Amita Gupta, MD, MHS

Role: 
Director
Professor of Medicine and Public Health
Amita Gupta, MD, MHS

Dr. Gupta is Deputy Director of the Johns Hopkins (JH) Center for Clinical Global Health Education (CCGHE), and Professor of Infectious Diseases at the JH School of Medicine, with a joint appointment in International Health at the JH Bloomberg School of Public Health.

Board certified by the American Board of Internal Medicine in infectious diseases, Dr. Gupta specializes in international public health, clinical research, and education in infectious diseases, HIV/AIDS, and tuberculosis (TB). Since 2002, her work has been focused primarily on India, where she leads several Indo-JHU research collaborations. She serves in leadership positions for the RePORT consortium for TB research, funded by the US National Institutes of Health (NIH) and the government of India, including on the RePORT International Executive Committee, as US Chair of RePORT India, and as PI of the multi-site C-TRIUMPH research consortium.

In 2019, Dr. Gupta was appointed for a 4-year term to the NIAID Council, the chief advisory committee for National Institute of Allergy and Infectious Diseases at the U.S. National Institutes of Health. She is Co-principal Investigator of the NIH-funded Baltimore-Washington-India HIV and Infectious Diseases Clinical Trials Unit (BWI-CTU), and she is an active clinical investigator in multi-country HIV/TB trials conducted by the AIDS Clinical Trials Group (ACTG) and the International Maternal Pediatric Adolescent AIDS Trials Network (IMPAACT), and has served as protocol chair for high impact studies. Additionally, she has been awarded research grants from the NIH, CDC, and several philanthropic foundations to investigate TB in children and pregnant women, malnutrition, infection and inflammation, HIV treatment outcomes, and antibiotic resistance. ​Learn about CCGHE India Research Partnerships

Dr. Gupta is an author of more than 100 peer-reviewed research publications and 7 book chapters on prevention and treatment of HIV, TB, and other infectious diseases, predominantly in low- and middle-income settings. She has also mentored more than 30 junior scientists in India and the US to run research studies and submit their own scientific findings to peer-reviewed publications.

From 2000–2002, Dr. Gupta worked in the US Public Health Service for the Centers for Disease Control and Prevention (CDC), where she was engaged in global public health projects in the US, Guatemala, Vietnam, and Micronesia.

Dr. Gupta received an undergraduate degree from MIT, a Doctor of Medicine from Harvard Medical School, and a Master of Health Sciences in clinical investigation from JH Bloomberg School of Public Health. She completed her internal medicine training at San Francisco General Hospital-University of California, San Francisco, followed by a post-doctoral fellowships with the Epidemic Intelligence Service at the US Centers for Disease Control and Prevention (Foodborne and Diarrheal Diseases) and at the JHU School of Medicine (Infectious Diseases).


Research Program Building and Leadership

  • 2019-present: NIAID Council
  • 2007-present: Chair, IMPAACT P1078, A Randomized Clinical Trial to Evaluate the Safety of Immediate (antepartum-initiated) Versus Deferred Reduction in TB Incidence and Mortality Among HIV-Infected Women and Their Infants in High TB Incidence Settings
  • 2008-present: Protocol Vice-Chair of ACTG 5274, Reducing Early Mortality Among Patients with Advanced HIV Disease: A Randomized Strategy Trial Comparing the Safety and Efficacy of an Individualized Patient TB Treatment Approach to a Public Health Pre-emptive TB Treatment Approach in Resource-Limited Settings (REMEMBER)
  • 2008-2014: Protocol Vice-Chair ACTG 5263, A Randomized Comparison of Three Chemotherapy Regimens as an Adjunct to Antiretroviral Therapy for Treatment of Advanced AIDS-KS in Resource-Limited Settings
  • 2008-2012: Co-investigator ACTG 5267, A Phase I, Safety, Tolerability, and Pharmacokinetic Interaction Study of Single-Dose TMC207 and Efavirenz in Health Volunteers
  • 2008-2012: Co-investigator ACTG 5253 Sensitivity and Specificity of Mycobacterium Tuberculosis Screening and Diagnostics in HIV-Infected Individuals
  • 2009-present: Protocol Vice Chair ACTG 5279, Phase III Clinical Trial of Short-Course Rifapentine/Isoniazid for the Prevention of Active Tuberculosis in HIV-Infected Adults with Latent Tuberculosis Infection
  • 2010: Invited by NIAID, NIH to be a part of a NIH delegation to assess scope of TB research in India. Accompanied the Deputy Director of the Division of AIDS, the Associate Director of International Health Programs, NIAID and other NIH delegates on site visits to 15 Indian institutions throughout the country
  • 2010-2013: Co-investigator IMPAACT P1091 Administration of Polysaccharide or Conjugated Pneumococcal Vaccines to HIV-Infected Pregnant Women: Safety and Magnitude, Persistence, and Transplacental Transfer of Vaccine-serotype pneumococcal anti-capsular Antibodies
  • 2011-2012: Selected to participate in the Johns Hopkins School of Medicine’s Office in Science and Medicine (OWISM) Leadership Program for Women Faculty
  • 2012-present: Co-investigator IMPAACT P1026s, Pharmacokinetic Properties of Antiretroviral Therapy in Pregnancy
  • 2012-2014: Co-investigator, IMPAACT CS4108 Protocol Team, Diagnosis of Intrathoracic Tuberculosis in HIV-infected and Uninfected Children Using Novel Sampling Strategies and the GeneXpert® MTB/RIF Assay  
  • 2012-present: Member, ACTG TB Transformative Science Group
  • 2014-present: IMPAACT TB Scientific Committee Vice-Chair
  • 2014-present: Co-investigator IMPAACT 2001 Protocol Team, PK and Safety of INH and Rifapentine in Pregnancy
  • 2014-2016: US Co-chair, NIH-India Government, Regional Prospective Observational Research in Tuberculosis (RePORT)
  • 2014-present: Co-chair PHOENIX ACTG A5300/IMPAACT 2003 MDR TB contact prophylaxis trial; Large multi-country trial in development
  • 2015-present: Member, Union Interest Group in Maternal-Infant TB working group
  • 2015-present: Member, IeDEA TB working group
  • 2016-present: US Chair, TB Research Consortium, RePORT India
  • 2016-present: Member, Executive Committee, RePORT International
  • 2017: Selected to participate in the Johns Hopkins Leadership Development Program (LDP)
  • 2018: Participant, Technical Consultation on Advances in Clinical Trial Design for Development of New TB Treatments, WHO Report generation
     

Management of Multidrug-resistant Tuberculosis among ART Programs in Low- and Middle-income Countries within the Global IeDEA Network

Post Date: 
2019-07-22
Purpose The purpose of the IeDEA MDR-TB survey is to study the clinical management of HIV patients co-infected with MDR-TB or XDR-TB from the perspective of healthcare workers in ART programs participating in the IeDEA global cohort consortium. Specifically, we aim: to describe diagnostic, referral...

Visual Field Loss in HIV-Positive Patients of Non-Infectious HIV Retinopathy

Post Date: 
2019-06-02
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New study will assess HIV+ patients and determine the prevalence of visual field loss due to noninfectious HIV retinopathy

Immune Correlates of LTBI in HIV-exposed Infants

Post Date: 
2019-04-29
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About 2 billion people worldwide harbor asymptomatic latent TB infection (LTBI), activation of which results in progression to TB disease. In areas of high tuberculosis (TB) prevalence, infants and young children have a 3-fold higher risk of progression and death from TB at age < 5 years...

Prevalence of Tuberculosis in Severely Malnourished Indian Children

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2018-12-18
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Dr. Muralidhar Tambe, BJGMC Severely malnourished children are vulnerable population for communicable and non-communicable disease. Diagnosis of TB among...

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
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New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
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We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Immune Responses and Effect of Disulfiram on MTB Infected PBMCs as a Potential Host Directed Therapy

Post Date: 
2018-11-26
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Dr. Mandar Paradkar is lead investigator for this study that is assessing the immune responses of adult pulmonary TB patients enrolled in the CTRIUMPh study, using PBMC samples of those with harmful use of alcohol assessed by AUDIT scores ≥ 8 compared to non-alcoholics (AUDIT < 8). Aim 1: To...

Characterization of TB-specific T Cell Responses in Highly-exposed, but Uninfected Health Care Workers in India

Post Date: 
2018-10-25
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Jyothi Rengarajan, MD, Emory University. Primary Research Question Do health care workers who remain TST negative, despite high-exposure to TB,...

Vaginal Microbiota in HIV Infected and Uninfected Pregnant Women (Stand Alone)

Post Date: 
2018-10-16
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Amita Gupta, MD, MHS, and Shilpa Naik, MD, are PIs for this study; Rupak Shivakoti, PhD, MSPH, is Co-Investigator The makeup of vaginal microbiota is dynamic and may play a role in the birth outcomes of pregnant women. While HIV and pregnancy both uniquely impact vaginal microbiota, the impact of...

Validating a Novel Functional Correlate of Immune Protection of Tuberculosis

Post Date: 
2018-10-03
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This C-TRIUMPH study is a longitudinal assessment of PBMC samples of progressors and non-progressors among adult household contacts of active TB patients. The purpose of the study is to probe the functional diversity of T cell responses to several of the antigens encoded by Mtb simultaneously in...

Assessing the Impact of Psychosocial Involvement in Health Care Workers with and without Active Tuberculosis at the Byramjee Jeejeebhoy Government Medical College, Pune, India

Post Date: 
2018-09-13
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. The overall goal is to understand the psychosocial involvement in health care workers with and without active tuberculosis. The specific aims of this study are: To understand the...

Assessment of Depression and Anxiety among HIV-infected Adolescents in Pune, India

Post Date: 
2018-07-22
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This study is conducted under the TREAT Asia Network and funded by amfAR. PURPOSE The purpose of this study is to estimate the prevalence of depression and anxiety among adolescents living with HIV in India and their determinants. DESIGN Cross-sectional, single time point, conveniently sampled...

Assessing Psychological Distress among Tuberculosis Patients and Their Household Members

Post Date: 
2018-07-17
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By assessing psychological distress, Indo-JHU researchers hope to better understand the correlation between depression and TB severity.

Evaluating the Source of Neonatal Bloodstream Infections due to Classically Hospital Acquired Pathogens in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2018-07-12
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This study is part of CDC's Safe Healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Program under Domain 7: International HAI and Other Adverse Healthcare Event Prevention. The PIs for this study are Dr. Julia Johnson of Johns Hopkins and Dr. Shilpa Naik of BJGMC. CoPIs are Dr...

Assessing the Feasibility and Acceptability of a Computer-based Avatar-delivered Alcohol Reduction Intervention

Post Date: 
2018-07-05
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Study is assessing whether computer-delivered alcohol screening and intervention helps overcome barriers to treatment in India.

Molecular Signatures of Tuberculosis-Diabetes Interaction: Metabolomics Study

Post Date: 
2018-06-15
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This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Type 2 diabetes mellitus (DM) is an acquired host...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Transcriptomics Study

Post Date: 
2018-06-15
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This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Type 2 diabetes is an acquired host factor that...

Gut Microbiota of HIV Infected Pregnant Women

Post Date: 
2018-06-14
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Birth Outcomes in HIV Both antiretroviral-therapy (ART)-naïve and ART-experienced HIV-infected pregnant women have higher incidences of pre-term birth (PTB) compared to HIV-uninfected women. For example, the global prevalence of PTB is around 8%, while the rates in in HIV-infected populations are...

Assessing Tuberculosis Transmission Dynamics, Drug Resistance and Recurrence Using Whole Genome Sequencing in Pune, India

Post Date: 
2018-06-12
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Indo-JHU researchers are using combined geospatial and genotyping methods to describe TB transmission dynamics in a hyperlocal region of Pune City in Western India.

Optimal Approach for TB Screening among HIV Infected Indian Children

Post Date: 
2018-06-11
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This study was terminated May 20, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. Determining TB status (ie, uninfected, latent, and active TB disease) is more difficult among children, particularly HIV-infected children. Diagnosis of TB disease is...

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Use of smartphone-based video Directly Observed Therapy (vDOT) in tuberculosis care: Single-arm, prospective feasibility study

Post Date: 
2019-08-30
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Journal of Medical Internet Research
Video-based monitoring is increasingly used as an efficient and low cost alternative to in-person observation and monitoring of TB patients. It showed promise in the high TB setting of India, too.

Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

Post Date: 
2019-08-15
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PLOS Medicine
PLOS Medicine: Dr. Amita Gupta and colleagues discuss the scientific and ethical basis for including pregnant and lactation women, children, and HIV+ patients in tuberculosis therapeutic clinical trials.

High risk for latent tuberculosis infection among medical residents and nursing students in India

Post Date: 
2019-07-08
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PLoS One
PLoS ONE: Self-reported TB exposure is underreported, and uptake of LTBI prevention therapy remains low

Mobile phone access and comfort: implications for HIV and tuberculosis care in India and South Africa.

Post Date: 
2019-07-01
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International Journal of Tuberculosis and Lung Disease
SETTING: India and South Africa shoulder the greatest burden of tuberculosis (TB) and human immunodeficiency virus (HIV) infection respectively, but care retention is suboptimal. OBJECTIVE: We conducted a study in Pune, India, and Matlosana, South Africa to identify the factors associated with...

Age-specific prevalence of TB infection among household contacts of pulmonary tuberculosis: Is it time for TB preventive therapy?

Post Date: 
2019-06-21
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Transactions of the Royal Society of Tropical Medicine and Hygiene
BACKGROUND: Household contacts (HHCs) of TB patients are at high risk of developing evidence of latent TB infection (LTBI) and active disease from the index patient. We estimated the age-specific prevalence of LTBI and the force of infection (FI), as a measure of recent transmission, among HHCs of...

Assessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD

Post Date: 
2019-05-23
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PLoS One
New in PLoS One: We found a high burden of lung function defects and COPD in tuberculosis cases who successfully completed treatment, suggesting a need for lung function screening as part of patient management.

High prevalence of insulin resistance and occurrence prior to hyperinsulinemia threshold among people living with HIV in Pune, India

Post Date: 
2019-05-21
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Diabetes Metabolic Syndrome: Clinical Research & Reviews
BACKGROUND Diabetes prevalence in HIV is not well characterized for India, despite the high burden of both individual diseases. Epidemiology of insulin resistance (IR): a precursor to diabetes, and its associated risk factors are also poorly understood in Asian Indian people living with HIV (PLHIV...

Sub-therapeutic rifampicin concentration is associated with unfavourable tuberculosis treatment outcomes

Post Date: 
2019-05-10
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Clinical Infectious Diseases
Rifampicin concentrations were sub-therapeutic in most Indian patients taking a thrice-weekly TB regimen

Feasibility of identifying household contacts of rifampin- and multidrug-resistant tuberculosis cases at high risk of progression to tuberculosis disease

Post Date: 
2019-03-28
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Clinical Infectious Diseases
We assessed multidrug-resistant tuberculosis (MDR-TB) cases and their household contacts (HHCs) to inform the development of an interventional clinical trial.

Willingness to take multidrug-resistant tuberculosis (MDR-TB) preventive therapy among Adult and adolescent household contacts of MDR-TB index cases: an international multi-site cross-sectional study

Post Date: 
2019-03-28
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Clinical Infectious Diseases
Abstract BACKGROUND: Household contacts (HHCs) of individuals with multidrug-resistant tuberculosis (MDR-TB) are at high risk of infection and subsequent disease. There is limited evidence on the willingness of MDR-TB HHCs to take MDR-TB preventive therapy (TPT) to decrease their risk of TB disease...

Maternal health outcomes among HIV-infected breastfeeding women with high CD4 counts: results of a treatment strategy trial

Post Date: 
2019-03-20
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HIV Clinical Trials
BACKGROUND: IMPAACT PROMISE 1077BF/FF was a randomized study of antiretroviral therapy (ART) strategies for pregnant and postpartum women with high CD4+ T-cell counts. We describe postpartum outcomes for women in the study who were randomized to continue or discontinue ART after delivery. METHODS:...

One month of rifapentine plus isoniazid to prevent HIV-related tuberculosis

Post Date: 
2019-03-14
Publication: 
New England Journal of Medicine
Exciting findings from A5279: One month of Rifapentine with isonaizid is as effective as a 9-month course of isoniazid alone!

Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India.

Post Date: 
2019-03-04
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Public Health Nutrition
Abstract OBJECTIVE: To assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population. DESIGN: Cross-sectional analysis assessing food...

Few eligible for the newly recommended short course MDR-TB regimen at a large Mumbai private clinic

Post Date: 
2019-01-28
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BMC Infectious Diseases
BACKGROUND: India has the world's highest tuberculosis burden, and Mumbai is particularly affected by multidrug resistant tuberculosis (MDR-TB). WHO recommends short, intensive treatment ("Short Course") for previously untreated pulmonary MDR-TB patients but does not require universal drug...

HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries

Post Date: 
2019-01-07
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International Journal of Tuberculosis and Lung Disease
International Journal of Tuberculosis and Lung Disease : The Indo-JHU Clinical Research Parentership participated in this multinational study to determine if it's feasible to provide HIV testing for household contacts of MDR-TB cases.

Is there a connection between gestational diabetes, human immunodeficiency virus infection, and tuberculosis?

Post Date: 
2019-01-01
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International Journal of Tuberculosis and Lung Disease
IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Drug-resistant Enterobacteriaceae colonization is associated with healthcare utilization and antimicrobial use among inpatients in Pune, India

Post Date: 
2018-10-04
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BMC Infectious Diseases
BACKGROUND: Healthcare exposure may increase drug-resistant Enterobacteriaceae colonization risk. Nascent antimicrobial stewardship efforts in low- and middle-income countries require setting-specific data. We aimed to evaluate risk factors for inpatient drug resistant Enterobacteriaceae...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

Post Date: 
2018-10-01
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International Journal of Tuberculosis and Lung Disease
Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

Post Date: 
2018-09-24
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BMC Medicine
Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

Report of the Technical Consultation on Advances in Clinical Trial Design for Development of New TB Treatments

Post Date: 
2018-09-17
Publication: 
WHO Task Force on Introduction of New TB Drugs and Treatment Regimens
Dr. Amita Gupta was a member of this TB technical consultation, convened in March 2018 in Switzerland.

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Pitfalls in Chest X-ray Scoring of Patients Receiving Treatment for Active Tuberculosis in Pune, India

Post Date: 
2019-03-28
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Orsini E , Gupte A, Paradkar M, Jain D, Raskar S, Lokhande R, Mave V, Gupta A. Pitfalls in Chest X-ray Scoring of Patients Receiving Treatment for Active Tuberculosis in Pune, India. Johns Hopkins Global Health Day 2019. Baltimore, MD. March 28, 2019.

Pregnancy is associated with decreased serum isoniazid levels in women living with HIV

Post Date: 
2019-03-07
Gausi K , Denti P, Weisner L, Wallis C, Onyango-Makumbi C, Chipato T, Theron G, Bradford S, Costello D, Browning R, Chakhtoura N, Weinberg A, Montepiedra G, Gupta A and the IMPAACT P1078 (TB APPRISE) Study Group Team. Pregnancy is associated with decreased serum isoniazid levels in women living...

Preventing tuberculosis in people with HIV infection

Post Date: 
2019-03-06
Gupta A. Choices and dilemmas: Preventing tuberculosis in people with HIV infection. Coinfections: Tuberculosis, Hepatitis B and C, and HIV Symposium. CROI 2019. Seattle, Washington. March 4-7, 2019.

The prevalence of perinatal depression and associated birth outcomes in Pune, India

Post Date: 
2019-02-11
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Grossman TB , Mathad JS, Suryavanshi N, Alexander M, Mave V, Bhosale R, Gupta A. The prevalence of perinatal depression and associated birth outcomes in Pune, India. Society for Maternal-Fetal Medicine 39th Annual Pregnancy Meeting. Las Vegas, NV. February 11-16, 2019.

Impact of Standard or Increased Moxifloxacin Dose Among MDR-TB Patients in Mumbai with Low-Level Resistance

Post Date: 
2019-02-04
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Tornheim JA , Udwadia ZF, Porwal S, Kishore G, Gajjar I, Karane M, Shivakumar SVBY, Rodrigues C, Gupta A. Impact of Standard or Increased Moxifloxacin Dose Among MDR-TB Patients in Mumbai with Low-Level Resistance. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT)...

IL-6, TIMP-2 and TGFβ-2 Are Associated with Respiratory Impairment During and Following Successful Treatment of Pulmonary Tuberculosis

Post Date: 
2019-02-04
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Gupte A , Paradkar M, Selvaraju S, Kumar P, Lokhande R, Kulkarni V, Hanna LE, Thiruvengadam K, Sekar K, Momin A, Shivakumar SVBY, Gupte N, Babu S, Salvi S, Golub J, Checkley W, Bollinger RC, Andrade B, Mave V, Chandrasekaran P, Gupta A. IL-6, TIMP-2 and TGFβ-2 are associated with respiratory...

Determination of Plasma Clofazimine Levels by Liquid Chromatography-Mass Spectrometry

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2019-02-04
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Chawla PK , Lokhande RV, Naik PR, Dherai AJ, Udwadia ZF, Mahashur AA, Pinto L, Soman R, Rodrigues C, Gupta A, Tornheim JA, Martinson N, Variava E, Weisner L, Joubert A, Ashavaid TF. Determination of Plasma Clofazimine Levels by Liquid Chromatography-Mass Spectrometry. 8th Annual Regional...

Determination of Serum Linezolid Levels by HPLC

Post Date: 
2019-02-04
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Chawla PK , Lokhande RV, NaiF PR, Dherai AJ, Udwadia ZF, Mahashur AA, Soman R, Rodrigues C, Gupta A, Tornheim JA, Ashavaid TK. Determination of Serum Linezolid Levels by HPLC. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India Joint Leadership meeting – ‘’...

Mental Health and TB: High Prevalence of Depression among Drug-resistant TB Patients not Associated with Cycloserine

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2019-02-04
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Shivakumar SVBY , Tornheim JA, Gajjar I, Porwal S, Kishore G, Karane M, Sayed S, Chawla PK, Rodrigues C, Ashavaid TK, Gupta A, Udwadia ZF. Mental Health and TB: High prevalence of depression among drug-resistant TB patients not associated with cycloserine. 8th Annual Regional Prospective...

Quality of Life Among MDR-TB Patients from the Public Sector in Mumbai

Post Date: 
2019-02-04
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Gajjar IN , Udwadia ZF, Kishore G, Karane M, Sayed S, Sawant N, Chawla PK, Rodrigues C, Ashavaid TK, Shivakumar SVBY, Gupta A, Tornheim JA. Quality of Life Among MDR-TB Patients from the Public Sector in Mumbai. 8th Annual Regional Prospective Observational Research for Tuberculosis (RePORT) India...

Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance

Post Date: 
2019-02-04
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Kambli P , Tornheim JA, Soundararajan L, Priyadarshini S, Gupta R, Ramprasad VL, Gupta A, Rodrigues C. Whole Genome Sequencing of Mycobacterium Tuberculosis Directly from Clinical Samples Accurately Identifies Drug Resistance. 8th Annual Regional Prospective Observational Research for Tuberculosis...

Host Lipidomic Profile Associated with Adverse Tuberculosis Treatment Outcomes

Post Date: 
2019-02-04
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Shivakoti R , Chandrasekaran P, Hannah LE, Thiruvengadam K, Saravanan N, Karunaianatham R, Gupta A, Mave V, Gupte N, Kulkarni V, Pradhan N, Gupte A, Paradkar M, Shivakumar SVBY, Bharadwaj, Kagal A, Gaikwad S, Sangle S, Borkowski K, Newman J, Fiehn O. Host Lipidomic Profile Associated with Adverse...

Does Smoking Have an Impact on TB Treatment Outcomes?

Post Date: 
2018-10-27
Thomas B, Kannan T, Rani V, Gupte N, Gupta A, Deluca A, Suryavanshi N, Kohli R, Chandrasekaran P for the CTRIUMPH RePORT India Study Team. Does Smoking Have an Impact on TB Treatment Outcomes? A Prospective Cohort Study from India. Session: Tobacco Use in Various Populations: Implications for...

Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India

Post Date: 
2018-10-27
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Dhumal G, DeLuca A, Chandanwale A, Kadam D, Joshi S, Kinikar A, Suryavanshi N, Mave V, Gupta A, Bollinger R. Impact of Fogarty HIV-TB Training Program on ‘Institutional Research Capacity Building’ at the Byramjee Jeejeebhoy Government Medical College (BJGMC), Pune, India. Session: Building...

Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes

Post Date: 
2018-10-27
Mathad J, Alexander M, Bhosale R, Shere D, Kulkarni V, Kumar P, Babu S, Gupta A for the PRACHITi Study team. Gestational Diabetes Suppresses the Inflammatory Response to M. tuberculosis in Pregnant Women in Pune, India. Session: Clinical Investigation for TB and Diabetes. 49th Annual Union World...

Managing Tuberculosis in Pregnancy. Meet the Expert Session

Post Date: 
2018-10-26
Gupta A. Managing Tuberculosis in Pregnancy. Meet the Expert Session. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Factors Associated with Loss to Follow-up and Mortality in Public Sector MDR TB Treatment in Western Maharashtra, India from 2015-2016

Post Date: 
2018-10-26
Murrill M, More SW, Kamble S, Kulkarni V, Dowdy D, Gupta A. Factors Associated with Loss to Follow-up and Mortality in Public Sector MDR TB Treatment in Western Maharashtra, India from 2015-2016. 49th Annual Union World Conference on Lung Health. The Hague, The Netherlands. October 24,-27, 2018.

Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin

Post Date: 
2018-10-26
Mave V, Gupte N, Gaikwad S, Barthwal M, Chon S, Gupte A, Gupta A, Golub J. Mortality Risk Doubled in Tuberculosis Patients with Diabetes Not Receiving Metformin. Presented at 49th Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

Addressing policy needs for controlling TB and multidrug-resistant TB (MDR-TB): a biosocial inquiry among patients in Pune city in Western Maharashtra, India

Post Date: 
2018-10-26
Atre S. Addressing policy needs for controlling TB and multidrug-resistant TB (MDR-TB): a biosocial inquiry among patients in Pune city in Western Maharashtra, India. Presented at 49th Union World Conference on Lung Health. The Hague, The Netherlands. October 24-27, 2018.

BRIEF TB Treatment of Latent TB Infection With One Month of Isoniazid & Rifapentine in HIV-Infected People: Interaction of Treatment & CD4 Count

Post Date: 
2018-10-25
Swindells S, Ramchandami R, Gupta A, Sanchez J, Juste MAJ, Mwelase N, Chaisson R, BRIEF TB Study Team. BRIEF TB Treatment of Latent TB Infection With One Month of Isoniazid & Rifapentine in HIV-Infected People: Interaction of Treatment & CD4 Count. Session: TB Infection: From Latent to...

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Shivani Mehta

Baltimore, Maryland
Shivani Mehta is a BS/BA candidate (2018) in public health at the Johns Hopkins Krieger School of Arts and Sciences, who is working with Drs. Rupak Shivakoti and Mallika Alexander on Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes. Ms. Mehta spent June and July 2016 at BJGMC in Pune, India, working under Dr. Alexander. Awards 2016 Global Health Established Field Placement Grant 2016 Johns Hopkins Provost Undergradulate Research Award for 2016-17 From Ms. Mehta's Field Report: This week, as the patients come in, I have been sitting with the counselors and...

Erica Orsini, MD

Pune, India
From January 3, 2018 to February 26, 2018, Dr. Orsini worked under Drs. Vidya Mave and Amita Gupta to observe clinical rounds and provide support to the BJGMC Clinical Research Site. She also supported provides the CTRIUMPh substudy entitled “Residual Respiratory Impairment Following Pulmonary TB” and the study entitled “Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients.”

Abhilash Suresh

Baltimore, Maryland
Abhilash Suresh is a BS candidate in biomedical engineering at Johns Hopkins Whiting School of Engineering (2018), who worked with Drs. Akshay Gupte and Shri Vijay Bala Yogendra Shivakumar on the C-TRIUMPH substudy on Residual Respiratory Impairment Following Pulmonary Tuberculosis. During May and June 2016 he conducted a field placement in Chennai, India, at the National Institute for Research in Tuberculosis where he worked under Dr. Shivakumar. Awards 2016 Global Health Established Field Placement Grant From Mr. Suresh's Field Report: This placement opened my eyes to how healthcare works...

Lubaina Arsiwala

Lubaina Arsiwala
Dr. Arsiwala is a Johns Hopkins Masters of Health Science student with a Bachelor in Dental Survey from DY Patil University School of Dentistry, Navi Mumbai, India. She visited BJGMC from June 18, 2018, to August 11, 2018, to provide support to the BJGMC Clinical Research Site. She is working with Dr. Matthew Robinson to support to ongoing studies, including “Antimicrobial Use and Diagnosis among Hospitalized Febrile Patients in Pune, India” and “Prevalence and Risk Factors for Oral Cancer among HIV-Infected Adults.” Dr. Arsiwala received funding for her visit through the Johns Hopkins Global...

Saraniya Tharmarajah

Saraniya Tharmarajah is a public health studies student at the Johns Hopkins Krieger School of Arts and Sciences (2017). During June-July 2015, she conducted a field study placement at the National Institute of Research in Tuberculosis in Chennai, India, where she worked on the C-TRIUMPH lung health substudy. Ms. Tharmarajah is a 2015 recipient of the Global Health Established Field Placement Grant.

Pranay Vishwanath

Baltimore, Maryland
Pranay-Vishwanath
Pranay Vishwanath is a master's candidate in the field of Bioinformatics at Johns Hopkins University in Baltimore, and anticipated to graduate in Fall 2018. He is working with Drs. Amita Gupta and Jeffrey Tornheim, and is focusing on organization of data and generation/streamlining of bioinformatic pipelines for analysis of TB drug resistance assays. He received a bachelor's degree in Biotechnology at the Hong Kong University of Science & Technology in 2016.

Prarthana Vasudevan

Baltimore, Maryland
Prar Vasudevan is an international health graduate student at the Johns Hopkins School of Public Health. In Autumn 2015, she conducted a field placement in Pune, India, at BJGMC under Dr. Vidya Mave, where she worked on the study titled Maternal Inflammation, Diet and Gut Microbiome in HIV: Impact on Infant Outcomes. She is a 2015 recipient of the Global Health Established Field Placement Grant. From Prar Vasudevan's Field Report: At BJMC, I had the opportunity to make rounds in the hospital’s ART Clinic, Labor & Delivery wards, and children’s wards. I was immediately struck by the fact...

Jessica Elf, MPH, PhD

Post Doctoral Fellow
Dr. Jessica Elf was a post doctoral fellow in the Department of International Health at the Johns Hopkins School of Public Health. Her primary research focus was on the epidemiology and health impacts of tobacco use and exposure to indoor air pollution from the combustion of biomass fuels. She is a former Fogarty Fellow who lived and worked in Pune, India conducting research for her thesis project, which investigated the association between indoor air pollution and tuberculosis. She completed her undergraduate education in nutrition at the University of Florida and received an MPH and PhD the...

Jeff Tornheim, MD, MPH

Infectious Disease Fellow
Baltimore, Maryland
Jeff Tornheim, MD, MPH, is a clinical fellow in the Division of Infectious Disease here at Johns Hopkins University School of Medicine. After completing undergraduate studies in International Development and Economics at Brandeis University he moved to East Africa where he engaged in health system strengthening for returning refugees to South Sudan and worked with the Centers for Disease Control and Prevention (CDC) on the epidemiology of pneumonia and diarrhea in Western Kenya. He completed a joint MD/MPH at Mount Sinai School of Medicine, with his thesis evaluating the impact of water...

Matt Robinson, MD

Research Fellow
Baltimore, Maryland
Matthew Robinson, MD, is a research fellow in the Division of Infectious Diseases at Johns Hopkins University School of Medicine. His research focuses on the diagnosis of acute febrile illness and its implication on antimicrobial stewardship and resistance in tropical low- and middle-income countries. Matt is working with Dr. Gupta, Dr. Mave, and Dr. Cosgrove to assess the etiology of febrile illness in patients presenting to a hospital in Pune, India and to determine how diagnosis impacts antibiotic use. He is also working on a CDC-funded project to evaluate the source of antimicrobial...

Aarti Avinash Kinikar, MD: Pediatrics

BJGMC-JHU Fogarty HIV-TB Program Trainee
Pune, India
Education : MBBS (1984); DCH (1988); MD-Paediatrics (1988), DNB-Paediatrics (2003); MRCP-UK (1995). Medical Education- Grant Medical College – Mumbai University, India.

Akshay Gupte, PhD, MBBS, MSPH

Junior Investigator
Akshay Gupte
Akshay Gupte is a junior investigator trained in medicine, clinical research, and global health. His research interests include exploring approaches to host directed adjuvant therapies in tuberculosis (TB) and studying the impact of TB and HIV on lung health of populations. Dr. Gupte leads an Indo-US collaborative study exploring the impact of TB disease; alone and in combination with smoking, air pollution, HIV and diabetes mellitus; on respiratory impairment and risk of chronic obstructive pulmonary disease in India. He is also a co-investigator on the CTRIUMPH study—a multi-center cohort...

Amit Kale, MS: Orthopedics

BJGMC-JHU Fogarty HIV-TB Program Trainee
Pune, India
I am working as associate professor in orthopedics. Currently, I am conducting various drug trials for rheumatoid arthritis.

Anita Basavaraj, MD: Gastroenterology

BJGMC-JHU Fogarty HIV-TB Program Trainee
Pune, India
Dr Anita Basavaraj has done her MBBS from Nagpur University with Honors in Surgery (1987). Thereafter she did her MD in Medicine (1990) and her Diplomat of National Board (D.N.B.) in 1992.She has done her post graduate Diploma in geriatric Medicine (P.G.D.G.M.) winning the university Gold Medal by virtue of standing first in the country (2012), which is a distant education venture run by Indira Gandhi National Open University (IGNOU).

Geeta Shrikar Pardeshi, MD: Preventive and Social Medicine

BJGMC-JHU Fogarty HIV-TB Program Trainee
Pune, India
I have led research projects related to Reproductive and Child Health, Sanitation and Infectious diseases. As part of the BJGMC JHU Fogarty training program in HIV-TB, I have research interest in TB epidemiology. I am interested in studying the association of co-morbidities with clinical presentation and treatment outcomes in tuberculosis.

Sunita Girish, PhD: Medical Biochemistry

BJGMC-JHU Fogarty HIV-TB Program Trainee
Pune, India
Education : Ph.D, Pune University, 2005 (Medical Biochemistry) title “Antioxidant Status in Leprosy.” Overview : How to improve health systems to combat various infectious diseases like Leprosy, Tuberculosis and HIV in developing countries, is a research and policy issue that affects many aspects of public health. My research interests include further to understand molecular level changes in cystic fibrosis which is under diagnosed .My interests also involve innovations in molecular techniques dealing with infectious diseases, help governments in developing countries to improve and modify...

Akshay Gupte, PhD, MBBS, MSPH

Junior Investigator
Akshay Gupte
Dr. Gupte is a junior investigator trained in medicine, clinical research, and global health. He recently completed his doctoral training in the Department of International Health at the Johns Hopkins Bloomberg School of Public Health (JHSPH). His research interests include exploring approaches to host directed adjuvant therapies in tuberculosis (TB) and studying the impact of TB and HIV on lung health of populations. Dr. Gupte leads an Indo-US collaborative study exploring the impact of TB disease alone, and in combination with smoking, air pollution, HIV and diabetes mellitus; on...

Sangita Shelke, MD: Preventive and Social Medicine; Diplomas in Nutrition, Hospital Administration, Psychological counseling

BJGMC-JHU Fogarty HIV-TB Program Trainee
Pune, India
Indeed TB is a social disease with so many social problems especially the women suffering from TB/HIV undergoes a pathetic life situation. Women are silent suffers, of both HIV and TB in male dominated society of India. My ultimate desire is if I can make a difference in the lives of these silent suffers.

Jessica Elf, MPH, PhD

Assistant Professor, Colorado State University
Dr. Jessica Elf is an Assistant Professor of Epidemiology in the Department of Environmental and Radiological Health Sciences at Colorado State University. Dr. Elf’s research focuses on the epidemiology and health impacts of air pollution and tobacco use, with an emphasis on the HIV and tuberculosis (TB) co-epidemic. Her work aims to describe the overlap of air pollution and tobacco with these epidemics and the subsequent impact on TB and HIV health outcomes. In addition to risk characterization, her work focuses on subsequent mitigation strategies and interventions that are effective,...

Dr. Smita Deshpande: Microbiology

BJGMC-JHU Fogarty HIV-TB Program Trainee
My research interests have been: Rapid diagnostic methods for Acute pyogenic meningitis, Diagnosis of enteric fever , Role of Methicillin resistance Staph aureus in infections, Molecular diagnosis of Leptospirosis, Rapid diagnosis of MDR-TB by REMA ( Resasurine Micro titre Plate Assay)and by Line Probe Assay.

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Amita Gupta Named to NIAID Council

Post Date: 
2019-09-06
Amita Gupta
CCGHE Deptuy Director Amita Gupta was recently appointed for a 4-year term to the NIAID Advisory Council at the National Institutes of Health

FDA OKs 'Game Changer' Pretomanid for Highly Resistant TB

Post Date: 
2019-08-14
Amita Gupta
Medscape: Dr. Amita Gupta weighs in on the FDA approval of a new drug for XDR-TB

NIH Launches Large TB Prevention Trial for People Exposed to Multidrug-Resistant TB

Post Date: 
2019-06-25
Tuberculosis bacteria
NIH Press Release : NIH announces a large international clinical trial to prevent multidrug-resistant TB in children, adolescents, and adults who live with someone who has MDR-TB. CCGHE's Dr. Amita Gupta is a protocol chair.

TB prevention critical among people with HIV

Post Date: 
2019-03-12
Source: 
Infectious Disease News via Healio
Amita Gupta
Infectious Disease News caught up with Dr. Amita Gupta at CROI 2019 to talk about TB prevention among people living with HIV

Celebration of the Dedicated Participants and Staff of the REPRIEVE Study in Pune, India

Post Date: 
2019-02-18
REPRIEVE Team Members of the BJGMC Clinical Research Site
Staff and nearly 140 participants in the REPRIEVE study gathered for a community event in Pune, India

Gupta, Page named Hopkins Mission Honorees

Post Date: 
2018-10-02
Source: 
Hopkins Medicine
Honorees
125 honorees were selected for their outstanding dedication to Hopkins' core values; CCGHE's Amita Gupta and Kathleen Page were among them.

Bollinger Installed as Raj & Kamla Gupta Professor of Infectious Diseases

Post Date: 
2018-09-17
Raj and Kamla Gupta and Dr. Robert C. Bollinger
On September 5, CCGHE Director Dr. Robert C. Bollinger was installed as the inaugural recipient of the Raj and Kamla Gupta Professorship in Infectious Diseases, funded by the Ujala Foundation.

Doctor who tackled HIV and other infectious diseases in India honored

Post Date: 
2018-09-11
Source: 
India Abroad
Robert Bollinger
India Abroad article highlights the dedication of the Raj and Kamla Gupta Professorship in Infectious Diseases.

Amita Gupta and Sujata Bhatia: Doing a World of Good

Post Date: 
2018-08-29
Source: 
American Institute of Chemical Engineers
Amita Gupta
Amita Gupta is interviewed by AIChE about the intersection of chemical engineering and medicine.

BJGMC Clinical Research Team Exceeds 6,000 Participant Enrollments in 4 Years

Post Date: 
2018-08-03
Group Photo, BJGMC Clinical Research Site, 2016, Pune, India
The Indo-JHU Clinical Research partnership at BJGMC in Pune, India, is now one of the top enrollers among all ACTG research sites internationally.

Isoniazid preventive therapy: do the risks outweigh the benefits in pregnant women with HIV?

Post Date: 
2018-03-13
Source: 
aidsmap
. . . Isoniazid preventive therapy (IPT) during and after pregnancy in women living with HIV on antiretroviral therapy (ART) in tuberculosis (TB) endemic areas in Africa, Asia and Haiti resulted in serious adverse events quite possibly attributable to isoniazid with no significant reduction in TB...

Adverse pregnancy outcomes with isoniazid preventive therapy in HIV

Post Date: 
2018-03-09
Source: 
Infectious Disease Advisor
. . . The safety of IPT in pregnant women with HIV is unknown, especially with regard to its combination with highly active antiretroviral therapy (ART). Amita Gupta, MD, deputy director of the Johns Hopkins University Center for Clinical Global Health Education at the Johns Hopkins...

No difference in safety for HIV+ pregnant women deferring TB Tx

Post Date: 
2018-03-09
Source: 
MedPage Today
First randomized clinical trail of IPT in pregnant and postpartum women may suggest need for WHO guideline change.

Preventive TB therapy during pregnancy causes excessive adverse events

Post Date: 
2018-03-08
Source: 
Healio Infectious Disease News
. . . “Identifying ways to prevent TB during pregnancy and the postpartum period is a really important way to address maternal and infant health for a globally important disease such as tuberculosis,” Amita Gupta, MD, MHS, associate professor of medicine and international health and deputy director...

Study Results for IMPAACT P1078 Presented at CROI 2018

Post Date: 
2018-03-07
Source: 
IMPAACT Network News
IMPAACT Network News: Dr. Amita Gupta presented findings at CROI 2018.

One-Month Tuberculosis Prophylaxis as Effective as Nine-Month Regimen for People Living with HIV

Post Date: 
2018-03-05
NIH Logo
The Indo-JHU Clinical Research Partnership participated in this important study that could change TB prevention for people living with HIV.

Tip Sheet: Johns Hopkins Researchers Present at Annual CROI Meeting

Post Date: 
2018-03-01
Newswise — Amita Gupta, M.D., deputy director of the Johns Hopkins University Center for Clinical Global Health Education at the Johns Hopkins University School of Medicine, will present a multicounty study of preventive treatment for tuberculosis (TB) in HIV-infected pregnant and postpartum women—...

2017 Year in Review

Post Date: 
2018-02-19
What a year! Our 2017 Year In Review outlines the most ambitious 365 days we’ve had to date.

Uniting for a Healthier India

Post Date: 
2018-02-14
"The Indo-US clinical research & education partnership started with a single NIH grant to study maternal-infant HIV transmission." Now with 76 studies underway, this short film chronicles the history & impact of our work in India.

Celebrating Johns Hopkins Medicine's impact in India

Post Date: 
2017-12-13
Source: 
The Campaign for Johns Hopkins Medicine
In 4 years, the CCGHE has tripled its capacity for conducting research on grave health threats, thanks to strong philanthropic support.

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