Amita Gupta, MD, MHS

Role: 
Director
Associate Professor of Medicine and Public Health

Dr. Gupta is Deputy Director of the Johns Hopkins (JH) Center for Clinical Global Health Education (CCGHE), and Associate Professor of Infectious Diseases at the JH School of Medicine, with a joint appointment in International Health at the JH Bloomberg School of Public Health.

Board certified by the American Board of Internal Medicine in infectious diseases, Dr. Gupta specializes in international public health, clinical research, and education in infectious diseases, HIV/AIDS, and tuberculosis (TB). Since 2002, her work has been focused primarily on India, where she leads several Indo-JHU research collaborations. She serves in leadership positions for the RePORT consortium for TB research, funded by the US National Institutes of Health (NIH) and the government of India, including on the RePORT International Executive Committee, as US Chair of RePORT India, and as PI of the multi-site C-TRIUMPH research consortium.

Dr. Gupta is Co-principal Investigator of the NIH-funded Baltimore-Washington-India HIV and Infectious Diseases Clinical Trials Unit (BWI-CTU), and she is an active clinical investigator in multi-country HIV/TB trials conducted by the AIDS Clinical Trials Group (ACTG) and the International Maternal Pediatric Adolescent AIDS Trials Network (IMPAACT). Additionally, she has been awarded research grants from the NIH, CDC, and several philanthropic foundations to investigate TB in children and pregnant women, malnutrition, infection and inflammation, HIV treatment outcomes, and antibiotic resistance. ​Learn about CCGHE India Research Partnerships

Dr. Gupta is an author of more than 100 peer-reviewed research publications and 7 book chapters on prevention and treatment of HIV, TB, and other infectious diseases, predominantly in low- and middle-income settings. She has also mentored more than 30 junior scientists in India and the US to run research studies and submit their own scientific findings to peer-reviewed publications.

From 2000–2002, Dr. Gupta worked in the US Public Health Service for the Centers for Disease Control and Prevention (CDC), where she was engaged in global public health projects in the US, Guatemala, Vietnam, and Micronesia.

Dr. Gupta received an undergraduate degree from MIT, a Doctor of Medicine from Harvard Medical School, and a Master of Health Sciences in clinical investigation from JH Bloomberg School of Public Health. She completed her internal medicine training at San Francisco General Hospital-University of California, San Francisco, followed by a post-doctoral fellowships with the Epidemic Intelligence Service at the US Centers for Disease Control and Prevention (Foodborne and Diarrheal Diseases) and at the JHU School of Medicine (Infectious Diseases).

 

Zika Surveillance among Antenatal Clinic Outpatients in BJ Government Medical College and Sassoon General Hospitals, Pune, India

Post Date: 
2017-08-31
Country: 
India leads the world in dengue cases. CCGHE researchers are keeping an eye on Zika among pregnant women, which is transmitted by the same mosquito & can cause devastating birth defects.

Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients in Pune, India

Post Date: 
2017-08-07
Country: 
Antimicrobial resistance, a leading threat to human health, is enabled by unnecessary antibiotic use. Strategies to reduce unnecessary antibiotic use in India, the world’s largest antibiotic consumer, are urgently needed. Although most patients hospitalized in India with acute febrile illness...

Vaginal Microbiota in HIV Infected Pregnant Women

Post Date: 
2017-07-14
Country: 
Led by Dr. Rupak Shivakoti, this is a nested cross-sectional study of 30 HIV-infected and 60 non-HIV infected pregnant women. Pregnant women that are part of the parent study (“Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis” referred to as PRACHITI study from here on) will...

Understanding Quality of Life during and Loss to Follow-up from Drug-Resistant Tuberculosis Treatment in Pune, India

Post Date: 
2017-05-15
Country: 
This study will examine a) risk factors for loss to follow-up from DR-TB treatment, b) actively trace DR-TB patients lost to follow-up from treatment and c) establish a prospective observational cohort of MDR-TB, XDR-TB and DS-TB patients as well as healthy controls nested within ongoing RNTCP...

MDR-TB Free: Monitoring Adverse Effects, Utilizing Resources Optimally, Knowing Resistance Patterns, and Treatment Strategy

Post Date: 
2017-03-24
Country: 
Purpose: To establish an observational cohort of MDR-TB cases and household contacts with accompanying biorepository at PD Hinduja National Hospital and Medical Research Centre Primary Objectives: Cohort A: To document participant outcomes including early treatment response, MDR-TB treatment-...

RePORT: C-TRIUMPH: Biomarkers for Tuberculosis Diagnosis and Treatment Response

Post Date: 
2017-03-24
Country: 
Aims: To develop non-sputum, blood-based tools for TB diagnosis and treatment, we urgently need biomarkers that identify active TB (ATB) cases and accurately distinguish them from latent TB infection (LTBI). Such biomarkers, when validated in diverse populations, can be developed into improved...

Impact of HIV and Diabetes Mellitus on TB Drug Resistance and Recurrence

Post Date: 
2017-03-02
Country: 
Tuberculosis (TB) is the leading cause of mortality globally. With increasing burden of HIV and diabetes mellitus (DM), there is a critical need to understand the microbial response and ensuing disease dynamics of TB in the HIV-infected and diabetic host to optimally control TB globally. Among...

Multicenter Study of the Accuracy of the BD MAX MDR-TB Assay for Detection of M. tuberculosis Complex and Mutations Associated with Resistance to Rifampin or Isoniazid

Post Date: 
2017-03-01
Country: 
In a multi-country study, we are assessing the accuracy of the BD MAX rapid MDR-TB assay to detect rifampin and isoniazid resistance.

TREAT Asia: Pediatric HIV Observational Database

Post Date: 
2017-02-09
Country: 
TREAT Asia Pediatric HIV Observational Database (TApHOD) is a collaborative observational cohort study of infants, children, and adolescents living with HIV. TApHOD study participants are enrolled and followed at selected TREAT Asia Network clinical sites in the Asia-Pacific region. Participating...

TREAT Asia Observational Database

Post Date: 
2017-02-09
The TREAT Asia Observational Database's primary study objective is to: Examine HIV natural history, including the relationship between access to ART, demographics, and disease progression; short- and long-term responses to ART; impact of co-infections; HIV drug resistance patterns; and toxicity of...

Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2017-01-17
Country: 
Johns Hopkins neonatologist Dr. Julia Johnson is lead investigator for a systematic study of the epidemiology of neonatal sepsis in the Neonatal Intensive Care Unit in tertiary care facilities in India. This study is providing important baseline data to serve as the basis for future interventional...

Prevalence and Risk Factors for Oral Cancer among HIV-Infected Adults

Post Date: 
2016-12-13
Country: 
The study is designed as a cross-sectional, single time point study for opportunistic oral cancer screening of HIV-infected and non- HIV adults 21 years or older in an urban hospital. All participants will undergo screening for oral cancer and oral potentially malignant disorders (OPMD) by visual...

Cost-effectiveness of Xpert MTB/RIF for Diagnosing Pulmonary Tuberculosis in HIV-positive Patients

Post Date: 
2016-12-01
Country: 
This is a prospective cross-sectional study which will be conducted at BJGMC in Pune, India. The aim of this study is to see whether Xpert MTB/RIF is useful for early detection of pulmonary tuberculosis, and therefore cost-effective, as compared with sputum microscopy and the gold standard tests...

The Evaluation of Clinical Profile and Mortality of Children Admitted with Tuberculosis in Pediatric Intensive Care Unit at Sassoon General Hospitals, Pune

Post Date: 
2016-10-27
Country: 
This retrospective descriptive analytical study reviews the clinical profile and outcome of children with pulmonary tuberculosis (TB) and extra-pulmonary tuberculosis admitted to a Pediatric Intensive Care Unit (PICU) in a tertiary care hospital. The study will evaluate the clinical profile and...

The Evaluation of Clinical Profile and Mortality of Children Admitted with Tuberculosis in Pediatric Intensive-Care Unit at Sassoon General Hospitals, Pune

Post Date: 
2016-10-27
Country: 
Tuberculosis (TB) is one of the most common causes of infection-related death globally. TB was declared global public health emergency in 1993 by World HealthOrganization (WHO). Mortality due to TB is increasing due to emergence of multidrug resistant (MDR) strains and HIV-TB co-infection,...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date: 
2016-09-19
Country: 
Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005. We...

RePORT: C-TRIUMPH: Substudy on Transcriptomic and Metabolomic Analysis of Microbiologically Confirmed Pediatric Tuberculosis Patients and Uninfected Household Contacts

Post Date: 
2016-09-01
Country: 
The objectives for this study are to: Assess the RNAseq, microRNA, and metabolic signature differences between confirmed pediatric TB patients and age- and sex-matched controls who are all household contacts of known cases but have remained TST and IGRA negative. Determine which of the published...

Establishing an Observational Cohort Database for Patient Care and Research at the Hinduja Hospital Chest Clinic

Post Date: 
2016-08-30
Country: 
India has the largest burden of global tuberculosis (TB), accounting for one quarter of the total number of cases reported. Together with South Africa, India sees one-third of the total number of deaths from TB. Drug-resistant strains of the disease are also on the rise, with India having one of...

Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes

Post Date: 
2016-07-01
Country: 
The primary objective of this study is to determine the feasibility and operational logistics of collecting stool for microbiome analysis, detailed nutritional assessment using a food-frequency questionnaire for dietary intake and serum for inflammatory markers in order to determine factors that...

A Randomized Therapeutic Interventional Comparative Study between Three Different Modalities of Paediatric Antitubercular Treatment

Post Date: 
2016-06-13
This study, conducted and concluded in 2013, evaluated three different TB treatment regimens in children attending Sassoon General Hospital in Pune, India. A convenience sample size of n=100 children were enrolled in the study. The study investigators in India have asked the JHU faculty listed on...

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Cardiovascular risk in an HIV-infected population in India

Post Date: 
2017-07-03
Publication: 
Heart Asia
Country: 
Findings: HIV+ Indian patients who had cardiovascular disease at a younger age appear to be at imminent risk for morbidity.

Maternal syphilis: An independent risk factor for mother to infant human immunodeficiency virus transmission

Post Date: 
2017-06-15
Publication: 
Sexually Transmitted Diseases
Country: 
Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study. Maternal syphilis...

Pulmonary infections in pregnancy

Post Date: 
2017-06-01
Publication: 
Seminars in Respiratory and Critical Care Medicine
Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

Treatment of pulmonary tuberculosis

Post Date: 
2017-04-27
Publication: 
Handbook of Tuberculosis
This chapter addresses the treatment of pulmonary tuberculosis highlighting drug classes, recommended regimens, adverse drug reactions, drug-drug interactions, and practical aspects of monitoring, The principles of treatment of latent tuberculosis are also addressed including whom to treat, what...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

Post Date: 
2017-04-15
Publication: 
Journal of Infectious Diseases
Country: 
Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date: 
2017-04-01
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
SETTING: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children . DESIGN: Children (age 5 years or younger) with suspected TB were...

High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

Post Date: 
2017-03-21
Publication: 
Indian Journal of Medical Microbiology
Country: 
Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date: 
2017-02-06
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. Methods: We...

The ripple effect: why promoting female leadership in global health matters

Post Date: 
2016-12-21
Publication: 
Public Health Action
Leadership positions in global health are greatly skewed toward men; the imbalance is more pronounced in low- and middle-income countries (LMICs). The under-representation of women in leadership is a threat to gender equality, and also impacts the improvement of women's health outcomes globally. In...

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date: 
2016-10-01
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon γ, tumor necrosis factor...

Efficacy of six-week extended-dose nevirapine varies by infant birth weight with greatest relative efficacy in low birth weight infants

Post Date: 
2016-09-30
Publication: 
PLOS One
Country: 
Low birth weight (LBW), defined by the World Health Organization (WHO) as birth weight less than 2500 g, is a significant public health issue in resource-limited settings, particularly in Sub Saharan Africa and South Asia where the estimated annual incidence is 14% and 28–31%, respectively, and the...

Continued elevation of interleukin-18 and interferon-γ after initiation of antiretroviral therapy and clinical failure in a diverse multicountry human immunodeficiency virus cohort

Post Date: 
2016-07-27
Publication: 
Open Forum Infectious Diseases
Country: 
Background: We assessed immune activation after antiretroviral therapy (ART) initiation to understand clinical failure in diverse settings. Methods: We performed a case-control study in ACTG Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS). Cases were defined as...

Epidemiological impact of achieving UNAIDS 90-90-90 targets for HIV care in India: a modelling study

Post Date: 
2016-07-07
Publication: 
BMJ Open
Country: 
Objective: Recent UNAIDS ‘90-90-90’ targets propose that to end the HIV epidemic by 2030, 90% of persons living with HIV (PLWH) worldwide should know their diagnosis, 90% of diagnosed PLWH should be on antiretroviral therapy (ART) and 90% of PLWH on ART should be virally suppressed by 2020. We...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-07-01
Publication: 
Journal of Infectious Diseases
Country: 
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

Post Date: 
2016-06-01
Publication: 
International Journal of Tuberculosis and Lung Disease
Country: 
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on a...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

Post Date: 
2016-04-01
Publication: 
The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-04-01
Publication: 
The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of...

High tuberculosis risk among medical trainees, Pune, India

Post Date: 
2016-03-22
Publication: 
Emerging Infectious Diseases
Country: 
During 2012–2013, at a public hospital in Pune, India, 26 (3.9%) cases of tuberculosis were reported among 662 medical trainees, representing an estimated incidence of 3,279 cases/100,000 person-years. Three of these infections were isoniazid-resistant, 1 was multidrug-resistant, and 1 occurred in...

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Post Date: 
2016-03-19
Publication: 
The Lancet
Background: Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is recommended in HIV-positive adults, but subclinical tuberculosis can...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

Post Date: 
2016-02-25
Publication: 
BMJ Open
Country: 
Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and latent TB...

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Trends in Glycated Hemoglobin Levels and Implications for Diabetes Screening among Pulmonary Tuberculosis Cases Undergoing Treatment in India

Post Date: 
2017-09-13
Presentation Location: 
Rio de Janiero, Brazil
Country: 
Event & Convener: 
3rd Annual RePORT International Meeting, RICC
Poster Presentation. Gupte AN , Mave V, Meshram S, Lokhande R, Kadam D, Dharmshale S, Bharadwaj R, Kagal A, Pradhan N, Deshmukh S, Atre S, Sahasrabudhe T, Barthwal M, Meshram S, Kakrani A, Kulkarni V, Raskar S, Suryavanshi S, Shivakoti R, Chon S, Selvin E, Gupte N, Gupta A, Golub JE

High Burden of Dysglycemia among Contacts of Tuberculosis Patients in India: Is it Time to Screen Them All?

Post Date: 
2017-09-13
Presentation Location: 
Rio De Janiero, Brazil
Country: 
Event & Convener: 
RePORT International Conference, RICC
Poster Presentation. Shivakumar SVBY , Chandrasekaran P, Paradkar M, Danasekaran K, Kumar AMV, Ramachandran G, Thomas B, Suryavarshini N, Kohli R, Thiruvengadam K, Gupte N, Kulkarni V, Hannah LE, Gomathy NS, Pradhan N, Dolla CK, Gupte A, DeLuca A, Meshram S, Kagal AD, Golub J, Selvaraj K, Murali L...

Gene Expression Profiles of Pediatric Tuberculosis Patients and Exposed Controls from India

Post Date: 
2017-09-13
Presentation Location: 
Rio de Janiero, Brazil
Country: 
Event & Convener: 
RePORT International Conference. RICC
Poster Presentation. Tornheim JA , Paradkar M, Madugundu A, Gupte N, Kulkarni V, Sreenivasamurthy S, Raja R, Pradhan N, Shivakumar SVBY, Valvi C, Kohli R, Chandrasekaran P, Mave V, Pandey A, Gupta A.

Linezolid Experience among MDRTB Patients in Mumbai

Post Date: 
2017-09-13
Presentation Location: 
Milan, Italy
Country: 
Event & Convener: 
ERS International Congress. European Respiratory Society
Poster Presentation. Tornheim J, Ganatra S, Deluca A, Banka R, Rodrigues C, Gupta A, Udwadia Z .

Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens

Post Date: 
2017-07-26
Presentation Location: 
Paris, France
Country: 
Event & Convener: 
IAS 2017. International AIDS Society
Poster Presentation. Bhattacharya D , Gupta A, Tierney C, Huang S, Peters M, Chipato T, Martinson F, Dula D, George K, Chaktoura N, Klingman K, Gnanashanmugam D, Currier J, Fowler MG.

Hepatotoxicity in HIV+ Postpartum Women Initiating Efavirenz-Containing Regimens in PROMISE P1077

Post Date: 
2017-05-31
Presentation Location: 
Washington, DC
Event & Convener: 
2017 IMPAACT Annual Meeting
Invited presenter. IMPAACT Plenary Session 2.

A5300B/IMPAACT 2003B – PHOENix MDR TB: Protecting Households on Exposure to Newly Diagnosed Index Multidrug-Resistant TB Patients

Post Date: 
2017-05-30
Presentation Location: 
Washington, DC
Event & Convener: 
2017 IMPAACT Annual Meeting
Invited presenter. Adherence Working Group Meeting.

A5300/I2003/PHOENIx Trial Update

Post Date: 
2017-05-30
Presentation Location: 
Washington, DC
Event & Convener: 
2017 IMPAACT Annual Meeting
Invited presenter. Tuberculosis Scientific Committee.

A5300/I2003/PHOENIx Preparatory Study of MDR TB Cases and Their Household Contacts: Operational Feasibility to Inform PHOENIx Trial

Post Date: 
2017-05-29
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
2017 IMPAACT Annual Meeting
Invited presenter. MDR-TB Training Session.

Knowledge, Attitudes and Practices About Multidrug-Resistant Tuberculosis (MDR-TB) and Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases

Post Date: 
2017-05-22
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
American Thoracic Society 2017 International Conference
Poster Presentation. Suryavanshi N, Shah S, Murrill M , Gupta A.

It Simply Won’t Work Here – Few Eligible for the Newly Recommended Short Course MDR-TB Regimen in a Mumbai Private Clinic

Post Date: 
2017-05-21
Presentation Location: 
Washington, DC
Country: 
Event & Convener: 
American Thoracic Society 2017 International Conference
Poster Presentation. Tornheim J , DeLuca A, Ganatra S, Radhika B, Gupta A, Udwadia Z.

Validity of Reported Measures of Secondhand Smoke Exposure in Indian Households: Mishri Preparation a Potentially Overlooked Source in Low-Income Indian Communities

Post Date: 
2017-03-10
Presentation Location: 
Florence, Italy
Event & Convener: 
23rd Annual Meeting of the Society for Research on Nicotine & Tobacco (SRNT)
Oral presentation. Elf JL , Kinikar AA, Khadse S, Mave V, Gupte N, Kulkarni V, Patekar S, Raichur P, Cohen J, Breysse PN, Gupta A, Golub JE.

HIV Testing Uptake Among Household Contacts of MDR-TB Index Cases in Eight Countries

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Event & Convener: 
CROI 2017
Poster Presentation. Opollo VS, Wu X, Lando R, Swindells S, Gupta A, Hesseling A, Dawson R, Hughes MD, Shah S

Impact of INH Adherence on TB Incidence and Mortality by Week 96 in ACTG 5274 Trial 

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Country: 
Event & Convener: 
CROI 2017
Poster Presentation. Gupta A , Sun X, Miyahara S, Matoga M, Langat D, Riviere C, Bisson C, Kumwenda J, Hosseinipour MC, for the ACTG A5274/REMEMBER Study Team

Inflammation Biomarkers Predict Clinical Treatment Failure in HIV-infected Adults

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Country: 
Event & Convener: 
CROI 2017
Poster Presentation. Shivakoti R , Gupte N, Pillay S, Riviere C, Cardoso SW, Balagopal A, Semba R, Campbell T, Gupta A

Risk Factors for Death in Advanced HIV-Infected Adults in an Empiric TB Therapy Trial

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Country: 
Event & Convener: 
CROI 2017
Poster Presentation. Bisson G, Ramchandani R , Miyahara S, Sun X, Bao J, Gupta A, Hosseinipour MC, Kumwenda J

Hepatotoxicity in People with Advanced Immunosuppression taking Isoniazid Preventive Therapy and Antiretroviral Therapy

Post Date: 
2017-02-14
Presentation Location: 
Seattle, Washington
Event & Convener: 
CROI 2017
Poster Presentation. Ngongondo M , Miyahara S, Hughes MD, Sun X, Gupta A, Kumwenda J, Torres TS, Bisson G, Hosseinipour MC

Household Contact Tracing of Adult Pulmonary TB Patients in India: Prevalence of TB Disease and Infection

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Chandrasekaran P , Thiruvengadam K, Gupte N, Luck EH, Mave M, Gupte A, Gupta A, Swaminathan S

Impact of Drug Susceptibility Testing on Drug Choice in a Tuberculosis Cohort with High Rates of Drug Resistance from the Private Sector in Mumbai

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. Tornheim JA , Ganatra S, DeLuca A, Banka R, Gupta A, Udwadia ZF

Alcohol Use Among Adult Pulmonary and Extra-pulmonary TB Cases in the C-TRIUMPH India Cohort

Post Date: 
2017-02-03
Presentation Location: 
Hyderabad, India
Country: 
Event & Convener: 
6th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership Meeting
Poster presentation. John S , DeLuca A, Paradkar M, Nayagam R, Shivakumar SVBY, Gupte A, Gupte N, Thomas B, Suryavanshi N, Kolhi R, Golub J, Kulkarni V, Pradhan N, Mave V, Chandrasekaran P, Gupta A

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Saraniya Tharmarajah

Saraniya Tharmarajah is a public health studies student at the Johns Hopkins Krieger School of Arts and Sciences (2017). During June-July 2015, she conducted a field study placement at the National Institute of Research in Tuberculosis in Chennai, India, where she worked on the C-TRIUMPH lung health substudy. Ms. Tharmarajah is a 2015 recipient of the Global Health Established Field Placement Grant.

Prarthana Vasudevan

Baltimore, Maryland
Prar Vasudevan is an international health graduate student at the Johns Hopkins School of Public Health. In Autumn 2015, she conducted a field placement in Pune, India, at BJGMC under Dr. Vidya Mave, where she worked on the study titled Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes. She is a 2015 recipient of the Global Health Established Field Placement Grant. From Prar Vasudevan's Field Report: At BJMC, I had the opportunity to make rounds in the hospital’s ART Clinic, Labor & Delivery wards, and children’s wards. I was immediately struck by the fact...

Akshay Gupte, MBBS, MSPH

Doctoral Student
Akshay Gupte, MBBS, MPH
Akshay Gupte, MBBS, MSPH, is a doctoral student in the Department of International Health at the Johns Hopkins Bloomberg School of Public Health (JHSPH). His research interests include exploring the impact of infectious diseases on lung health of populations and exploring approaches to host directed therapies to limit lung injury in TB. As part of his doctoral research, Akshay is leading a Indo-US collaborative study aimed at exploring the impact of TB disease—alone and in combination with HIV and diabetes mellitus—on pulmonary impairment and risk of chronic lung diseases in India. Akshay is...

Jessica Elf, MPH, PhD

Post Doctoral Fellow
Jessica Elf, MPH, PhD
Jessica Elf, MPH, PhD, is a post doctoral fellow in the Department of International Health at the Johns Hopkins School of Public Health. Her primary research focus has been on the epidemiology and health impacts of tobacco use and exposure to indoor air pollution from the combustion of biomass fuels. She is a former Fogarty Fellow who lived and worked in Pune, India conducting research for her thesis project, which investigated the association between indoor air pollution and tuberculosis. She completed her undergraduate education in nutrition at the University of Florida and received an MPH...

Jeff Tornheim, MD, MPH

Infectious Disease Fellow
Jeff Tornheim, MD, MPH
Jeff Tornheim, MD, MPH, is a clinical fellow in the Division of Infectious Disease here at Johns Hopkins University School of Medicine. After completing undergraduate studies in International Development and Economics at Brandeis University he moved to East Africa where he engaged in health system strengthening for returning refugees to South Sudan and worked with the Centers for Disease Control and Prevention (CDC) on the epidemiology of pneumonia and diarrhea in Western Kenya. He completed a joint MD/MPH at Mount Sinai School of Medicine, with his thesis evaluating the impact of water...

Matt Robinson, MD

Infectious Disease Fellow
Baltimore, Maryland
Matt Robinson, MD
Matthew Robinson, MD, is a clinical fellow in the Division of Infectious Diseases at Johns Hopkins University School of Medicine. His research interests include evaluating the etiology of febrile illness in resource limited settings using conventional and novel diagnostic techniques. Matt is working with Dr. Gupta and Dr. Mave to assess the etiology of febrile illness in patients presenting to a hospital in Pune, India. After completing his undergraduate and medical training at Northwestern University, he completed internal medicine residency at New York University. During medical school, he...

Matthew Murrill

Baltimore, Maryland
Matthew Murrill
Matthew Murrill is an MD-PhD student in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. In 2016, he was named an IDSA Education and Research Foundation Medical Scholar. After completing undergraduate studies in chemistry at Maryville College, he moved to Kolkata, India, as a Fulbright-Nehru fellow to research the sources and health effects of groundwater arsenic contamination in Eastern India with the School of Environmental Studies - Jadavpur University. He then worked for Calcutta Kids, a non-governmental organization, to establish a childhood diarrhea...

Shivani Mehta

Baltimore, Maryland
Shivani Mehta is a BS/BA candidate (2018) in public health at the Johns Hopkins Krieger School of Arts and Sciences, who is working with Drs. Rupak Shivakoti and Mallika Alexander on Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes. Ms. Mehta spent June and July 2016 at BJGMC in Pune, India, working under Dr. Alexander. Awards 2016 Global Health Established Field Placement Grant 2016 Johns Hopkins Provost Undergradulate Research Award for 2016-17 From Ms. Mehta's Field Report: This week, as the patients come in, I have been sitting with the counselors and...

Abhilash Suresh

Baltimore, Maryland
Abhilash Suresh is a BS candidate in biomedical engineering at Johns Hopkins Whiting School of Engineering (2018), who worked with Drs. Akshay Gupte and Shri Vijay Bala Yogendra Shivakumar on the C-TRIUMPH substudy on Residual Respiratory Impairment Following Pulmonary Tuberculosis. During May and June 2016 he conducted a field placement in Chennai, India, at the National Institute for Research in Tuberculosis where he worked under Dr. Shivakumar. Awards 2016 Global Health Established Field Placement Grant From Mr. Suresh's Field Report: This placement opened my eyes to how healthcare works...

Johns Hopkins University Task Force on Women's Academic Careers in Medicine

Post Date: 
2015-01-01
Natasha Chida: Member, 2013-Present Amita Gupta: Member, 2015-Present

Regional Prospective Observational Research for Tuberculosis (RePORT) India Executive Committee

Post Date: 
2014-01-01
US Chair, 2016-Present US Co-chair, 2014-2016

IMPAACT Clinical Trial Network Tuberculosis Scientific Committee

Post Date: 
2012-01-01
Vice Chair Elect, 2012-Present

2012 43rd Union World Conference on Lung Health Conference Committee

Post Date: 
2012-01-01
Abstract Reviewer, 2012

ACTG Clincial Trial Group, Women's Health Inter-Network Scientific Committee

Post Date: 
2011-01-01
Tuberculosis Working Group Member, 2011-2013

ACTG Tuberculosis Transformative Science Group

Post Date: 
2011-01-01
Amita Gupta: Elected Member, 2011-2013 Vidya Mave: Elected Member, 2016-2017

International Union Against Tuberculosis and Lung Disease

Post Date: 
2009-01-01
Amita Gupta, Member, 2009-Present. Maunank Shah, Member, 2009–Present.

National Institutes of Health/National Institute of Child Health and Human Development Study Section

Post Date: 
2008-01-01
Invited RO1 Grant Reviewer, 2008 ZHD1 DSR-K (07) 1- Diagnostic and pharmacokinetic research in pediatric HIV/TB and effects of co-infection on the central nervous system

Johns Hopkins Center for Global Health Grant Review Committee

Post Date: 
2008-01-01
Amita Gupta: Grants Reviewer, 2010 Amita Gupta: Faculty Grants Reviewer, 2008

American Academy of HIV Medicine

Post Date: 
2008-01-01
Amita Gupta: Member, 2008-Present

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Reduced Level of Disease Possible in India by the Centennial

Post Date: 
2017-08-22
Source: 
India Abroad
Photo of Dr. Amita Gupta
India ranks highest in global disease burden. Dr. Amita Gupta weighs in on how to reverse that.

Indo-Hopkins Partnership Seeks Causes of Sepsis in the NICU

Post Date: 
2017-08-10
Sepsis among newborns in the neonatal intensive care unit (NICU) is a big problem in India, and a complex one to untangle.

How can we encourage female leaders in global health?

Post Date: 
2017-08-09
Source: 
Global Health Matters
Fogarty Director Dr. Roger Glass asks why so few women are leading global health centers at med schools or filling other leadership roles.

Health on the Go: Mobile Clinic Delivers TB Services at Point of Need

Post Date: 
2017-03-24
Thanks to Raj and Bharti Shah, CTIS, & the NB Shah Charitable Trust, we are able to reach more people in Maharashtra who need care

CROI 2017 Highlighted ACTG Network Presentations

Post Date: 
2017-02-28
Source: 
ACTG Newsletter
A5274: Impact of INH adherence on TB incidence and mortality by week 96 in REMEMBER Trial Amita Gupta, MD, MHS, Baltimore-Washington-India Clinical Trials Unit, co-PI and Investigator, Johns Hopkins University Clinical Research Site The A5274/REMEMBER trial team previously reported that among those...

Amita Gupta Appointed US Chair for India TB Research Consortium

Post Date: 
2016-05-11
“After more than 40 years of little discovery, interest, or funding for TB research, we are at a nexus of advancement."

Proactively treating HIV patients at risk for tuberculosis with multi-drug TB regimens doesn't save more lives

Post Date: 
2016-03-20
Source: 
Health Canal
The number one killer of HIV patients in resource-limited areas, including parts of Africa and India, is tuberculosis (TB), underscoring the need for optimal treatments and effective strategies to address this deadly co-infection. But TB is harder to detect in HIV-infected patients and diagnostic...

Common TB treatment in HIV: no added benefit?

Post Date: 
2016-03-18
Source: 
Pharmaceutical Processing Online
In a report on the REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study—a 10-nation, randomized clinical trial of adult outpatients—investigators concluded that there was no added benefit of using four drugs for TB over just using one drug, isoniazid, to...

Multidrug TB prophylaxis not needed in advanced HIV

Post Date: 
2016-03-18
Source: 
MedPage Today
Patients with advanced HIV infection initiating anti-retroviral therapy who were treated with isoniazid alone to prevent tuberculosis had similar survival rates as patients treated with a standard four-drug anti-tuberculosis regimen in a multi-national, randomized, controlled trial.

Proactively treating HIV patients at risk for tuberculosis with multi-drug TB regimens doesn't save more lives

Post Date: 
2016-03-18
Source: 
Infection Control Today
In what investigators say is a surprise finding, results of a new study appear to strongly affirm the effectiveness of prescribing the anti-tuberculosis drug isoniazid alone — in place of the standard four-drug regimen — to prevent TB and reduce death in

Common treatment of TB in advanced HIV patients doesn't save more lives

Post Date: 
2016-03-17
Source: 
Medical Xpress
In a report on the so-called REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study—a 10-nation, randomized clinical trial of adult outpatients—investigators concluded that there was no added benefit of using four drugs for TB over just using one drug,...

Proactively treating HIV patients at risk for tuberculosis with multidrug TB therapy doesn’t save more lives

Post Date: 
2016-03-17
In what investigators say is a surprise finding, results of a new study appear to strongly affirm the effectiveness of prescribing the anti-tuberculosis drug isoniazid alone — in place of the standard four-drug regimen — to prevent TB and reduce death in people with advanced HIV/AIDS infections...

Advancing Global TB Research through RePORT

Post Date: 
2016-02-29
Regional Prospective Observational Research for Tuberculosis (RePORT) International is a large, international tuberculosis research effort being undertaken by 4 regional consortia: RePORT Brazil, RePORT South Africa, RePORT Indonesia, and RePORT India. While each region collects and maintains its...

Now, docs to get TB leave as cases mount

Post Date: 
2016-02-24
Source: 
Pune Mirror
Too many cases of tuberculosis (TB) among medical trainees and resident doctors in the state have prompted the medical education department to sanction medical leaves exclusively for the malady. This is the first time any state has taken such a step in India. Unusual working hours; close contact...

VIDEO: Amita Gupta, MD, MHS, reviews TB prevention in patients with HIV

Post Date: 
2016-02-24
Source: 
Infectious Disease News, via Healio
In this video with Healio.com, Amita Gupta, MD, MHS, associate professor medicine and international health and deputy director of the Center for Clinical Global Health Education at Johns Hopkins University School of Medicine, discusses research related to the prevention of tuberculosis in patients...

Tuberculosis test may underreport in pregnant women with HIV

Post Date: 
2016-01-28
Source: 
Infectious Disease Advisor
Pregnancy may confound tuberculosis (TB) tests results in women with HIV, according to research published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine .

Tuberculosis scare in HIV positive pregnant women: most widely-used tuberculosis test fails to diagnose illness

Post Date: 
2016-01-28
Source: 
International Business Times
The most commonly-used tuberculosis (TB) test, TST, has failed to detect TB in HIV positive pregnant women. A research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine has revealed that the TB test failed to accurately diagnose the...

New cases of HIV in India could fall by 38% with early ART and better retention, finds study

Post Date: 
2015-10-23
Source: 
The BMJ
Starting antiretroviral therapy (ART) early in India could reduce new infections by 18% and AIDS mortality by 9%, a study has found. Better retention in care could reduce new cases by 38% over the next 20 years. The study used dynamic compartmental modelling to compare early ART initiation (at CD4...

CCGHE Faculty and Fogarty Scholars Meet with BJGMC Leadership

Post Date: 
2015-06-22
Baltimore, MD—Dr. Ajay S. Chandanwale, Dean, and other faculty leadership of Byramjee Jeejeebhoy Government Medical College (BJGMC) in Pune, India, arrived at the Johns Hopkins Medical Campus today to meet with CCGHE faculty and Fogarty Scholars who are in Baltimore attending the Hopkins Summer...

Researcher tackles TB in India

Post Date: 
2015-01-06
Source: 
AIDS Clinical Trials Group Network
As a child, Amita Gupta, MD, witnessed infectious diseases firsthand while visiting extended family in India. “I spent summers in India and saw the effects of polio, hepatitis B, tuberculosis and malaria,” she says. “Then when I was in college, I was galvanized by the world of HIV activism. I found...

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