Antiretroviral therapy

Hard-to-Reach Populations: Implications for Ending the AIDS Epidemic

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2019-04-25
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The Rakai region in Uganda was the initial epicenter of the HIV epidemic in East Africa and continues to be a high burden area, with an HIV prevalence of ~13%. Through the open, population-based Rakai Community Cohort Study (RCCS), we reported that combination HIV prevention (CHP) decreased...

P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”

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2019-02-06
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Full Title: P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”: V irologic E fficacy and S afety of ART Combinations with T AF/TDF, E FV, and D...

Assessment of Depression and Anxiety among HIV-infected Adolescents in Pune, India

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2018-07-22
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This study is conducted under the TREAT Asia Network and funded by amfAR. PURPOSE The purpose of this study is to estimate the prevalence of depression and anxiety among adolescents living with HIV in India and their determinants. DESIGN Cross-sectional, single time point, conveniently sampled...

Technology Based Community Health Nursing to Improve Combination Anti-Retroviral Therapy (cART) Adherence and Virologic Suppression in Youth Living With HIV (Tech2Check)

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2018-07-11
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Dr. Maunank Shah is a co-Investigator on this clinical trial. Human immunodeficiency virus (HIV) infection has disproportionately persisted as a public health threat to adolescents and young adults (AYA) from minority communities in the United States. HIV has evolved into a chronic disease, which...

Multidisciplinary Research Training to Understand and Reduce HIV Incidence in Uganda

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2018-05-10
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Dr. Larry Chang is PI for this multi-year (2018-2023) training grant sponsored by the Fogarty International Center at the National Institute of Health. Abstract While substantial progress has been made in the global HIV response, impact has been uneven. Uganda provides a prime case study. Uganda...

Impact of HIV and Diabetes Mellitus on TB Drug Resistance and Recurrence

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2017-03-02
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Tuberculosis (TB) is the leading cause of mortality globally. With increasing burden of HIV and diabetes mellitus (DM), there is a critical need to understand the microbial response and ensuing disease dynamics of TB in the HIV-infected and diabetic host to optimally control TB globally. Among...

TREAT Asia Pediatric HIV Observational Database

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2017-02-09
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Studies conducted under the TREAT Asia Network and funded by amfAR. TREAT Asia Pediatric HIV Observational Database (TApHOD) is a collaborative observational cohort study of infants, children, and adolescents living with HIV. TApHOD study participants are enrolled and followed at selected TREAT...

TREAT Asia Observational Database

Post Date: 
2017-02-09
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Study conducted under the TREAT Asia Network and funded by amfAR. The TREAT Asia Observational Database's primary study objective is to: Examine HIV natural history, including the relationship between access to ART, demographics, and disease progression; short- and long-term responses to ART;...

Cost-effectiveness of Xpert MTB/RIF for Diagnosing Pulmonary Tuberculosis in HIV-positive Patients

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2016-12-01
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This is a prospective cross-sectional study which will be conducted at BJGMC in Pune, India. The aim of this study is to see whether Xpert MTB/RIF is useful for early detection of pulmonary tuberculosis, and therefore cost-effective, as compared with sputum microscopy and the gold standard tests...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

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2016-09-19
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Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

Prevalence Survey of Risk Factors for Tuberculosis and Non-communicable Diseases in an HIV-positive Population in Pune, India

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2015-08-17
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This study is conducted under the TREAT Asia Network and funded by amfAR. The primary objective of this study is to assess the prevalence of risk factors for tuberculosis and non-communicable diseases (NCDs)--coronary artery disease and diabetes mellitus--among HIV-positive patients. The study will...

Community Health Workers, mHealth, and Combination HIV Prevention in a Hotspot: A Randomized Trial (mLAKE)

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2015-04-01
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Led by Dr. Larry Chang, the mLAKE study in Uganda is examining whether community health workers equipped with cellphones and the emocha Mobile Health platform are able to successfully promote HIV treatment and prevention services in households in a fishing community in East Africa with a very high...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

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2011-01-01
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This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

HIV Latino Outreach Program, Baltimore City Health Department

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2008-01-01
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Dr. Kathleen Page founded and directs the Baltimore City Health Department’s HIV Latino Outreach Program, which provides more than 1000 HIV tests per year to Baltimore's Latino community, and provides linkages to care services for those testing positive.

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

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2007-02-02
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Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

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2007-01-01
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Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

Evaluation of Provider, Patient and Pharmacy Knowledge, Attitudes and Practices Regarding HIV Care and Use of Antiretroviral Therapy in Pune, India

Post Date: 
2004-03-29
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This study ended in 2007. Antiretroviral therapy (ART) has dramatically affected morbidity and mortality among HIV-infected persons in industrialized countries. In India, where approximately 4.3 million persons are estimated to be HIV-infected (NACO), the use of ART has been limited because of the...

Mother-to-Child Transmission (MTCT) of HIV: India SWEN Study

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2002-06-07
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This study was officially terminated August 2018. Primary and secondary analyses of the India SWEN study, an NIH-funded phase III randomized controlled trial of an extended nevirapine prophylaxis regimen among 783 HIV-infected pregnant women and their breastfed infants in Pune, India.

Technology-enhanced Peer Navigation to Improve Injection Drug User (IDU) Engagement in HIV Care

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2000-01-01
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This study is evaluating an mHealth-enhanced peer navigation intervention for improving retention-in-care and adherence to antiretroviral therapy (ART) for out-of-care, HIV-infected injection drug users (IDUs). The CCGHE-developed emocha® is assisting peer navigators (former IDUs successfully...

Symptom screening for active tuberculosis in pregnant women living with HIV

Post Date: 
2019-01-24
Publication: 
Cochrane Database of Systematic Reviews
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting. To...

Economic and epidemiologic impact of guidelines for early ART initiation irrespective of CD4 count in Spain

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2018-11-05
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PLoS One
INTRODUCTION: Emerging data suggest that early antiretroviral therapy (ART) could reduce serious AIDS and non-AIDS events and deaths but could also increase costs. In January 2016, the Spanish guidelines were updated to recommend ART at any CD4 count. However, the epidemiologic and economic impacts...

Enhanced immigration enforcement in the USA and the transnational continuity of HIV care for Latinx migrants in deportation proceedings

Post Date: 
2018-10-15
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Lancet HIV
In our work as clinicians, researchers, and immigrant rights advocates, we have noted increased anxiety about the possibility of deportation and disruptions in care among immigrants with HIV. Before the 2016 US elections, patients rarely asked about HIV treatment in their home countries. However,...

Results of early virologic monitoring may facilitate differentiated care monitoring strategies for clients on ART, Rakai, Uganda

Post Date: 
2018-10-15
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Publication: 
Open Forum Infectious Diseases
BACKGROUND: Viral load (VL) monitoring is standard of care in HIV-infected persons initiated on antiretroviral therapy (ART). We evaluated the predictive value of VL measurements at 6 and 12 months after initiation of firstline ART to estimate the future risk of virologic failure (VF). METHODS: HIV...

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

Post Date: 
2018-09-24
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BMC Medicine
Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

Challenges of TB and co-treatment: updates and insights

Post Date: 
2018-08-04
Publication: 
Current Opinion in HIV and AIDS
PURPOSE OF REVIEW: In the past few years, tuberculosis (TB) has overtaken HIV as the infectious disease with the highest global mortality. Successful management of this syndemic will require improved diagnostic tests, shorter preventive therapies, and more effective treatments, particularly in...

Loss to follow‐up and mortality among HIV‐infected adolescents receiving antiretroviral therapy in Pune, India

Post Date: 
2018-06-25
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HIV Medicine
Over 6 years, one-third of HIV+ adolescents in this study discontinued medical treatment, indicating a critical need for retention counselling and closer clinical monitoring.

Hepatotoxicity during isoniazid preventive therapy and antiretroviral therapy in people living with HIV with severe immunosuppression: a secondary analysis of a multi-country open-label randomized controlled clinical trial

Post Date: 
2018-05-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
BACKGROUND: Hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) has not been well studied in severely immunosuppressed people with HIV. Our objective was to determine risk factors for hepatotoxicity in severely immunosuppressed individuals taking IPT...

Prevention of HIV-1 transmission through breastfeeding:efficacy of safety of maternal antiretroviral therapy versus infant nevirapine prophylaxis for duration of breastfeeding in HIV-1-infected women with high CD4 cell count (IMPAACT PROMISE)

Post Date: 
2018-04-01
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Journal of Acquired Immune Deficiency Syndromes
BACKGROUND: No randomized trial has directly compared the efficacy of prolonged infant antiretroviral prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child transmission throughout the breastfeeding period. SETTING: Fourteen sites in Sub-Saharan Africa and India...

HIV viral suppression and geospatial patterns of HIV antiretroviral therapy treatment facility use in Rakai, Uganda

Post Date: 
2018-03-27
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AIDS
OBJECTIVE: To assess geospatial patterns of HIV antiretroviral therapy (ART) treatment facility use and whether they were impacted by viral load suppression. METHODS: We extracted data on the location and type of care services utilized by HIV-positive persons accessing ART between February 2015 and...

Intestinal barrier dysfunction and microbial translocation in HIV-infected pregnant women is associated with preterm birth

Post Date: 
2018-03-24
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Clinical Infectious Diseases
Our results show select immune markers can identify women at higher risk for PTB in HIV-1-infected populations and suggest modulating gut barrier integrity and microbial translocation may affect PTB.

The validity of self-reported antiretroviral use in persons living with HIV: a population-based study

Post Date: 
2018-01-28
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AIDS
OBJECTIVE: To assess the validity of self-reported antiretroviral therapy use (ART) using population-based cohort data. METHODS: Self-reported ART use and nonuse was compared with a validated laboratory assay in 557 HIV-positive participants in the Rakai Community Cohort Study surveyed between...

What will it take to reduce HIV incidence in the United States: A mathematical modeling analysis

Post Date: 
2018-01-06
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Open Forum Infectious Diseases
Modeling and simulations suggest that cutting HIV incidence in half by 2025 will require 95% of people living with HIV to be engaged in care.

Identifying models of HIV care and treatment service delivery in Tanzania, Uganda, and Zambia using cluster analysis and Delphi survey

Post Date: 
2017-12-06
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BMC Health Services Research
BACKGROUND: Organization of HIV care and treatment services, including clinic staffing and services, may shape clinical and financial outcomes, yet there has been little attempt to describe different models of HIV care in sub-Saharan Africa (SSA). Information about the relative benefits and...

HIV prevention efforts and incidence in HIV in Uganda

Post Date: 
2017-11-30
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New England Journal of Medicine
In a large study in Uganda, Dr. Larry Chang and colleagues found that combination HIV prevention has population level implications, reducing new infections by 42%.

Impact of a community health worker HIV treatment and prevention intervention in an HIV hotspot fishing community in Rakai, Uganda (mLAKE): study protocol for a randomized controlled trial

Post Date: 
2017-10-23
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Publication: 
Trials
Abstract Background: Effective yet practical strategies are needed to increase engagement in HIV treatment and prevention services, particularly in high-HIV-prevalence hotspots. We designed a community-based intervention called "Health Scouts" to promote uptake and adherence to HIV services in a...

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults

Post Date: 
2017-10-23
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AIDS
Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. Methods: We used data from a multisite randomized trial comparing empiric vs...

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-07-01
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Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral therapy (ART) initiation in HIV-infected individuals is not well characterized...

The impact of preexposure prophylaxis among men who have sex with men: An individual-based model

Post Date: 
2017-06-01
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Journal of Acquired Immune Deficiency Syndromes
Objectives Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation. Design We...

Design and implementation of a community health worker HIV treatment and prevention intervention in an HIV hot spot fishing community in Rakai, Uganda

Post Date: 
2017-05-22
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Journal of the International Association of Providers of AIDS Care
Abstract Innovative approaches are needed to increase engagement in HIV treatment and prevention services, particularly in HIV hot spots. Here, we detail our design, training approach, and early implementation experiences of a community-based HIV intervention called "health scouts." The...

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Preventing tuberculosis in people with HIV infection

Post Date: 
2019-03-06
Gupta A. Choices and dilemmas: Preventing tuberculosis in people with HIV infection. Coinfections: Tuberculosis, Hepatitis B and C, and HIV Symposium. CROI 2019. Seattle, Washington. March 4-7, 2019.

Association of Maternal Viral Load and CD4 Count with Perinatal HIV-1 Transmission Risk during Breastfeeding in the PROMISE Postpartum Component

Post Date: 
2018-07-26
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Flynn P, Taha T, Cababasay M, Butler K, Fowler MG, Mofenson L, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanshanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S, Vhembo T, Bobat R, Mmbaga B, Masenya M, Nyati M, Theron G, Mulenga H...

Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster Randomized Trial

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2018-07-24
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Suryavanshi N, Kadam A, Hegde A, Sivalenka S, Kumar VS, McKenzie-White J, Kanade S, Gupta A, Bollinger RC, Shankar A, Gupte N, Mave V. Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster...

Health-related Quality of Life in the A5274 Trial of TB Therapy in Advanced HIV

Post Date: 
2018-07-22
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Lando R, Sun X, Miyahara S, Hosseinpour MC, Bisson GP, Kumwenda J, Gupta A, Nyirenda M, Katendey K, Torres TS, Suryavanshi N, Beulah F, Opollo V, Shah NS on behalf of the A5274 study team. Health-related Quality of Life in the A5274 Trial of TB Therapy in Advanced HIV. TB 2018, Amsterdam, The...

Role of Maternal Viral Load and CD4 Count on Perinatal HIV-1 Transmission during Breastfeeding in the PROMISE Postpartum Component

Post Date: 
2018-07-20
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Flynn P, Taha T, Cababasay M, Butler K, Fowler MG, Mofenson L, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanshanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S , Vhembo T, Bobat R, Mmbaga B, Masenya M, Nyati M, Theron G, Mulenga H...

Similar Clinical Outcomes Between Formula and Breastfeeding Women In PROMISE

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2018-03-07
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Hoffman RM , Angelidou K, Brummel S, Saidi F, Dula DE, Mave V, Fairlie L, Theron G, Kamateeka M, Chipato T, Violari A, Chakhtoura N, Currier JS, Fowler MG, for the IMPAACT PROMISE 1077BF/FF Team. Similar Clinical Outcomes Between Formula and Breastfeeding Women In PROMISE. CROI 2018. Boston, MA...

Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens

Post Date: 
2017-07-26
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Bhattacharya D , Gupta A, Tierney C, Huang S, Peters M, Chipato T, Martinson F, Dula D, George K, Chaktoura N, Klingman K, Gnanashanmugam D, Currier J, Fowler MG. Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens. IAS 2017. International AIDS Society. Paris, France...

Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens in PROMISE P1077

Post Date: 
2017-05-31
Amita Gupta. Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens in PROMISE P1077. 2017 IMPAACT Annual Meeting. Washington, DC. 2017

IMPAACT 2001: Trial of the Pharmacokinetics, Tolerability, and Safety of Once-Weekly Rifapentine and Isoniazid in HIV-infected and HIV-1-uninfected Pregnant and Postpartum Women with Latent Tuberculosis Infection

Post Date: 
2017-05-30
Jyoti Mathad. IMPAACT 2001: Trial of the Pharmacokinetics, Tolerability, and Safety of Once-Weekly Rifapentine and Isoniazid in HIV-infected and HIV-1-uninfected Pregnant and Postpartum Women with Latent Tuberculosis Infection. 2017 IMPAACT Annual Meeting. Washington, DC. 2017.

Hepatotoxicity in People with Advanced Immunosuppression taking Isoniazid Preventive Therapy and Antiretroviral Therapy

Post Date: 
2017-02-14
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Ngongondo M , Miyahara S, Hughes MD, Sun X, Gupta A, Kumwenda J, Torres TS, Bisson G, Hosseinipour MC. Hepatotoxicity in People with Advanced Immunosuppression taking Isoniazid Preventive Therapy and Antiretroviral Therapy. CROI 2017. Seattle, Washington. 2017.

Presentation, Etiology, and Outcome of Febrile Indian Patients Differs by HIV Status

Post Date: 
2016-11-16
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Kadam D, Robinson M , Kagal A, Bharadwaj R, Raichur P, Kanade S, Sachs J, Gupte N, Gupta A, Mave V. Presentation, Etiology, and Outcome of Febrile Indian Patients Differs by HIV Status. 65th Annual Meeting, American Society of Tropical Medicine and Hygiene. Atlanta, GA.

A Cluster-Randomized Trial to Promote Combination HIV Prevention Using M-health-Supported CHWs in a High-Prevalence Fishing Community: Design and Baseline Characteristics of the mLAKE Trial in Rakai, Uganda

Post Date: 
2016-07-21
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Chang L, Mbabali I, Kong X, Hutton H, Long A, Thomas A, Bugos E, Ssekasanvu J, Kennedy C, Amico R, Nalugoda F, Reynolds S, Quinn T, Serwadda D, Wawer M, Gray R, Nakigozi G. A Cluster-Randomized Trial to Promote Combination HIV Prevention Using M-health-Supported CHWs in a High-Prevalence Fishing...

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth

Post Date: 
2016-06-10
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Shivakoti, R. Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome, and Preterm Birth. JHU Center for AIDS Research Annual Meeting. Baltimore, MD.

Best Practices in Antiretroviral Therapy: Managing Antiretroviral Therapy in HIV-Infected Patients with Viral Hepatitis Coinfection

Post Date: 
2016-05-18
Gupta, A. Best Practices in Antiretroviral Therapy: Managing Antiretroviral Therapy in HIV-Infected Patients with Viral Hepatitis Coinfection. Gupta A. Best Practices in Antiretroviral Therapy: Managing Antiretroviral Therapy in HIV-Infected Patients with Viral Hepatitis Coinfection. Contemporary...

Double Trouble: Managing and Preventing TB and HIV

Post Date: 
2016-04-20
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Gupta, A. Double Trouble: Managing and Preventing TB and HIV. DY Patil University. Pune, India.

High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India

Post Date: 
2016-02-24
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Mave V , Kadam D, Salvi S, Basavaraj A, Joshi S, Chandanwale A, Gupte N, Bollinger RC, Gupta A. High TB Risk in HIV-Positive Patients on Second line Antiretrovirals in Pune, India. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community

Post Date: 
2016-02-23
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Kagaayi J, Grabowski MK, Nakigozi G, Kigozi G, Nalugoda F, Ssekubugu R, Gray RH, Serwadda D, Wawer MJ, Chang L. Combination HIV Prevention and HIV Incidence in a Ugandan Hotspot Fishing Community. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

Incidence and Risk Factors for TB among HIV+ Children in India

Post Date: 
2015-12-05
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Kinikar AA , DeLuca A, Gupte N, Kadam DB, Khadse S, Chandanwale A, Gupta A, Bollinger R. Incidence and Risk Factors for TB among HIV+ Children in India. The 46th Union World Conference on Lung Health. Cape Town, South Africa.

Charting a Course in Interdisciplinary Research by Building Bridges with a Clinical Trial of Mother-infant HIV Transmission

Post Date: 
2015-06-12
Bollinger, R. Charting a Course in Interdisciplinary Research by Building Bridges with a Clinical Trial of Mother-infant HIV Transmission. Johns Hopkins Center for AIDS Research. Baltimore, MD.

Obesity and Inflammation in Resource-Driven Settings of ART Initiation

Post Date: 
2015-02-24
Erlandson KM, Gupte N, Lama JR, Patcharaphan S, Mwelase T, Balagopal A, Asmuth D, Campbell TB, Gupta A. Obesity and Inflammation in Resource-Driven Settings of ART Initiation. Conference on Retroviruses and Opportunistic Infections 2015. Seattle, WA. 2015.

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