Disease diagnosis

Clinical Sites:

This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Jyothi Rengarajan, MD, Emory University. Primary Research Question Do health care workers who remain TST negative, despite high-exposure to TB,...

Optimal Approach for TB Screening among HIV Infected Indian Children

Post Date:

2018-06-11

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This study was terminated May 20, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. Determining TB status (ie, uninfected, latent, and active TB disease) is more difficult among children, particularly HIV-infected children. Diagnosis of TB disease is...

Validation of Transcriptional Signature to Predict Active TB Disease among Advanced HIV Patients

Post Date:

2017-08-15

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There have been tremendous advances in the diagnosis of patients with tuberculosis (TB) based on nucleic acid amplification of bacteria in the sputum. The GenXpert MTB/RIF provides results in 2 hours. However, in HIV-infected sputum smear is often negative for AFB and the sensitivity of GenXpert...

Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients in Pune, India

Post Date:

2017-08-07

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Antimicrobial resistance, a leading threat to human health, is enabled by unnecessary antibiotic use. Strategies to reduce unnecessary antibiotic use in India, the world’s largest antibiotic consumer, are urgently needed. Although most patients hospitalized in India with acute febrile illness...

Biomarkers for Tuberculosis Diagnosis and Treatment Response

Post Date:

2017-03-24

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NIRT

This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Aims: To develop non-sputum, blood-based tools for TB diagnosis and...

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

Post Date:

2017-03-01

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In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

Cost-effectiveness of Xpert MTB/RIF for Diagnosing Pulmonary Tuberculosis in HIV-positive Patients

Post Date:

2016-12-01

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This is a prospective cross-sectional study which will be conducted at BJGMC in Pune, India. The aim of this study is to see whether Xpert MTB/RIF is useful for early detection of pulmonary tuberculosis, and therefore cost-effective, as compared with sputum microscopy and the gold standard tests...

Comparison of Available Purified-protein Derivative (PPD) Tuberculin Skin Test (TST) Antigen Solutions in Detecting Latent Tuberculosis Infection in India

Post Date:

2016-04-21

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NIRT

This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Given the worldwide shortage of PPD TST antigen solutions, it is...

The Human Virome in Health and Disease

Post Date:

2016-02-21

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This study is part of the Antimicrobial Resistance study referenced below, Some samples were used from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB...

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome and Preterm Birth

Post Date:

2014-10-28

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Clinical Sites:

NIRT

This study was terminated May 7, 2018. P regnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection, is suppressed in pregnancy. Thus,...

miLINC: MDR-TB South Africa - Patient Linkage to and Retention in Care

Post Date:

2014-10-06

Countries:

South Africa

Mycobacterium tuberculosis (TB) remains the leading cause of death among persons living with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) in southern Africa. Drug-resistant TB remains a growing threat to public health despite advances made in diagnosis and...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date:

2014-06-14

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Hinduja Hospital

Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

Tuberculosis Noon Conference

Post Date:

2013-10-24

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This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

Bacterial Antimicrobial Resistance Patterns in Pune, India

Post Date:

2013-01-10

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Clinical Sites:

DY Patil

Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

Project Connect Baltimore: Connecting Young Males to Sexual/Reproductive Healthcare

Post Date:

2012-10-01

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To design, implement and evaluate a male-friendly and culturally appropriate guide for increasing access to and use of human immunodeficiency virus (HIV)/sexually transmitted disease (STD) testing and sexual/reproductive healthcare (SRHC) among African American and Latino males.

PreventionRx Study: Home-based Counseling and Testing in Uganda

Post Date:

2010-10-21

Countries:

Uganda

This study was terminated August 29, 2014. A ‘platform’ for evaluating combination HIV prevention & care-HIV counseling & testing is essential to optimize HIV services. In collaboration with the University of Washington and the Integrated Community Based Initiatives (ICOBI) NGO in Uganda,...

HIV Latino Outreach Program, Baltimore City Health Department

Post Date:

2008-01-01

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Dr. Kathleen Page founded and directs the Baltimore City Health Department’s HIV Latino Outreach Program, which provides more than 1000 HIV tests per year to Baltimore's Latino community, and provides linkages to care services for those testing positive.

Calibration and Application of a Simple Sensitive/Less Sensitive Assay Applicable to Resource-Limited Countries for Determination of Recent HIV Infection and Incidence Estimates

Post Date:

2007-03-22

Countries:

This study was terminated March 31, 2007. Sensitive/Less Sensitive assays (S/LS) to distinguish between recent and established HIV infections have been successfully applied to identify recently infected persons and determine HIV incidence. However, all currently used S/LS assays require laboratory...

Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study

Post Date:

2019-07-29

Countries:

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Publication:

Lancet HIV

BACKGROUND: Antiretroviral therapy (ART) management is challenging for individuals in resource-limited settings presenting for third-line treatment because of complex resistance patterns, partly due to reduced access to viral load monitoring. We aimed to evaluate use of newer antiretroviral drugs...

Users beware! Biological variation in complete blood counts over short time intervals

Post Date:

2019-05-29

Publication:

BMJ Evidence Based Medicine

New publication in BMJ Evidence Based Medicine looks at CBC count variations in blood drawn over a short time period

Symptom screening for active tuberculosis in pregnant women living with HIV

Post Date:

2019-01-24

Publication:

Cochrane Database of Systematic Reviews

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting. To...

HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries

Post Date:

2019-01-07

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Publication:

International Journal of Tuberculosis and Lung Disease

International Journal of Tuberculosis and Lung Disease : The Indo-JHU Clinical Research Parentership participated in this multinational study to determine if it's feasible to provide HIV testing for household contacts of MDR-TB cases.

Atypical mycobacterial infections following plastic surgery procedures abroad: a multidisciplinary algorithm for diagnosis and treatment

Post Date:

2018-12-28

Abstract: Medical tourism has become increasingly popular in recent years. The most commonly sought procedures are cosmetic. The recent rise in medical tourism has been mirrored by an increase in the incidence of M. abscessus infections, atypical mycobacteria ubiquitous in aquatic environments...

Multiplex-PCR to detect pAmpC β-lactamases among Enterobacteriaceae at a tertiary care laboratory in Mumbai, India

Post Date:

2018-12-13

Countries:

Clinical Sites:

Hinduja Hospital

Publication:

Microbiology

Drug-resistance due to AmpC β-lactamases represents a growing problem worldwide. In this study, a previously collected sample of 108 cefoxitin-resistant clinical isolates was assessed for AmpC β-lactamase production through routine phenotypic testing and double-disc cefoxitin/cloxcallin (DD-CC),...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

Post Date:

2018-10-01

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Publication:

International Journal of Tuberculosis and Lung Disease

Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

Ovarian mass - tuberculosis or malignancy? Need for early intensified evaluation

Post Date:

2018-09-14

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Publication:

EXCLI Journal

Letter to the Editor Dear Editor, We read with interest the case report by Chien et al. on Peritoneal Tuberculosis (TB) mimicking ovarian cancer (Chien et al., 2016[1]). We want to congratulate the authors on this case report. We encountered a similar case in our clinical setting in western India...

Internal medicine residents' knowledge and practice of pulmonary tuberculosis diagnosis

Post Date:

2018-06-27

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Publication:

Open Forum Infectious Diseases

BACKGROUND: Internal medicine physicians are often the first providers to encounter patients with a new diagnosis of tuberculosis. Given the public health risks of missed tuberculosis cases, assessing internal medicine residents' ability to diagnose tuberculosis is important. METHODS: Internal...

Pyrosequencing to resolve discrepant Xpert MTB/RIF and Mycobacterial Growth Indicator Tube 960

Post Date:

2018-03-26

Countries:

Clinical Sites:

Hinduja Hospital

Publication:

Lung India

Lung India: Indo-JHU researchers find that pyrosequencing can clear up discrepancies about drug resistance in TB.

The use of clinical decision support in reducing diagnosis of and treatment of asymptomatic bacteriuria

Post Date:

2017-12-06

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Publication:

Journal of Hospital Medicine

Clinical decision support embedded within the electronic health record is a potential antibiotic stewardship strategy for hospitalized patients.

Antibiotic utilization and the role of suspected and diagnosed mosquito borne illness among adults and children with acute febrile illness in Pune, India

Post Date:

2017-12-04

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Publication:

Clinical Infectious Diseases

Mosquito-borne disease identification is associated with reduced empiric antibiotic use and faster antibiotic discontinuation.

A qualitative study exploring factors influencing clinical decision-making for influenza-like illness in Solapur city, Maharashtra, India

Post Date:

2017-07-03

Countries:

Publication:

Anthropology and Medicine

Abstract The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical pluralism becomes...

Presence of human hepegivirus-1 in a cohort of people who inject drugs

Post Date:

2017-06-07

Publication:

Annals of Internal Medicine

Findings on the sensitivity of next-generation metagenomic sequencing for discovery of new viral infections.

Tuberculosis screening among persons with diabetes mellitus in Pune, India

Post Date:

2017-06-02

Countries:

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Publication:

BMC Infectious Diseases

Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking care at a large...

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date:

2017-04-01

Countries:

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Publication:

International Journal of Tuberculosis and Lung Disease

Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or younger) with suspected TB were...

Prevalence of HIV testing provision at community organizations serving young people in a mid-Atlantic city, 2013-2014

Post Date:

2017-03-31

Countries:

Publication:

Public Health Reports

Objectives: Little is known about the prevalence of human immunodeficiency virus (HIV) testing at community organizations or the organizational characteristics associated with testing. The objective of this study was to describe (1) the prevalence of HIV testing at community organizations serving...

Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date:

2017-03-27

Publication:

The American Journal of Tropical Medicine and Hygiene

After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

Cost-effectiveness of CRAG-LFA screening for cryptococcal meningitis among people living with HIV in Uganda

Post Date:

2017-03-23

Countries:

Uganda

Publication:

BMC Infectious Diseases

Background : Cryptococcal meningitis (CM) constitutes a significant source of mortality in resource-limited regions. Cryptococcal antigen (CRAG) can be detected in the blood before onset of meningitis. We sought to determine the cost-effectiveness of implementing CRAG screening using the recently...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date:

2016-06-15

Countries:

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Publication:

American Journal of Respiratory and Critical Care Medicine

Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Bloodstream Infections among Neonates Admitted to Neonatal Intensive Care Units in Pune, India

Post Date:

2018-05-05

Countries:

Clinical Sites:

DY Patil

Johnson J , Rajput U, Valvi C, Bharadwaj R, Parikh T, Agarkhedkar S, Robinson M, Randive B, Gupte N, Smith R, Westercamp M, Mave V, Manabe Y, Milstone A, for the CDC SHEPheRD India Study Team. Bloodstream Infections among Neonates Admitted to Neonatal Intensive Care Units in Pune, India. Pediatric...

Importance of Diagnosis of TB Infection in Pregnant Women in India: Findings from a Cohort Study in Pune, India

Post Date:

2018-04-24

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Mathad J. Importance of Diagnosis of TB Infection in Pregnant Women in India: Findings from a Cohort Study in Pune, India. Oral Presentation. Presented at Global Health Research Initiative’s Scientific Conference, Weill Cornell Medical College, April 24, 2018.

Hyperhomocysteinemia Screening: A Missed Opportunity to Mitigate CVD Risk among Asian Indian HIV-infected Adults?

Post Date:

2017-12-28

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Clinical Sites:

Marbaniang I , Sangle S, Kulkarni V, Deshpande P, Shere D, Gupte N, Gupta A, Mave V. Hyperhomocysteinemia Screening: A Missed Opportunity to Mitigate CVD Risk among Asian Indian HIV-infected Adults? AAPI Global Health Summit. American Association of Physicians of Indian Origin. Kolkata, India.

HIV Testing Uptake Among Household Contacts of MDR-TB Index Cases in Eight Countries

Post Date:

2017-02-14

Opollo VS, Wu X, Lando R, Swindells S, Gupta A, Hesseling A, Dawson R, Hughes MD, Shah S. HIV Testing Uptake Among Household Contacts of MDR-TB Index Cases in Eight Countries. CROI 2017. Seattle, Washington. 2017.

Xpert® MTB/RIF Assay for Pulmonary Tuberculosis Diagnosis in Patients with Diabetes Mellitus

Post Date:

2016-10-27

Clinical Sites:

Mave V , Gupte N, Meshram S, Kagal A, Gupta A, Bharadwaj R, Pradhan N, Deshmukh S, Atre S, Golub J. Xpert® MTB/RIF Assay for Pulmonary Tuberculosis Diagnosis in Patients with Diabetes Mellitus. 47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease...

Etiology of Acute Febrile Illness among Hospitalized Adults and Children at a Public Tertiary-Care Center in Pune, India

Post Date:

2016-10-27

Countries:

Robinson M , Balasubramanian U, Raichur P, Kadam D, Khadse S, Marbaniang I, Kanade S, Sachs J, Basavaraj A, Bharadwaj R, Kinikar A, Kulkarni V, Kagal A, Gupta A, Mave V. Etiology of Acute Febrile Illness among Hospitalized Adults and Children at a Public Tertiary-Care Center in Pune, India. ID Week...

Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care

Post Date:

2016-07-20

Countries:

South Africa

Farley JE , Seiguer S, Naicker M, McKenzie-White J, Greg C, Elmi M, Stevens W, Stewart-Isherwood L. Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care. 21st International AIDS Conference...

Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India

Post Date:

2015-12-04

Countries:

Clinical Sites:

Girish S, Dharmashle S, Desai S, Kagal A, Bharadwaj R, Chandanwale A, Lokhande R, Kadam DB, DeLuca A, Gupte N, Jain D, Gupta A, Bollinger R, Mave V. Utility of GeneXpert for Diagnosis of Rifampicin-resistant Extra-pulmonary TB—A Retrospective Review of 70 Cases, SGH, Pune, India, The 46th Union...

Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women

Post Date:

2015-10-11

Vaidya A , Tambe S, Bhosale R, Mave V, Elf J, Pradhan N, Nevrekar N, Patil S, Kagal A, Joshi S, Chandanwale A, Gupta A, MathadJ. Operational Challenges Undermine WHO TB Symptom Screen in Pregnant Women. ID Week 2015. San Diego, CA. San Diego, CA. 2015

Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics

Post Date:

2015-10-11

Chida N, Gupta A, Bollinger B, Melia M. Developing a Validated Tool to Assess Internal Medicine and Infectious Disease Trainees’ Ability to Obtain and Interpret TB Diagnostics. ID Week 2015. San Diego, CA. 2015

A Man from Central America with Progressive Shortness of Breath

Post Date:

2015-10-07

Chida, N. A Man from Central America with Progressive Shortness of Breath. ID Week 2015. San Diego, CA. 2015.

The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India

Post Date:

2015-05-01

Countries:

Clinical Sites:

Elf JL , Kinikar A, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Breysse P, Gupta A, Golub J. The Association of Exposure to Air Pollution from Biomass Fuels, Kerosene, and Secondhand Tobacco Smoke with TB in Adult Women and Children in Pune, India. American Thoracic Society...

Barriers and Delays in TB Diagnosis and Treatment: Does Gender Matter?

Post Date:

2014-11-17

Gupta, A. Barriers and Delays in TB Diagnosis and Treatment: Does Gender Matter? PATH Gender & TB Experts Meeting. Washington, DC.

Integrating Active Tuberculosis Case Finding and Isoniazid Preventive Therapy with Antenatal Services

Post Date:

2013-11-03

Gupta, A. Integrating Active Tuberculosis Case Finding and Isoniazid Preventive Therapy with Antenatal Services. 44th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Paris, France.

Update in TB Diagnosis, Treatment and Prevention

Post Date:

2013-04-19

Gupta, A. Update in TB Diagnosis, Treatment and Prevention. Brazil-Hopkins AIDS Conference. Rio de Janeiro, Brazil.

Fever in a Traveler

Post Date:

2012-05-09

Bollinger R, Philip A. Fever in a Traveler. Topics in Clinical Medicine. Johns Hopkins University. Baltimore, MD.

Test and Treat

Post Date:

2012-04-11

Bollinger, R. Test and Treat. Brazil-Hopkins AIDS Conference. Rio de Janeiro, Brazil.

Update in TB Diagnosis, Treatment and Prevention

Post Date:

2012-01-31

Countries: