Inflammation

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date: 
2016-09-19
Country: 
Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes

Post Date: 
2016-07-01
Country: 
The primary objective of this study is to determine the feasibility and operational logistics of collecting stool for microbiome analysis, detailed nutritional assessment using a food-frequency questionnaire for dietary intake and serum for inflammatory markers in order to determine factors that...

Predictive Val. of TB-symptom Screen in HIV-infected & -uninfected Pregnant Women in Pune, India. Substudy: Studying Molecular Mechanisms Leading to Suppressed Immunity in Pregnancy & Studying Relationship between Diet, Gut Microbiome, & Inflammation

Post Date: 
2014-10-28
Country: 
Pregnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection, is suppressed in pregnancy. Thus, pregnant women are especially vulnerable to TB...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2010-01-01
Country: 
Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death during the first 24 months of HAART) is more than 3-fold higher in resource limited settings (RLS) than...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
Country: 
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date: 
2016-10-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon γ, tumor necrosis factor...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-07-01
Publication: 
Journal of Infectious Diseases
Country: 
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-04-01
Publication: 
The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

Post Date: 
2016-04-01
Publication: 
The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of...

Concurrent anemia and elevated CRP predicts HIV clinical treatment failure, including TB, post-antiretroviral therapy initiation

Post Date: 
2015-07-01
Publication: 
Clinical Infectious Diseases
Background: Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (HIV)...

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Post Date: 
2015-02-26
Publication: 
PLOS One
Objective: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. Design: Nested case-control study (n = 332) within ACTG PEARLS trial of three ART regimens among 1571 HIV-infected,...

Inflammation Biomarkers Predict Clinical Treatment Failure in HIV-infected Adults

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Country: 
Event & Convener: 
CROI 2017
Poster Presentation. Shivakoti R , Gupte N, Pillay S, Riviere C, Cardoso SW, Balagopal A, Semba R, Campbell T, Gupta A

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth

Post Date: 
2016-06-10
Presentation Location: 
Baltimore, MD
Country: 
Event & Convener: 
JHU Center for AIDS Research Annual Meeting
Presentation

Obesity and Inflammation in Resource-Driven Settings of ART Initiation

Post Date: 
2015-02-24
Presentation Location: 
Seattle, WA
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2015
Poster Discussion. Erlandson KM, Gupte N, Lama JR, Patcharaphan S, Mwelase T, Balagopal A, Asmuth D, Campbell TB, Gupta A.

Metabolic Complications/Inflammation

Post Date: 
2015-01-10
Presentation Location: 
Mumbai, India
Country: 
Event & Convener: 
5th National Conference on HIV/AIDS Therapy
Panel Discussion: TB and HIV Co-Morbidities & IRIS.

Metabolic Complications/Inflammation Lecture

Post Date: 
2015-01-10
Presentation Location: 
Mumbai, India
Event & Convener: 
5th National Conference on HIV/AIDS Therapy
TB and HIV Co-Morbidities & IRIS Panel Discussion. Gupta A

Inflammatory Markers and Incident TB: An International Case-Control Study

Post Date: 
2014-04-24
Presentation Location: 
Baltimore, MD
Event & Convener: 
Center for TB Research. Johns Hopkins School of Medicine
Lecture

Update in TB and IRIS

Post Date: 
2012-04-12
Presentation Location: 
Rio de Janeiro, Brazil
Event & Convener: 
Brazil-Hopkins AIDS Conference
Presentation