Infection: Diagnosis and Treatment. Oral Presentation. Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse P, Gupta A, Golub J.

Barriers and Delays in TB Diagnosis and Treatment: Does Gender Matter?

Post Date: 
2014-11-17
Presentation Location: 
Washington, DC
Event & Convener: 
PATH Gender & TB Experts Meeting
Presentation

Integrating Active Tuberculosis Case Finding and Isoniazid Preventive Therapy with Antenatal Services

Post Date: 
2013-11-03
Presentation Location: 
Paris, France
Event & Convener: 
44th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease
Invited speaker. Symposium: Best Practices in Implementing TB/HIV Collaborative Activities in Maternal and Child Health Settings

Update in TB Diagnosis, Treatment and Prevention

Post Date: 
2013-04-19
Presentation Location: 
Rio de Janeiro, Brazil
Event & Convener: 
Brazil-Hopkins AIDS Conference
Presentation

Fever in a Traveler

Post Date: 
2012-05-09
Presentation Location: 
Baltimore, MD
Event & Convener: 
Topics in Clinical Medicine. Johns Hopkins University
Lecture. Bollinger R, Philip A

Test and Treat

Post Date: 
2012-04-11
Presentation Location: 
Rio de Janeiro, Brazil
Event & Convener: 
Brazil-Hopkins AIDS Conference
Presentation

Update in TB Diagnosis, Treatment and Prevention

Post Date: 
2012-01-31
Presentation Location: 
Mumbai, India
Country: 
Event & Convener: 
4th National Conference on HIV/AIDS Therapy. Human Healthcare and Research Foundation
Presentation

TB in pregnancy and novel TB diagnostics

Post Date: 
2009-04-28
Presentation Location: 
Pune, India
Event & Convener: 
BJ Medical College Grand Rounds. BJ Medical College
Presentation

TB Noon Conference

Post Date: 
2013-10-24
Country: 
CCGHE webcasts Tuberculosis (TB) Noon Conference live and provides a global audience with open access to all live and archived sessions via the CCGHE website. Led by Drs. Maunank Shah, Jonathan Golub, Richard Chaisson, these meetings bring together Johns Hopkins TB researchers and trainees in an...