Maunank Shah, MD, PhD

Role: 
Faculty
Associate Professor of Medicine
Maunank Shah, MD, PhD

Dr. Shah is Associate Professor in the Division of Infectious Diseases at Johns Hopkins (JH) School of Medicine, and a faculty member of both the JH Center for Clinical Global Health Education and the JH Center for TB Research. He is Medical Director for the Baltimore City Tuberculosis Program, an attending physician at the Johns Hopkins Hospital, and is board certified in infectious diseases and internal medicine. 

Dr. Shah’s research involves evaluating and implementing novel HIV and tuberculosis (TB) intervention strategies in resource constrained settings. He evaluates new TB diagnostic technologies (examples include the urinary LAM assays, Xpert MTB/Rif, Quantiferon-gold-in-tube) and assesses the cost-effectiveness of emerging strategies for HIV and TB care in South Africa, Uganda, India, and Baltimore.  He has expertise in conducting economic evaluations, and he currently leads efforts to develop mathematical transmission models to examine the economic and epidemiological impact of the HIV continuum of care domestically and globally. Additionally, his research interests include evaluating the use of mobile health (mHealth) technologies to optimize adherence to TB therapy.  He is the inventor of the miDOT platform to allow HIPAA compliant, patient-centered video-based asynchronous directly observed therapy (DOT) and improved case management for patients with TB.  In collaboration with emocha Mobile Health Inc, he is evaluating the role of miDOT for improving HIV and TB outcomes in Maryland, as well as around the globe, with a goal to leverage these innovative approaches to improve patient outcomes for a variety of infectious and chronic diseases. 

Dr. Shah serves on the Maryland Tuberculosis Guidelines committee, and he leads online TB educational activities at the Center for Clinical Global Health Education. He is committed to teaching and mentoring, and is a 2016 recipient of the Johhns Hopkins Center for Global Health's Faculty Advising Award. He has been an invited speaker at numerous international and domestic conferences, medical and public health schools, and other educational forums. Additionally, Dr. Shah serves as co-director for the microbiology and infectious disease curriculum for students at Johns Hopkins School of Medicine. Dr. Shah also serves as a clinical TB expert and provides medical consultations for the CDC funded Regional TB Training and Consultation Center (RTMCC) for the Northeast region (Global TB Institute).He is the inventor and principal investigator for HIV-ASSIST (HIV Antiretroviral Selection Support and Interactive Search Tool), an online interactive site in development that allows for patient centered, individualized, and evidence-based decision making and education for providers choosing ART regimens for people living with HIV (www.HIV-ASSIST.org; under development).  

He is Associate Editor for the recently launched open source journal for the Infectious Disease Society of America—OFID, and he is an author of more than 25 peer-reviewed studies. He is a member of the International Union for TB and Lung Disease, the International AIDS Society, and the Infectious Diseases Society of America.

Dr. Shah earned his PhD in clinical investigation and public health, with expertise in decision-analysis, epidemiology, and biostatistics, from the Johns Hopkins Bloomberg School of Public Health. He completed his infectious diseases fellowship at Johns Hopkins School of Medicine and his internal medicine residency at Emory University, where he also served as Chief Resident. He received his MD from the University of California, San Francisco, and a BS in biology from the University of Virginia.

 

MDR-TB Free: Monitoring Adverse Effects, Utilizing Resources Optimally, Knowing Resistance Patterns, and Treatment Strategy

Post Date: 
2017-03-24
Country: 
Purpose: To establish an observational cohort of MDR-TB cases and household contacts with accompanying biorepository at PD Hinduja National Hospital and Medical Research Centre Primary Objectives: Cohort A: To document participant outcomes including early treatment response, MDR-TB treatment-...

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

Post Date: 
2017-03-01
Country: 
In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

miDOT (Directly Observed Therapy)

Post Date: 
2015-11-01
Designed by Dr. Maunank Shah, the miDOT mobile health application is a video-based Directly Observed Therapy interface that uses the emocha Mobile Health platform to remotely connect patients on long-term tuberculosis therapy with clinicians who are required to witness patients taking medication...

TB Case Conference

Post Date: 
2013-02-25
Country: 
CCGHE broadcasts live TB Case Conferences and provides a global audience with open access to all live and archived webcasts via the CCGHE website. Hosted by Dr. Maunank Shah (Johns Hopkins), this case-based conference serves as a forum where clinicians caring for individuals with active TB can...

Challenges in the evaluation of interventions to improve engagement along the HIV care continuum in the United States: a systematic review

Post Date: 
2017-07-17
Publication: 
AIDS and Behavior
Country: 
Dr. Maunank Shah & colleagues review interventions to keep HIV patients linked to care.

The impact of preexposure prophylaxis among men who have sex with men: An individual-based model

Post Date: 
2017-06-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Country: 
Objectives Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation. Design We...

The impact of preexposure prophylaxis among men who have sex with men: an individual based model

Post Date: 
2017-06-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives : Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation. Design : We...

Extrapulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
M. tuberculosis (MTB) can cause disease in almost any organ of the body. Extrapulmonary tuberculosis (EPTB) is defined as tuberculosis (TB) disease outside of the lung parenchyma [1]. Much like pulmonary TB, EPTB can occur as a primary infection or as reactivation of a latent focus with subsequent...

Cost-effectiveness of CRAG-LFA screening for cryptococcal meningitis among people living with HIV in Uganda

Post Date: 
2017-03-23
Publication: 
BMC Infectious Diseases
Country: 
Background : Cryptococcal meningitis (CM) constitutes a significant source of mortality in resource-limited regions. Cryptococcal antigen (CRAG) can be detected in the blood before onset of meningitis. We sought to determine the cost-effectiveness of implementing CRAG screening using the recently...

Carbapenems against Mycobacterium tuberculosis: a review of the evidence

Post Date: 
2016-11-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Carbapenems, a more recent β-lactam class, represent a unique anti-tuberculosis option, as emerging evidence demonstrates that they target the Mycobacterium tuberculosis cell wall and β-lactamase. This provides a potentially new agent against M. tuberculosis, in particular for multidrug-resistant (...

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults

Post Date: 
2016-08-16
Publication: 
Cochrane Database of Systematic Reviews
Country: 
Background: Rapid detection of tuberculosis (TB) among people living with human immunodeficiency virus (HIV) is a global health priority. HIV-associated TB may have different clinical presentations and is challenging to diagnose. Conventional sputum tests have reduced sensitivity in HIV-positive...

High proportion of extrapulmonary tuberculosis in a low prevalence setting: a retrospective cohort study

Post Date: 
2016-04-29
Publication: 
Public Health
Country: 
Objectives: The proportion of extrapulmonary tuberculosis (EPTB) cases in the United States (US) has been rising due to a slower rate of decline in EPTB compared to pulmonary tuberculosis (PTB). The purpose of this study was to characterise the clinical and treatment differences between EPTB and...

Effect of the US National HIV/AIDS Strategy targets for improved HIV care engagement: a modelling study

Post Date: 
2016-03-15
Publication: 
Lancet HIV
Country: 
Background : The recently updated White House National HIV/AIDS Strategy (NHAS) includes specific progress indicators to improve the HIV care continuum in the USA, but the economic and epidemiological effect of achieving those indicators remains unclear. We aimed to project the impact of achieving...

Infectious Diseases (ID) Learning Unit: How rapidly to evaluate for active tuberculosis disease in low-prevalence settings

Post Date: 
2016-03-11
Publication: 
Open Forum Infectious Diseases
Country: 
With declining tuberculosis (TB) incidence in low-prevalence settings, many clinicians are likely unaware that the approach to diagnosing active TB is evolving with newer technologies. Rapid molecular assays are commercially available, and more are likely to enter the market in the coming years...

The epidemiologic and economic impact of improving HIV testing, linkage, and retention in care in the United States

Post Date: 
2016-01-15
Publication: 
Clinical Infectious Diseases
Country: 
Background : Recent guidelines advocate early antiretroviral therapy (ART) to decrease human immunodeficiency virus (HIV) morbidity and prevent transmission, but suboptimal engagement in care may compromise impact. We sought to determine the economic and epidemiologic impact of incomplete...

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date: 
2016-01-01
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The cost-...

Recurrent Aeromonas bacteremia due to contaminated well water

Post Date: 
2015-10-20
Publication: 
Open Forum Infectious Diseases
Country: 
Although they are ubiquitous to aquatic environments, Aeromonas species have traditionally been considered nonvirulent; however, in the past 30 years, they have emerged as important human pathogens that can cause a wide spectrum of disease. In this study, we describe a case of recurrent Aeromonas...

Economic and epidemiological impact of early antiretroviral therapy initiation in India

Post Date: 
2015-10-01
Publication: 
Journal of the International AIDS Society
Country: 
Introduction: Recent WHO guidance advocates for early antiretroviral therapy (ART) initiation at higher CD4 counts to improve survival and reduce HIV transmission. We sought to quantify how the cost-effectiveness and epidemiological impact of early ART strategies in India are affected by attrition...

Post-arrival tuberculosis screening at a local health department of high-risk immigrants

Post Date: 
2015-07-15
Publication: 
American Journal of Public Health
Country: 
Objectives : We sought to characterize postimmigration tuberculosis (TB) care for Class B immigrants and refugees at the Baltimore City Health Department TB program (BCHD), and to determine the proportion of immigrants with active TB or latent TB infection (LTBI) in this high-risk population...

Policy Guidance: The Use of Lateral-Flow Urine LAM for Diagnosis and Screening of Active TB in People Living with HIV

Post Date: 
2015-06-30
Publication: 
WHO: The Use of Lateral-Flow Urine LAM for Diagnosis and Screening of Active TB in People Living with HIV
Background : Tests based on the detection of mycobacterial lipoarabinomannan (LAM) antigen in urine have emerged as potential point-of-care tests for tuberculosis (TB). LAM antigen is a lipopolysaccharide present in mycobacterial cell walls, which is released from metabolically active or...

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda

Post Date: 
2015-02-15
Publication: 
BMC Infectious Diseases
Country: 
Background : Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be missed; delays in diagnosis can be fatal. Given the duration for MTB growth in...

Analysis of latent tuberculosis infection treatment adherence among refugees and other patient groups referred to the Baltimore City Health Department TB clinic

Post Date: 
2015-02-15
Publication: 
Journal of Immigrant and Minority Health
Country: 
We sought to determine the proportion of refugee patients at the Baltimore City Health Department Tuberculosis program (BCHD-TB) successfully completing latent tuberculosis infection (LTBI) treatment, as compared to other referral groups, and to identify factors associated with treatment completion...

Implementing a large scale systematic tuberculosis screening program in correctional facilities in South Africa

Post Date: 
2015-01-08
Publication: 
Open Forum Infectious Diseases
Country: 
Background : Tuberculosis (TB) prevalence is high in correctional facilities in southern Africa. With support from local South African nongovernmental organizations, the South African Department of Correctional Services initiated a program of systematically screening newly admitted and current...

Complications of tuberculosis

Post Date: 
2014-10-15
Publication: 
Current Opinion in Infectious Diseases
Purpose of review : Diagnosis and management of tuberculosis (TB) remains challenging and complex because of the heterogeneity of disease presentations. Despite effective treatment, TB disease can lead to significant short-and long-term health consequences. We review potential acute and chronic...

Pages

Cost-effectiveness of Isonaizid Preventive Therapy for HIV-Infected Pregnant Women in India

Post Date: 
2015-02-24
Presentation Location: 
Seattle, WA
Country: 
Event & Convener: 
Conference on Retroviruses and Opportunistic Infections 2015
Poster Presentation. Kapoor S, Chida N, Gupta A, Shah M

Johns Hopkins Education Policy and Curriculum Committee

Post Date: 
2015-01-01
Maunank Shah, Member, 2015.

Maryland Tuberculosis Guidelines Committee

Post Date: 
2014-01-01
Maunank Shah, Member, 2014.

Johns Hopkins Hospital Microbiology Search Committee

Post Date: 
2014-01-01
Maunank Shah, Member, 2014.

CDC/PEPFAR HIV Implementation Research Study Group

Post Date: 
2012-01-01
Maunank Shah, Member, 2002.

International Union Against Tuberculosis and Lung Disease

Post Date: 
2009-01-01
Amita Gupta, Member, 2009-Present. Maunank Shah, Member, 2009–Present.

International AIDS Society

Post Date: 
2006-01-01
Bob Bollinger, Member, 2004–Present. Larry Chang, Member, 2000–Present. Amita Gupta, Member, 2006 – Present. Vidya Mave, Member, 2008–Present. Maunank Shah, 2009–Present.

Emory University Residency Leadership Committee

Post Date: 
2006-01-01
Maunank Shah, Member, 2006–2007.

Infectious Disease Society of America

Post Date: 
1991-01-01
Bob Bollinger, Member 1991–Present. Larry Chang, Member, 2006–Present. Amita Gupta, Member 2001–Present. Maunank Shah, Member 2009–Present.

TB Noon Conference

Post Date: 
2013-10-24
Country: 
CCGHE webcasts Tuberculosis (TB) Noon Conference live and provides a global audience with open access to all live and archived sessions via the CCGHE website. Led by Drs. Maunank Shah, Jonathan Golub, Richard Chaisson, these meetings bring together Johns Hopkins TB researchers and trainees in an...

Emocha Mobile Health expands to opioid addiction treatment

Post Date: 
2017-06-23
Source: 
Baltimore Sun
Photo of emocha mobile health application
Baltimore Sun: emocha received award to expand miDOT capabilities to help care providers treat opioid addiction.

emocha is looking to help treat opioid addiction

Post Date: 
2017-06-16
Source: 
Technical.ly Baltimore
emocha received a $1.7 million grant from the National Institute on Drug Abuse to complete the research studies ahead of its commercial release. The technology will be used in clinic-based treatment, with observation of take-home being a next step. The grant will help the startup validate the...

Emocha launches pilot to help recovering opioid addicts

Post Date: 
2017-06-15
Source: 
Baltimore Business Journal
Emocha will be piloting its platform in partnership with two opioid recovery clinics based at the University of Washington in Seattle and Boston University.

Company tests mobile health for tuberculosis treatment

Post Date: 
2017-05-23
Source: 
NIH: News and Events
Preliminary data show 93% treatment adherence using video observation, with savings of more than $1,000 per TB patient over 6 months

Emocha Mobile Health lands new contracts for its medication monitoring app

Post Date: 
2016-08-30
Source: 
The Baltimore Sun
A Baltimore startup with a mobile application to keep tuberculosis patients on track with their medication regimen is expanding with new contracts in California and big ideas for how the technology can improve oversight of medications for other illnesses. Emocha Mobile Health, founded in 2013 on...

Digital health tools target medication adherence, population health

Post Date: 
2016-08-30
Source: 
mHealth Intelligence
Public health officials in three central California counties will be using a medication management app to help tuberculosis patients stick to their schedules. Officials in Contra Costa, Fresno and Merced counties are contracting with Emocha Mobile Health in a bid to curb the region’s high rate of...

Emocha brings TB adherence tech to California as part of national expansion

Post Date: 
2016-08-02
Source: 
MedCity News
Emocha, a digital health startup seeking to create more flexibility for tuberculosis patients to meet the requirements for Directly Observed Therapy, or DOT, has added a new set of customers in California as part of a national expansion.

Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in HIV-positive adults

Post Date: 
2016-05-11
Source: 
Science Daily
An international review team has prepared a systematic review to assess the accuracy of a point-of-care urine test for diagnosing and screening tuberculosis (TB) in people living with human immunodeficiency virus (HIV).

Mobile Technology Developed at Hopkins Medicine Transforming TB Care in Texas

Post Date: 
2016-04-19
Harris County Public Health Environmental Services Hailed TB Elimination Champion by CDC The US Centers for Disease Control and Prevention recently named Harris County Public Health Environmental Services among its 2016 TB Elimination Champions for improving tuberculosis (TB) patient outcomes in...

Amid international growth, emocha gets grant to look at Maryland TB treatment

Post Date: 
2015-11-23
Source: 
Technical.ly Baltimore
emocha Mobile Health received a Small Business Innovation Research grant to further development of its mobile app that provides video-based healthcare observations in some cases where visits were previously required. The NIH grant, which is for about $200,000 over two years, will allow the Johns...

New cases of HIV in India could fall by 38% with early ART and better retention, finds study

Post Date: 
2015-10-23
Source: 
The BMJ
Starting antiretroviral therapy (ART) early in India could reduce new infections by 18% and AIDS mortality by 9%, a study has found. Better retention in care could reduce new cases by 38% over the next 20 years. The study used dynamic compartmental modelling to compare early ART initiation (at CD4...

Mobile app developed by JHU grads helps monitor Ebola, tuberculosis patients

Post Date: 
2015-05-13
Source: 
The HUB at Johns Hopkins
Listening to Morad Elmi list off the recent developments at emocha Mobile Health Inc., the company he co-founded with fellow Johns Hopkins Carey Business School graduate Sebastian Seiguer, it's hard not to be impressed by the breadth and scope of the startup's work. In the past six months, the...

Baltimore tests mobile app for monitoring TB patients

Post Date: 
2014-10-24
Source: 
The Daily Record
The Baltimore City Health Department is piloting a mobile app that helps patients adhere to their medication regimen while reducing the burden on clinicians of monitoring those patients. The app, called miDOT, was developed by a company called emocha Mobile Health Inc., which is working out of the...

Health department launches TB trial with emocha app

Post Date: 
2014-10-22
Source: 
Technical.ly Baltimore
Tuberculosis is both tough to treat and medically cumbersome to manage. Under directly observed therapy, a medical professional has to watch a patient take his or her medication for at least six months. A Baltimore health IT startup may help lighten that load. The Baltimore City Health Department...