Pregnancy

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Birth Outcomes in HIV Both antiretroviral-therapy (ART)-naïve and ART-experienced HIV-infected pregnant women have higher incidences of pre-term birth (PTB) compared to HIV-uninfected women. For example, the global prevalence of PTB is around 8%, while the rates in in HIV-infected populations are...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

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2016-07-05

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This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association of gestational age with...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

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2014-10-28

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This is a cross sectional observational study will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom screen will have a higher positive predictive value (PPV) in HIV-seronegative pregnant...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

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2014-09-01

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This study was terminated April 16, 2018. Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune changes of pregnancy, women are particularly at...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

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2014-09-01

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This is a cross sectional observational study known as PRACHITI (PRegnancy And CHanges In TuberculosIs), Purpose: TB is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

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2014-04-01

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Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in Botswana, Haiti, South Africa, Tanzania, Thailand, Uganda, and Zimbabwe, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. Background Tuberculosis (TB) is the...

Immunomodulatory Properties of BCG: Implications for MTCT

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2008-06-01

To evaluate the immune activating properties of BCG vaccination in neonatal CD4 cells and test the hypothesis that neonatal BCG vaccination leads to activation of immune response that may increase the susceptibility to HIV infection in breast-fed infants of HIV-positive mothers.

Screening and diagnosis of gestational diabetes in India: A systematic review and meta analysis

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2018-03-26

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Acta Diabetologica

Review article on prevalence and screening and diagnostic methods for gestational diabetes in India.

Intestinal barrier dysfunction and microbial translocation in HIV-infected pregnant women is associated with preterm birth

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2018-03-24

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Clinical Infectious Diseases

Our results show select immune markers can identify women at higher risk for PTB in HIV-1-infected populations and suggest modulating gut barrier integrity and microbial translocation may affect PTB.

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

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2017-07-01

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International Journal of Tuberculosis and Lung Disease

Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression...

Pulmonary infections in pregnancy

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2017-06-01

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Seminars in Respiratory and Critical Care Medicine

Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

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2016-06-15

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American Journal of Respiratory and Critical Care Medicine

Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the immunology behind discordance in...

The availability of emergency obstetric care in the context of the JSY cash transfer programme in Madhya Pradesh, India

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2016-05-18

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BMC Pregnancy and Childbirth

Abstract Background: Since 2005, India has implemented a national cash transfer programme, the Janani Suraksha Yojana (JSY), which provides women a cash transfer upon giving birth in an existing public facility. This has resulted in a steep rise in facility births across the country. The early...

Assessment of the quality of clinical documentation in India's JSY cash transfer program for facility births in Madhya Pradesh

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2016-02-15

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International Journal of Gynaecology and Obstetrics

Abstract Objective: To gain insight into the quality of care in facilities implementing the Janani Suraksha Yojana (JSY) cash transfer program in Madhya Pradesh, India, by reviewing the level of documentation in the clinical records of women who delivered. Methods: The present retrospective,...

Toward earlier inclusion of pregnant and postpartum women in TB drug trials: consensus statements from an International Expert Panel

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2016-01-04

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Clinical Infectious Diseases

Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15–44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials...

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

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2016-01-01

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International Journal of Tuberculosis and Lung Disease

Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The cost-...

Availability and distribution of safe abortion services in rural areas: a facility assessment study in Madhya Pradesh, India

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2015-03-20

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Global Health Action

Abstract Background: Unsafe abortion contributes to a significant portion of maternal mortality in India. Access to safe abortion care is known to reduce maternal mortality. Availability and distribution of abortion care facilities can influence women's access to these services, especially in rural...

Quality of obstetric referral services in India's JSY cash transfer programme for institutional births: a study from Madhya Pradesh province

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2014-05-08

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PLoS One

Abstract Background: India launched JSY cash transfer programme to increase access to emergency obstetric and neonatal care (EmONC) by incentivising in-facility births. This increased in-facility births from 30%in 2005 to 73% in 2012 however, decline in maternal mortality follows a secular trend...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

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2014-03-21

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PLOS One

Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Availability of treatment for eclampsia in public health institutions in Maharashtra, India

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2013-03-15

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Journal of Health, Population, and Nutrition

Abstract Severe pre-eclampsia and eclampsia are common causes of maternal deaths worldwide and more so in developing countries. Magnesium sulphate (MgSO4) is now the most-recommended drug of choice to treat these conditions. Despite favourable policies for the use of MgSO4 treatment in India,...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

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2012-12-15

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Clinical Infectious Diseases

Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in women...

Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India

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2011-12-15

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AIDS Care

Little is known about birth outcomes for HIV-infected women in India. We examine maternal and neonatal birth outcomes in HIV-infected women within the context of enhanced pre-natal care associated with a randomized clinical trial conducted in Pune, India. Birth outcomes of 212 HIV-infected pregnant...

Public private partnerships for emergency obstetric care: lessons from Maharashtra

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2011-01-15

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Indian Journal of Community Medicine

Abstract Background: The National Rural Health Mission of India advocates public private partnerships (PPPs) to meet its "service guarantee" of Emergency obstetric care (EmOC) provision. The Janani Suraksha Yojana (JSY) has a provision of Rs. 1500 for contracting in obstetric specialists...

Repeated pregnancy in HIV positive Indian women with known HIV status

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2008-09-29

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AIDS Care

HIV-positive women of reproductive age face challenges in decision making related to pregnancy. Understanding factors influencing repeat pregnancies in women with known HIV status are necessary to guide interventions and counseling strategies to better inform and support them. We compared three...

Low utilization of HIV testing during pregnancy: what are the barriers to HIV testing for women in rural India?

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2008-02-01

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Journal of Acquired Immune Deficiency Syndromes

Introduction: Sixty percent of India's HIV cases occur in rural residents. Despite government policy to expand antenatal HIV screening and prevention of maternal-to-child transmission (PMTCT), little is known about HIV testing among rural women during pregnancy. Methods: Between January and March...

Are we really making motherhood safe? A study of provision of iron supplements and emergency obstetric care in rural Maharashtra

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2007-11-30

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National Medical Journal of India

Abstract Background: The Government of India launched the National Rural Health Mission (NRHM) in 2005 to improve healthcare delivery and strengthen the public health system. Prevention and management of anaemia during pregnancy and access to quality emergency obstetric care services are important...

Feasibility of voluntary counseling and testing services for HIV among pregnant women presenting in labor in Pune, India

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2005-08-01

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international Journal of STD & AIDS

Factors affecting the eligibility and acceptability of voluntary counselling and rapid HIV testing (VCT) were examined among pregnant womenpresenting in labour in Pune, India. Of the 6702 total women appearing at the delivery room from April 2001 to March 2002, 4638 (69%) were admitted for normal...

Perinatal Depression among HIV and TB Infected and Uninfected Women in an Urban Slum in India: Prevalence and Associated Birth Outcomes

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2018-10-04

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Grossman TB , Bhosale R, Alexander M, Suryavanshi N, Mave V, Jain D, Patil NU, Gupta A, Mathad JS. Perinatal depression among HIV and TB infected and uninfected women in an urban slum in India: prevalence and associated birth outcomes. IDSA. ID Week 2018. San Francisco, CA. October 3-7, 2018.

High Prevalence of Dengue among Pregnant Women in India

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2018-08-27

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Alexander M, Naik S, Robinson M , Sapkal G, Deshpande P, Kulkarni V, Nimkar S, Sambarey P, Kinikar A, Mave V, Suryavanshi N, Gupte N, Bollinger R, Gupta A, Bharadwaj R, Mathad J. High Prevalence of Dengue among Pregnant Women in India. 2018 International Conference on Emerging Infectious Diseases...

Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster Randomized Trial

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2018-07-24

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Suryavanshi N, Kadam A, Hegde A, Sivalenka S, Kumar VS, McKenzie-White J, Kanade S, Gupta A, Bollinger RC, Shankar A, Gupte N, Mave V. Mobile Health and Behavioral PMTCT Intervention among Community Health Workers Improves Exclusive Breastfeeding and Early Infant Diagnosis in India: A Cluster...

Importance of Diagnosis of TB Infection in Pregnant Women in India: Findings from a Cohort Study in Pune, India

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2018-04-24

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Mathad J. Importance of Diagnosis of TB Infection in Pregnant Women in India: Findings from a Cohort Study in Pune, India. Oral Presentation. Presented at Global Health Research Initiative’s Scientific Conference, Weill Cornell Medical College, April 24, 2018.

Randomized Trial of Safety of Isoniazid Preventive Therapy During or After Pregnancy

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2018-03-07

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Gupta A, Montepiedra G, Aaron L, Theron G, McCarthy K, Onyango-Makumbi C, Chipate T, Masheto G, Shin K, Zimmer B, Sterling TR, Chakhtoura N, Jean-Philippe P, Weinberg A for the IMPAACT P1078/TB APPRISE Study Team. Randomized Trial of Safety of Isoniazid Preventive Therapy During or After Pregnancy...

Inflammation in HIV-Infected Pregnant Women is Associated with Pre-term Birth

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2018-03-07

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Shivakoti R , Gupte N, Kumar NP, Kulkarni V, Balasubramanian U, Bhosale R, Sambarey P, Kinikar A, Bharadwaj R, Patil S, Inamdar S, Suryavanshi N, Babu S, Bollinger R, Gupta A. Inflammation in HIV-Infected Pregnant Women is Associated with Pre-term Birth. CROI 2018. Boston, MA. 2018

Meet the Expert: Managing Tuberculosis in Pregnant Women and Newborns

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2017-10-13

Gupta A. Meet the Expert: Managing Tuberculosis in Pregnant Women and Newborns. 48th Annual Union World Conference of Lung Health. Guadalajara, Mexico.

Impact of Immune Changes of Pregnancy and HIV Infection on Tuberculosis

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2017-02-03

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Mathad J, Alexander M , Bhosale R, Naik S, Shivakoti R, Mave V, Suryavanshi N, Gupte N, Kulkarni V, Pradan N, Patil N, Gupta A. Impact of Immune Changes of Pregnancy and HIV Infection on Tuberculosis. 6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint...

Pharmacokinetic Aspects of 3HP in Special Populations

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2016-10-29

Mathad J. Pharmacokinetic Aspects of 3HP in Special Populations. 47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Liverpool, England.

IMPAACT P1078: Background, Design and Baseline Data

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2016-10-29

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Mathad J on behalf of Gupta A and P1078 Study Team. IMPAACT P1078: Background, Design and Baseline Data, 47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Liverpool, England.

TB and Diabetes in Pregnancy: Current Knowledge and Research Gaps

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2016-10-24

Gupta, A. TB and Diabetes in Pregnancy: Current Knowledge and Research Gaps. 47th Union World Conference on Lung Health. International Union for Tuberculosis and Lung Disease. Liverpool, England.

Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women

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2016-02-24

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Mathad J, Bhosale R, Balasubramanian U, Deshpande P, Kanade S, Mave V, Gupta A. Pregnancy Intensifies the IFN-gamma Suppression of HIV in TB-infected Indian Women. Conference on Retroviruses and Opportunistic Infections 2016. Boston, MA. 2016.

TB and Pregnancy

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2016-01-12

Gupta, A. TB and Pregnancy. TB Grand Rounds Webinar. Rutgers Global Tuberculosis Institute. Newark, NJ.

Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women

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2015-12-04

Gupta, A., Mathad, J. Current Research on the Pathophysiology, Immunology, Prevention and Treatment of TB in Pregnant Women. International Union for Tuberculosis and Lung Disease. 46th Union World Conference on Lung Health. Capetown, South Africa.

Does Quality of Delivery Care Differ Between Public and Private Facilities in Madhya Pradesh, India?: An Exit Interview Study of Routine Delivery Care Practices

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2015-10-20

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