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Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH)
Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB research. RePORT India is a member of a multilateral consortium (RePORT International) whose mission is to advance TB science, strengthen TB research capacity and infrastructure, and foster international collaboration among TB researchers.
C-TRIUMPH is establishing three cohorts composed of approximately 1200 TB patients, their household contacts (n~3,200) and controls (n~500) to study host and microbial factors associated with TB transmission, disease progression and treatment outcomes. It is a multidisciplinary initiative involving leading socio-behavioral, epidemiology, clinical and basic science researchers at: the National Institute of Research in Tuberculosis (NIRT), Chennai, India; Byramjee Jeejeebhoy Government Medical College Clinical Research Site (BJGMC CRS), Pune, India; the Institute of Genomics and Integrative Biology (IGIB), New Delhi, India; the Chest Research Foundation (CRF), Pune, India; the University of Washington (UW), Seattle, WA, USA; the University of California San Francisco (UCSF), San Francisco, CA, USA; and JHU, Baltimore, MD, USA.
This clinical TB cohort research effort addresses host and microbial factors associated with 1) Poor response to TB treatment, 2) Progression to active TB disease and 3) TB transmission/acquisition. This study will involve two sites in India: BJGMC in Pune and NIRT in Chennai to establish long term longitudinal cohorts of TB patients and their contacts. The aim of this initiative is to build and enhance biomedical and clinical research capacity in India.