Presentations

Mental Health and TB: High Prevalence of Depression among Drug-resistant TB Patients not Associated with Cycloserine

Post Date: 
2019-02-04
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Hinduja Hospital
Shivakumar SVBY , Tornheim JA, Gajjar I, Porwal S, Kishore G, Karane M, Sayed S, Chawla PK, Rodrigues C, Ashavaid TK, Gupta A, Udwadia ZF. Mental Health and TB: High prevalence of depression among drug-resistant TB patients not associated with cycloserine. 8th Annual Regional Prospective…

Quality of Life Among MDR-TB Patients from the Public Sector in Mumbai

Post Date: 
2019-02-04
   |   
Countries: 
India
   |   
Clinical Sites: 
Hinduja Hospital
Gajjar IN , Udwadia ZF, Kishore G, Karane M, Sayed S, Sawant N, Chawla PK, Rodrigues C, Ashavaid TK, Shivakumar SVBY, Gupta A, Tornheim JA. Quality of Life Among MDR-TB Patients from the Public Sector in Mumbai. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India…

Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance

Post Date: 
2019-02-04
   |   
Countries: 
India
   |   
Clinical Sites: 
Hinduja Hospital
Kambli P , Tornheim JA, Soundararajan L, Priyadarshini S, Gupta R, Ramprasad VL, Gupta A, Rodrigues C. Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance. 8th Annual Regional Prospective Observational Research for Tuberculosis…

Does Smoking Have an Impact on TB Treatment Outcomes?

Post Date: 
2018-10-27
Thomas B, Kannan T, Rani V, Gupte N, Gupta A, Deluca A, Suryavanshi N, Kohli R, Chandrasekaran P for the CTRIUMPH RePORT India Study Team. Does Smoking Have an Impact on TB Treatment Outcomes? A Prospective Cohort Study from India. Session: Tobacco Use in Various Populations: Implications for…

Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India

Post Date: 
2018-10-27
   |   
Clinical Sites: 
BJGMC
Dhumal G, DeLuca A, Chandanwale A, Kadam D, Joshi S, Kinikar A, Suryavanshi N, Mave V, Gupta A, Bollinger R. Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India. Session: Building…

Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes

Post Date: 
2018-10-27
Mathad J, Alexander M, Bhosale R, Shere D, Kulkarni V, Kumar P, Babu S, Gupta A for the PRACHITi Study team. Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes. 49th Annual Union World…

TB Stigma and Its Impact on Enrolling Household Contacts in Clinical Trials and Cohort Studies: An Indian Perspective

Post Date: 
2018-10-27
Suryavanshi N. TB Stigma and Its Impact on Enrolling Household Contacts in Clinical Trials and Cohort Studies: An Indian Perspective. Symposium: Tuberculosis Contact Investigation in High Tuberculosis Burden Settings. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands…

Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin

Post Date: 
2018-10-26
Mave V, Gupte N, Gaikwad S, Barthwal M, Chon S, Gupte A, Gupta A, Golub J. Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin. Presented at 49th Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Addressing policy needs for controlling TB and multidrug-resistant TB (MDR-TB): a biosocial inquiry among patients in Pune city in Western Maharashtra, India

Post Date: 
2018-10-26
Atre S. Addressing policy needs for controlling TB and multidrug-resistant TB (MDR-TB): a biosocial inquiry among patients in Pune city in Western Maharashtra, India. Presented at 49th Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Managing Tuberculosis in Pregnancy. Meet the Expert Session

Post Date: 
2018-10-26
Gupta A. Managing Tuberculosis in Pregnancy. Meet the Expert Session. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Factors Associated with Loss to Follow-up and Mortality in Public Sector MDR TB Treatment in Western Maharashtra, India from 2015-2016

Post Date: 
2018-10-26
Murrill M, More SW, Kamble S, Kulkarni V, Dowdy D, Gupta A. Factors Associated with Loss to Follow-up and Mortality in Public Sector MDR TB Treatment in Western Maharashtra, India from 2015-2016. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24,-27, 2018.

The TEKO trial: implementation of the QuantiFERON®-TB Gold In-Tube test at CD4 blood draw for diagnosing latent tuberculosis among newly diagnosed HIV-infected adults in South Africa

Post Date: 
2018-10-26
Golub J, Lebina L, Chon S, Cohn S, Jack T, Masonoke K, Variava E, Martinson N, TEKO team. The TEKO trial: implementation of the QuantiFERON®-TB Gold In-Tube test at CD4 blood draw for diagnosing latent tuberculosis among newly diagnosed HIV-infected adults in South Africa. 49th Annual Union World…

Utility of QGIT as an Adjunct to TST for Screening of Latent Tuberculosis Infection among Indian Healthcare Workers

Post Date: 
2018-10-26
Girish S, Kinikar A, Pardeshi G, Shelke S, Basavaraj A, Chandanwale A, Gupte N, Bollinger R. Utility of QGIT as an Adjunct to TST for Screening of Latent Tuberculosis Infection among Indian Healthcare Workers. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24…

What Is the Right Dose of Pyrazinamide?

Post Date: 
2018-10-25
Dooley K. What Is the Right Dose of Pyrazinamide? Symposium: Optimisation of Standard Drugs in the Treatment of Tuberculosis, Finally?

BRIEF TB Treatment of Latent TB Infection With One Month of Isoniazid & Rifapentine in HIV-Infected People: Interaction of Treatment & CD4 Count

Post Date: 
2018-10-25
Swindells S, Ramchandami R, Gupta A, Sanchez J, Juste MAJ, Mwelase N, Chaisson R, BRIEF TB Study Team. BRIEF TB Treatment of Latent TB Infection With One Month of Isoniazid & Rifapentine in HIV-Infected People: Interaction of Treatment & CD4 Count. Session: TB Infection: From Latent to…

Impact of Maternal Isoniazid Preventive Therapy (IPT) Timing on Acquisition of Infant TB Infection (TBI) in the IMPAACT P1078/TB APPRISE Trial

Post Date: 
2018-10-25
Gupta A , Aaron L, Montepiedra G, Theron G, Chipato T, Onyango-Makumbi C, Stranix-Chibanda L, Weinberg A, for the IMPAACT P1078/TB APPRISE Study Team. Impact of Maternal Isoniazid Preventive Therapy (IPT) Timing on Acquisition of Infant TB Infection (TBI) in the IMPAACT P1078/TB APPRISE Trial. 49th…

Preventive Therapy for PLWH – 3HP. MTE HIV Meet the Expert Session

Post Date: 
2018-10-25
Dooley K. Preventive Therapy for PLWH – 3HP. MTE HIV Meet the Expert Session. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Alcohol Use Disorder, Drinking Patterns, and Tuberculosis Treatment Failure in Indian Patients

Post Date: 
2018-10-25
Samyra R Cox, Andrea Deluca, Beena Thomas, Nishi Suryavanshi, Divyashri Jain, Mandar Paradkar, Nikhil Gupte, Akshay Gupte, Bob Bollinger, Shri Vijay Bala Yogendra Shivakumar, Kannan Thiruvengadam, Geetanjali Chander, Vidya Mave, Padmapriyadarshini Chandrasekaran, Amita Gupta for the CTRIUMPh Study…

Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis

Post Date: 
2018-10-25
   |   
Countries: 
India
Gupte A, Kumar P, Kulkarni V, Bharadwaj R, Andrade B, Mave V, Chandrasekaran P, Gupta A. Interleukin-6, Interleukin-13 and Interferon-γ as Potential Biomarkers for Treatment Failure in Pulmonary Tuberculosis. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-…

Challenges in TB Diagnosis in Pregnant Women in India: Findings from a Cohort Study in Pune, India

Post Date: 
2018-10-25
Alexander M, Bhosale R, Gupte N, Deshpande P, Kulkarni V, Chandanwale A, Gupta A, Mathad J. Challenges in TB Diagnosis in Pregnant Women in India: Findings from a Cohort Study in Pune, India. Session: LTBI Screening: Challenges and Opportunities. 49th Annual Union World Conference on Lung Health…

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Prevalence of and Risk Factors for Diabetes mellitus among Pulmonary Tuberculosis Patients in Pune, India.

Post Date: 
2016-07-16
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
DY Patil
Golub, J., Gupta, A. Prevalence of and Risk Factors for Diabetes mellitus among Pulmonary Tuberculosis Patients in Pune, India. TB2016. International AIDS Society. Durban, South Africa. 2016.

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

Post Date: 
2016-04-01
   |   
Countries: 
Brazil
Haiti
India
Malawi
Peru
South Africa
Thailand
United States
Zimbabwe
   |   
Clinical Sites: 
BJGMC
Publication: 
The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial…

Profile of bone marrow examination in HIV/AIDS patients to detect opportunistic infections, especially tuberculosis

Post Date: 
2005-01-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
iIndian Journal of Pathology and Microbiology
Morphological evaluation of 140 bone marrow aspirations received in haematopathology laboratory with serologically established HIV infection, along with other relevant special haematological tests, was done during 1st Jan 1999 – 31st Dec 2002 at state government run tertiary care General…

An international outbreak of salmonellosis associated with raw almonds contaminated with a rare phage type of Salmonella enteriditis

Post Date: 
2005-01-15
   |   
Countries: 
United States
Publication: 
Journal of Food Protection
During the winter of 2000 to 2001, an outbreak due to Salmonella Enteritidis (SE) phage type 30 (PT30), a rare strain, was detected in Canada. The ensuing investigation involved Canadian and American public health and food regulatory agencies and an academic research laboratory. Enhanced…

Limited evolution in the HIV type 1 pol region among acute seroconverters in Pune, India

Post Date: 
2005-01-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
AIDS Research and Human Retroviruses
India has the second largest burden of HIV-1-infected persons worldwide. Access to antiretroviral drugs in India is increasing. We analyzed HIV-1 protease and reverse transcriptase sequences in 12 acute seroconverters from Pune, India, and evaluated HIV-1 evolution in these individuals over…

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date: 
2016-01-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
International Journal of Tuberculosis and Lung Disease
Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The…

Determinants of default from tuberculosis treatment among patients with drug-susceptible tuberculosis in Karachi, Pakistan: a mixed methods study

Post Date: 
2015-11-12
   |   
Countries: 
Pakistan
Publication: 
PLOS One
Purpose: Non-adherence to tuberculosis therapy can lead to drug resistance, prolonged infectiousness, and death; therefore, understanding what causes treatment default is important. Pakistan has one of the highest burdens of tuberculosis in the world, yet there have been no qualitative…

Pediatric tuberculous meningitis: model-based approach to determining optimal doses of anti-tuberculosis drugs for children

Post Date: 
2015-10-22
   |   
Countries: 
India
Indonesia
South Africa
   |   
Clinical Sites: 
BJGMC
Publication: 
Clinical Pharmacology and Therapeutics
Pediatric tuberculous meningitis (TBM) is a highly morbid, often fatal disease. Standard treatment includes isoniazid, rifampin, pyrazinamide, and ethambutol. Current rifampin dosing achieves low cerebrospinal fluid (CSF) concentrations, and CSF penetration of ethambutol is poor. In adult…

Economic and epidemiological impact of early antiretroviral therapy initiation in India

Post Date: 
2015-10-01
   |   
Countries: 
India
Publication: 
Journal of the International AIDS Society
Introduction: Recent WHO guidance advocates for early antiretroviral therapy (ART) initiation at higher CD4 counts to improve survival and reduce HIV transmission. We sought to quantify how the cost-effectiveness and epidemiological impact of early ART strategies in India are affected by…

Pre-cART elevation of CRP and CD4+ T-cell immune activation associated with HIV clinical progression in a multinational case-cohort study

Post Date: 
2015-10-01
   |   
Countries: 
Brazil
Haiti
India
Malawi
Peru
South Africa
Thailand
United States
Zimbabwe
   |   
Clinical Sites: 
BJGMC
NIRT
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Despite the success of combination antiretroviral therapy (cART), a subset of HIV-infected patients who initiate cART develop early clinical progression to AIDS; therefore, some cART initiators are not fully benefitted by cART. Immune activation pre-cART may predict clinical…

RePORT International: advancing tuberculosis biomarker research through global collaboration

Post Date: 
2015-10-15
   |   
Countries: 
India
Indonesia
   |   
Clinical Sites: 
BJGMC
NIRT
Publication: 
Clinical Infectious Diseases
Progress in tuberculosis clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active tuberculosis, and subsequent cure, relapse, or failure. Regional Prospective Observational Research for Tuberculosis (RePORT) International represents a…

Mother and child both matter: reconceptualizing the prevention of mother-to-child transmission care continuum

Post Date: 
2015-09-08
Publication: 
Current Opinion in HIV and AIDS
Purpose of review: To propose a prevention of mother-to-child transmission (PMTCT) care continuum that defines the programmatic steps necessary to provide HIV care to the HIV-infected pregnant woman and her infant during the risk period for HIV transmission. Recent…

Contraceptive use and factors associated with postpartum surgical sterilization among HIV-infected women in Pune, India

Post Date: 
2015-08-21
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Journal of HIV/AIDS & Social Services
The authors desire to better understand contraceptive practices and factors associated with surgical tubal ligation (STL) among HIV-infected women. Secondary data were obtained from HIV-infected women enrolled in a National Institutes of Health–funded clinical trial assessing the efficacy of…

Effectiveness of peer support on care engagement and preventive care intervention utilization among pre-antiretroviral therapy, HIV-infected adults in Rakai, Uganda: a randomized trial

Post Date: 
2015-08-14
   |   
Countries: 
Uganda
Publication: 
AIDS and Behavior
442 pre-ART, HIV-infected adults were randomized to peer support consisting of structured home visits to promote clinic attendance and preventive care intervention use or standard of care. At baseline, 62 % reported previously visiting an HIV clinic, 45 % reported taking cotrimoxazole…

Development of global health education at Johns Hopkins University School of Medicine: a student-driven initiative

Post Date: 
2015-07-27
Publication: 
Medical Education Online
Global health is increasingly present in the formal educational curricula of medical schools across North America. In 2008, students at Johns Hopkins University School of Medicine (JHUSOM) perceived a lack of structured global health education in the existing curriculum and began working with…

Failure to use and sustain male condom usage: lessons learned from a prospective study among men attending STI clinic in Pune, India

Post Date: 
2015-08-13
   |   
Countries: 
India
Publication: 
PLOS One
Background: Sustained or consistent use of condoms by men remains a challenge. A study was carried out to identify factors associated with failure to use condoms consistently by men attending STD clinics in Pune, India. Method: Among 14137 STI clinic…

Efavirenz pharmacokinetics in HIV-infected persons receiving rifapentine and isoniazid for tuberculosis prevention

Post Date: 
2015-06-16
   |   
Countries: 
South Africa
Thailand
United States
Publication: 
Clinical Infectious Diseases
Background: Concomitant use of rifamycins to treat or prevent tuberculosis can result in subtherapeutic concentrations of antiretroviral drugs. We studied the interaction of efavirenz with daily rifapentine and isoniazid in human immunodeficiency virus (HIV)-infected individuals receiving a 4…

Impact of patient-selected care buddies on adherence to HIV care, disease progression and conduct of daily life among pre-antiretroviral HIV-infected patients in Rakai, Uganda: a randomized controlled trial

Post Date: 
2015-06-01
   |   
Countries: 
Uganda
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Data are limited on effects of household or community support persons (“care buddies”) on enrollment into and adherence to pre-antiretroviral HIV care. We assessed the impact of care buddies on adherence to HIV clinic appointments, HIV progression, and conduct of daily life among…

Utilizing mHealth methods to identify patterns of high risk illicit drug use

Post Date: 
2015-06-01
   |   
Countries: 
United States
Publication: 
Drug and Alcohol Dependence
Introduction: We assessed patterns of illicit drug use using mobile health (mHealth) methods and subsequent health care indicators among drug users in Baltimore, MD. Methods: Participants of the EXposure Assessment in Current Time (EXACT) study were provided…

Durable suppression of HIV-1 after virologic monitoring-based antiretroviral adherence counseling in Rakai, Uganda

Post Date: 
2015-05-26
   |   
Countries: 
Uganda
Publication: 
PLOS One
Objectives: HIV viral load is recommended for monitoring antiretroviral treatment and identifying treatment failure. We assessed the durability of viral suppression after viral load-triggered adherence counseling among patients with HIV viremia 6 months after ART initiation. …

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