Pregnancy

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

Post Date: 
2016-07-05
Country: 
This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association of gestational age with...

Predictive Val. of TB-symptom Screen in HIV-infected & -uninfected Pregnant Women in Pune, India. Substudy: Studying Molecular Mechanisms Leading to Suppressed Immunity in Pregnancy & Studying Relationship between Diet, Gut Microbiome, & Inflammation

Post Date: 
2014-10-28
Country: 
Pregnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection, is suppressed in pregnancy. Thus, pregnant women are especially vulnerable to TB...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

Post Date: 
2014-10-28
Country: 
This is a cross sectional observational study that will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom screen will have a higher positive predictive value (PPV) in HIV-seronegative...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date: 
2014-09-01
Country: 
Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at risk of reactivation and progression to...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date: 
2014-09-01
Country: 
Purpose: TB is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not understood. Our recent research shows that pregnant women...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date: 
2014-04-01
Country: 
Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in Botswana, Haiti, South Africa, Tanzania, Thailand, Uganda, and Zimbabwe, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. Background Tuberculosis (TB) is the...

Immunomodulatory Properties of BCG: Implications for MTCT

Post Date: 
2008-06-01
To evaluate the immune activating properties of BCG vaccination in neonatal CD4 cells and test the hypothesis that neonatal BCG vaccination leads to activation of immune response that may increase the susceptibility to HIV infection in breast-fed infants of HIV-positive mothers.

Pulmonary infections in pregnancy

Post Date: 
2017-06-01
Publication: 
Seminars in Respiratory and Critical Care Medicine
Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date: 
2016-01-14
Publication: 
American Journal of Respiratory and Critical Care Medicine
Country: 
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

Toward earlier inclusion of pregnant and postpartum women in TB drug trials: consensus statements from an International Expert Panel

Post Date: 
2016-01-04
Publication: 
Clinical Infectious Diseases
Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15–44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials...

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date: 
2016-01-01
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The cost-...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

Post Date: 
2014-03-21
Publication: 
PLOS One
Country: 
Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date: 
2012-12-15
Publication: 
Clinical Infectious Diseases
Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in women...

Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India

Post Date: 
2011-12-15
Publication: 
AIDS Care
Country: 
Little is known about birth outcomes for HIV-infected women in India. We examine maternal and neonatal birth outcomes in HIV-infected women within the context of enhanced pre-natal care associated with a randomized clinical trial conducted in Pune, India. Birth outcomes of 212 HIV-infected pregnant...

Repeated pregnancy in HIV positive Indian women with known HIV status

Post Date: 
2008-09-29
Publication: 
AIDS Care
Country: 
HIV-positive women of reproductive age face challenges in decision making related to pregnancy. Understanding factors influencing repeat pregnancies in women with known HIV status are necessary to guide interventions and counseling strategies to better inform and support them. We compared three...

Low utilization of HIV testing during pregnancy: what are the barriers to HIV testing for women in rural India?

Post Date: 
2008-02-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Introduction: Sixty percent of India's HIV cases occur in rural residents. Despite government policy to expand antenatal HIV screening and prevention of maternal-to-child transmission (PMTCT), little is known about HIV testing among rural women during pregnancy. Methods: Between January and March...

Feasibility of voluntary counseling and testing services for HIV among pregnant women presenting in labor in Pune, India

Post Date: 
2005-08-01
Publication: 
international Journal of STD & AIDS
Country: 
Factors affecting the eligibility and acceptability of voluntary counselling and rapid HIV testing (VCT) were examined among pregnant womenpresenting in labour in Pune, India. Of the 6702 total women appearing at the delivery room from April 2001 to March 2002, 4638 (69%) were admitted for normal...

Impact of Immune Changes of Pregnancy and HIV Infection on Tuberculosis

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Mathad J, Alexander M , Bhosale R, Naik S, Shivakoti R, Mave V, Suryavanshi N, Gupte N, Kulkarni V, Pradan N, Patil N, Gupta A

Pharmacokinetic Aspects of 3HP in Special Populations

Post Date: 
2016-10-29
Presentation Location: 
Liverpool, England
Event & Convener: 
47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Presentation. Mathad J.

IMPAACT P1078: Background, Design and Baseline Data

Post Date: 
2016-10-29
Presentation Location: 
Liverpool, England
Country: 
Event & Convener: 
47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Presentation. Mathad J on behalf of Gupta A and P1078 Study Team TB APPRISE: Phase IV Randomized Double-blind Placebo-controlled Trial to Evaluate the Safety of Immediate (Antepartum-initiated) vs. Deferred (Postpartum-initiated) Isoniazid Preventive Therapy among HIV-infected Women in High TB...

TB and Diabetes in Pregnancy: Current Knowledge and Research Gaps

Post Date: 
2016-10-24
Presentation Location: 
Liverpool, England
Event & Convener: 
47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease.
Presentation. Workshop: Integrated Care and Research for Tuberculosis, Diabetes, and HIV/AIDS: Challenges, Strategies, and Clinical Solutions

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

Post Date: 
2016-02-24
Presentation Location: 
Boston, MA
Country: 
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2016
Poster Presentation: Tuberculosis and Pregnancy. Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A.

TB and Pregnancy

Post Date: 
2016-01-12
Presentation Location: 
Newark, NJ
Event & Convener: 
TB Grand Rounds Webinar. Rutgers Global Tuberculosis Institute
Lecturer

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

Post Date: 
2015-12-04
Presentation Location: 
Capetown, South Africa
Event & Convener: 
International Union for Tuberculosis and Lung Disease. 46th Union World Conference on Lung Health.
Symposium: Maternal and Infant TB: Advancing our Understanding of Pathogenesis, Treatment and Prevention.

Tuberculosis in Pregnant Women and Infants

Post Date: 
2015-08-26
Presentation Location: 
Atlanta, GA
Event & Convener: 
International Conference on Emerging Infectious Diseases
Presentation

Tuberculosis in Peripartum Women and Infants

Post Date: 
2015-08-26
Presentation Location: 
Atlanta, GA
Event & Convener: 
International Conference on Emerging Infectious Diseases
Presentation

TB in Pregnancy

Post Date: 
2015-03-05
Presentation Location: 
Mumbai, India
Country: 
Event & Convener: 
RePORT India TB Workshop
Presentation

Tuberculosis in Pregnancy

Post Date: 
2015-02-25
Presentation Location: 
Seattle, WA
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2015
Presentation. Session: Tuberculosis: Magic Bullets and Moving Targets.

TB in Pregnancy

Post Date: 
2014-09-08
Presentation Location: 
Washington, DC
Event & Convener: 
Interscience Conference on Antimicrobial Agents and Chemotherapy
Presentation. Conundrums in TB Symposium

TB in Pregnancy

Post Date: 
2014-05-12
Presentation Location: 
Mumbai, India
Event & Convener: 
Hinduja Hospital
Lecture

Integrating Prevention and Treatment of HIV/TB in Pregnancy

Post Date: 
2014-01-31
Presentation Location: 
Chennai, India
Event & Convener: 
International Science Symposium on HIV and Infectious Diseases
Presentation

Towards Earlier Involvement of Children and Pregnant Women in Trials of New TB Drugs

Post Date: 
2013-05-23
Presentation Location: 
Baltimore, MD
Event & Convener: 
Expert Consensus Panel for Pregnant Women. National Institute of Allergy and Infectious Diseases, National Institutes of Health
Group leader

TB in Pregnant and Postpartum Women

Post Date: 
2013-05-16
Presentation Location: 
Baltimore, MD
Event & Convener: 
Seminar. Johns Hopkins Center for TB Research
Presentation

TB in Pregnant Women

Post Date: 
2012-01-05
Presentation Location: 
Philadelphia, PA
Event & Convener: 
Infectious Diseases Grand Rounds. University of Pennsylvania School of Medicine
Grand Rounds

High Prevalence of Vitamin D Deficiency among HIV-infected Breastfeeding Mothers in Pune, India, Has No Association with Mother-to-child Transmission of HIV

Post Date: 
2011-07-17
Presentation Location: 
Rome, Italy
Event & Convener: 
6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
Presentation.

Aspects of Congenital/Neonatal TB and Detection of TB in Pregnancy in HIV-infected/Uninfected

Post Date: 
2010-11-13
Presentation Location: 
Berlin, Germany
Event & Convener: 
41st Union World Conference on Lung Health
Presentation

Nutrition and disease progression Pre- and Post-HAART: can good nutrition delay time to and response to HAART?

Post Date: 
2010-07-27
Presentation Location: 
Washington, DC
Event & Convener: 
Nutrition in Clinical Management of HIV Infected Adolescents (>14 yr) and Adults including Pregnant and Lactating Women: What do we know, what can we do, and where do we go from here? NIH
Presentation

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