Maunank Shah, MD, PhD

Role: 
Faculty
Associate Professor of Medicine

Dr. Shah is Associate Professor in the Division of Infectious Diseases at Johns Hopkins (JH) School of Medicine, and a faculty member of both the JH Center for Clinical Global Health Education and the JH Center for TB Research. He is Medical Director for the Baltimore City Tuberculosis Program, an attending physician at the Johns Hopkins Hospital, and is board certified in infectious diseases and internal medicine. 

Dr. Shah’s research involves evaluating and implementing novel HIV and tuberculosis (TB) intervention strategies in resource constrained settings. He has evaluates new TB diagnostic technologies (examples include the urinary LAM assays, Xpert MTB/Rif, Quantiferon-gold-in-tube) and assesses the cost-effectiveness of emerging strategies for HIV and TB care in South Africa, Uganda, India, and Baltimore.  He has expertise in conducting economic evaluations, and he has lead efforts to develop mathematical transmission models to examine the economic and epidemiological impact of the HIV continuum of care domestically and globally (www.jheem.org).  Additionally, his research interests include evaluating the use of mobile health (mHealth) technologies to optimize adherence to TB therapy.  He is a co-inventor of an electronic DOT (directly observed therapy) platform (www.emocha.com) to allow HIPAA compliant, patient-centered video-based asynchronous directly observed therapy (DOT) and improved case management for patients with TB.  In collaboration with emocha Mobile Health Inc, he is evaluating the role of miDOT for improving HIV and TB outcomes in Maryland, as well as around the globe, with a goal to leverage these innovative approaches to improve patient outcomes for a variety of infectious and chronic diseases. 

Dr. Shah serves on the Maryland Tuberculosis Guidelines committee, has led evidence review for WHO TB diagnostics guidelines, on urinary LAM usage, and he leads online TB educational activities at the Center for Clinical Global Health Education. He is committed to teaching and mentoring, and is a 2016 recipient of the Johns Hopkins Center for Global Health's Faculty Advising Award, and was inducted into the Distinguished Teaching Society of Johns Hopkins University in 2017. He has been an invited speaker at numerous international and domestic conferences, medical and public health schools, and other educational forums, and received the 2020 National TB Controllers Association Robert Koch Award and the 2019 David Glasser Award for TB control.  Additionally, Dr. Shah serves as co-director for the microbiology and infectious disease curriculum for students at Johns Hopkins School of Medicine. Dr. Shah also serves as a clinical TB expert and provides medical consultations for the CDC funded Regional TB Center of Excellence (COE) for the Northeast region (Global TB Institute).

He is the inventor and principal investigator for HIV-ASSIST (HIV Antiretroviral Selection Support and Interactive Search Tool), an online interactive site that allows for patient centered, individualized, and evidence-based decision making and education for providers choosing ART regimens for people living with HIV (www.HIV-ASSIST.com), and has advised the development of an online electronic TB consultation platform (www.rutgers.idcrowd.org) for the Northeast regional CDC funded TB COE.

He is Associate Editor for the open source journal for the Infectious Disease Society of America—OFID, and he is an author of more than 60 peer-reviewed studies. He is a member of the International Union for TB and Lung Disease, the International AIDS Society, and the Infectious Diseases Society of America.

Dr. Shah earned his PhD in clinical investigation and public health, with expertise in decision-analysis, epidemiology, and biostatistics, from the Johns Hopkins Bloomberg School of Public Health. He completed his infectious diseases fellowship at Johns Hopkins School of Medicine and his internal medicine residency at Emory University, where he also served as Chief Resident. He received his MD from the University of California, San Francisco, and a BS in biology from the University of Virginia.

MDR-TB Free: Monitoring Adverse Effects, Utilizing Resources Optimally, Knowing Resistance Patterns, and Treatment Strategy

Post Date: 
2017-03-24
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This study is also known as MDR-TB MUKT: M onitoring Adverse Effects, U tilizing Resources Optimally, K nowing Resistance Patterns, and T reatment Strategy. Purpose: To establish an observational cohort of MDR-TB cases and household contacts with accompanying biorepository at PD Hinduja National...

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

Post Date: 
2017-03-01
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In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

Tuberculosis Noon Conference

Post Date: 
2013-10-24
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This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

TB Case Conference

Post Date: 
2013-02-25
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CCGHE broadcasts live TB Case Conferences and provides a global audience with open access to all live and archived webcasts via the CCGHE website. Hosted by Dr. Maunank Shah (Johns Hopkins), this case-based conference serves as a forum where clinicians caring for individuals with active TB can...

Evaluating the Concordance of Clinician Antiretroviral Prescribing Practices and HIV-ASSIST, an Online Clinical Decision Support Tool

Post Date: 
2019-12-02
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Publication: 
Journal of General Internal Medicine
Recent studies have shown that more than half of HIV care is provided by primary care practitioners.However, clinicians with experience and expertise in HIV medicine are declining.

Use of smartphone-based video Directly Observed Therapy (vDOT) in tuberculosis care: Single-arm, prospective feasibility study

Post Date: 
2019-08-30
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Publication: 
Journal of Medical Internet Research
Video-based monitoring is increasingly used as an efficient and low cost alternative to in-person observation and monitoring of TB patients. It showed promise in the high TB setting of India, too.

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date: 
2016-01-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The...

Economic and epidemiological impact of early antiretroviral therapy initiation in India

Post Date: 
2015-10-01
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Publication: 
Journal of the International AIDS Society
Introduction: Recent WHO guidance advocates for early antiretroviral therapy (ART) initiation at higher CD4 counts to improve survival and reduce HIV transmission. We sought to quantify how the cost-effectiveness and epidemiological impact of early ART strategies in India are affected by...

Complications of tuberculosis

Post Date: 
2014-10-15
Publication: 
Current Opinion in Infectious Diseases
Purpose of review : Diagnosis and management of tuberculosis (TB) remains challenging and complex because of the heterogeneity of disease presentations. Despite effective treatment, TB disease can lead to significant short-and long-term health consequences. We review potential acute and...

Economic challenges associated with tuberculosis diagnostic development

Post Date: 
2014-08-15
Publication: 
Expert Review of Pharmacoeconomics and Outcomes Research
Tuberculosis remains a global health crisis in part due to underdiagnosis. Technological innovations are needed to improve diagnostic test accuracy and reduce the reliance on expensive laboratory infrastructure. However, there are significant economic challenges impeding the development and...

Cost-effectiveness of rapid susceptibility testing against second line drugs for tuberculosis

Post Date: 
2014-06-15
Publication: 
International Journal of Tuberculosis and Lung Disease
Background : Drug susceptibility testing (DST) against second-line tuberculosis drugs (SLDs) is essential for improving outcomes among multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) cases. Objective : To evaluate the potential cost-...

QuantiFERON-TB Gold In-Tube for the detection of Mycobacterium tuberculosis infection in children with household tuberculosis contact

Post Date: 
2011-05-05
Publication: 
International Journal of Tuberculosis and Lung Disease
Setting : Improved strategies are needed for detecting Mycobacterium tuberculosis infection in children in TB-endemic settings. Objective : To determine the prevalence of M. tuberculosis infection by tuberculin skin testing (TST) and by the QuantiFERON-TB Gold In-Tube (...

Quantitative analysis of a urine-based assay for lipoarabinomannan in patients with tuberculosis

Post Date: 
2010-08-15
Publication: 
Journal of Clinical Microbiology
Abstract Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with...

Hematogenous osteomyelitis mimicking osteosarcoma due to Community Associated Methicillin-Resistant Staphylococcus aureus

Post Date: 
2007-06-15
Publication: 
Infection
Community Associated Methicillin - Resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen with increasing clinical significance. Initially recognized as a cause of skin and soft tissue infections, it has soon been shown to cause life threatening illnesses. We describe two cases of...