Drug resistance

Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients in Pune, India

Post Date: 
2017-08-07
Country: 
Antimicrobial resistance, a leading threat to human health, is enabled by unnecessary antibiotic use. Strategies to reduce unnecessary antibiotic use in India, the world’s largest antibiotic consumer, are urgently needed. Although most patients hospitalized in India with acute febrile illness...

Understanding Quality of Life during and Loss to Follow-up from Drug-Resistant Tuberculosis Treatment in Pune, India

Post Date: 
2017-05-15
Country: 
This study will examine a) risk factors for loss to follow-up from DR-TB treatment, b) actively trace DR-TB patients lost to follow-up from treatment and c) establish a prospective observational cohort of MDR-TB, XDR-TB and DS-TB patients as well as healthy controls nested within ongoing RNTCP...

Impact of HIV and Diabetes Mellitus on TB Drug Resistance and Recurrence

Post Date: 
2017-03-02
Country: 
Tuberculosis (TB) is the leading cause of mortality globally. With increasing burden of HIV and diabetes mellitus (DM), there is a critical need to understand the microbial response and ensuing disease dynamics of TB in the HIV-infected and diabetic host to optimally control TB globally. Among...

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

Post Date: 
2017-03-01
Country: 
In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

TREAT Asia Observational Database

Post Date: 
2017-02-09
The TREAT Asia Observational Database's primary study objective is to: Examine HIV natural history, including the relationship between access to ART, demographics, and disease progression; short- and long-term responses to ART; impact of co-infections; HIV drug resistance patterns; and toxicity of...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India: Substudy on the Introduction of Triage to a Triage Naïve Emergency Department in Pune, India, and the Effects on Patient Flow

Post Date: 
2017-01-01
Country: 
Despite state-of-the-art inpatient facilities, Sassoon General Hospital (SGH) in Pune, India, does not currently have a method of triaging the large volume of patients they care for on a daily basis. Based on prior studies in low to middle income countries with underdeveloped emergency medical...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date: 
2016-09-19
Country: 
Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

Establishing an Observational Cohort Database for Patient Care and Research at the Hinduja Hospital Chest Clinic

Post Date: 
2016-08-30
Country: 
India has the largest burden of global tuberculosis (TB), accounting for one quarter of the total number of cases reported. Together with South Africa, India sees one-third of the total number of deaths from TB. Drug-resistant strains of the disease are also on the rise, with India having one of...

Whole Genome Sequencing and Trek Sensititre Testing of Stored Isolates of Drug-resistant Tuberculosis from a Clinical Cohort at Hinduja Hospital, Mumbai

Post Date: 
2016-05-02
Country: 
Among HIV-positive TB patients presenting to Médecins San Frontières (MSF) clinics in Mumbai, 78% carried MDR-TB strains, with nearly half also found to have additional drug resistance. A previously published cohort of 202 patients cared for at these MSF clinics have enrolled in a cross-sectional...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India: Substudy on the Characterization of the Human Virome

Post Date: 
2016-02-21
Country: 
Objective 1: To use novel molecular techniques to characterize the human virome in the circulating blood of patients in clinical settings who presented to an acute care setting with an acute febrile illness and in whom a diagnosis cannot be achieved by conventional methods. Healthy controls will be...

Whole Genome Sequencing of Clinical Isolates from Patients with Multidrug Resistant Tuberculosis in India 

Post Date: 
2015-11-12
Country: 
Comparative genomic analysis using whole genome sequencing (WGS) offers an opportunity to understand the specific mutations associated with drug resistance and the phenotypic behavior of TB. As treatment programs incorporate more molecular diagnostics such as Xpert MTB/RIF and line probe assays, it...

A5300/IMPAACT2003: Study of MDR TB Cases and Their Household Contacts: Operational Feasibility to Inform PHOENIx Trial Design

Post Date: 
2015-09-01
Country: 
Dr. Amita Gupta is Protocol Co-Chair for this multinational study being conducted in Haiti, South Africa, Uganda, and in India by the Baltimore-Washington-India Clinical Trials Unit, of which CCGHE is a member. This is a cross-sectional study of adult MDR TB index cases and their identified adult...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India: Substudy on Community Health-Seeking Behavior Among Patients Admitted with Acute Febrile Illness

Post Date: 
2015-05-28
Objectives: To describe the patterns of health-care seeking behavior and prior outpatient care among patients admitted with acute febrile illness to Sassoon Hospital To determine the effects of outpatient behaviors and prior treatments on the antimicrobial resistance patterns of stool colonizing...

Barriers for Intervention to Prevent Occupationally Acquired Tuberculosis in Healthcare Workers

Post Date: 
2015-05-21
Country: 
Observational study to assess the current status of implementation of interventions for preventing occupationally acquired TB in HCW. Identify the barriers to implementing these interventions

miLINC: MDR-TB South Africa - Patient Linkage to and Retention in Care

Post Date: 
2014-10-06
Country: 
Mycobacterium tuberculosis (TB) remains the leading cause of death among persons living with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) in southern Africa. Drug-resistant TB remains a growing threat to public health despite advances made in diagnosis and...

Impact of Diabetes on TB Treatment Outcomes

Post Date: 
2013-02-01
Country: 
CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Acute Febrile Illness and Antimicrobial Resistance Patterns in Pune, India

Post Date: 
2013-01-10
Country: 
Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
Country: 
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in this...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

Post Date: 
2017-04-15
Publication: 
Journal of Infectious Diseases
Country: 
Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Post Date: 
2017-03-24
Publication: 
The Lancet Respiratory Medicine
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tuberculosis control has been effective in some regions of the world, these gains are threatened by the increasing...

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

Post Date: 
2016-05-06
Publication: 
Journal of Public Health Policy
Country: 
Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

Blood stream infections

Post Date: 
2014-07-01
Publication: 
BioMed Research International
Blood stream infection (BSI) is one of the most devastating preventable complications in Critical Care Units. It has far-reaching consequences resulting in prolonged length of hospital-stay, high costs to the individual and exchequer, and, in many instances, loss of life. Although exact rates of...

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

Post Date: 
2013-07-18
Publication: 
Clinical Microbiology
Country: 
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second line...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date: 
2012-12-15
Publication: 
Clinical Infectious Diseases
Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in women...

HIV transmitted drug resistance in adult and pediatric populations in Panama

Post Date: 
2011-12-15
Publication: 
Revista Panamerica de Salud Publica--Pan American Journal of Public Health
Country: 
Objective: To investigate the prevalence of transmitted drug-resistant HIV among adults in Panama by using a modified World Health Organization Threshold Survey (WHO-TS) and to investigate rates of initial resistance among HIV-positive infants in Panama. Methods: At the Gorgas Memorial Institute,...

Tuberculosis in women and children

Post Date: 
2010-12-15
Publication: 
The Lancet
Apart from improvement of tuberculosis control, innovative strategies to advance tuberculosis prevention and treatment in women and children would contribute to the attainment of Millennium Development Goals 4 and 5 by reduction of the mortality rate in young children and women of reproductive age...

One-, two-, and three-class resistance among HIV-infected patients on antiretroviral therapy in private care clinics: Mumbai, India

Post Date: 
2010-01-26
Publication: 
AIDS Research and Human Retroviruses
Country: 
HIV-infected patients receiving antiretroviral (ARV) therapy (ART) in India are not all adequately virally suppressed. We analyzed ARV drug resistance in adults receiving ART in three private clinics in Mumbai, India. HIV viral load was measured in 200 patients with the Roche AMPLICOR HIV-1 Monitor...

Hematogenous osteomyelitis mimicking osteosarcoma due to Community Associated Methicillin-Resistant Staphylococcus aureus

Post Date: 
2007-06-15
Publication: 
Infection
Community Associated Methicillin - Resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen with increasing clinical significance. Initially recognized as a cause of skin and soft tissue infections, it has soon been shown to cause life threatening illnesses. We describe two cases of...

Antimicrobial-resistant Shigella sonnei: Limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility

Post Date: 
2005-06-15
Publication: 
Journal of Pediatric Infectious Diseases
Background: Antimicrobial-resistant Shigella sonnei is a growing problem in the United States and poses treatment challenges particularly among children. Azithromycin is recommended as an alternative oral agent for shigellosis. Methods: All isolates of Shigella submitted to Johns Hopkins clinical...

Knowledge, Attitudes and Practices About Multidrug-Resistant Tuberculosis (MDR-TB) and Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases

Post Date: 
2017-05-22
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
American Thoracic Society 2017 International Conference
Poster Presentation. Suryavanshi N, Shah S, Murrill M , Gupta A.

It Simply Won’t Work Here – Few Eligible for the Newly Recommended Short Course MDR-TB Regimen in a Mumbai Private Clinic

Post Date: 
2017-05-21
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
American Thoracic Society 2017 International Conference
Poster Presentation. Tornheim J , DeLuca A, Ganatra S, Radhika B, Gupta A, Udwadia Z.

Communicating Whole Genome Sequencing Results for Tuberculosis: What Does It Mean and Who Needs to Know?

Post Date: 
2017-04-25
Presentation Location: 
Mumbai, India
Country: 
Event & Convener: 
Foundation for Medical Research
Invited lecture.

HIV Testing Uptake Among Household Contacts of MDR-TB Index Cases in Eight Countries

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Event & Convener: 
CROI 2017
Poster Presentation. Opollo VS, Wu X, Lando R, Swindells S, Gupta A, Hesseling A, Dawson R, Hughes MD, Shah S

Impact of Drug Susceptibility Testing on Drug Choice in a Tuberculosis Cohort with High Rates of Drug Resistance from the Private Sector in Mumbai

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Tornheim JA , Ganatra S, DeLuca A, Banka R, Gupta A, Udwadia ZF

The Impact of Health Seeking Behavior on Community-acquired Multi-drug Resistant Stool Colonization among Hospitalized Febrile Illness Patients in Pune, India

Post Date: 
2016-10-29
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster Session: Antibiotic Stewardship: Outpatient and ED. Sachs J , Bharadwaj R, Khadse S, Kadam D, Kagal A, Shaikh N, Shingada K, Raichur P, Kanade S, Suryanvanshi N, Gupta A, Robinson M, Mave V.

Impact of Drug Susceptibility Testing on Drug Choice in a Tuberculosis Cohort with High Rates of Drug Resistance from the Private Sector in Mumbai

Post Date: 
2016-10-27
Presentation Location: 
New Orleans, LA
Country: 
Event & Convener: 
ID Week 2016
Poster Abstract Session: Tuberculosis Treatment and Outcome. Udwadia ZF, Tornheim JA , Ganatra S, DeLuca A, Banka R, Gupta A

Vancomycin-resistant Enterococcal Bacteraemia: Is Daptomycin as Effective as Linezolid?

Post Date: 
2016-10-04
Presentation Location: 
San Diego, CA
Event & Convener: 
Infectious Diseases Society of America. 2007 Annual Meeting.
Presentation.

Rapid Diagnosis, Linkage and Treatment Initiation of Patients with Drug-resistant Tuberculosis in South Africa: The miLINC Solution to Improve Access to Care

Post Date: 
2016-07-20
Presentation Location: 
Durban, South Africa
Country: 
Event & Convener: 
21st International AIDS Conference. International AIDS Society.
Poster Presentation. Farley JE , Seiguer S, Naicker M, McKenzie-White J, Greg C, Elmi M, Stevens W, Stewart-Isherwood L

Prevalence of and Risk Factors for Diabetes mellitus among Pulmonary Tuberculosis Patients in Pune, India.

Post Date: 
2016-07-16
Presentation Location: 
Durban, South Africa
Country: 
Event & Convener: 
TB2016. International AIDS Society.
Poster presentation.

Clinical, Social, and Meteorological Factors Associated with Dengue and Malaria Diagnosis in Adults in Pune, India

Post Date: 
2016-03-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
17th International Congress on Infectious Diseases
Poster Session. Kadam D, Raichur P, Chandanwale A, Joshi S, Robinson M, Marbaniang I, Kagal A, Bharadwaj, Mave V.

Frequent Resistant Gram Negative Rod Stool Colonization among Patients Admitted with Acute Febrile Illness in Pune, India

Post Date: 
2016-03-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
17th International Congress on Infectious Diseases
Poster Presentation. Bharadwaj RS, Robinson M, Marbaniang I, Kagal A, Raichur PA, Kulkami V, Balasubramanian U, Onawale P, Kanade S, Nelson G, Gupta A, Mave V.

PMTCT, infant feeding and response to ART treatment and resistance in women and children

Post Date: 
2009-03-26
Presentation Location: 
Maseru, Lesotho
Event & Convener: 
US State Department Workshop. Baylor Center for Excellence Pediatric Hospital
Presentation

RSA Bacteremia: Vancomycin Levels and Clearance of Bacteremia

Post Date: 
2008-10-25
Presentation Location: 
Washington, DC
Event & Convener: 
Infectious Diseases Society of America. 2008 Annual Meeting.
Presentation.

Ceftriaxone-resistant Salmonella

Post Date: 
2008-06-21
Presentation Location: 
Kuala Lumpur, Malaysia
Event & Convener: 
International Conference on Infectious Diseases
Presentation

TB Noon Conference

Post Date: 
2013-10-24
Country: 
CCGHE webcasts Tuberculosis (TB) Noon Conference live and provides a global audience with open access to all live and archived sessions via the CCGHE website. Led by Drs. Maunank Shah, Jonathan Golub, Richard Chaisson, these meetings bring together Johns Hopkins TB researchers and trainees in an...